Academic Journal
Προβολή σε EDS

Polymaleic acid-calcium complexes induce intrafibrillar mineralization and dentin remineralization as well as occlusion of dentinal tubules.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Polymaleic acid-calcium complexes induce intrafibrillar mineralization and dentin remineralization as well as occlusion of dentinal tubules.
Συγγραφείς: Shen Y; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Qiu Y; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Zheng H; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Wang Y; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Jin X; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Li M; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Zhang Y; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Zhang H; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Jiang W; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Wu Z; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Fu B; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China., Shen D; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China. Electronic address: sdn@zju.edu.cn., Zhou Z; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China. Electronic address: 11818406@zju.edu.cn.
Πηγή: Dental materials : official publication of the Academy of Dental Materials [Dent Mater] 2026 Aug; Vol. 42 (8), pp. 1346-1357. Date of Electronic Publication: 2026 Mar 16.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 8508040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0097 (Electronic) Linking ISSN: 01095641 NLM ISO Abbreviation: Dent Mater Subsets: MEDLINE
Imprint Name(s): Publication: 1998- : Kidlington, Oxford, UK : Elsevier Science
Original Publication: Copenhagen : Munksgaard, c1985-
Ιατρικοί όροι (MeSH): Dentin*/drug effects , Dentin*/ultrastructure , Tooth Remineralization*/methods , Maleates*/pharmacology , Maleates*/chemistry , Calcium*/pharmacology , Calcium*/chemistry, Dentin Permeability/drug effects ; Humans ; Animals ; Rabbits ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; In Vitro Techniques ; Saliva, Artificial ; Polyethylenes
Περίληψη: Objectives: The aim of this study is to evaluate the effectiveness of polyelectrolyte-cation complexes pre-precursor (PCCP) process using polymaleic acid (PMA) for inducing intrafibrillar mineralization, dentin remineralization and occlusion of dentinal tubules.
Methods: Collagen fibrils were successively treated with PMA-Ca suspension and phosphate solution, 5 min each, and incubated in artificial saliva for 2 days. Demineralized dentin of human dentin disks and rabbit's incisors were treated as aforementioned, 20 min each, and followed by 2 days of incubation. They were identified by scanning/transmission electron microscopy (SEM/TEM) and high resolution TEM (HRTEM) with selected area electron diffraction (SAED). The mechanical properties of de- and remineralized dentin were evaluated by nanoindentation test. The dentin permeability testing of de- and remineralized dentin treated with different ways was conducted. The oral mucosa irritations of mineralization media were evaluated.
Results: The intrafibrillar mineralization and in vitro/in vivo remineralization of demineralized dentin were successfully achieved. The mechanical properties of remineralized dentin were recovered from demineralized dentin (P < 0.001) close to natural dentin (P > 0.05). The dentinal tubules were occluded exceeding 100 µm and dentin permeability was significantly decreased (P < 0.001). No evident mucosa irritation was detected.
Conclusions: The PMA-Ca suspension following phosphate group could effectively induce in vitro/in vivo remineralization of demineralized dentin with in-depth occlusion of open dentin tubules and great reduction of dentin permeability. The effectiveness of PCCP process using PMA was validated.
Clinical Significance: The PCCP process using PMA could be used for management of dentin caries and dentin hypersensitivity.
(Copyright © 2026 Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare no competing conflicts of interest.
Contributed Indexing: Keywords: Dentin hypersensitivity; Dentin remineralization; Intrafibrillar mineralization; Occlusion of dentinal tubules; Polymaleic acid
Substance Nomenclature: 0 (Maleates)
9011-16-9 (poly(methyl vinyl ether-co-maleic anhydride))
SY7Q814VUP (Calcium)
0 (Saliva, Artificial)
0 (Polyethylenes)
Entry Date(s): Date Created: 20260318 Date Completed: 20260711 Latest Revision: 20260711
Update Code: 20260711
DOI: 10.1016/j.dental.2026.03.155
PMID: 41846173
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.dental.2026.03.155?
