Academic Journal
High cholesterol absorption efficiency enhances proatherogenic properties of low-density lipoprotein particles.
| Τίτλος: | High cholesterol absorption efficiency enhances proatherogenic properties of low-density lipoprotein particles. |
|---|---|
| Συγγραφείς: | Öörni K; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland.; Molecular and Integrative Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Äikäs L; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland.; Molecular and Integrative Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Ruuth M; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland., Tigistu-Sahle F; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland.; Molecular and Integrative Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Käkelä R; Molecular and Integrative Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.; Helsinki University Lipidomics Unit, HiLIPID, Helsinki Institute of Life Science, HiLIFE, and Biocenter Finland, Helsinki, Finland., Wester I; Raisio Group plc, Raisio, Finland., Gylling H; Heart and Lung Center, Cardiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Simonen P; Heart and Lung Center, Cardiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. |
| Πηγή: | Journal of internal medicine [J Intern Med] 2026 Jun; Vol. 299 (6), pp. 711-725. Date of Electronic Publication: 2026 Apr 02. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8904841 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2796 (Electronic) Linking ISSN: 09546820 NLM ISO Abbreviation: J Intern Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford : Blackwell Scientific Publications, c1989- |
| Ιατρικοί όροι (MeSH): | Atherosclerosis*/blood , Atherosclerosis*/etiology , Atherosclerosis*/metabolism , Lipoproteins, LDL*/blood , Lipoproteins, LDL*/metabolism , Cholesterol*/blood , Cholesterol*/metabolism , Intestinal Absorption*, Cholestanol/blood ; Proteoglycans/metabolism ; Humans ; Female ; Male ; Middle Aged |
| Περίληψη: | Background and Aims: High cholesterol absorption efficiency is determined by genetic variation in small intestinal sterol transporters and affects one-third of individuals. Their risk for atherosclerotic cardiovascular disease (ASCVD) is increased compared with low cholesterol absorbers, despite similar serum lipid concentrations. We investigated the association of cholesterol absorption efficiency with proatherogenic properties of low-density lipoproteins (LDLs). Methods: The study cohort consisted of 90 middle-aged participants, 56 females and 34 males, without lipid-lowering therapy or ASCVD. They were divided into low (n = 45) and high (n = 45) cholesterol absorbers by the median value of serum cholestanol to cholesterol ratio. LDL aggregation susceptibility and binding of lipoproteins to proteoglycans were determined as biomarkers of lipoprotein atherogenicity. Nuclear magnetic resonance spectroscopy, mass spectrometry, and gas-liquid chromatography were used to determine lipoprotein subclass profile, LDL lipidome, and serum concentrations of cholesterol and noncholesterol sterols, respectively. Results: Age, dietary cholesterol, and serum total cholesterol or lipoprotein cholesterol levels did not differ between the groups. In the high absorbers, LDL particles were larger, and LDL aggregation susceptibility and the binding of lipoproteins to proteoglycans were increased in the low absorbers. Of LDL surface lipids, sphingomyelin 42:3;O2, and phosphatidylcholine (PC) 32:0 correlated positively, whereas PC 32:1 correlated negatively with serum cholestanol levels. These LDL surface lipids were also associated with increased LDL aggregation susceptibility and proteoglycan-binding. Conclusions: The present findings suggest that increased proatherogenic properties in high cholesterol absorbers may contribute to increased ASCVD risk. Registration: https://clinicaltrials.gov/study/NCT01315964. (© 2026 The Author(s). Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.) |
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| Grant Information: | Jenny and Antti Wihuri Foundation; 315568 Research Council of Finland; 332564 Research Council of Finland; Sigrid Jusélius Foundation; NNF19OC0057411 Novo Nordisk Foundation; Raisio Nutrition Ltd; Finnish Foundation for Cardiovascular Research |
| Contributed Indexing: | Keywords: atherosclerosis; atherosclerotic cardiovascular disease; cholesterol absorption; cholesterol metabolism; lipidomics; low‐density lipoprotein aggregation; proteoglycan‐binding |
| Molecular Sequence: | ClinicalTrials.gov NCT01315964 |
| Substance Nomenclature: | 0 (Lipoproteins, LDL) 97C5T2UQ7J (Cholesterol) 8M308U816E (Cholestanol) 0 (Proteoglycans) |
| Entry Date(s): | Date Created: 20260402 Date Completed: 20260714 Latest Revision: 20260714 |
| Update Code: | 20260714 |
| PubMed Central ID: | PMC13137395 |
| DOI: | 10.1111/joim.70085 |
| PMID: | 41927512 |
| Βάση Δεδομένων: | MEDLINE |
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