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Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025.

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Τίτλος: Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025.
Συγγραφείς: Tagliafico L; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy. Electronic address: luca.tagliafico@unige.it., Canevelli M; Department of Human Neuroscience, Sapienza University, Rome, Italy; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Barreto PS; IHU HealthAge, Toulouse, France; Institute on Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France; CERPOP, UMR 1295, Université Paul Sabatier, Toulouse, France., Cesari M; Child, Adolescent and Older People Unit, Department of Sexual, Reproductive, Maternal, Child, Adolescent and Ageing Health, World Health Organization, Geneva, Switzerland., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Vellas B; IHU HealthAge, Toulouse, France; Institute on Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France; CERPOP, UMR 1295, Université Paul Sabatier, Toulouse, France., Rolland Y; IHU HealthAge, Toulouse, France; Institute on Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France; CERPOP, UMR 1295, Université Paul Sabatier, Toulouse, France.
Συλλογικό Έργο: ICFSR Task Force
Πηγή: The Journal of frailty & aging [J Frailty Aging] 2026 Apr; Vol. 15 (2), pp. 100147. Date of Electronic Publication: 2026 Mar 19.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Serdi Edition Country of Publication: United States NLM ID: 101604797 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2260-1341 (Print) Linking ISSN: 22601341 NLM ISO Abbreviation: J Frailty Aging Subsets: MEDLINE
Imprint Name(s): Original Publication: Toulouse : Serdi Edition
Ιατρικοί όροι (MeSH): Sarcopenia*/therapy , Healthy Aging*/physiology , Geroscience*/methods , Frailty*, Aging/physiology ; Humans ; Clinical Trials as Topic ; Advisory Committees ; Biomarkers ; Aged
Περίληψη: The Intrinsic Capacity, Frailty and Sarcopenia Research (ICFSR) Task Force convened in March 2025 to discuss geroscience-oriented pre-clinical and clinical trials aimed at promoting healthy aging. Key topics included the use of aging biomarkers in clinical trials, senotherapeutics, metabolism-targeting medications, and therapeutic strategies beyond pharmacological approaches. The discussions highlighted the growing interest in, and accumulating evidence for, geroscience interventions. Several future challenges were identified, including the need for a deeper understanding of the biology of aging and the validation of aging biomarkers against relevant clinical outcomes, such as frailty and intrinsic capacity. Furthermore, to accelerate innovation in the field, there is a need to enhance clinical trial methodologies and harmonization-for example, by defining a minimum common dataset of biological, physiological, and clinical factors for geroscience clinical studies-and to foster a paradigm shift, particularly among regulatory authorities.
(Copyright © 2026. Published by Elsevier Masson SAS.)
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Given their role as Editor-in-Chief and Honorary Editor-in-Chief of the Journal of Frailty & Aging, Marco Canevelli and Matteo Cesari were not involved in the peer review of this article and had no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to another journal Editor. Luca Tagliafico reports to be funded by the Nutrition Research Grant 2025 provided by Nestlé Health Science. Philipe de Souto Barreto reports a relationship with Pfizer that includes funding grants. Luigi Ferrucci reports a relationship with the National Institute on Aging Intramural Research Program. The other Authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The following ICFSR Task Force members are affiliated with or employees of industrial partners: Albert Higgins-Chen: TruDiagnostic; Amos Baruch: Calico Life Sciences; Alexander Casdin and Micah Webster: Empirium Bio; Bashayer Al-Mubarak: Hevolution Foundation; Claire Bigot: Physiogenex; Dobri Kiprov: Global Apheresis Inc. and Circulate; Felipe Sierra: Hevolution Foundation; Gustavo Duque: TSI Pharmaceuticals; Jeroen Aerssens: Rejuvenate Biomed; Jerome Feige: Nestlé Research; John Groarke and Michelle Rossulek: Pfizer Inc.; John Newman: Component Health; Selah Therapeutics, Junevity; Jose Maria Lopez Pedrosa and Suzette Pereira: Abbott Nutrition;Kevin Slawin: Senotherapeutix, Inc.; Leigh Macconell: Hightide Therapeutics; Leila Hicheur and Serge Da Mariana: Groupe IRCEM; Mahajan Ravi: Apollo Hospitals Group; Michelle Rossulek: Pfizer Inc.; Núria Barcons and Stefanie Rau: Nestlé Health Science; Yuta Lee: Accelerated Biosciences.
