Academic Journal
Tumor and red blood cell fatty acid composition as a potential indicator of outcomes in breast cancer: Findings from a retrospective cohort study.
| Τίτλος: | Tumor and red blood cell fatty acid composition as a potential indicator of outcomes in breast cancer: Findings from a retrospective cohort study. |
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| Συγγραφείς: | Munhoz J; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada., Goruk S; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada., Mazurak V; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada., Ghosh S; Department of Public Health Sciences, Henry Ford Health, Detroit, MI, USA; Department of Oncology, Division of Medical Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada., Hemmings DG; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB T5G 0B6, Canada., Field CJ; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB, T6G 2E1, Canada. Electronic address: cjfield@ualberta.ca. |
| Πηγή: | Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2026 Jul; Vol. 209, pp. 102733. Date of Electronic Publication: 2026 Mar 05. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 8802730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2823 (Electronic) Linking ISSN: 09523278 NLM ISO Abbreviation: Prostaglandins Leukot Essent Fatty Acids Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Edinburgh ; New York : Churchill Livingstone, c1988- |
| Ιατρικοί όροι (MeSH): | Breast Neoplasms*/blood , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/mortality , Erythrocytes*/metabolism , Erythrocytes*/chemistry , Fatty Acids*/blood , Fatty Acids*/metabolism, Docosahexaenoic Acids/blood ; Eicosapentaenoic Acid/blood ; Fatty Acids, Omega-3/blood ; Biomarkers, Tumor/blood ; Triglycerides/blood ; Humans ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Adult ; Phospholipids |
| Περίληψη: | The fatty acid composition of breast tumors may influence disease outcomes, but its use as a biomarker and its relationship with circulating fatty acids remain unclear. This study evaluated the composition of fatty acids in tumors and red blood cells (RBCs) of breast cancer patients to assess the relationship with tumor characteristics, RBC fatty acids, and survival. Paired (n = 122) frozen tumor and RBC samples from breast cancer patients were analyzed by gas-liquid chromatography. In the multivariable-adjusted model, the RBC fatty acid composition of n-3 fatty acids, including eicosapentaenoic acid (EPA, β = 0.13, 95 %CI: 0.05, 0.22), docosahexaenoic acid (DHA, β = 0.17, 95 %CI: 0.05, 0.28), and total n-3 (β = 0.17, 95 %CI: 0.05, 0.29) were positively associated with the fatty acid composition of tumor phospholipids and triglycerides. The relative percentage of linoleic acid and DHA in tumor phospholipids, and DHA and arachidonic acid in tumor triglycerides varied by tumor hormone receptor status. In multivariable-adjusted Cox analyses, the total monounsaturated fatty acid (MUFA) composition of tumor phospholipids was associated with poorer overall survival (hazard ratio = 1.10, 95 %CI: 1.01, 1.20) and disease-free survival (hazard ratio = 1.09, 95 %CI: 1.01, 1.18). This study demonstrates the significance of using circulating n-3 PUFAs to predict tumor fatty acid composition, supporting their use as an accessible indicator of tumor n-3 fatty acid status. Although fatty acids differed by hormone receptor status, their relationship with survival was not confirmed. The MUFA composition of tumors may be clinically relevant to survival outcomes, but requires further investigation. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Docosahexaenoic acid; Omega-3 fatty acids; Omega-3 index; Tumor phospholipids |
| Substance Nomenclature: | 0 (Fatty Acids) 25167-62-8 (Docosahexaenoic Acids) AAN7QOV9EA (Eicosapentaenoic Acid) 0 (Fatty Acids, Omega-3) 0 (Biomarkers, Tumor) 0 (Phospholipids) 0 (Triglycerides) |
| Entry Date(s): | Date Created: 20260317 Date Completed: 20260613 Latest Revision: 20260613 |
| Update Code: | 20260615 |
| DOI: | 10.1016/j.plefa.2026.102733 |
| PMID: | 41844486 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1532-2823 |
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| DOI: | 10.1016/j.plefa.2026.102733 |