Academic Journal
Προβολή σε EDS

Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.
Συγγραφείς: Liu J; Neural Engineering Center, Pennsylvania State University, University Park, Pennsylvania, USA.; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, Pennsylvania, USA., Gluckman BJ; Neural Engineering Center, Pennsylvania State University, University Park, Pennsylvania, USA.; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, Pennsylvania, USA.; Neurosurgery Department, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.; Biomedical Engineering Department, Pennsylvania State University, University Park, Pennsylvania, USA.
Πηγή: Epilepsia [Epilepsia] 2026 Jun; Vol. 67 (6), pp. 3171-3184. Date of Electronic Publication: 2026 Mar 20.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE
Imprint Name(s): Publication: Malden, MA : Blackwell Science
Original Publication: Copenhagen : Munskgaard
Ιατρικοί όροι (MeSH): Seizures*/physiopathology , Seizures*/metabolism , Hippocampus*/metabolism , Hippocampus*/physiopathology , Cortical Spreading Depression*/physiology , Oxygen*/metabolism , Brain*/physiopathology , Brain*/metabolism, Extracellular Space/metabolism ; Animals ; Male ; Female ; Rats ; Rats, Sprague-Dawley ; Disease Models, Animal
Περίληψη: Objective: Spreading depolarization (SD) is a phenomenon underlying various neurological conditions, including epilepsy. Researchers have suspected that local tissue oxygenation breakdown induces spontaneous SD. In this study, we investigated the relationship between spontaneous epileptic seizures and SD, with a focus on the role of local tissue oxygenation during the transition from seizure to seizure-associated SD.
Methods: We applied a long pulse voltametric method to characterize local tissue oxygenation and extracellular space (ECS) volume change in the hippocampus (HC) of freely moving epileptic rats (six males and three females). Recordings were performed during the normal state of vigilance, spontaneous seizures, seizure-associated SD events, and their transitions.
Results: No significant breakdown in local tissue oxygenation of HC was detected before the SD onset during the seizure to SD transition. In contrast, decreased ECS volume in the HC was observed before SD onset during this transition.
Significance: Using a novel electrochemical approach in freely behaving rats with intact cerebral autoregulation, we demonstrate that there is no significant breakdown of local tissue oxygenation during seizure to SD transition. However, the ECS begins to shrink during seizure, before SD onset, suggesting that ECS shrinkage may play a leading role in this transition. These findings refine our understanding of the mechanisms driving seizure-associated SD and suggest that ECS may represent a potential therapeutic target in epilepsy and SD-associated neurological disorders.
(© 2026 The Author(s). Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
Σχόλια: Update of: bioRxiv. 2025 Sep 19:2025.09.17.676836. doi: 10.1101/2025.09.17.676836.. (PMID: 41000902)
References: Neuroscience. 1978;3(11):1045-59. (PMID: 745780)
Neurobiol Dis. 2017 Aug;104:24-32. (PMID: 28438505)
J Neurophysiol. 2014 Jul 15;112(2):205-12. (PMID: 24598521)
J Cereb Blood Flow Metab. 1997 Feb;17(2):191-203. (PMID: 9040499)
J Clin Neurosci. 2016 Feb;24:22-7. (PMID: 26461911)
Nat Med. 2011 Apr;17(4):439-47. (PMID: 21475241)
J Physiol. 1999 Sep 1;519 Pt 2:415-25. (PMID: 10577057)
Respir Physiol. 1967 Dec;3(3):307-17. (PMID: 6083204)
J Cell Physiol. 1989 Sep;140(3):505-11. (PMID: 2550474)
