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Mild Traumatic Brain Injury Alters Hippocampal Sharp-Wave Ripple Properties: Implications in Memory Impairments.

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Τίτλος: Mild Traumatic Brain Injury Alters Hippocampal Sharp-Wave Ripple Properties: Implications in Memory Impairments.
Συγγραφείς: Noble B; Smalley Curl Institute Applied Physics Graduate Program, Rice University, Houston, Texas, USA.; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA., Homma R; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA., Broussard JI; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA., Robinson D; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA., Moore AN; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA., Dash PK; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.
Πηγή: Journal of neurotrauma [J Neurotrauma] 2026 Oct; Vol. 43 (19-20), pp. 1670-1680. Date of Electronic Publication: 2026 Mar 18.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9042 (Electronic) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE
Imprint Name(s): Publication: Larchmont, NY : Mary Ann Liebert
Original Publication: New York, NY : Mary Ann Liebert, c1988-
Ιατρικοί όροι (MeSH): Memory Disorders*/physiopathology , Memory Disorders*/etiology , Brain Concussion*/physiopathology , Brain Concussion*/complications , Hippocampus*/physiopathology , CA1 Region, Hippocampal*/physiopathology, Animals ; Male ; Rats ; Local Field Potential Measurement ; Rats, Sprague-Dawley
Περίληψη: A large body of evidence has shown that sharp wave ripples (SWRs), highly synchronized oscillations of the local field potential (LFP) in the CA1 pyramidal layer of the hippocampus, play a prominent role in memory consolidation. SWRs typically occur in periods of non-REM sleep, but have also been observed during awake rest periods of animals engaged in cognitive tasks. These events have been observed in rodents, non-human primates, and humans, suggesting they are evolutionarily conserved and contribute to memory formation. Numerous neurological diseases and insults, including traumatic brain injury (TBI), impair learning and memory. Mild TBI (mTBI) is the most prevalent form of TBI, and can cause memory impairments that, in some cases, last for months-to-years. Clinical and experimental studies have shown that these impairments can occur in the absence of visible physical damage to the hippocampus. In the present study, we examined whether an mTBI alters the properties of SWRs in rodents. Seven days after a mild fluid percussion injury (mFPI), recording electrodes were implanted into the CA1 subfield of the hippocampus of sham and injured rats. After seven days of recovery, LFPs and the activity of CA1 neurons were simultaneously recorded. Recordings were carried out when animals were exploring an arena containing two objects, one of which was moved between recording sessions. This allowed us to evaluate how changes in the environment affected SWR incidence and properties. Our data show that compared to uninjured controls, mFPI rats had reduced numbers of SWR events. Of the SWRs recorded, those from mTBI rats had shorter durations, reduced power, and higher frequencies than those in control animals. We also found that the modulation of the activity of CA1 pyramidal neurons by SWRs was markedly impaired in mTBI animals. Taken together, our data indicate that mTBI alters the electrophysiological properties of SWRs and reduces the synchronization of pyramidal neuron activity to SWRs. These electrophysiological changes may have implications in mTBI-associated memory impairments.
Competing Interests: Author Disclosure StatementAll authors do not have any potential conflicts of interest to disclose.
Contributed Indexing: Keywords: concussion; hippocampus; learning and memory; neuronal function; traumatic brain injury
Entry Date(s): Date Created: 20260318 Date Completed: 20260903 Latest Revision: 20260903
Update Code: 20260903
DOI: 10.1177/08977151261434221
PMID: 41847818
Βάση Δεδομένων: MEDLINE
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PubType: Academic Journal
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  Data: Mild Traumatic Brain Injury Alters Hippocampal Sharp-Wave Ripple Properties: Implications in Memory Impairments.
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  Data: <searchLink fieldCode="AU" term="%22Noble+B%22">Noble B</searchLink>; Smalley Curl Institute Applied Physics Graduate Program, Rice University, Houston, Texas, USA.; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Homma+R%22">Homma R</searchLink>; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Broussard+JI%22">Broussard JI</searchLink>; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Robinson+D%22">Robinson D</searchLink>; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Moore+AN%22">Moore AN</searchLink>; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Dash+PK%22">Dash PK</searchLink>; Department of Neurobiology and Anatomy, The University of Texas McGovern Medical School, Houston, Texas, USA.
