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Tumor and red blood cell fatty acid composition as a potential indicator of outcomes in breast cancer: Findings from a retrospective cohort study.

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Τίτλος: Tumor and red blood cell fatty acid composition as a potential indicator of outcomes in breast cancer: Findings from a retrospective cohort study.
Συγγραφείς: Munhoz J; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada., Goruk S; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada., Mazurak V; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada., Ghosh S; Department of Public Health Sciences, Henry Ford Health, Detroit, MI, USA; Department of Oncology, Division of Medical Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada., Hemmings DG; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB T5G 0B6, Canada., Field CJ; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada. Electronic address: cjfield@ualberta.ca.
Πηγή: Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2026 Jul; Vol. 209, pp. 102733. Date of Electronic Publication: 2026 Mar 05.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 8802730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2823 (Electronic) Linking ISSN: 09523278 NLM ISO Abbreviation: Prostaglandins Leukot Essent Fatty Acids Subsets: MEDLINE
Imprint Name(s): Original Publication: Edinburgh ; New York : Churchill Livingstone, c1988-
Ιατρικοί όροι (MeSH): Breast Neoplasms*/blood , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/mortality , Erythrocytes*/metabolism , Erythrocytes*/chemistry , Fatty Acids*/blood , Fatty Acids*/metabolism, Docosahexaenoic Acids/blood ; Eicosapentaenoic Acid/blood ; Fatty Acids, Omega-3/blood ; Biomarkers, Tumor/blood ; Triglycerides/blood ; Humans ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Adult ; Phospholipids
Περίληψη: The fatty acid composition of breast tumors may influence disease outcomes, but its use as a biomarker and its relationship with circulating fatty acids remain unclear. This study evaluated the composition of fatty acids in tumors and red blood cells (RBCs) of breast cancer patients to assess the relationship with tumor characteristics, RBC fatty acids, and survival. Paired (n = 122) frozen tumor and RBC samples from breast cancer patients were analyzed by gas-liquid chromatography. In the multivariable-adjusted model, the RBC fatty acid composition of n-3 fatty acids, including eicosapentaenoic acid (EPA, β = 0.13, 95 %CI: 0.05, 0.22), docosahexaenoic acid (DHA, β = 0.17, 95 %CI: 0.05, 0.28), and total n-3 (β = 0.17, 95 %CI: 0.05, 0.29) were positively associated with the fatty acid composition of tumor phospholipids and triglycerides. The relative percentage of linoleic acid and DHA in tumor phospholipids, and DHA and arachidonic acid in tumor triglycerides varied by tumor hormone receptor status. In multivariable-adjusted Cox analyses, the total monounsaturated fatty acid (MUFA) composition of tumor phospholipids was associated with poorer overall survival (hazard ratio = 1.10, 95 %CI: 1.01, 1.20) and disease-free survival (hazard ratio = 1.09, 95 %CI: 1.01, 1.18). This study demonstrates the significance of using circulating n-3 PUFAs to predict tumor fatty acid composition, supporting their use as an accessible indicator of tumor n-3 fatty acid status. Although fatty acids differed by hormone receptor status, their relationship with survival was not confirmed. The MUFA composition of tumors may be clinically relevant to survival outcomes, but requires further investigation.
(Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Docosahexaenoic acid; Omega-3 fatty acids; Omega-3 index; Tumor phospholipids
Substance Nomenclature: 0 (Fatty Acids)
25167-62-8 (Docosahexaenoic Acids)
AAN7QOV9EA (Eicosapentaenoic Acid)
0 (Fatty Acids, Omega-3)
0 (Biomarkers, Tumor)
0 (Phospholipids)
0 (Triglycerides)
Entry Date(s): Date Created: 20260317 Date Completed: 20260613 Latest Revision: 20260613
Update Code: 20260615
DOI: 10.1016/j.plefa.2026.102733
PMID: 41844486
Βάση Δεδομένων: MEDLINE
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  Data: Tumor and red blood cell fatty acid composition as a potential indicator of outcomes in breast cancer: Findings from a retrospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Munhoz+J%22">Munhoz J</searchLink>; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Goruk+S%22">Goruk S</searchLink>; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Mazurak+V%22">Mazurak V</searchLink>; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Ghosh+S%22">Ghosh S</searchLink>; Department of Public Health Sciences, Henry Ford Health, Detroit, MI, USA; Department of Oncology, Division of Medical Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada.<br /><searchLink fieldCode="AU" term="%22Hemmings+DG%22">Hemmings DG</searchLink>; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB T5G 0B6, Canada.<br /><searchLink fieldCode="AU" term="%22Field+CJ%22">Field CJ</searchLink>; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada. Electronic address: cjfield@ualberta.ca.
