Academic Journal
Leveraging nature's experiments: David Crews' legacy in behavioral neuroendocrinology.
| Τίτλος: | Leveraging nature's experiments: David Crews' legacy in behavioral neuroendocrinology. |
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| Συγγραφείς: | Sakata JT; Department of Biology, McGill University, Canada; Integrated Program in Neuroscience, McGill University, Canada. Electronic address: jon.sakata@mcgill.ca., Woolley SC; Department of Biology, McGill University, Canada; Integrated Program in Neuroscience, McGill University, Canada., Gillette R; Department of Integrative Biology, University of Texas at Austin, USA., Nelson RJ; Department of Neuroscience, West Virginia University, USA., Rhen T; Department of Biology, University of North Dakota, USA. Electronic address: turk.rhen@und.edu. |
| Πηγή: | Hormones and behavior [Horm Behav] 2026 Apr; Vol. 180, pp. 105908. Date of Electronic Publication: 2026 Mar 06. |
| Τύπος έκδοσης: | Journal Article; Historical Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Academic Press Country of Publication: United States NLM ID: 0217764 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6867 (Electronic) Linking ISSN: 0018506X NLM ISO Abbreviation: Horm Behav Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, London, Academic Press. |
| Ιατρικοί όροι (MeSH): | Neuroendocrinology*/history , Behavior, Animal*/physiology, Sexual Behavior, Animal/physiology ; Sex Differentiation/physiology ; Animals ; Biological Evolution ; History, 20th Century ; History, 21st Century ; Social Behavior |
| Περίληψη: | Evolution provides a magnificent set of natural experiments, offering a window into factors shaping morphology, physiology, behavior, and reproductive strategies. David Crews (18 April 1947-16 September 2025) embraced the power of natural experiments to gain insight into biological mechanisms and championed the study of reptiles to uncover general principles of behavioral biology. Here we synthesize his decades of research into comparative and behavioral neuroendocrinology, underscoring how his studies on temperature-dependent sex determination, neural and hormonal mechanisms of sexual differentiation, the evolution of brain mechanisms for social behavior, and transgenerational epigenetic inheritance revealed some of the most fascinating and unimaginable mechanisms of reproduction. While he focused on biological mechanisms in lizards, snakes, and turtles, his research has implications beyond reptiles, challenging dogma and forcing reconsideration of classic paradigms and frameworks. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The authors of the review paper outlining David Crews' legacy were either trainees (JTS, SCW, RG, and TR) or colleagues (RJN). Our paper summarizes his various contributions to the field of behavioral neuroendocrinology and aims to highlight the breadth and depth of his contributions. |
| Contributed Indexing: | Keywords: Aggression; Behavioral neuroscience; Comparative neuroscience; Evolution; Hypothalamus; Lizard; Sexual behavior; Sexual differentiation; Snake; Social behavior; Turtle |
| Entry Date(s): | Date Created: 20260307 Date Completed: 20260710 Latest Revision: 20260807 |
| Update Code: | 20260807 |
| DOI: | 10.1016/j.yhbeh.2026.105908 |
| PMID: | 41793959 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1095-6867 |
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| DOI: | 10.1016/j.yhbeh.2026.105908 |