Sci Rep. 2019 Jun 17;9(1):8661. (PMID: 31209253)
Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2415358122. (PMID: 40339120)
J Cereb Blood Flow Metab. 1994 Jan;14(1):7-11. (PMID: 8263059)
J Cereb Blood Flow Metab. 2012 Feb;32(2):376-86. (PMID: 22008729)
Neurotherapeutics. 2010 Oct;7(4):424-38. (PMID: 20880506)
Glia. 1989;2(1):25-44. (PMID: 2523337)
Adv Exp Med Biol. 2003;543:39-55. (PMID: 14713113)
Exp Neurol. 2014 Mar;253:1-15. (PMID: 24368193)
PLoS One. 2015 Aug 25;10(8):e0135536. (PMID: 26305777)
J Physiol. 1919 May 20;52(6):409-15. (PMID: 16993405)
Adv Exp Med Biol. 1994;345:799-806. (PMID: 8079789)
J Physiol. 2005 May 15;565(Pt 1):279-94. (PMID: 15774524)
Appl Opt. 2009 Apr 1;48(10):D169-77. (PMID: 19340106)
Front Integr Neurosci. 2017 Apr 24;11:9. (PMID: 28484378)
J Cereb Blood Flow Metab. 2011 Jan;31(1):17-35. (PMID: 21045864)
Analyst. 2017 Aug 7;142(16):2912-2920. (PMID: 28715004)
Biochim Biophys Acta. 1989 Nov 20;1014(2):141-4. (PMID: 2554973)
Brain. 2006 Dec;129(Pt 12):3224-37. (PMID: 17067993)
J Physiol. 2021 Mar;599(6):1769-1782. (PMID: 33215707)
Nat Rev Neurosci. 2014 Jun;15(6):379-93. (PMID: 24857965)
J Physiol. 2021 Jun;599(12):3195-3220. (PMID: 33942325)
Nat Commun. 2021 Jul 19;12(1):4497. (PMID: 34282153)
Brain. 2005 Sep;128(Pt 9):2042-51. (PMID: 15901647)
Trends Neurosci. 2004 Aug;27(8):489-95. (PMID: 15271497)
J Neurosci Methods. 2010 Nov 30;193(2):217-25. (PMID: 20817029)
Philos Trans R Soc Lond B Biol Sci. 2016 Oct 5;371(1705):. (PMID: 27574302)
Brain. 2012 Jan;135(Pt 1):259-75. (PMID: 22120143)
Neuroreport. 2006 Apr 3;17(5):499-503. (PMID: 16543814)
Elife. 2016 Nov 22;5:. (PMID: 27874832)
J Neurosci. 2014 Aug 27;34(35):11733-43. (PMID: 25164668)
Physiol Rev. 2008 Oct;88(4):1277-340. (PMID: 18923183)
Exp Brain Res. 2022 Mar;240(3):733-749. (PMID: 35064796)
Brain Res. 1993 May 7;610(2):276-82. (PMID: 8100471)
Neuron. 2018 Mar 7;97(5):1004-1021. (PMID: 29518355)
Biophys J. 2017 Nov 21;113(10):2133-2142. (PMID: 28755756)
Exp Brain Res. 1980;40(4):432-9. (PMID: 6254790)
J Neurosci. 2009 Mar 4;29(9):2814-23. (PMID: 19261877)
J Neurophysiol. 1947 Nov;10(6):409-14. (PMID: 20268874)
Proc R Soc Lond B Biol Sci. 1951 Jun;138(891):241-64. (PMID: 14853968)
Trends Neurosci. 2002 Dec;25(12):621-5. (PMID: 12446129)
Brain Res Brain Res Rev. 2001 Dec;38(1-2):33-60. (PMID: 11750926)
Nat Commun. 2021 May 27;12(1):3190. (PMID: 34045465)
Physiol Res. 2002;51 Suppl 1:S85-93. (PMID: 12479789)
Eur J Neurosci. 2011 Jan;33(2):322-37. (PMID: 21105915)
Physiol Rev. 1997 Jul;77(3):731-58. (PMID: 9234964)
Front Neurol. 2018 Feb 01;9:19. (PMID: 29449828)
eNeuro. 2020 Dec 10;7(6):. (PMID: 33303561)
J Neurochem. 2024 May;168(5):868-887. (PMID: 37787065)
J Neurosci Methods. 2011 Feb 15;195(2):135-42. (PMID: 21115045)
J Neurophysiol. 2005 Aug;94(2):943-51. (PMID: 15800073)
Magn Reson Med. 1993 Jan;29(1):12-8. (PMID: 8380480)
Annu Rev Neurosci. 2006;29:449-76. (PMID: 16776593)
Biochim Biophys Acta. 1992 Dec 9;1112(2):161-6. (PMID: 1333801)
Neurosci Lett. 2007 Sep 7;424(2):133-8. (PMID: 17714868)
Nat Neurosci. 2007 Jun;10(6):754-62. (PMID: 17468748)
Neuron. 2015 Mar 04;85(5):1117-31. (PMID: 25741731)
Semin Neurol. 2009 Sep;29(4):406-18. (PMID: 19742415)
Physiol Rev. 2015 Jul;95(3):953-93. (PMID: 26133935)
J Cereb Blood Flow Metab. 1990 Jan;10(1):115-22. (PMID: 2105327)
Epilepsy Res. 2024 Mar;201:107337. (PMID: 38461594)
Sci Transl Med. 2015 Apr 8;7(282):282ra46. (PMID: 25855492)
J Cereb Blood Flow Metab. 2004 Oct;24(10):1172-82. (PMID: 15529018)
J Exp Biol. 1998 Apr;201(Pt 8):1141-52. (PMID: 9510526)
