Academic Journal
Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.
| Τίτλος: | Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain. |
|---|---|
| Συγγραφείς: | Liu J; Neural Engineering Center, Pennsylvania State University, University Park, Pennsylvania, USA.; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, Pennsylvania, USA., Gluckman BJ; Neural Engineering Center, Pennsylvania State University, University Park, Pennsylvania, USA.; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, Pennsylvania, USA.; Neurosurgery Department, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.; Biomedical Engineering Department, Pennsylvania State University, University Park, Pennsylvania, USA. |
| Πηγή: | Epilepsia [Epilepsia] 2026 Jun; Vol. 67 (6), pp. 3171-3184. Date of Electronic Publication: 2026 Mar 20. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE |
| Imprint Name(s): | Publication: Malden, MA : Blackwell Science Original Publication: Copenhagen : Munskgaard |
| Ιατρικοί όροι (MeSH): | Seizures*/physiopathology , Seizures*/metabolism , Hippocampus*/metabolism , Hippocampus*/physiopathology , Cortical Spreading Depression*/physiology , Oxygen*/metabolism , Brain*/physiopathology , Brain*/metabolism, Extracellular Space/metabolism ; Animals ; Male ; Female ; Rats ; Rats, Sprague-Dawley ; Disease Models, Animal |
| Περίληψη: | Objective: Spreading depolarization (SD) is a phenomenon underlying various neurological conditions, including epilepsy. Researchers have suspected that local tissue oxygenation breakdown induces spontaneous SD. In this study, we investigated the relationship between spontaneous epileptic seizures and SD, with a focus on the role of local tissue oxygenation during the transition from seizure to seizure-associated SD. Methods: We applied a long pulse voltametric method to characterize local tissue oxygenation and extracellular space (ECS) volume change in the hippocampus (HC) of freely moving epileptic rats (six males and three females). Recordings were performed during the normal state of vigilance, spontaneous seizures, seizure-associated SD events, and their transitions. Results: No significant breakdown in local tissue oxygenation of HC was detected before the SD onset during the seizure to SD transition. In contrast, decreased ECS volume in the HC was observed before SD onset during this transition. Significance: Using a novel electrochemical approach in freely behaving rats with intact cerebral autoregulation, we demonstrate that there is no significant breakdown of local tissue oxygenation during seizure to SD transition. However, the ECS begins to shrink during seizure, before SD onset, suggesting that ECS shrinkage may play a leading role in this transition. These findings refine our understanding of the mechanisms driving seizure-associated SD and suggest that ECS may represent a potential therapeutic target in epilepsy and SD-associated neurological disorders. (© 2026 The Author(s). Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.) |
| Σχόλια: | Update of: bioRxiv. 2025 Sep 19:2025.09.17.676836. doi: 10.1101/2025.09.17.676836.. (PMID: 41000902) |
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| Grant Information: | R01 EB014641 United States EB NIBIB NIH HHS; R01 EB019804 United States EB NIBIB NIH HHS; R01EB014641 United States NH NIH HHS; R01EB019804 United States NH NIH HHS |
| Contributed Indexing: | Keywords: epilepsy; extracellular space; pulse voltammetry; spreading depolarization |
| Substance Nomenclature: | S88TT14065 (Oxygen) |
| Entry Date(s): | Date Created: 20260320 Date Completed: 20260622 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13285254 |
| DOI: | 10.1002/epi.70207 |
| PMID: | 41859779 |
| Βάση Δεδομένων: | MEDLINE |
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