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DNA-triggered AIM2 condensation orchestrates immune activation and regulation.

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Τίτλος: DNA-triggered AIM2 condensation orchestrates immune activation and regulation.
Συγγραφείς: Li Q; School of Life Science, Beijing Institute of Technology, Beijing 100081, China.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Geng X; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Yan H; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Li Z; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Shi M; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China., Zhu Z; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Niu T; Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Zhao C; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Shu K; University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Gao Y; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Feng H; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Liu S; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Jiang Q; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China., Bu P; University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Li D; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, IDG/McGovern Institute for Brain Research, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China., Gao P; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China.
Πηγή: Protein & cell [Protein Cell] 2026 Sep 01; Vol. 17 (9), pp. 807-820.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: Germany NLM ID: 101532368 Publication Model: Print Cited Medium: Internet ISSN: 1674-8018 (Electronic) Linking ISSN: 1674800X NLM ISO Abbreviation: Protein Cell Subsets: MEDLINE
Imprint Name(s): Publication: 2023- : [Oxford] : Oxford University Press
Original Publication: Heidelberg : Beijing, China : Springer ; Higher Education Press
Ιατρικοί όροι (MeSH): DNA-Binding Proteins*/immunology , DNA-Binding Proteins*/chemistry , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Inflammasomes*/immunology , Inflammasomes*/metabolism , DNA*/immunology , DNA*/chemistry , DNA*/metabolism , Immunity, Innate*, Animals ; Humans ; Innate Immunity Recognition ; Mice ; Phase Separation
Περίληψη: The innate immune sensor AIM2 detects cytosolic DNA and initiates inflammatory responses, yet its activation mechanism remains incompletely understood. Here, we show that AIM2 undergoes liquid-liquid phase separation upon DNA binding, forming dynamic condensates both in vitro and in cells. These condensates serve as platforms for inflammasome and PANoptosome assembly, promoting immune activation across multiple pathways. Direct structural determination from condensates reveals the assembly of active-form ASC filaments. Mechanistically, liquid-phase condensation is governed by multivalent interactions involving different AIM2 domains, including previously uncharacterized regions and species-specific elements. In vitro and in vivo assays show that mutants specifically disrupting condensation impair immune complex assembly, cell death initiation, antimicrobial defense, and intestinal homeostasis. Moreover, AIM2-DNA condensates function as regulatory hubs targeted by host- and pathogen-derived factors to balance immune homeostasis or facilitate immune evasion. These findings establish liquid-phase condensation as a fundamental mechanism of AIM2 activation and a potential therapeutic target.
(© The Author(s) 2026. Published by Oxford University Press on behalf of Higher Education Press.)
References: Proc Natl Acad Sci U S A. 2010 May 25;107(21):9771-6. (PMID: 20457908)