eNeuro. 2026 Jan 22;13(1):. (PMID: 41419336)
J Neuroinflammation. 2025 Jul 9;22(1):178. (PMID: 40634990)
Sleep. 2012 Jul 01;35(7):909-19. (PMID: 22754037)
Magn Reson Med. 1994 Aug;32(2):189-98. (PMID: 7968441)
Stereotact Funct Neurosurg. 2017;95(1):1-5. (PMID: 28088802)
Physiol Rev. 2001 Jul;81(3):1065-96. (PMID: 11427692)
Grant Information: R01 EB014641 United States EB NIBIB NIH HHS; R01 EB019804 United States EB NIBIB NIH HHS; R01EB014641 United States NH NIH HHS; R01EB019804 United States NH NIH HHS
Contributed Indexing: Keywords: epilepsy; extracellular space; pulse voltammetry; spreading depolarization
Substance Nomenclature: S88TT14065 (Oxygen)
Entry Date(s): Date Created: 20260320 Date Completed: 20260622 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13285254
DOI: 10.1002/epi.70207
PMID: 41859779
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=15281167&ISBN=&volume=67&issue=6&date=20260601&spage=3171&pages=3171-3184&title=Epilepsia&atitle=Tissue%20oxygenation%20dynamics%20during%20transition%20from%20seizure%20to%20spreading%20depolarization%20in%20rat%20brain.&aulast=Liu%20J&id=DOI:10.1002/epi.70207
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 41859779
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Neural Engineering Center, Pennsylvania State University, University Park, Pennsylvania, USA.; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Gluckman+BJ%22">Gluckman BJ</searchLink>; Neural Engineering Center, Pennsylvania State University, University Park, Pennsylvania, USA.; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, Pennsylvania, USA.; Neurosurgery Department, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.; Biomedical Engineering Department, Pennsylvania State University, University Park, Pennsylvania, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%222983306R%22">Epilepsia</searchLink> [Epilepsia] 2026 Jun; Vol. 67 (6), pp. 3171-3184. <i>Date of Electronic Publication: </i>2026 Mar 20.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Blackwell+Science%22">Blackwell Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2983306R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-1167 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200139580%22">00139580 </searchLink><i>NLM ISO Abbreviation: </i>Epilepsia <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Publication</i>: Malden, MA : Blackwell Science<br /><i>Original Publication</i>: Copenhagen : Munskgaard
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Seizures%22">Seizures*</searchLink>/<searchLink fieldCode="MM" term="%22Seizures+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Seizures%22">Seizures*</searchLink>/<searchLink fieldCode="MM" term="%22Seizures+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Hippocampus%22">Hippocampus*</searchLink>/<searchLink fieldCode="MM" term="%22Hippocampus+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Hippocampus%22">Hippocampus*</searchLink>/<searchLink fieldCode="MM" term="%22Hippocampus+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Cortical+Spreading+Depression%22">Cortical Spreading Depression*</searchLink>/<searchLink fieldCode="MM" term="%22Cortical+Spreading+Depression+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Oxygen%22">Oxygen*</searchLink>/<searchLink fieldCode="MM" term="%22Oxygen+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain%22">Brain*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain%22">Brain*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+metabolism%22">metabolism</searchLink><br /><searchLink fieldCode="MH" term="%22Extracellular+Space%22">Extracellular Space</searchLink>/<searchLink fieldCode="MH" term="%22Extracellular+Space+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%22">Rats</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%2C+Sprague-Dawley%22">Rats, Sprague-Dawley</searchLink> ; <searchLink fieldCode="MH" term="%22Disease+Models%2C+Animal%22">Disease Models, Animal</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Spreading depolarization (SD) is a phenomenon underlying various neurological conditions, including epilepsy. Researchers have suspected that local tissue oxygenation breakdown induces spontaneous SD. In this study, we investigated the relationship between spontaneous epileptic seizures and SD, with a focus on the role of local tissue oxygenation during the transition from seizure to seizure-associated SD.<br />Methods: We applied a long pulse voltametric method to characterize local tissue oxygenation and extracellular space (ECS) volume change in the hippocampus (HC) of freely moving epileptic rats (six males and three females). Recordings were performed during the normal state of vigilance, spontaneous seizures, seizure-associated SD events, and their transitions.<br />Results: No significant breakdown in local tissue oxygenation of HC was detected before the SD onset during the seizure to SD transition. In contrast, decreased ECS volume in the HC was observed before SD onset during this transition.<br />Significance: Using a novel electrochemical approach in freely behaving rats with intact cerebral autoregulation, we demonstrate that there is no significant breakdown of local tissue oxygenation during seizure to SD transition. However, the ECS begins to shrink during seizure, before SD onset, suggesting that ECS shrinkage may play a leading role in this transition. These findings refine our understanding of the mechanisms driving seizure-associated SD and suggest that ECS may represent a potential therapeutic target in epilepsy and SD-associated neurological disorders.<br /> (© 2026 The Author(s). Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
– Name: Comment
  Label: Comments
  Group: Commnt
  Data: Update of: bioRxiv. 2025 Sep 19:2025.09.17.676836. doi: 10.1101/2025.09.17.676836.. (PMID: <searchLink fieldCode="PM" term="%2241000902%22">41000902)</searchLink>
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Neuroscience. 1978;3(11):1045-59. (PMID: <searchLink fieldCode="PM" term="%22745780%22">745780)</searchLink><br />Neurobiol Dis. 2017 Aug;104:24-32. (PMID: <searchLink fieldCode="PM" term="%2228438505%22">28438505)</searchLink><br />J Neurophysiol. 2014 Jul 15;112(2):205-12. (PMID: <searchLink fieldCode="PM" term="%2224598521%22">24598521)</searchLink><br />J Cereb Blood Flow Metab. 1997 Feb;17(2):191-203. (PMID: <searchLink fieldCode="PM" term="%229040499%22">9040499)</searchLink><br />J Clin Neurosci. 2016 Feb;24:22-7. (PMID: <searchLink fieldCode="PM" term="%2226461911%22">26461911)</searchLink><br />Nat Med. 2011 Apr;17(4):439-47. (PMID: <searchLink fieldCode="PM" term="%2221475241%22">21475241)</searchLink><br />J Physiol. 1999 Sep 1;519 Pt 2:415-25. (PMID: <searchLink fieldCode="PM" term="%2210577057%22">10577057)</searchLink><br />Respir Physiol. 1967 Dec;3(3):307-17. (PMID: <searchLink fieldCode="PM" term="%226083204%22">6083204)</searchLink><br />J Cell Physiol. 