Academic Journal
Effects of Extracorporeal Life Support Volume on Neonatal Mortality in Congenital Diaphragmatic Hernia: A Retrospective Cohort Study.
| Τίτλος: | Effects of Extracorporeal Life Support Volume on Neonatal Mortality in Congenital Diaphragmatic Hernia: A Retrospective Cohort Study. |
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| Συγγραφείς: | Guner YS; Department of Surgery, University of California Irvine Medical Center, Orange, CA; Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, CA., Martino A; Department of Surgery, University of California Irvine Medical Center, Orange, CA., Giron A; Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, CA. Electronic address: andreina.giron@choc.org., Flyer Z; Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, CA., Murthy K; Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine, Chicago, IL., Di Nardo M; Pediatric Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Schomberg J; Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, CA., Grover TR; Department of Pediatrics, University of Colorado, Denver, CO., Hammond JD; Department of Pediatrics, University of California Irvine, Orange, CA., Yu PT; Department of Surgery, University of California Irvine Medical Center, Orange, CA; Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, CA., Goodman LF; Department of Surgery, University of California Irvine Medical Center, Orange, CA; Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, CA., Gowda SH; Division of Neonatology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX., Harting MT; Department of Pediatric Surgery, University of Texas McGovern Medical School and Children's Memorial Hermann Hospital, Houston, TX., Jancelewicz T; Division of Pediatric Surgery, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, TN., Nguyen DV; Department of Medicine, University of California Irvine, Irvine, CA. |
| Πηγή: | The Journal of pediatrics [J Pediatr] 2026 Jun; Vol. 293, pp. 115062. Date of Electronic Publication: 2026 Mar 13. |
| Τύπος έκδοσης: | Journal Article; Multicenter Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Mosby Country of Publication: United States NLM ID: 0375410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6833 (Electronic) Linking ISSN: 00223476 NLM ISO Abbreviation: J Pediatr Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: St. Louis, MO : Mosby |
| Ιατρικοί όροι (MeSH): | Hernias, Diaphragmatic, Congenital*/mortality , Hernias, Diaphragmatic, Congenital*/therapy , Extracorporeal Membrane Oxygenation*/statistics & numerical data , Hospitals, High-Volume*/statistics & numerical data , Infant Mortality*, Hospitals, Low-Volume/statistics & numerical data ; Humans ; Retrospective Studies ; Infant, Newborn ; Female ; Male ; Hospital Mortality |
| Περίληψη: | We conducted a retrospective cohort study of 29 499 neonatal cases requiring extracorporeal life support (ECLS) at 237 centers from 2000 to 2023; there were 6747 infants with congenital diaphragmatic hernia (CDH) and 22 752 without CDH. Infants with CDH treated at ECLS centers with low total neonatal volumes (<28.5 total cases) had increased odds of inpatient mortality compared with those at high-volume centers (> 140 total cases, adjusted odds ratio [aOR]: 1.9; 95% confidence interval [CI]: 1.2-2.9). Similarly, centers with low non-CDH ECLS volumes were associated with higher odds of mortality among infants with CDH (aOR: 1.7; 95% CI: 1.1-2.5). Combined analysis of neonates with and without CDH also showed that low-volume centers were associated with higher odds of mortality compared with high-volume centers (aOR: 1.6; 95% CI: 1.3-2.0). These findings underscore the importance of procedural experience and support further investigation into the potential best practices adopted by high-volume centers. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors have no conflicts of interest or competing interests to declare. No funding, grants, equipment, or drugs were provided by the NIH, Wellcome Trust, HHMI, or any other external sources. |
| Contributed Indexing: | Keywords: CDH; ECLS; ECMO; quality |
| Entry Date(s): | Date Created: 20260314 Date Completed: 20260711 Latest Revision: 20260711 |
| Update Code: | 20260711 |
| DOI: | 10.1016/j.jpeds.2026.115062 |
| PMID: | 41831781 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1097-6833 |
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| DOI: | 10.1016/j.jpeds.2026.115062 |