Academic Journal
Προβολή σε EDS

Real-Time Assessment of Dentinal Fluid Flow Reduction by Desensitising Agents Using Subnanolitre Flow Measuring System.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Real-Time Assessment of Dentinal Fluid Flow Reduction by Desensitising Agents Using Subnanolitre Flow Measuring System.
Συγγραφείς: Kim S; Department of Oral Anatomy and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea., Yamaguchi S; AI Research Unit, Graduate School of Dentistry, The University of Osaka, Osaka, Japan., Lee IB; Department of Conservative Dentistry, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea., Park YS; Department of Oral Anatomy and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea; Department of Integrated Dentistry, School of Dentistry, Seoul National University, Seoul, Republic of Korea. Electronic address: ayoayo7@snu.ac.kr.
Πηγή: International dental journal [Int Dent J] 2026 Jun; Vol. 76 (3), pp. 109487. Date of Electronic Publication: 2026 Mar 10.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 0374714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-595X (Electronic) Linking ISSN: 00206539 NLM ISO Abbreviation: Int Dent J Subsets: MEDLINE
Imprint Name(s): Publication: 2021- : London : Elsevier
Original Publication: London : FDI World Dental
Ιατρικοί όροι (MeSH): Dentinal Fluid*/drug effects , Dentin Desensitizing Agents*/pharmacology , Dentin*/drug effects , Dentin*/ultrastructure, Sodium Fluoride/pharmacology ; Toothpastes/pharmacology ; Dentin Permeability/drug effects ; Dentin Sensitivity/drug therapy ; Animals ; Cattle ; Microscopy, Electron, Scanning ; In Vitro Techniques ; Fluoride Treatment
Περίληψη: Objective: This study aimed to evaluate and compare the dentinal tubule-occluding efficacy of various desensitising toothpastes and a sodium fluoride varnish using a subnanolitre scaled fluid flow measuring device (NFMD).
Methods: Bovine dentin specimens were treated with four desensitising toothpastes (Colgate, Median, Bamboo Salt, and Sensodyne), a 2.1% sodium fluoride professionally-deliverable varnish (Clinpro), and distilled water (DW). Real-time dentinal fluid flow (DFF) was measured under simulated pulpal pressure (32 cm H₂O) for 1000 seconds using the NFMD system. Each toothpaste was applied directly to assess its chemical occlusion capability, with measurements recorded before, during, and after material removal. Surface morphology and the extent of tubule occlusion were examined using field-emission scanning electron microscopy (FE-SEM) in both cross-sectional and surface views. Data were analysed by one-way analysis of variance.
Results: A significant overall treatment effect was observed (P < .001). Bamboo Salt, Sensodyne, and Colgate showed greater mean reductions than Clinpro, whereas Median did not outperform the DW group. SEM findings supported these trends, revealing substantial tubule occlusion for Bamboo Salt and Sensodyne and minimal occlusion for Median and DW.
Conclusion: Desensitising toothpastes reduced dentinal permeability to levels comparable to a sodium fluoride varnish. Real-time fluid flow measurement using NFMD enabled functional validation of dentinal tubule occlusion beyond surface morphology.
Clinical Relevance: Commonly available desensitising toothpastes can provide meaningful reductions in dentinal permeability. Understanding how different formulations interact with exposed dentin may help guide product selection based on a patient's specific needs. Real-time assessments of dentinal fluid movement may also assist in evaluating emerging desensitising technologies.
(Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.)
Competing Interests: Conflict of interest None disclosed.