1989 Sep;140(3):505-11. (PMID: <searchLink fieldCode="PM" term="%222550474%22">2550474)</searchLink><br />Sci Rep. 2019 Jun 17;9(1):8661. (PMID: <searchLink fieldCode="PM" term="%2231209253%22">31209253)</searchLink><br />Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2415358122. (PMID: <searchLink fieldCode="PM" term="%2240339120%22">40339120)</searchLink><br />J Cereb Blood Flow Metab. 1994 Jan;14(1):7-11. (PMID: <searchLink fieldCode="PM" term="%228263059%22">8263059)</searchLink><br />J Cereb Blood Flow Metab. 2012 Feb;32(2):376-86. (PMID: <searchLink fieldCode="PM" term="%2222008729%22">22008729)</searchLink><br />Neurotherapeutics. 2010 Oct;7(4):424-38. (PMID: <searchLink fieldCode="PM" term="%2220880506%22">20880506)</searchLink><br />Glia. 1989;2(1):25-44. (PMID: <searchLink fieldCode="PM" term="%222523337%22">2523337)</searchLink><br />Adv Exp Med Biol. 2003;543:39-55. (PMID: <searchLink fieldCode="PM" term="%2214713113%22">14713113)</searchLink><br />Exp Neurol. 2014 Mar;253:1-15. (PMID: <searchLink fieldCode="PM" term="%2224368193%22">24368193)</searchLink><br />PLoS One. 2015 Aug 25;10(8):e0135536. (PMID: <searchLink fieldCode="PM" term="%2226305777%22">26305777)</searchLink><br />J Physiol. 1919 May 20;52(6):409-15. (PMID: <searchLink fieldCode="PM" term="%2216993405%22">16993405)</searchLink><br />Adv Exp Med Biol. 1994;345:799-806. (PMID: <searchLink fieldCode="PM" term="%228079789%22">8079789)</searchLink><br />J Physiol. 2005 May 15;565(Pt 1):279-94. (PMID: <searchLink fieldCode="PM" term="%2215774524%22">15774524)</searchLink><br />Appl Opt. 2009 Apr 1;48(10):D169-77. (PMID: <searchLink fieldCode="PM" term="%2219340106%22">19340106)</searchLink><br />Front Integr Neurosci. 2017 Apr 24;11:9. (PMID: <searchLink fieldCode="PM" term="%2228484378%22">28484378)</searchLink><br />J Cereb Blood Flow Metab. 2011 Jan;31(1):17-35. (PMID: <searchLink fieldCode="PM" term="%2221045864%22">21045864)</searchLink><br />Analyst. 2017 Aug 7;142(16):2912-2920. (PMID: <searchLink fieldCode="PM" term="%2228715004%22">28715004)</searchLink><br />Biochim Biophys Acta. 1989 Nov 20;1014(2):141-4. (PMID: <searchLink fieldCode="PM" term="%222554973%22">2554973)</searchLink><br />Brain. 2006 Dec;129(Pt 12):3224-37. (PMID: <searchLink fieldCode="PM" term="%2217067993%22">17067993)</searchLink><br />J Physiol. 2021 Mar;599(6):1769-1782. (PMID: <searchLink fieldCode="PM" term="%2233215707%22">33215707)</searchLink><br />Nat Rev Neurosci. 2014 Jun;15(6):379-93. (PMID: <searchLink fieldCode="PM" term="%2224857965%22">24857965)</searchLink><br />J Physiol. 2021 Jun;599(12):3195-3220. (PMID: <searchLink fieldCode="PM" term="%2233942325%22">33942325)</searchLink><br />Nat Commun. 2021 Jul 19;12(1):4497. (PMID: <searchLink fieldCode="PM" term="%2234282153%22">34282153)</searchLink><br />Brain. 2005 Sep;128(Pt 9):2042-51. (PMID: <searchLink fieldCode="PM" term="%2215901647%22">15901647)</searchLink><br />Trends Neurosci. 2004 Aug;27(8):489-95. (PMID: <searchLink fieldCode="PM" term="%2215271497%22">15271497)</searchLink><br />J Neurosci Methods. 2010 Nov 30;193(2):217-25. (PMID: <searchLink fieldCode="PM" term="%2220817029%22">20817029)</searchLink><br />Philos Trans R Soc Lond B Biol Sci. 2016 Oct 5;371(1705):. (PMID: <searchLink fieldCode="PM" term="%2227574302%22">27574302)</searchLink><br />Brain. 2012 Jan;135(Pt 1):259-75. (PMID: <searchLink fieldCode="PM" term="%2222120143%22">22120143)</searchLink><br />Neuroreport. 2006 Apr 3;17(5):499-503. (PMID: <searchLink fieldCode="PM" term="%2216543814%22">16543814)</searchLink><br />Elife. 2016 Nov 22;5:. (PMID: <searchLink fieldCode="PM" term="%2227874832%22">27874832)</searchLink><br />J Neurosci. 