Academic Journal
Cellular reprogramming beyond pluripotency.
| Τίτλος: | Cellular reprogramming beyond pluripotency. |
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| Συγγραφείς: | Núñez-Quintela V; Laboratory of Cell Senescence, Cancer and Aging, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. Electronic address: victor.nunez.quintela@rai.usc.es., Li H; Cellular Plasticity in Age-related Pathologies, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Université Paris Cité, Institut Pasteur, Paris, France., Collado M; Laboratory of Cell Senescence, Cancer and Aging, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain; Department of Immunology and Oncology (DIO), Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain. Electronic address: manuel.collado@usc.es. |
| Πηγή: | Trends in molecular medicine [Trends Mol Med] 2026 Aug; Vol. 32 (8), pp. 810-821. Date of Electronic Publication: 2026 Mar 20. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966035 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-499X (Electronic) Linking ISSN: 14714914 NLM ISO Abbreviation: Trends Mol Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford, UK : Elsevier Science Ltd., c2001- |
| Ιατρικοί όροι (MeSH): | Cellular Reprogramming*/genetics , Aging*/genetics , Pluripotent Stem Cells*/cytology , Pluripotent Stem Cells*/metabolism, Humans ; Animals ; Regeneration |
| Περίληψη: | Aging, once viewed as an irreversible process, is now considered a modifiable process. Recent advances in cellular reprogramming reveal that transient expression of reprogramming factors can reverse molecular hallmarks of aging while preserving somatic cell identity. This 'partial reprogramming' rejuvenates tissues, restores regenerative capacity, and, in some models, extends lifespan without the tumorigenic risks of full dedifferentiation. In this review, we summarize genetic and chemical strategies for partial reprogramming, discuss their tissue-specific effects in vivo, and evaluate their implications for tissue regeneration and age-related disease. We further examine key challenges for clinical translation, including safety, delivery strategies, and temporal control of reprogramming. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of interests The authors declare no competing interests. |
| Contributed Indexing: | Keywords: aging; chemical reprogramming; partial genetic reprogramming; rejuvenation |
| Entry Date(s): | Date Created: 20260321 Date Completed: 20260812 Latest Revision: 20260812 |
| Update Code: | 20260813 |
| DOI: | 10.1016/j.molmed.2026.01.007 |
| PMID: | 41864756 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1471-499X |
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| DOI: | 10.1016/j.molmed.2026.01.007 |