References: J Dent. 2019 Sep;88:103170. (PMID: 31325467)
Oral Health Prev Dent. 2011;9(4):353-67. (PMID: 22238734)
Int J Clin Pediatr Dent. 2023 Sep-Oct;16(5):698-706. (PMID: 38162235)
Korean J Pain. 2013 Oct;26(4):347-55. (PMID: 24156000)
Int Dent J. 2014 Mar;64 Suppl 1:16-21. (PMID: 24571700)
Oper Dent. 2013 Jul-Aug;38(4):419-28. (PMID: 23110582)
J Am Dent Assoc. 2006 Jul;137(7):990-8; quiz 1028-9. (PMID: 16803826)
Clin Oral Investig. 2013 Mar;17 Suppl 1:S63-71. (PMID: 23271217)
J Clin Diagn Res. 2016 Oct;10(10):ZC51-ZC54. (PMID: 27891458)
Contemp Clin Dent. 2018 Jul-Sep;9(3):330-336. (PMID: 30166822)
BMC Oral Health. 2015 Sep 03;15:104. (PMID: 26335205)
Caries Res. 2008;42(1):2-7. (PMID: 18042984)
Cochrane Database Syst Rev. 2006 Jul 19;(3):CD001476. (PMID: 16855970)
J Dent. 2019 Apr;83:1-6. (PMID: 30710652)
J Dent. 2019 Feb;81:1-6. (PMID: 30639724)
Materials (Basel). 2023 Jul 19;16(14):. (PMID: 37512363)
J Clin Dent. 2009;20(1):23-31. (PMID: 19489189)
Am J Dent. 2023 Dec;36(6):267-273. (PMID: 38092744)
Arch Oral Biol. 2008 Feb;53(2):105-8. (PMID: 17977511)
J Clin Dent. 2009;20(4):123-30. (PMID: 19831165)
J Dent Sci. 2025 Apr;20(2):844-853. (PMID: 40224037)
Dent Mater J. 2020 Sep 29;39(5):855-861. (PMID: 32461510)
Endod Dent Traumatol. 1991 Aug;7(4):145-52. (PMID: 1915127)
J Am Dent Assoc. 2019 Apr;150(4S):S47-S59. (PMID: 30797259)
Sci Rep. 2017 Dec 20;7(1):17909. (PMID: 29263431)
Biomedicines. 2023 Sep 05;11(9):. (PMID: 37760904)
Am J Dent. 2010 May;23 Spec No A:20A-27A. (PMID: 21284248)
Braz Oral Res. 2012 Sep-Oct;26(5):410-7. (PMID: 23018228)
Clin Oral Investig. 2013 Mar;17 Suppl 1:S9-19. (PMID: 23224116)
Dent Mater. 2021 Nov;37(11):1714-1723. (PMID: 34548177)
Int Dent J. 2024 Dec;74(6):1233-1238. (PMID: 38614882)
Odontology. 2025 Oct;113(4):1456-1466. (PMID: 40009270)
BMC Oral Health. 2022 Nov 11;22(1):483. (PMID: 36368979)
J Adv Res. 2026 Jun;84:509-523. (PMID: 40998255)
Am J Dent. 2013 Feb;26(1):10-4. (PMID: 23724543)
J Conserv Dent. 2017 Jul-Aug;20(4):269-272. (PMID: 29259366)
J Clin Periodontol. 1983 Jul;10(4):351-63. (PMID: 6350374)
Front Oral Health. 2025 Jun 05;6:1550127. (PMID: 40538421)
Sci Rep. 2023 Mar 31;13(1):5271. (PMID: 37002263)
Sci Rep. 2019 May 22;9(1):7681. (PMID: 31118458)
J Dent Res. 1985 Apr;64 Spec No:613-20. (PMID: 3857264)
Arch Oral Biol. 2000 May;45(5):355-61. (PMID: 10739856)
Clin Oral Investig. 2024 Jul 30;28(8):457. (PMID: 39078468)
Malays J Med Sci. 2003 Jan;10(1):27-36. (PMID: 23365497)
J Phys Chem Lett. 2017 Apr 6;8(7):1599-1603. (PMID: 28301160)
Contributed Indexing: Keywords: Dentinal fluid flow; dentin hypersensitivity; desensitising toothpaste; subnanolitre-scaled fluid flow measuring device
Substance Nomenclature: 0 (Dentin Desensitizing Agents)
8ZYQ1474W7 (Sodium Fluoride)
0 (Toothpastes)
Entry Date(s): Date Created: 20260311 Date Completed: 20260710 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC12994060
DOI: 10.1016/j.identj.2026.109487
PMID: 41812584
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.identj.2026.109487?