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  Data: <searchLink fieldCode="JN" term="%228811626%22">Journal of neurotrauma</searchLink> [J Neurotrauma] 2026 Oct; Vol. 43 (19-20), pp. 1670-1680. <i>Date of Electronic Publication: </i>2026 Mar 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mary+Ann+Liebert%22">Mary Ann Liebert </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8811626 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-9042 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208977151%22">08977151 </searchLink><i>NLM ISO Abbreviation: </i>J Neurotrauma <i>Subsets: </i>MEDLINE
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  Data: <i>Publication</i>: Larchmont, NY : Mary Ann Liebert<br /><i>Original Publication</i>: New York, NY : Mary Ann Liebert, c1988-
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  Data: <searchLink fieldCode="MM" term="%22Memory+Disorders%22">Memory Disorders*</searchLink>/<searchLink fieldCode="MM" term="%22Memory+Disorders+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Memory+Disorders%22">Memory Disorders*</searchLink>/<searchLink fieldCode="MM" term="%22Memory+Disorders+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain+Concussion%22">Brain Concussion*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+Concussion+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain+Concussion%22">Brain Concussion*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+Concussion+complications%22">complications</searchLink> <br /><searchLink fieldCode="MM" term="%22Hippocampus%22">Hippocampus*</searchLink>/<searchLink fieldCode="MM" term="%22Hippocampus+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22CA1+Region%2C+Hippocampal%22">CA1 Region, Hippocampal*</searchLink>/<searchLink fieldCode="MM" term="%22CA1+Region%2C+Hippocampal+physiopathology%22">physiopathology</searchLink><br /><searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%22">Rats</searchLink> ; <searchLink fieldCode="MH" term="%22Local+Field+Potential+Measurement%22">Local Field Potential Measurement</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%2C+Sprague-Dawley%22">Rats, Sprague-Dawley</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A large body of evidence has shown that sharp wave ripples (SWRs), highly synchronized oscillations of the local field potential (LFP) in the CA1 pyramidal layer of the hippocampus, play a prominent role in memory consolidation. SWRs typically occur in periods of non-REM sleep, but have also been observed during awake rest periods of animals engaged in cognitive tasks. These events have been observed in rodents, non-human primates, and humans, suggesting they are evolutionarily conserved and contribute to memory formation. Numerous neurological diseases and insults, including traumatic brain injury (TBI), impair learning and memory. Mild TBI (mTBI) is the most prevalent form of TBI, and can cause memory impairments that, in some cases, last for months-to-years. Clinical and experimental studies have shown that these impairments can occur in the absence of visible physical damage to the hippocampus. In the present study, we examined whether an mTBI alters the properties of SWRs in rodents. Seven days after a mild fluid percussion injury (mFPI), recording electrodes were implanted into the CA1 subfield of the hippocampus of sham and injured rats. After seven days of recovery, LFPs and the activity of CA1 neurons were simultaneously recorded. Recordings were carried out when animals were exploring an arena containing two objects, one of which was moved between recording sessions. This allowed us to evaluate how changes in the environment affected SWR incidence and properties. Our data show that compared to uninjured controls, mFPI rats had reduced numbers of SWR events. Of the SWRs recorded, those from mTBI rats had shorter durations, reduced power, and higher frequencies than those in control animals. We also found that the modulation of the activity of CA1 pyramidal neurons by SWRs was markedly impaired in mTBI animals. Taken together, our data indicate that mTBI alters the electrophysiological properties of SWRs and reduces the synchronization of pyramidal neuron activity to SWRs. These electrophysiological changes may have implications in mTBI-associated memory impairments.
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  Data: Author Disclosure StatementAll authors do not have any potential conflicts of interest to disclose.
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  Data: <i>Keywords: </i>concussion; hippocampus; learning and memory; neuronal function; traumatic brain injury
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  Data: 10.1177/08977151261434221
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  Data: 41847818
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=41847818
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      – Type: doi
        Value: 10.1177/08977151261434221
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        StartPage: 1670
    Subjects:
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Local Field Potential Measurement
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      – SubjectFull: Rats, Sprague-Dawley
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      – SubjectFull: Memory Disorders physiopathology
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      – SubjectFull: Memory Disorders etiology
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      – SubjectFull: Hippocampus physiopathology
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      – SubjectFull: CA1 Region, Hippocampal physiopathology
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      – TitleFull: Mild Traumatic Brain Injury Alters Hippocampal Sharp-Wave Ripple Properties: Implications in Memory Impairments.
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              Text: 2026 Oct
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