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Lathyrane diterpenoids with anti-renal fibrotic activity from the aboveground parts of Euphorbia wallichii.

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Τίτλος: Lathyrane diterpenoids with anti-renal fibrotic activity from the aboveground parts of Euphorbia wallichii.
Συγγραφείς: Ma RF; School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China; School of Biological Science and Technology, University of Jinan, Jinan 250022, China., Liu KY; School of Biological Science and Technology, University of Jinan, Jinan 250022, China., Pan YB; School of Biological Science and Technology, University of Jinan, Jinan 250022, China., Zhang H; School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_zhangh@ujn.edu.cn.
Πηγή: Phytochemistry [Phytochemistry] 2026 Jul; Vol. 247, pp. 114875. Date of Electronic Publication: 2026 Mar 11.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE
Imprint Name(s): Publication: 2003- : London : Elsevier
Original Publication: 1961-2003: Oxford : Pergamon Press.
Ιατρικοί όροι (MeSH): Euphorbia*/chemistry , Diterpenes*/chemistry , Diterpenes*/pharmacology , Diterpenes*/isolation & purification , Kidney*/drug effects , Kidney*/pathology, Fibrosis/drug therapy ; Nitric Oxide/biosynthesis ; Nitric Oxide/antagonists & inhibitors ; Wnt Signaling Pathway/drug effects ; Transforming Growth Factor beta1/pharmacology ; Transforming Growth Factor beta1/antagonists & inhibitors ; Humans ; Animals ; Mice ; Molecular Structure ; RAW 264.7 Cells ; Structure-Activity Relationship
Περίληψη: Eighteen lathyrane diterpenoids, comprising nine unreported (1-9) and nine known analogues (10-18), were isolated from the aboveground parts of Euphorbia wallichii. The structures of these compounds were established by detailed interpretation of MS and NMR data, with the absolute configurations assigned via comparison of experimental and calculated ECD spectra. Biological evaluation of selected compounds revealed no significant inhibition against NO production in RAW264.7 macrophages and no cytotoxicity against MDA-MB-231, A549, MCF-7, and HeLa cancer cell lines. However, several of them exerted a significant suppressing effect on TGF-β1-induced upregulation of fibrotic biomarkers in human kidney tubular HK-2 cells, and the anti-renal fibrotic potential of compound 8 may be associated with its inhibition on the Wnt/β-catenin signaling pathway.
(Copyright © 2026 Elsevier Ltd. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Antifibrosis; Euphorbia wallichii; Euphorbiaceae; Lathyrane diterpenoid; Wnt/β-catenin
Substance Nomenclature: 0 (Diterpenes)
0 (lathyrane)
31C4KY9ESH (Nitric Oxide)
0 (Transforming Growth Factor beta1)
Entry Date(s): Date Created: 20260313 Date Completed: 20260711 Latest Revision: 20260711
Update Code: 20260711
DOI: 10.1016/j.phytochem.2026.114875
PMID: 41825821
Βάση Δεδομένων: MEDLINE
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  Data: Lathyrane diterpenoids with anti-renal fibrotic activity from the aboveground parts of Euphorbia wallichii.
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  Data: <searchLink fieldCode="AU" term="%22Ma+RF%22">Ma RF</searchLink>; School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.<br /><searchLink fieldCode="AU" term="%22Liu+KY%22">Liu KY</searchLink>; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.<br /><searchLink fieldCode="AU" term="%22Pan+YB%22">Pan YB</searchLink>; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_zhangh@ujn.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220151434%22">Phytochemistry</searchLink> [Phytochemistry] 2026 Jul; Vol. 247, pp. 114875. <i>Date of Electronic Publication: </i>2026 Mar 11.
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  Data: <i>Publication</i>: 2003- : London : Elsevier<br /><i>Original Publication</i>: 1961-2003: Oxford : Pergamon Press.