Immunol Rev. 2020 Sep;297(1):83-95. (PMID: 32713036)
Cell Host Microbe. 2018 Feb 14;23(2):254-265.e7. (PMID: 29447697)
Nat Commun. 2015 Jul 22;6:7827. (PMID: 26197926)
Nature. 2020 Apr;580(7805):647-652. (PMID: 32350463)
Cell. 2014 Mar 13;156(6):1193-1206. (PMID: 24630722)
Cell. 2015 Jul 2;162(1):45-58. (PMID: 26095253)
Pharmacol Res. 2022 Dec;186:106533. (PMID: 36332811)
Cell Death Differ. 2013 Sep;20(9):1149-60. (PMID: 23645208)
Nature. 2021 Sep;597(7876):415-419. (PMID: 34471287)
Cell Res. 2013 Jun;23(6):855-8. (PMID: 23567559)
J Biol Chem. 2013 May 10;288(19):13225-35. (PMID: 23530044)
Nature. 2009 Mar 26;458(7237):509-13. (PMID: 19158676)
Cell Rep. 2015 Dec 1;13(9):1922-36. (PMID: 26655906)
Cell Host Microbe. 2010 May 20;7(5):412-9. (PMID: 20417169)
Nucleic Acids Res. 2021 Sep 20;49(16):9389-9403. (PMID: 34387695)
Nature. 2021 May;593(7860):607-611. (PMID: 33883744)
Nature. 2016 Jul 06;535(7610):153-8. (PMID: 27383986)
Nat Immunol. 2010 May;11(5):395-402. (PMID: 20351692)
J Immunol. 2010 Jul 15;185(2):818-21. (PMID: 20562263)
Trends Biochem Sci. 2017 Apr;42(4):245-254. (PMID: 27932073)
Nature. 2021 Apr;592(7853):296-301. (PMID: 33731931)
Cell Rep. 2013 Jul 25;4(2):327-39. (PMID: 23850291)
Nat Immunol. 2010 May;11(5):385-93. (PMID: 20351693)
Cell Mol Immunol. 2017 Jan;14(1):127-142. (PMID: 27524110)
Nature. 2009 Mar 26;458(7237):514-8. (PMID: 19158675)
Science. 2009 Feb 20;323(5917):1057-60. (PMID: 19131592)
Nature. 2015 Oct 29;526(7575):666-71. (PMID: 26375259)
Cell Discov. 2015;1:. (PMID: 26583071)
Immunol Rev. 2015 May;265(1):6-21. (PMID: 25879280)
Mol Cell. 2002 Aug;10(2):417-26. (PMID: 12191486)
Eur J Immunol. 2016 Feb;46(2):269-80. (PMID: 26626159)
Immunity. 2012 Apr 20;36(4):561-71. (PMID: 22483801)
Nature. 2015 Oct 29;526(7575):660-5. (PMID: 26375003)
Front Cell Infect Microbiol. 2019 Nov 26;9:406. (PMID: 31850239)
Nature. 2016 Jul 7;535(7610):111-6. (PMID: 27281216)
Mol Cell. 2021 Jul 1;81(13):2823-2837.e9. (PMID: 34015248)
Science. 2018 Aug 17;361(6403):704-709. (PMID: 29976794)
Cell Mol Immunol. 2023 Dec;20(12):1513-1526. (PMID: 38008850)
J Virol. 2020 Dec 9;95(5):. (PMID: 33298538)
Nucleic Acids Res. 2023 Apr 11;51(6):2574-2585. (PMID: 36864667)
Eur J Immunol. 2019 Nov;49(11):1998-2011. (PMID: 31372985)
Nat Rev Immunol. 2016 Jul;16(7):407-20. (PMID: 27291964)
J Mol Biol. 2014 Apr 3;426(7):1420-7. (PMID: 24406744)
Nature. 2024 Sep;633(8029):433-441. (PMID: 39112714)
Nat Immunol. 2009 Mar;10(3):266-72. (PMID: 19158679)
Grant Information: 2025ZD01904303 National Science and Technology Major Project of China; 32325028 National Natural Science Foundation of China; 32130057 National Natural Science Foundation of China; 32571417 National Natural Science Foundation of China; 2024YFA1307400 National Key R&D Program of China; XDB1310000 Strategic Priority Research Program; Z220018 Beijing Natural Science Foundation; JZHKYPT-2021-05 Basic Research Program Based on Major Scientific Infrastructures-CAS; YSBR-074 CAS Project for Young Scientists in Basic Research
Contributed Indexing: Keywords: AIM2; PANoptosome; inflammasome; innate immune; phase separation
Substance Nomenclature: 0 (DNA-Binding Proteins)
0 (AIM2 protein, human)
0 (Inflammasomes)
9007-49-2 (DNA)
0 (Aim2 protein, mouse)
Entry Date(s): Date Created: 20260326 Date Completed: 20260827 Latest Revision: 20260923
Update Code: 20260923
PubMed Central ID: PMC13521274
DOI: 10.1093/procel/pwag024
PMID: 41883156
Βάση Δεδομένων: MEDLINE
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  Data: DNA-triggered AIM2 condensation orchestrates immune activation and regulation.
