Academic Journal
Completion of Doxycycline Treatment Regimens for Syphilis During the 2023-2024 Benzathine Penicillin G Shortage, Baltimore City Health Department Clinics, Baltimore City, Maryland.
| Τίτλος: | Completion of Doxycycline Treatment Regimens for Syphilis During the 2023-2024 Benzathine Penicillin G Shortage, Baltimore City Health Department Clinics, Baltimore City, Maryland. |
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| Συγγραφείς: | Schumacher CM; From the Department of Pediatrics, Center for Child and Community Health Research, Johns Hopkins School of Medicine, Baltimore, MD., Gilliams E; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD., Greenbaum A; Sexual Health and Wellness Clinic, Baltimore City Health Department, Baltimore, MD., Hamill MM; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD.; Sexual Health and Wellness Clinic, Baltimore City Health Department, Baltimore, MD. |
| Πηγή: | Sexually transmitted diseases [Sex Transm Dis] 2026 Aug 01; Vol. 53 (8), pp. e58-e61. Date of Electronic Publication: 2026 Apr 02. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: J B Lippincott Country of Publication: United States NLM ID: 7705941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-4521 (Electronic) Linking ISSN: 01485717 NLM ISO Abbreviation: Sex Transm Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: Philadelphia Pa : J B Lippincott Original Publication: Philadelphia, Lippincott. |
| Ιατρικοί όροι (MeSH): | Syphilis*/drug therapy , Penicillin G Benzathine*/supply & distribution , Doxycycline*/therapeutic use , Doxycycline*/supply & distribution , Anti-Bacterial Agents*/supply & distribution , Anti-Bacterial Agents*/therapeutic use, Baltimore/epidemiology ; Humans ; Female ; Male ; Adult ; Middle Aged |
| Περίληψη: | During the 2023-2024 benzathine penicillin G shortage, Baltimore City sexual health clinics assessed syphilis treatment completion among patients prescribed doxycycline. Among 312 patients prescribed doxycycline, 42% were contacted, of whom 80% reported completing treatment. Results underscore the need to understand treatment completion during current and future benzathine penicillin G shortages. (Copyright © 2026 American Sexually Transmitted Diseases Association. All rights reserved.) |
| Competing Interests: | Conflict of Interest and Sources of Funding: The work was supported in part by the US Centers for Disease Control and Prevention grants: NH25PS005187, NH25PS005259 (to C.M.S.). The authors declare no conflict of interest. |
| References: | Hamill MM, Ghanem KG, Tuddenham S. State-of-the-art review: Neurosyphilis. Clin Infect Dis 2024;78:e57–e68. Stafford IA, Workowski KA, Bachmann LH. Syphilis complicating pregnancy and congenital syphilis. N Engl J Med 2024;390:242–253. US Centers for Disease Control and Prevention. Sexually Transmitted Infections Surveillance 2023. US Department of Health and Human Services; 2024. Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep 2021;70:1–187. Pfizer. Availability Update for Bicillin® L-A (penicillin G benzathine injectable suspension) and Bicillin® C-R (penicillin G benzathine and penicillin G procaine injectable suspension) Prefilled Syringes. July 12, 2023. Available at: https://www.fda.gov/media/169427/download . Accessed January 18, 2026. Bachmann LH, Mermin JH. Dear Colleage Letter: FDA Announcement on Availability of Extencilline. January 16, 2024. Available at: https://www.cdc.gov/sti/php/from-the-director/2024-01-16-bachmann-extencilline.html . Accessed January 18, 2026. Kalyarnaraman N. Maryland Department of Health Dear Colleague Letter: URGENT: Critial Penicillin G Benzathine (Bicillin) Shortage Earliest Anticipated Recovery Date - Quarter 2, 2024. Online; 2023. Bachmann LH, Stoner B. Dear Colleague Letter: Bicillin L-A. July 18, 2025. Available at: https://www.cdc.gov/sti/php/from-the-director/2025-07-bicillin-recall.html . Accessed December 1, 2025. Apato A, Cruz SN, Desai D, et al. Doxycycline adherence for the management of Chlamydia trachomatis infections. Am J Emerg Med 2024;81:136–139. Augenbraun M, Bachmann L, Wallace T, et al. Compliance with doxycycline therapy in sexually transmitted diseases clinics. Sex Transm Dis 1998;25:1–4. Bachmann LH, Stephens J, Richey CM, et al. Measured versus self-reported compliance with doxycycline therapy for chlamydia-associated syndromes: High therapeutic success rates despite poor compliance. Sex Transm Dis 1999;26:272–278. Ridelman D, Heisler S, Groves A. Adherence to doxycycline for uncomplicated genitourinary chlamydia: A prospective observational study. J Am Coll Emerg Physicians Open 2024;5:e13137. |
| Substance Nomenclature: | RIT82F58GK (Penicillin G Benzathine) N12000U13O (Doxycycline) 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20260402 Date Completed: 20260701 Latest Revision: 20260701 |
| Update Code: | 20260702 |
| DOI: | 10.1097/OLQ.0000000000002323 |
| PMID: | 41925363 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1537-4521 |
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| DOI: | 10.1097/OLQ.0000000000002323 |