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  Data: <searchLink fieldCode="MM" term="%22Euphorbia%22">Euphorbia*</searchLink>/<searchLink fieldCode="MM" term="%22Euphorbia+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Diterpenes%22">Diterpenes*</searchLink>/<searchLink fieldCode="MM" term="%22Diterpenes+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Diterpenes%22">Diterpenes*</searchLink>/<searchLink fieldCode="MM" term="%22Diterpenes+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Diterpenes%22">Diterpenes*</searchLink>/<searchLink fieldCode="MM" term="%22Diterpenes+isolation+%26+purification%22">isolation & purification</searchLink> <br /><searchLink fieldCode="MM" term="%22Kidney%22">Kidney*</searchLink>/<searchLink fieldCode="MM" term="%22Kidney+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Kidney%22">Kidney*</searchLink>/<searchLink fieldCode="MM" term="%22Kidney+pathology%22">pathology</searchLink><br /><searchLink fieldCode="MH" term="%22Fibrosis%22">Fibrosis</searchLink>/<searchLink fieldCode="MH" term="%22Fibrosis+drug+therapy%22">drug therapy</searchLink> ; <searchLink fieldCode="MH" term="%22Nitric+Oxide%22">Nitric Oxide</searchLink>/<searchLink fieldCode="MH" term="%22Nitric+Oxide+biosynthesis%22">biosynthesis</searchLink> ; <searchLink fieldCode="MH" term="%22Nitric+Oxide%22">Nitric Oxide</searchLink>/<searchLink fieldCode="MH" term="%22Nitric+Oxide+antagonists+%26+inhibitors%22">antagonists & inhibitors</searchLink> ; <searchLink fieldCode="MH" term="%22Wnt+Signaling+Pathway%22">Wnt Signaling Pathway</searchLink>/<searchLink fieldCode="MH" term="%22Wnt+Signaling+Pathway+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Transforming+Growth+Factor+beta1%22">Transforming Growth Factor beta1</searchLink>/<searchLink fieldCode="MH" term="%22Transforming+Growth+Factor+beta1+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Transforming+Growth+Factor+beta1%22">Transforming Growth Factor beta1</searchLink>/<searchLink fieldCode="MH" term="%22Transforming+Growth+Factor+beta1+antagonists+%26+inhibitors%22">antagonists & inhibitors</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink> ; <searchLink fieldCode="MH" term="%22Molecular+Structure%22">Molecular Structure</searchLink> ; <searchLink fieldCode="MH" term="%22RAW+264%2E7+Cells%22">RAW 264.7 Cells</searchLink> ; <searchLink fieldCode="MH" term="%22Structure-Activity+Relationship%22">Structure-Activity Relationship</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Eighteen lathyrane diterpenoids, comprising nine unreported (1-9) and nine known analogues (10-18), were isolated from the aboveground parts of Euphorbia wallichii. The structures of these compounds were established by detailed interpretation of MS and NMR data, with the absolute configurations assigned via comparison of experimental and calculated ECD spectra. Biological evaluation of selected compounds revealed no significant inhibition against NO production in RAW264.7 macrophages and no cytotoxicity against MDA-MB-231, A549, MCF-7, and HeLa cancer cell lines. However, several of them exerted a significant suppressing effect on TGF-β1-induced upregulation of fibrotic biomarkers in human kidney tubular HK-2 cells, and the anti-renal fibrotic potential of compound 8 may be associated with its inhibition on the Wnt/β-catenin signaling pathway.<br /> (Copyright © 2026 Elsevier Ltd. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>Antifibrosis; Euphorbia wallichii; Euphorbiaceae; Lathyrane diterpenoid; Wnt/β-catenin
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  Label: Substance Nomenclature
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  Data: 0 (Diterpenes)<br />0 (lathyrane)<br />31C4KY9ESH (Nitric Oxide)<br />0 (Transforming Growth Factor beta1)
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  Data: 20260711
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  Data: 10.1016/j.phytochem.2026.114875
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  Label: PMID
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  Data: 41825821
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=41825821
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        Value: 10.1016/j.phytochem.2026.114875
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        Text: English
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        StartPage: 114875
    Subjects:
      – SubjectFull: Fibrosis drug therapy
        Type: general
      – SubjectFull: Nitric Oxide biosynthesis
        Type: general
      – SubjectFull: Nitric Oxide antagonists & inhibitors
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      – SubjectFull: Wnt Signaling Pathway drug effects
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      – TitleFull: Lathyrane diterpenoids with anti-renal fibrotic activity from the aboveground parts of Euphorbia wallichii.
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              Text: 2026 Jul
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