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  Data: <searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; School of Life Science, Beijing Institute of Technology, Beijing 100081, China.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.<br /><searchLink fieldCode="AU" term="%22Geng+X%22">Geng X</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Yan+H%22">Yan H</searchLink>; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Shi+M%22">Shi M</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Niu+T%22">Niu T</searchLink>; Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.<br /><searchLink fieldCode="AU" term="%22Zhao+C%22">Zhao C</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Shu+K%22">Shu K</searchLink>; University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.<br /><searchLink fieldCode="AU" term="%22Feng+H%22">Feng H</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Q%22">Jiang Q</searchLink>; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China.<br /><searchLink fieldCode="AU" term="%22Bu+P%22">Bu P</searchLink>; University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, IDG/McGovern Institute for Brain Research, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China.<br /><searchLink fieldCode="AU" term="%22Gao+P%22">Gao P</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The innate immune sensor AIM2 detects cytosolic DNA and initiates inflammatory responses, yet its activation mechanism remains incompletely understood. Here, we show that AIM2 undergoes liquid-liquid phase separation upon DNA binding, forming dynamic condensates both in vitro and in cells. These condensates serve as platforms for inflammasome and PANoptosome assembly, promoting immune activation across multiple pathways. Direct structural determination from condensates reveals the assembly of active-form ASC filaments. Mechanistically, liquid-phase condensation is governed by multivalent interactions involving different AIM2 domains, including previously uncharacterized regions and species-specific elements. In vitro and in vivo assays show that mutants specifically disrupting condensation impair immune complex assembly, cell death initiation, antimicrobial defense, and intestinal homeostasis. Moreover, AIM2-DNA condensates function as regulatory hubs targeted by host- and pathogen-derived factors to balance immune homeostasis or facilitate immune evasion. These findings establish liquid-phase condensation as a fundamental mechanism of AIM2 activation and a potential therapeutic target.<br /> (© The Author(s) 2026. Published by Oxford University Press on behalf of Higher Education Press.)
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Proc Natl Acad Sci U S A. 2010 May 25;107(21):9771-6. (PMID: <searchLink fieldCode="PM" term="%2220457908%22">20457908)</searchLink><br />Immunol Rev. 2020 Sep;297(1):83-95. (PMID: <searchLink fieldCode="PM" term="%2232713036%22">32713036)</searchLink><br />Cell Host Microbe. 2018 Feb 14;23(2):254-265.e7. (PMID: <searchLink fieldCode="PM" term="%2229447697%22">29447697)</searchLink><br />Nat Commun. 2015 Jul 22;6:7827. (PMID: <searchLink fieldCode="PM" term="%2226197926%22">26197926)</searchLink><br />Nature. 2020 Apr;580(7805):647-652. (PMID: <searchLink fieldCode="PM" term="%2232350463%22">32350463)</searchLink><br />Cell. 2014 Mar 13;156(6):1193-1206. (PMID: <searchLink fieldCode="PM" term="%2224630722%22">24630722)</searchLink><br />Cell. 2015 Jul 2;162(1):45-58. (PMID: <searchLink fieldCode="PM" term="%2226095253%22">26095253)</searchLink><br />Pharmacol Res. 2022 Dec;186:106533. (PMID: <searchLink fieldCode="PM" term="%2236332811%22">36332811)</searchLink><br />Cell Death Differ. 2013 Sep;20(9):1149-60. (PMID: <searchLink fieldCode="PM" term="%2223645208%22">23645208)</searchLink><br />Nature. 2021 Sep;597(7876):415-419. (PMID: <searchLink fieldCode="PM" term="%2234471287%22">34471287)</searchLink><br />Cell Res. 2013 Jun;23(6):855-8. (PMID: <searchLink fieldCode="PM" term="%2223567559%22">23567559)</searchLink><br />J Biol Chem. 2013 May 10;288(19):13225-35. (PMID: <searchLink fieldCode="PM" term="%2223530044%22">23530044)</searchLink><br />Nature. 2009 Mar 26;458(7237):509-13. (PMID: <searchLink fieldCode="PM" term="%2219158676%22">19158676)</searchLink><br />Cell Rep. 2015 Dec 1;13(9):1922-36. (PMID: <searchLink fieldCode="PM" term="%2226655906%22">26655906)</searchLink><br />Cell Host Microbe. 2010 May 20;7(5):412-9. (PMID: <searchLink fieldCode="PM" term="%2220417169%22">20417169)</searchLink><br />Nucleic Acids Res. 2021 Sep 20;49(16):9389-9403. 