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  Data: <searchLink fieldCode="JN" term="%228802730%22">Prostaglandins, leukotrienes, and essential fatty acids</searchLink> [Prostaglandins Leukot Essent Fatty Acids] 2026 Jul; Vol. 209, pp. 102733. <i>Date of Electronic Publication: </i>2026 Mar 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Churchill+Livingstone%22">Churchill Livingstone </searchLink><i>Country of Publication: </i>Scotland <i>NLM ID: </i>8802730 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-2823 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209523278%22">09523278 </searchLink><i>NLM ISO Abbreviation: </i>Prostaglandins Leukot Essent Fatty Acids <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: Edinburgh ; New York : Churchill Livingstone, c1988-
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  Data: <searchLink fieldCode="MM" term="%22Breast+Neoplasms%22">Breast Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Breast+Neoplasms+blood%22">blood</searchLink> <br /><searchLink fieldCode="MM" term="%22Breast+Neoplasms%22">Breast Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Breast+Neoplasms+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Breast+Neoplasms%22">Breast Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Breast+Neoplasms+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Breast+Neoplasms%22">Breast Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Breast+Neoplasms+mortality%22">mortality</searchLink> <br /><searchLink fieldCode="MM" term="%22Erythrocytes%22">Erythrocytes*</searchLink>/<searchLink fieldCode="MM" term="%22Erythrocytes+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Erythrocytes%22">Erythrocytes*</searchLink>/<searchLink fieldCode="MM" term="%22Erythrocytes+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Fatty+Acids%22">Fatty Acids*</searchLink>/<searchLink fieldCode="MM" term="%22Fatty+Acids+blood%22">blood</searchLink> <br /><searchLink fieldCode="MM" term="%22Fatty+Acids%22">Fatty Acids*</searchLink>/<searchLink fieldCode="MM" term="%22Fatty+Acids+metabolism%22">metabolism</searchLink><br /><searchLink fieldCode="MH" term="%22Docosahexaenoic+Acids%22">Docosahexaenoic Acids</searchLink>/<searchLink fieldCode="MH" term="%22Docosahexaenoic+Acids+blood%22">blood</searchLink> ; <searchLink fieldCode="MH" term="%22Eicosapentaenoic+Acid%22">Eicosapentaenoic Acid</searchLink>/<searchLink fieldCode="MH" term="%22Eicosapentaenoic+Acid+blood%22">blood</searchLink> ; <searchLink fieldCode="MH" term="%22Fatty+Acids%2C+Omega-3%22">Fatty Acids, Omega-3</searchLink>/<searchLink fieldCode="MH" term="%22Fatty+Acids%2C+Omega-3+blood%22">blood</searchLink> ; <searchLink fieldCode="MH" term="%22Biomarkers%2C+Tumor%22">Biomarkers, Tumor</searchLink>/<searchLink fieldCode="MH" term="%22Biomarkers%2C+Tumor+blood%22">blood</searchLink> ; <searchLink fieldCode="MH" term="%22Triglycerides%22">Triglycerides</searchLink>/<searchLink fieldCode="MH" term="%22Triglycerides+blood%22">blood</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Retrospective+Studies%22">Retrospective Studies</searchLink> ; <searchLink fieldCode="MH" term="%22Middle+Aged%22">Middle Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Aged%22">Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Phospholipids%22">Phospholipids</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The fatty acid composition of breast tumors may influence disease outcomes, but its use as a biomarker and its relationship with circulating fatty acids remain unclear. This study evaluated the composition of fatty acids in tumors and red blood cells (RBCs) of breast cancer patients to assess the relationship with tumor characteristics, RBC fatty acids, and survival. Paired (n = 122) frozen tumor and RBC samples from breast cancer patients were analyzed by gas-liquid chromatography. In the multivariable-adjusted model, the RBC fatty acid composition of n-3 fatty acids, including eicosapentaenoic acid (EPA, β = 0.13, 95 %CI: 0.05, 0.22), docosahexaenoic acid (DHA, β = 0.17, 95 %CI: 0.05, 0.28), and total n-3 (β = 0.17, 95 %CI: 0.05, 0.29) were positively associated with the fatty acid composition of tumor phospholipids and triglycerides. The relative percentage of linoleic acid and DHA in tumor phospholipids, and DHA and arachidonic acid in tumor triglycerides varied by tumor hormone receptor status. In multivariable-adjusted Cox analyses, the total monounsaturated fatty acid (MUFA) composition of tumor phospholipids was associated with poorer overall survival (hazard ratio = 1.10, 95 %CI: 1.01, 1.20) and disease-free survival (hazard ratio = 1.09, 95 %CI: 1.01, 1.18). This study demonstrates the significance of using circulating n-3 PUFAs to predict tumor fatty acid composition, supporting their use as an accessible indicator of tumor n-3 fatty acid status. Although fatty acids differed by hormone receptor status, their relationship with survival was not confirmed. The MUFA composition of tumors may be clinically relevant to survival outcomes, but requires further investigation.<br /> (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
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  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Data: <i>Keywords: </i>Docosahexaenoic acid; Omega-3 fatty acids; Omega-3 index; Tumor phospholipids
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        Value: 10.1016/j.plefa.2026.102733
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      – Code: eng
        Text: English
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        StartPage: 102733
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      – SubjectFull: Docosahexaenoic Acids blood
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      – SubjectFull: Eicosapentaenoic Acid blood
        Type: general
      – SubjectFull: Fatty Acids, Omega-3 blood
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        Type: general
      – SubjectFull: Female
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        Type: general
      – SubjectFull: Adult
        Type: general
      – SubjectFull: Phospholipids
        Type: general
      – SubjectFull: Breast Neoplasms blood
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      – SubjectFull: Fatty Acids blood
        Type: general
      – SubjectFull: Fatty Acids metabolism
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      – TitleFull: Tumor and red blood cell fatty acid composition as a potential indicator of outcomes in breast cancer: Findings from a retrospective cohort study.
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              Text: 2026 Jul
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