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Substance Nomenclature: 0 (Biomarkers)
Entry Date(s): Date Created: 20260321 Date Completed: 20260711 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13010422
DOI: 10.1016/j.tjfa.2026.100147
PMID: 41863810
Βάση Δεδομένων: MEDLINE
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  Data: Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025.
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  Data: <searchLink fieldCode="AU" term="%22Tagliafico+L%22">Tagliafico L</searchLink>; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy. Electronic address: luca.tagliafico@unige.it.<br /><searchLink fieldCode="AU" term="%22Canevelli+M%22">Canevelli M</searchLink>; Department of Human Neuroscience, Sapienza University, Rome, Italy; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Barreto+PS%22">Barreto PS</searchLink>; IHU HealthAge, Toulouse, France; Institute on Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France; CERPOP, UMR 1295, Université Paul Sabatier, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Cesari+M%22">Cesari M</searchLink>; Child, Adolescent and Older People Unit, Department of Sexual, Reproductive, Maternal, Child, Adolescent and Ageing Health, World Health Organization, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ferrucci+L%22">Ferrucci L</searchLink>; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Vellas+B%22">Vellas B</searchLink>; IHU HealthAge, Toulouse, France; Institute on Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France; CERPOP, UMR 1295, Université Paul Sabatier, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Rolland+Y%22">Rolland Y</searchLink>; IHU HealthAge, Toulouse, France; Institute on Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France; CERPOP, UMR 1295, Université Paul Sabatier, Toulouse, France.
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  Data: <searchLink fieldCode="JN" term="%22101604797%22">The Journal of frailty & aging</searchLink> [J Frailty Aging] 2026 Apr; Vol. 15 (2), pp. 100147. <i>Date of Electronic Publication: </i>2026 Mar 19.
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  Data: Journal Article; Review
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  Data: <searchLink fieldCode="MM" term="%22Sarcopenia%22">Sarcopenia*</searchLink>/<searchLink fieldCode="MM" term="%22Sarcopenia+therapy%22">therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Healthy+Aging%22">Healthy Aging*</searchLink>/<searchLink fieldCode="MM" term="%22Healthy+Aging+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Geroscience%22">Geroscience*</searchLink>/<searchLink fieldCode="MM" term="%22Geroscience+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Frailty%22">Frailty*</searchLink><br /><searchLink fieldCode="MH" term="%22Aging%22">Aging</searchLink>/<searchLink fieldCode="MH" term="%22Aging+physiology%22">physiology</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Clinical+Trials+as+Topic%22">Clinical Trials as Topic</searchLink> ; <searchLink fieldCode="MH" term="%22Advisory+Committees%22">Advisory Committees</searchLink> ; <searchLink fieldCode="MH" term="%22Biomarkers%22">Biomarkers</searchLink> ; <searchLink fieldCode="MH" term="%22Aged%22">Aged</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The Intrinsic Capacity, Frailty and Sarcopenia Research (ICFSR) Task Force convened in March 2025 to discuss geroscience-oriented pre-clinical and clinical trials aimed at promoting healthy aging. Key topics included the use of aging biomarkers in clinical trials, senotherapeutics, metabolism-targeting medications, and therapeutic strategies beyond pharmacological approaches. The discussions highlighted the growing interest in, and accumulating evidence for, geroscience interventions. Several future challenges were identified, including the need for a deeper understanding of the biology of aging and the validation of aging biomarkers against relevant clinical outcomes, such as frailty and intrinsic capacity. Furthermore, to accelerate innovation in the field, there is a need to enhance clinical trial methodologies and harmonization-for example, by defining a minimum common dataset of biological, physiological, and clinical factors for geroscience clinical studies-and to foster a paradigm shift, particularly among regulatory authorities.