    Name: ScienceDirect (all content) (s7799221)
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=18790097&ISBN=&volume=42&issue=8&date=20260801&spage=1346&pages=1346-1357&title=Dental materials : official publication of the Academy of Dental Materials&atitle=Polymaleic%20acid-calcium%20complexes%20induce%20intrafibrillar%20mineralization%20and%20dentin%20remineralization%20as%20well%20as%20occlusion%20of%20dentinal%20tubules.&aulast=Shen%20Y&id=DOI:10.1016/j.dental.2026.03.155
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 41846173
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Polymaleic acid-calcium complexes induce intrafibrillar mineralization and dentin remineralization as well as occlusion of dentinal tubules.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Shen+Y%22&quot;&gt;Shen Y&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Qiu+Y%22&quot;&gt;Qiu Y&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Zheng+H%22&quot;&gt;Zheng H&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Wang+Y%22&quot;&gt;Wang Y&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Jin+X%22&quot;&gt;Jin X&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Li+M%22&quot;&gt;Li M&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Zhang+Y%22&quot;&gt;Zhang Y&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Zhang+H%22&quot;&gt;Zhang H&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Jiang+W%22&quot;&gt;Jiang W&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Wu+Z%22&quot;&gt;Wu Z&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Fu+B%22&quot;&gt;Fu B&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Shen+D%22&quot;&gt;Shen D&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China. Electronic address: sdn@zju.edu.cn.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Zhou+Z%22&quot;&gt;Zhou Z&lt;/searchLink&gt;; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China. Electronic address: 11818406@zju.edu.cn.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%228508040%22&quot;&gt;Dental materials : official publication of the Academy of Dental Materials&lt;/searchLink&gt; [Dent Mater] 2026 Aug; Vol. 42 (8), pp. 1346-1357. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2026 Mar 16.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: &lt;i&gt;Publisher: &lt;/i&gt;&lt;searchLink fieldCode=&quot;PB&quot; term=&quot;%22Elsevier+Science%22&quot;&gt;Elsevier Science &lt;/searchLink&gt;&lt;i&gt;Country of Publication: &lt;/i&gt;England &lt;i&gt;NLM ID: &lt;/i&gt;8508040 &lt;i&gt;Publication Model: &lt;/i&gt;Print-Electronic &lt;i&gt;Cited Medium: &lt;/i&gt;Internet &lt;i&gt;ISSN: &lt;/i&gt;1879-0097 (Electronic) &lt;i&gt;Linking ISSN: &lt;/i&gt;&lt;searchLink fieldCode=&quot;IS&quot; term=&quot;%2201095641%22&quot;&gt;01095641 &lt;/searchLink&gt;&lt;i&gt;NLM ISO Abbreviation: &lt;/i&gt;Dent Mater &lt;i&gt;Subsets: &lt;/i&gt;MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: &lt;i&gt;Publication&lt;/i&gt;: 1998- : Kidlington, Oxford, UK : Elsevier Science&lt;br /&gt;&lt;i&gt;Original Publication&lt;/i&gt;: Copenhagen : Munksgaard, c1985-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin%22&quot;&gt;Dentin*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin%22&quot;&gt;Dentin*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+ultrastructure%22&quot;&gt;ultrastructure&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Tooth+Remineralization%22&quot;&gt;Tooth Remineralization*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Tooth+Remineralization+methods%22&quot;&gt;methods&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Maleates%22&quot;&gt;Maleates*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Maleates+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Maleates%22&quot;&gt;Maleates*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Maleates+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Calcium%22&quot;&gt;Calcium*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Calcium+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Calcium%22&quot;&gt;Calcium*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Calcium+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dentin+Permeability%22&quot;&gt;Dentin Permeability&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dentin+Permeability+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Animals%22&quot;&gt;Animals&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Rabbits%22&quot;&gt;Rabbits&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Microscopy%2C+Electron%2C+Scanning%22&quot;&gt;Microscopy, Electron, Scanning&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Microscopy%2C+Electron%2C+Transmission%22&quot;&gt;Microscopy, Electron, Transmission&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22In+Vitro+Techniques%22&quot;&gt;In Vitro Techniques&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Saliva%2C+Artificial%22&quot;&gt;Saliva, Artificial&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Polyethylenes%22&quot;&gt;Polyethylenes&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: The aim of this study is to evaluate the effectiveness of polyelectrolyte-cation complexes pre-precursor (PCCP) process using polymaleic acid (PMA) for inducing intrafibrillar mineralization, dentin remineralization and occlusion of dentinal tubules.