Academic Journal
Real-Time Assessment of Dentinal Fluid Flow Reduction by Desensitising Agents Using Subnanolitre Flow Measuring System.
| Τίτλος: | Real-Time Assessment of Dentinal Fluid Flow Reduction by Desensitising Agents Using Subnanolitre Flow Measuring System. |
|---|---|
| Συγγραφείς: | Kim S; Department of Oral Anatomy and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea., Yamaguchi S; AI Research Unit, Graduate School of Dentistry, The University of Osaka, Osaka, Japan., Lee IB; Department of Conservative Dentistry, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea., Park YS; Department of Oral Anatomy and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea; Department of Integrated Dentistry, School of Dentistry, Seoul National University, Seoul, Republic of Korea. Electronic address: ayoayo7@snu.ac.kr. |
| Πηγή: | International dental journal [Int Dent J] 2026 Jun; Vol. 76 (3), pp. 109487. Date of Electronic Publication: 2026 Mar 10. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 0374714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-595X (Electronic) Linking ISSN: 00206539 NLM ISO Abbreviation: Int Dent J Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2021- : London : Elsevier Original Publication: London : FDI World Dental |
| Ιατρικοί όροι (MeSH): | Dentinal Fluid*/drug effects , Dentin Desensitizing Agents*/pharmacology , Dentin*/drug effects , Dentin*/ultrastructure, Sodium Fluoride/pharmacology ; Toothpastes/pharmacology ; Dentin Permeability/drug effects ; Dentin Sensitivity/drug therapy ; Animals ; Cattle ; Microscopy, Electron, Scanning ; In Vitro Techniques ; Fluoride Treatment |
| Περίληψη: | Objective: This study aimed to evaluate and compare the dentinal tubule-occluding efficacy of various desensitising toothpastes and a sodium fluoride varnish using a subnanolitre scaled fluid flow measuring device (NFMD). Methods: Bovine dentin specimens were treated with four desensitising toothpastes (Colgate, Median, Bamboo Salt, and Sensodyne), a 2.1% sodium fluoride professionally-deliverable varnish (Clinpro), and distilled water (DW). Real-time dentinal fluid flow (DFF) was measured under simulated pulpal pressure (32 cm H₂O) for 1000 seconds using the NFMD system. Each toothpaste was applied directly to assess its chemical occlusion capability, with measurements recorded before, during, and after material removal. Surface morphology and the extent of tubule occlusion were examined using field-emission scanning electron microscopy (FE-SEM) in both cross-sectional and surface views. Data were analysed by one-way analysis of variance. Results: A significant overall treatment effect was observed (P < .001). Bamboo Salt, Sensodyne, and Colgate showed greater mean reductions than Clinpro, whereas Median did not outperform the DW group. SEM findings supported these trends, revealing substantial tubule occlusion for Bamboo Salt and Sensodyne and minimal occlusion for Median and DW. Conclusion: Desensitising toothpastes reduced dentinal permeability to levels comparable to a sodium fluoride varnish. Real-time fluid flow measurement using NFMD enabled functional validation of dentinal tubule occlusion beyond surface morphology. Clinical Relevance: Commonly available desensitising toothpastes can provide meaningful reductions in dentinal permeability. Understanding how different formulations interact with exposed dentin may help guide product selection based on a patient's specific needs. Real-time assessments of dentinal fluid movement may also assist in evaluating emerging desensitising technologies. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Conflict of interest None disclosed. |
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| Contributed Indexing: | Keywords: Dentinal fluid flow; dentin hypersensitivity; desensitising toothpaste; subnanolitre-scaled fluid flow measuring device |
| Substance Nomenclature: | 0 (Dentin Desensitizing Agents) 8ZYQ1474W7 (Sodium Fluoride) 0 (Toothpastes) |
| Entry Date(s): | Date Created: 20260311 Date Completed: 20260710 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC12994060 |
| DOI: | 10.1016/j.identj.2026.109487 |
| PMID: | 41812584 |
| Βάση Δεδομένων: | MEDLINE |
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