    Name: ScienceDirect (all content) (s7799221)
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=1875595X&ISBN=&volume=76&issue=3&date=20260601&spage=109487&pages=109487&title=International dental journal&atitle=Real-Time%20Assessment%20of%20Dentinal%20Fluid%20Flow%20Reduction%20by%20Desensitising%20Agents%20Using%20Subnanolitre%20Flow%20Measuring%20System.&aulast=Kim%20S&id=DOI:10.1016/j.identj.2026.109487
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 41812584
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Real-Time Assessment of Dentinal Fluid Flow Reduction by Desensitising Agents Using Subnanolitre Flow Measuring System.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Kim+S%22&quot;&gt;Kim S&lt;/searchLink&gt;; Department of Oral Anatomy and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Yamaguchi+S%22&quot;&gt;Yamaguchi S&lt;/searchLink&gt;; AI Research Unit, Graduate School of Dentistry, The University of Osaka, Osaka, Japan.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Lee+IB%22&quot;&gt;Lee IB&lt;/searchLink&gt;; Department of Conservative Dentistry, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Park+YS%22&quot;&gt;Park YS&lt;/searchLink&gt;; Department of Oral Anatomy and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea; Department of Integrated Dentistry, School of Dentistry, Seoul National University, Seoul, Republic of Korea. Electronic address: ayoayo7@snu.ac.kr.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%220374714%22&quot;&gt;International dental journal&lt;/searchLink&gt; [Int Dent J] 2026 Jun; Vol. 76 (3), pp. 109487. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2026 Mar 10.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: &lt;i&gt;Publisher: &lt;/i&gt;&lt;searchLink fieldCode=&quot;PB&quot; term=&quot;%22Elsevier%22&quot;&gt;Elsevier &lt;/searchLink&gt;&lt;i&gt;Country of Publication: &lt;/i&gt;England &lt;i&gt;NLM ID: &lt;/i&gt;0374714 &lt;i&gt;Publication Model: &lt;/i&gt;Print-Electronic &lt;i&gt;Cited Medium: &lt;/i&gt;Internet &lt;i&gt;ISSN: &lt;/i&gt;1875-595X (Electronic) &lt;i&gt;Linking ISSN: &lt;/i&gt;&lt;searchLink fieldCode=&quot;IS&quot; term=&quot;%2200206539%22&quot;&gt;00206539 &lt;/searchLink&gt;&lt;i&gt;NLM ISO Abbreviation: &lt;/i&gt;Int Dent J &lt;i&gt;Subsets: &lt;/i&gt;MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: &lt;i&gt;Publication&lt;/i&gt;: 2021- : London : Elsevier&lt;br /&gt;&lt;i&gt;Original Publication&lt;/i&gt;: London : FDI World Dental
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentinal+Fluid%22&quot;&gt;Dentinal Fluid*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentinal+Fluid+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Desensitizing+Agents%22&quot;&gt;Dentin Desensitizing Agents*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Desensitizing+Agents+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin%22&quot;&gt;Dentin*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin%22&quot;&gt;Dentin*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+ultrastructure%22&quot;&gt;ultrastructure&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Sodium+Fluoride%22&quot;&gt;Sodium Fluoride&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Sodium+Fluoride+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Toothpastes%22&quot;&gt;Toothpastes&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Toothpastes+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dentin+Permeability%22&quot;&gt;Dentin Permeability&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dentin+Permeability+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dentin+Sensitivity%22&quot;&gt;Dentin Sensitivity&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dentin+Sensitivity+drug+therapy%22&quot;&gt;drug therapy&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Animals%22&quot;&gt;Animals&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Cattle%22&quot;&gt;Cattle&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Microscopy%2C+Electron%2C+Scanning%22&quot;&gt;Microscopy, Electron, Scanning&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22In+Vitro+Techniques%22&quot;&gt;In Vitro Techniques&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Fluoride+Treatment%22&quot;&gt;Fluoride Treatment&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: This study aimed to evaluate and compare the dentinal tubule-occluding efficacy of various desensitising toothpastes and a sodium fluoride varnish using a subnanolitre scaled fluid flow measuring device (NFMD).