<br /> (Copyright © 2026. Published by Elsevier Masson SAS.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Given their role as Editor-in-Chief and Honorary Editor-in-Chief of the Journal of Frailty & Aging, Marco Canevelli and Matteo Cesari were not involved in the peer review of this article and had no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to another journal Editor. Luca Tagliafico reports to be funded by the Nutrition Research Grant 2025 provided by Nestlé Health Science. Philipe de Souto Barreto reports a relationship with Pfizer that includes funding grants. Luigi Ferrucci reports a relationship with the National Institute on Aging Intramural Research Program. The other Authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The following ICFSR Task Force members are affiliated with or employees of industrial partners: Albert Higgins-Chen: TruDiagnostic; Amos Baruch: Calico Life Sciences; Alexander Casdin and Micah Webster: Empirium Bio; Bashayer Al-Mubarak: Hevolution Foundation; Claire Bigot: Physiogenex; Dobri Kiprov: Global Apheresis Inc. and Circulate; Felipe Sierra: Hevolution Foundation; Gustavo Duque: TSI Pharmaceuticals; Jeroen Aerssens: Rejuvenate Biomed; Jerome Feige: Nestlé Research; John Groarke and Michelle Rossulek: Pfizer Inc.; John Newman: Component Health; Selah Therapeutics, Junevity; Jose Maria Lopez Pedrosa and Suzette Pereira: Abbott Nutrition;Kevin Slawin: Senotherapeutix, Inc.; Leigh Macconell: Hightide Therapeutics; Leila Hicheur and Serge Da Mariana: Groupe IRCEM; Mahajan Ravi: Apollo Hospitals Group; Michelle Rossulek: Pfizer Inc.; Núria Barcons and Stefanie Rau: Nestlé Health Science; Yuta Lee: Accelerated Biosciences.
– Name: Ref
  Label: References
  Group: RefInfo
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(PMID: <searchLink fieldCode="PM" term="%2239900648%22">39900648)</searchLink><br />J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):447-55. (PMID: <searchLink fieldCode="PM" term="%2223051977%22">23051977)</searchLink><br />J Clin Endocrinol Metab. 2023 Jul 14;108(8):1968-1980. (PMID: <searchLink fieldCode="PM" term="%2236740954%22">36740954)</searchLink><br />Annu Rev Nutr. 2017 Aug 21;37:51-76. (PMID: <searchLink fieldCode="PM" term="%2228826372%22">28826372)</searchLink><br />Cell Rep Med. 2025 Feb 18;6(2):101968. (PMID: <searchLink fieldCode="PM" term="%2239933528%22">39933528)</searchLink><br />NPJ Aging. 2024 Feb 6;10(1):12. (PMID: <searchLink fieldCode="PM" term="%2238321020%22">38321020)</searchLink><br />Geroscience. 2026 Apr;48(2):2013-2027. (PMID: <searchLink fieldCode="PM" term="%2241102476%22">41102476)</searchLink><br />Geroscience. 2024 Apr;46(2):2409-2424. 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        Text: English
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        StartPage: 100147
    Subjects:
      – SubjectFull: Aging physiology
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Clinical Trials as Topic
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      – SubjectFull: Advisory Committees
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      – SubjectFull: Biomarkers
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      – SubjectFull: Sarcopenia therapy
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      – SubjectFull: Healthy Aging physiology
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      – SubjectFull: Geroscience methods
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      – SubjectFull: Frailty
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      – TitleFull: Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025.
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              Text: 2026 Apr
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