2014 Aug 27;34(35):11733-43. (PMID: <searchLink fieldCode="PM" term="%2225164668%22">25164668)</searchLink><br />Physiol Rev. 2008 Oct;88(4):1277-340. (PMID: <searchLink fieldCode="PM" term="%2218923183%22">18923183)</searchLink><br />Exp Brain Res. 2022 Mar;240(3):733-749. (PMID: <searchLink fieldCode="PM" term="%2235064796%22">35064796)</searchLink><br />Brain Res. 1993 May 7;610(2):276-82. (PMID: <searchLink fieldCode="PM" term="%228100471%22">8100471)</searchLink><br />Neuron. 2018 Mar 7;97(5):1004-1021. (PMID: <searchLink fieldCode="PM" term="%2229518355%22">29518355)</searchLink><br />Biophys J. 2017 Nov 21;113(10):2133-2142. (PMID: <searchLink fieldCode="PM" term="%2228755756%22">28755756)</searchLink><br />Exp Brain Res. 1980;40(4):432-9. (PMID: <searchLink fieldCode="PM" term="%226254790%22">6254790)</searchLink><br />J Neurosci. 2009 Mar 4;29(9):2814-23. (PMID: <searchLink fieldCode="PM" term="%2219261877%22">19261877)</searchLink><br />J Neurophysiol. 1947 Nov;10(6):409-14. (PMID: <searchLink fieldCode="PM" term="%2220268874%22">20268874)</searchLink><br />Proc R Soc Lond B Biol Sci. 1951 Jun;138(891):241-64. (PMID: <searchLink fieldCode="PM" term="%2214853968%22">14853968)</searchLink><br />Trends Neurosci. 2002 Dec;25(12):621-5. (PMID: <searchLink fieldCode="PM" term="%2212446129%22">12446129)</searchLink><br />Brain Res Brain Res Rev. 2001 Dec;38(1-2):33-60. (PMID: <searchLink fieldCode="PM" term="%2211750926%22">11750926)</searchLink><br />Nat Commun. 2021 May 27;12(1):3190. (PMID: <searchLink fieldCode="PM" term="%2234045465%22">34045465)</searchLink><br />Physiol Res. 2002;51 Suppl 1:S85-93. (PMID: <searchLink fieldCode="PM" term="%2212479789%22">12479789)</searchLink><br />Eur J Neurosci. 2011 Jan;33(2):322-37. (PMID: <searchLink fieldCode="PM" term="%2221105915%22">21105915)</searchLink><br />Physiol Rev. 1997 Jul;77(3):731-58. (PMID: <searchLink fieldCode="PM" term="%229234964%22">9234964)</searchLink><br />Front Neurol. 2018 Feb 01;9:19. (PMID: <searchLink fieldCode="PM" term="%2229449828%22">29449828)</searchLink><br />eNeuro. 2020 Dec 10;7(6):. (PMID: <searchLink fieldCode="PM" term="%2233303561%22">33303561)</searchLink><br />J Neurochem. 2024 May;168(5):868-887. (PMID: <searchLink fieldCode="PM" term="%2237787065%22">37787065)</searchLink><br />J Neurosci Methods. 2011 Feb 15;195(2):135-42. (PMID: <searchLink fieldCode="PM" term="%2221115045%22">21115045)</searchLink><br />J Neurophysiol. 2005 Aug;94(2):943-51. (PMID: <searchLink fieldCode="PM" term="%2215800073%22">15800073)</searchLink><br />Magn Reson Med. 1993 Jan;29(1):12-8. (PMID: <searchLink fieldCode="PM" term="%228380480%22">8380480)</searchLink><br />Annu Rev Neurosci. 2006;29:449-76. (PMID: <searchLink fieldCode="PM" term="%2216776593%22">16776593)</searchLink><br />Biochim Biophys Acta. 1992 Dec 9;1112(2):161-6. (PMID: <searchLink fieldCode="PM" term="%221333801%22">1333801)</searchLink><br />Neurosci Lett. 2007 Sep 7;424(2):133-8. (PMID: <searchLink fieldCode="PM" term="%2217714868%22">17714868)</searchLink><br />Nat Neurosci. 2007 Jun;10(6):754-62. (PMID: <searchLink fieldCode="PM" term="%2217468748%22">17468748)</searchLink><br />Neuron. 2015 Mar 04;85(5):1117-31. (PMID: <searchLink fieldCode="PM" term="%2225741731%22">25741731)</searchLink><br />Semin Neurol. 2009 Sep;29(4):406-18. (PMID: <searchLink fieldCode="PM" term="%2219742415%22">19742415)</searchLink><br />Physiol Rev. 2015 Jul;95(3):953-93. (PMID: <searchLink fieldCode="PM" term="%2226133935%22">26133935)</searchLink><br />J Cereb Blood Flow Metab. 