Academic Journal
Comprehensive Review and Outlook of the Synthetic Urease Inhibitors for Agricultural Applications.
| Τίτλος: | Comprehensive Review and Outlook of the Synthetic Urease Inhibitors for Agricultural Applications. |
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| Συγγραφείς: | Song X; CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Science, Shenyang 110016, China., Zhang W; CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Science, Shenyang 110016, China.; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China., Bai Y; CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Science, Shenyang 110016, China., Zhang L; CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Science, Shenyang 110016, China., Hu J; CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Science, Shenyang 110016, China., Wu Z; CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Science, Shenyang 110016, China., Pan H; CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Science, Shenyang 110016, China. |
| Πηγή: | Journal of agricultural and food chemistry [J Agric Food Chem] 2026 Apr 01; Vol. 74 (12), pp. 9933-9957. Date of Electronic Publication: 2026 Mar 18. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, American Chemical Society. |
| Ιατρικοί όροι (MeSH): | Urease*/antagonists & inhibitors , Urease*/chemistry , Urease*/metabolism , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/pharmacology, Plant Proteins/chemistry ; Plant Proteins/antagonists & inhibitors ; Plant Proteins/metabolism ; Structure-Activity Relationship ; Molecular Docking Simulation ; Agriculture |
| Περίληψη: | The development of efficient urease inhibitors represents a promising strategy for agricultural applications. This review examines the status of commercial urease inhibitors and the challenges encountered while systematically summarizing the urease inhibitory activities and structure-activity relationships (SARs) of 339 synthetic compounds belonging to 12 structural types reported from 2001 to 2025. It emphasizes phosphoramidate, thiourea, coumarin, azine, and amine derivatives that exhibit potent urease inhibitory activity. Furthermore, SAR analysis indicates that derivatives containing electron-withdrawing substituents, such as halogens and nitro groups, demonstrate significantly higher urease inhibitory potency compared with those with electron-donating substituents, such as methyl groups. The review also compares the binding modes and key active sites of representative inhibitors from each subtype with those of plant urease (4H9M) and soil microbial urease (4CEU) through molecular docking analysis. Finally, it outlines the challenges and future research priorities for soil urease inhibitors. This review enhances our understanding of urease inhibitors and guides the development of highly effective soil urease inhibitors to address critical global environmental sustainability challenges. |
| Contributed Indexing: | Keywords: molecular docking; nitrogen use efficiency; stabilized fertilizer; structure−activity relationship; urease inhibitor |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) 0 (Enzyme Inhibitors) 0 (Plant Proteins) |
| Entry Date(s): | Date Created: 20260319 Date Completed: 20260711 Latest Revision: 20260711 |
| Update Code: | 20260711 |
| DOI: | 10.1021/acs.jafc.5c16741 |
| PMID: | 41852057 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1520-5118 |
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| DOI: | 10.1021/acs.jafc.5c16741 |