&lt;br /&gt;Methods: Collagen fibrils were successively treated with PMA-Ca suspension and phosphate solution, 5 min each, and incubated in artificial saliva for 2 days. Demineralized dentin of human dentin disks and rabbit&#39;s incisors were treated as aforementioned, 20 min each, and followed by 2 days of incubation. They were identified by scanning/transmission electron microscopy (SEM/TEM) and high resolution TEM (HRTEM) with selected area electron diffraction (SAED). The mechanical properties of de- and remineralized dentin were evaluated by nanoindentation test. The dentin permeability testing of de- and remineralized dentin treated with different ways was conducted. The oral mucosa irritations of mineralization media were evaluated.&lt;br /&gt;Results: The intrafibrillar mineralization and in vitro/in vivo remineralization of demineralized dentin were successfully achieved. The mechanical properties of remineralized dentin were recovered from demineralized dentin (P &amp;lt; 0.001) close to natural dentin (P &amp;gt; 0.05). The dentinal tubules were occluded exceeding 100 &#181;m and dentin permeability was significantly decreased (P &amp;lt; 0.001). No evident mucosa irritation was detected.&lt;br /&gt;Conclusions: The PMA-Ca suspension following phosphate group could effectively induce in vitro/in vivo remineralization of demineralized dentin with in-depth occlusion of open dentin tubules and great reduction of dentin permeability. The effectiveness of PCCP process using PMA was validated.&lt;br /&gt;Clinical Significance: The PCCP process using PMA could be used for management of dentin caries and dentin hypersensitivity.&lt;br /&gt; (Copyright &#169; 2026 Elsevier Inc. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of Competing Interest The authors declare no competing conflicts of interest.
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: &lt;i&gt;Keywords: &lt;/i&gt;Dentin hypersensitivity; Dentin remineralization; Intrafibrillar mineralization; Occlusion of dentinal tubules; Polymaleic acid
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Maleates)&lt;br /&gt;9011-16-9 (poly(methyl vinyl ether-co-maleic anhydride))&lt;br /&gt;SY7Q814VUP (Calcium)&lt;br /&gt;0 (Saliva, Artificial)&lt;br /&gt;0 (Polyethylenes)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: &lt;i&gt;Date Created: &lt;/i&gt;20260318 &lt;i&gt;Date Completed: &lt;/i&gt;20260711 &lt;i&gt;Latest Revision: &lt;/i&gt;20260711
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260711
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.dental.2026.03.155
– Name: AN
  Label: PMID
  Group: ID
  Data: 41846173
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=41846173
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.dental.2026.03.155
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1346
    Subjects:
      – SubjectFull: Dentin Permeability drug effects
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Rabbits
        Type: general
      – SubjectFull: Microscopy, Electron, Scanning
        Type: general
      – SubjectFull: Microscopy, Electron, Transmission
        Type: general
      – SubjectFull: In Vitro Techniques
        Type: general
      – SubjectFull: Saliva, Artificial
        Type: general
      – SubjectFull: Polyethylenes
        Type: general
      – SubjectFull: Dentin drug effects
        Type: general
      – SubjectFull: Dentin ultrastructure
        Type: general
      – SubjectFull: Tooth Remineralization methods
        Type: general
      – SubjectFull: Maleates pharmacology
        Type: general
      – SubjectFull: Maleates chemistry
        Type: general
      – SubjectFull: Calcium pharmacology
        Type: general
      – SubjectFull: Calcium chemistry
        Type: general
    Titles:
      – TitleFull: Polymaleic acid-calcium complexes induce intrafibrillar mineralization and dentin remineralization as well as occlusion of dentinal tubules.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Shen Y
      – PersonEntity:
          Name:
            NameFull: Qiu Y
      – PersonEntity:
          Name:
            NameFull: Zheng H
      – PersonEntity:
          Name:
            NameFull: Wang Y
      – PersonEntity:
          Name:
            NameFull: Jin X
      – PersonEntity:
          Name:
            NameFull: Li M
      – PersonEntity:
          Name:
            NameFull: Zhang Y
      – PersonEntity:
          Name:
            NameFull: Zhang H
      – PersonEntity:
          Name:
            NameFull: Jiang W
      – PersonEntity:
          Name:
            NameFull: Wu Z
      – PersonEntity:
          Name:
            NameFull: Fu B
      – PersonEntity:
          Name:
            NameFull: Shen D
      – PersonEntity:
          Name:
            NameFull: Zhou Z
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: 2026 Aug
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1879-0097
          Numbering:
            – Type: volume
              Value: 42
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Dental materials : official publication of the Academy of Dental Materials
              Type: main
ResultId 1