&lt;br /&gt;Methods: Bovine dentin specimens were treated with four desensitising toothpastes (Colgate, Median, Bamboo Salt, and Sensodyne), a 2.1% sodium fluoride professionally-deliverable varnish (Clinpro), and distilled water (DW). Real-time dentinal fluid flow (DFF) was measured under simulated pulpal pressure (32 cm H₂O) for 1000 seconds using the NFMD system. Each toothpaste was applied directly to assess its chemical occlusion capability, with measurements recorded before, during, and after material removal. Surface morphology and the extent of tubule occlusion were examined using field-emission scanning electron microscopy (FE-SEM) in both cross-sectional and surface views. Data were analysed by one-way analysis of variance.&lt;br /&gt;Results: A significant overall treatment effect was observed (P &amp;lt; .001). Bamboo Salt, Sensodyne, and Colgate showed greater mean reductions than Clinpro, whereas Median did not outperform the DW group. SEM findings supported these trends, revealing substantial tubule occlusion for Bamboo Salt and Sensodyne and minimal occlusion for Median and DW.&lt;br /&gt;Conclusion: Desensitising toothpastes reduced dentinal permeability to levels comparable to a sodium fluoride varnish. Real-time fluid flow measurement using NFMD enabled functional validation of dentinal tubule occlusion beyond surface morphology.&lt;br /&gt;Clinical Relevance: Commonly available desensitising toothpastes can provide meaningful reductions in dentinal permeability. Understanding how different formulations interact with exposed dentin may help guide product selection based on a patient&#39;s specific needs. Real-time assessments of dentinal fluid movement may also assist in evaluating emerging desensitising technologies.&lt;br /&gt; (Copyright &#169; 2026 The Authors. Published by Elsevier Inc. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Conflict of interest None disclosed.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: J Dent. 2019 Sep;88:103170. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2231325467%22&quot;&gt;31325467)&lt;/searchLink&gt;&lt;br /&gt;Oral Health Prev Dent. 2011;9(4):353-67. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2222238734%22&quot;&gt;22238734)&lt;/searchLink&gt;&lt;br /&gt;Int J Clin Pediatr Dent. 2023 Sep-Oct;16(5):698-706. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238162235%22&quot;&gt;38162235)&lt;/searchLink&gt;&lt;br /&gt;Korean J Pain. 2013 Oct;26(4):347-55. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2224156000%22&quot;&gt;24156000)&lt;/searchLink&gt;&lt;br /&gt;Int Dent J. 2014 Mar;64 Suppl 1:16-21. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2224571700%22&quot;&gt;24571700)&lt;/searchLink&gt;&lt;br /&gt;Oper Dent. 2013 Jul-Aug;38(4):419-28. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223110582%22&quot;&gt;23110582)&lt;/searchLink&gt;&lt;br /&gt;J Am Dent Assoc. 2006 Jul;137(7):990-8; quiz 1028-9. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2216803826%22&quot;&gt;16803826)&lt;/searchLink&gt;&lt;br /&gt;Clin Oral Investig. 2013 Mar;17 Suppl 1:S63-71. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223271217%22&quot;&gt;23271217)&lt;/searchLink&gt;&lt;br /&gt;J Clin Diagn Res. 2016 Oct;10(10):ZC51-ZC54. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2227891458%22&quot;&gt;27891458)&lt;/searchLink&gt;&lt;br /&gt;Contemp Clin Dent. 2018 Jul-Sep;9(3):330-336. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2230166822%22&quot;&gt;30166822)&lt;/searchLink&gt;&lt;br /&gt;BMC Oral Health. 2015 Sep 03;15:104. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2226335205%22&quot;&gt;26335205)&lt;/searchLink&gt;&lt;br /&gt;Caries Res. 2008;42(1):2-7. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2218042984%22&quot;&gt;18042984)&lt;/searchLink&gt;&lt;br /&gt;Cochrane Database Syst Rev. 2006 Jul 19;(3):CD001476. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2216855970%22&quot;&gt;16855970)&lt;/searchLink&gt;&lt;br /&gt;J Dent. 2019 Apr;83:1-6. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2230710652%22&quot;&gt;30710652)&lt;/searchLink&gt;&lt;br /&gt;J Dent. 2019 Feb;81:1-6. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2230639724%22&quot;&gt;30639724)&lt;/searchLink&gt;&lt;br /&gt;Materials (Basel). 2023 Jul 19;16(14):. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2237512363%22&quot;&gt;37512363)&lt;/searchLink&gt;&lt;br /&gt;J Clin Dent. 2009;20(1):23-31. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2219489189%22&quot;&gt;19489189)&lt;/searchLink&gt;&lt;br /&gt;Am J Dent. 2023 Dec;36(6):267-273. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238092744%22&quot;&gt;38092744)&lt;/searchLink&gt;&lt;br /&gt;Arch Oral Biol. 2008 Feb;53(2):105-8. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2217977511%22&quot;&gt;17977511)&lt;/searchLink&gt;&lt;br /&gt;J Clin Dent. 2009;20(4):123-30. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2219831165%22&quot;&gt;19831165)&lt;/searchLink&gt;&lt;br /&gt;J Dent Sci. 2025 Apr;20(2):844-853. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2240224037%22&quot;&gt;40224037)&lt;/searchLink&gt;&lt;br /&gt;Dent Mater J. 2020 Sep 29;39(5):855-861. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2232461510%22&quot;&gt;32461510)&lt;/searchLink&gt;&lt;br /&gt;Endod Dent Traumatol. 1991 Aug;7(4):145-52. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%221915127%22&quot;&gt;1915127)&lt;/searchLink&gt;&lt;br /&gt;J Am Dent Assoc. 2019 Apr;150(4S):S47-S59. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2230797259%22&quot;&gt;30797259)&lt;/searchLink&gt;&lt;br /&gt;Sci Rep. 2017 Dec 20;7(1):17909. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2229263431%22&quot;&gt;29263431)&lt;/searchLink&gt;&lt;br /&gt;Biomedicines. 2023 Sep 05;11(9):. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2237760904%22&quot;&gt;37760904)&lt;/searchLink&gt;&lt;br /&gt;Am J Dent. 2010 May;23 Spec No A:20A-27A. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2221284248%22&quot;&gt;21284248)&lt;/searchLink&gt;&lt;br /&gt;Braz Oral Res. 2012 Sep-Oct;26(5):410-7. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223018228%22&quot;&gt;23018228)&lt;/searchLink&gt;&lt;br /&gt;Clin Oral Investig. 2013 Mar;17 Suppl 1:S9-19. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223224116%22&quot;&gt;23224116)&lt;/searchLink&gt;&lt;br /&gt;Dent Mater. 2021 Nov;37(11):1714-1723. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2234548177%22&quot;&gt;34548177)&lt;/searchLink&gt;&lt;br /&gt;Int Dent J. 2024 Dec;74(6):1233-1238. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238614882%22&quot;&gt;38614882)&lt;/searchLink&gt;&lt;br /&gt;Odontology. 2025 Oct;113(4):1456-1466. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2240009270%22&quot;&gt;40009270)&lt;/searchLink&gt;&lt;br /&gt;BMC Oral Health. 2022 Nov 11;22(1):483. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2236368979%22&quot;&gt;36368979)&lt;/searchLink&gt;&lt;br /&gt;J Adv Res. 2026 Jun;84:509-523. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2240998255%22&quot;&gt;40998255)&lt;/searchLink&gt;&lt;br /&gt;Am J Dent. 2013 Feb;26(1):10-4. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223724543%22&quot;&gt;23724543)&lt;/searchLink&gt;&lt;br /&gt;J Conserv Dent. 2017 Jul-Aug;20(4):269-272. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2229259366%22&quot;&gt;29259366)&lt;/searchLink&gt;&lt;br /&gt;J Clin Periodontol. 1983 Jul;10(4):351-63. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%226350374%22&quot;&gt;6350374)&lt;/searchLink&gt;&lt;br /&gt;Front Oral Health. 2025 Jun 05;6:1550127. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2240538421%22&quot;&gt;40538421)&lt;/searchLink&gt;&lt;br /&gt;Sci Rep. 2023 Mar 31;13(1):5271. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2237002263%22&quot;&gt;37002263)&lt;/searchLink&gt;&lt;br /&gt;Sci Rep. 2019 May 22;9(1):7681. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2231118458%22&quot;&gt;31118458)&lt;/searchLink&gt;&lt;br /&gt;J Dent Res. 1985 Apr;64 Spec No:613-20. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%223857264%22&quot;&gt;3857264)&lt;/searchLink&gt;&lt;br /&gt;Arch Oral Biol. 2000 May;45(5):355-61. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210739856%22&quot;&gt;10739856)&lt;/searchLink&gt;&lt;br /&gt;Clin Oral Investig. 2024 Jul 30;28(8):457. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2239078468%22&quot;&gt;39078468)&lt;/searchLink&gt;&lt;br /&gt;Malays J Med Sci. 2003 Jan;10(1):27-36. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223365497%22&quot;&gt;23365497)&lt;/searchLink&gt;&lt;br /&gt;J Phys Chem Lett. 2017 Apr 6;8(7):1599-1603. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2228301160%22&quot;&gt;28301160)&lt;/searchLink&gt;
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: &lt;i&gt;Keywords: &lt;/i&gt;Dentinal fluid flow; dentin hypersensitivity; desensitising toothpaste; subnanolitre-scaled fluid flow measuring device
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Dentin Desensitizing Agents)&lt;br /&gt;8ZYQ1474W7 (Sodium Fluoride)&lt;br /&gt;0 (Toothpastes)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: &lt;i&gt;Date Created: &lt;/i&gt;20260311 &lt;i&gt;Date Completed: &lt;/i&gt;20260710 &lt;i&gt;Latest Revision: &lt;/i&gt;20260813
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260813
– Name: PubmedCentralID
  Label: PubMed Central ID
  Group: ID
  Data: PMC12994060
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.identj.2026.109487
– Name: AN
  Label: PMID
  Group: ID
  Data: 41812584
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=41812584
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.identj.2026.109487
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 109487
    Subjects:
      – SubjectFull: Sodium Fluoride pharmacology
        Type: general
      – SubjectFull: Toothpastes pharmacology
        Type: general
      – SubjectFull: Dentin Permeability drug effects
        Type: general
      – SubjectFull: Dentin Sensitivity drug therapy
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Cattle
        Type: general
      – SubjectFull: Microscopy, Electron, Scanning
        Type: general
      – SubjectFull: In Vitro Techniques
        Type: general
      – SubjectFull: Fluoride Treatment
        Type: general
      – SubjectFull: Dentinal Fluid drug effects
        Type: general
      – SubjectFull: Dentin Desensitizing Agents pharmacology
        Type: general
      – SubjectFull: Dentin drug effects
        Type: general
      – SubjectFull: Dentin ultrastructure
        Type: general
    Titles:
      – TitleFull: Real-Time Assessment of Dentinal Fluid Flow Reduction by Desensitising Agents Using Subnanolitre Flow Measuring System.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kim S
      – PersonEntity:
          Name:
            NameFull: Yamaguchi S
      – PersonEntity:
          Name:
            NameFull: Lee IB
      – PersonEntity:
          Name:
            NameFull: Park YS
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1875-595X
          Numbering:
            – Type: volume
              Value: 76
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: International dental journal
              Type: main
ResultId 1