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Behavioral Deficits and Cortical Network Dysfunction Following Repeated Mild Traumatic Brain Injuries.

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Τίτλος: Behavioral Deficits and Cortical Network Dysfunction Following Repeated Mild Traumatic Brain Injuries.
Συγγραφείς: Pinkowski NJ; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.; Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Hess BR; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Pacheco JM; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.; Department of Neurology, Thomas Jefferson, Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA., Hatcher DS; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., McDonald M; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Swindle AN; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Laboy Ramirez R; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Situ M; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Abdeljawad T; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Mehos CJ; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Mayer AR; Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico, USA.; Department of Neurology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA., McKenzie S; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Morton RA; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Πηγή: Journal of neurotrauma [J Neurotrauma] 2026 Sep; Vol. 43 (17-18), pp. 1506-1519. Date of Electronic Publication: 2026 Mar 14.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9042 (Electronic) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE
Imprint Name(s): Publication: Larchmont, NY : Mary Ann Liebert
Original Publication: New York, NY : Mary Ann Liebert, c1988-
Ιατρικοί όροι (MeSH): Brain Concussion*/physiopathology , Brain Concussion*/complications , Brain Concussion*/psychology , Nerve Net*/physiopathology , Cerebral Cortex*/physiopathology , Cortical Spreading Depression*/physiology , Behavior, Animal*/physiology, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Optogenetics
Περίληψη: Mild traumatic brain injury (mTBI) is a prevalent health concern, with more than 2.5 million cases occurring annually in the United States. Acute signs and symptoms of mTBIs may involve physical symptoms, as well as emotional, cognitive, and sleep-related issues. The underlying mechanisms of these symptoms remain elusive. Here, we describe that repeated closed skull mTBIs in mice are associated with acute behavioral deficits. We found that optogenetic-induced spreading depolarizations (SDs) are associated with similar behavioral deficits. Using in vivo electrophysiology, we confirmed the depression of cortical network activity following optogenetic-induced SDs. The timing of the high-frequency activity recovery coincided with the recovery of voluntary movement. Following the depression, there was a prolonged period of increased power in low frequencies (<30 Hz). Cortical dysfunction coincided temporally with motor behavioral deficits in the neurological severity score tasks. Our study provides evidence that repeated mTBIs or SDs are associated with worse behavioral deficits.
Competing Interests: Author Disclosure StatementNo competing financial interests exist for all authors.
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Grant Information: P30 GM159568 United States GM NIGMS NIH HHS; P20 GM109089 United States GM NIGMS NIH HHS; K12 GM106996 United States GM NIGMS NIH HHS; T32 GM144834 United States GM NIGMS NIH HHS; P30 GM103400 United States GM NIGMS NIH HHS; R01 NS106901 United States NS NINDS NIH HHS; T34 GM145428 United States GM NIGMS NIH HHS
Contributed Indexing: Keywords: behavioral assessment; electrophysiology; vascular reactivity
Entry Date(s): Date Created: 20260314 Date Completed: 20260808 Latest Revision: 20260922
Update Code: 20260922
PubMed Central ID: PMC13054653
DOI: 10.1177/08977151261425217
PMID: 41830200
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1557-9042
DOI:10.1177/08977151261425217