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(PMID: <searchLink fieldCode="PM" term="%2226626159%22">26626159)</searchLink><br />Immunity. 2012 Apr 20;36(4):561-71. (PMID: <searchLink fieldCode="PM" term="%2222483801%22">22483801)</searchLink><br />Nature. 2015 Oct 29;526(7575):660-5. (PMID: <searchLink fieldCode="PM" term="%2226375003%22">26375003)</searchLink><br />Front Cell Infect Microbiol. 2019 Nov 26;9:406. (PMID: <searchLink fieldCode="PM" term="%2231850239%22">31850239)</searchLink><br />Nature. 2016 Jul 7;535(7610):111-6. (PMID: <searchLink fieldCode="PM" term="%2227281216%22">27281216)</searchLink><br />Mol Cell. 2021 Jul 1;81(13):2823-2837.e9. (PMID: <searchLink fieldCode="PM" term="%2234015248%22">34015248)</searchLink><br />Science. 2018 Aug 17;361(6403):704-709. (PMID: <searchLink fieldCode="PM" term="%2229976794%22">29976794)</searchLink><br />Cell Mol Immunol. 2023 Dec;20(12):1513-1526. (PMID: <searchLink fieldCode="PM" term="%2238008850%22">38008850)</searchLink><br />J Virol. 2020 Dec 9;95(5):. (PMID: <searchLink fieldCode="PM" term="%2233298538%22">33298538)</searchLink><br />Nucleic Acids Res. 2023 Apr 11;51(6):2574-2585. (PMID: <searchLink fieldCode="PM" term="%2236864667%22">36864667)</searchLink><br />Eur J Immunol. 2019 Nov;49(11):1998-2011. (PMID: <searchLink fieldCode="PM" term="%2231372985%22">31372985)</searchLink><br />Nat Rev Immunol. 2016 Jul;16(7):407-20. (PMID: <searchLink fieldCode="PM" term="%2227291964%22">27291964)</searchLink><br />J Mol Biol. 2014 Apr 3;426(7):1420-7. (PMID: <searchLink fieldCode="PM" term="%2224406744%22">24406744)</searchLink><br />Nature. 2024 Sep;633(8029):433-441. (PMID: <searchLink fieldCode="PM" term="%2239112714%22">39112714)</searchLink><br />Nat Immunol. 2009 Mar;10(3):266-72. (PMID: <searchLink fieldCode="PM" term="%2219158679%22">19158679)</searchLink>
– Name: GrantInfo
  Label: Grant Information
  Group: Grant
  Data: 2025ZD01904303 National Science and Technology Major Project of China; 32325028 National Natural Science Foundation of China; 32130057 National Natural Science Foundation of China; 32571417 National Natural Science Foundation of China; 2024YFA1307400 National Key R&D Program of China; XDB1310000 Strategic Priority Research Program; Z220018 Beijing Natural Science Foundation; JZHKYPT-2021-05 Basic Research Program Based on Major Scientific Infrastructures-CAS; YSBR-074 CAS Project for Young Scientists in Basic Research
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>AIM2; PANoptosome; inflammasome; innate immune; phase separation
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (DNA-Binding Proteins)<br />0 (AIM2 protein, human)<br />0 (Inflammasomes)<br />9007-49-2 (DNA)<br />0 (Aim2 protein, mouse)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260326 <i>Date Completed: </i>20260827 <i>Latest Revision: </i>20260923
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260923
– Name: PubmedCentralID
  Label: PubMed Central ID
  Group: ID
  Data: PMC13521274
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1093/procel/pwag024
– Name: AN
  Label: PMID
  Group: ID
  Data: 41883156
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=41883156
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1093/procel/pwag024
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 807
    Subjects:
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Innate Immunity Recognition
        Type: general
      – SubjectFull: Mice
        Type: general
      – SubjectFull: Phase Separation
        Type: general
      – SubjectFull: DNA-Binding Proteins immunology
        Type: general
      – SubjectFull: DNA-Binding Proteins chemistry
        Type: general
      – SubjectFull: DNA-Binding Proteins genetics
        Type: general
      – SubjectFull: DNA-Binding Proteins metabolism
        Type: general
      – SubjectFull: Inflammasomes immunology
        Type: general
      – SubjectFull: Inflammasomes metabolism
        Type: general
      – SubjectFull: DNA immunology
        Type: general
      – SubjectFull: DNA chemistry
        Type: general
      – SubjectFull: DNA metabolism
        Type: general
      – SubjectFull: Immunity, Innate
        Type: general
    Titles:
      – TitleFull: DNA-triggered AIM2 condensation orchestrates immune activation and regulation.
        Type: main
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          Dates:
            – D: 01
              M: 09
              Text: 2026 Sep 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1674-8018
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: Protein & cell
              Type: main
ResultId 1