1990 Jan;10(1):115-22. (PMID: <searchLink fieldCode="PM" term="%222105327%22">2105327)</searchLink><br />Epilepsy Res. 2024 Mar;201:107337. (PMID: <searchLink fieldCode="PM" term="%2238461594%22">38461594)</searchLink><br />Sci Transl Med. 2015 Apr 8;7(282):282ra46. (PMID: <searchLink fieldCode="PM" term="%2225855492%22">25855492)</searchLink><br />J Cereb Blood Flow Metab. 2004 Oct;24(10):1172-82. (PMID: <searchLink fieldCode="PM" term="%2215529018%22">15529018)</searchLink><br />J Exp Biol. 1998 Apr;201(Pt 8):1141-52. (PMID: <searchLink fieldCode="PM" term="%229510526%22">9510526)</searchLink><br />eNeuro. 2026 Jan 22;13(1):. (PMID: <searchLink fieldCode="PM" term="%2241419336%22">41419336)</searchLink><br />J Neuroinflammation. 2025 Jul 9;22(1):178. (PMID: <searchLink fieldCode="PM" term="%2240634990%22">40634990)</searchLink><br />Sleep. 2012 Jul 01;35(7):909-19. (PMID: <searchLink fieldCode="PM" term="%2222754037%22">22754037)</searchLink><br />Magn Reson Med. 1994 Aug;32(2):189-98. (PMID: <searchLink fieldCode="PM" term="%227968441%22">7968441)</searchLink><br />Stereotact Funct Neurosurg. 2017;95(1):1-5. (PMID: <searchLink fieldCode="PM" term="%2228088802%22">28088802)</searchLink><br />Physiol Rev. 2001 Jul;81(3):1065-96. (PMID: <searchLink fieldCode="PM" term="%2211427692%22">11427692)</searchLink>
– Name: GrantInfo
  Label: Grant Information
  Group: Grant
  Data: R01 EB014641 United States EB NIBIB NIH HHS; R01 EB019804 United States EB NIBIB NIH HHS; R01EB014641 United States NH NIH HHS; R01EB019804 United States NH NIH HHS
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>epilepsy; extracellular space; pulse voltammetry; spreading depolarization
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: S88TT14065 (Oxygen)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260320 <i>Date Completed: </i>20260622 <i>Latest Revision: </i>20260813
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260813
– Name: PubmedCentralID
  Label: PubMed Central ID
  Group: ID
  Data: PMC13285254
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1002/epi.70207
– Name: AN
  Label: PMID
  Group: ID
  Data: 41859779
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=41859779
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/epi.70207
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 3171
    Subjects:
      – SubjectFull: Extracellular Space metabolism
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Rats, Sprague-Dawley
        Type: general
      – SubjectFull: Disease Models, Animal
        Type: general
      – SubjectFull: Seizures physiopathology
        Type: general
      – SubjectFull: Seizures metabolism
        Type: general
      – SubjectFull: Hippocampus metabolism
        Type: general
      – SubjectFull: Hippocampus physiopathology
        Type: general
      – SubjectFull: Cortical Spreading Depression physiology
        Type: general
      – SubjectFull: Oxygen metabolism
        Type: general
      – SubjectFull: Brain physiopathology
        Type: general
      – SubjectFull: Brain metabolism
        Type: general
    Titles:
      – TitleFull: Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Liu J
      – PersonEntity:
          Name:
            NameFull: Gluckman BJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1528-1167
          Numbering:
            – Type: volume
              Value: 67
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Epilepsia
              Type: main
ResultId 1