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Safety Assessment of Starch Phosphates as Used in Cosmetics.

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Title: Safety Assessment of Starch Phosphates as Used in Cosmetics.
Authors: Johnson W Jr; Cosmetic Ingredient Review Former Senior Scientific Analyst/Writer., Tucker R; Cosmetic Ingredient Review Former Scientific Analyst/Writer., Bergfeld WF; Expert Panel for Cosmetic Ingredient Safety Member., Belsito DV; Expert Panel for Cosmetic Ingredient Safety Member., Cohen DE; Expert Panel for Cosmetic Ingredient Safety Member., Klaassen CD; Expert Panel for Cosmetic Ingredient Safety Member., Liebler DC; Expert Panel for Cosmetic Ingredient Safety Former Member., Rettie AE; Expert Panel for Cosmetic Ingredient Safety Member., Ross D; Expert Panel for Cosmetic Ingredient Safety Member., Shank RC; Expert Panel for Cosmetic Ingredient Safety Former Member., Slaga TJ; Expert Panel for Cosmetic Ingredient Safety Former Member., Snyder PW; Expert Panel for Cosmetic Ingredient Safety Member., Tilton SC; Expert Panel for Cosmetic Ingredient Safety Member., Fiume M; Cosmetic Ingredient Review Senior Director., Heldreth B; Cosmetic Ingredient Review Executive Director.
Source: International journal of toxicology [Int J Toxicol] 2026 Feb; Vol. 45 (1_suppl), pp. 48S-67S. Date of Electronic Publication: 2026 Feb 28.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 9708436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1092-874X (Electronic) Linking ISSN: 10915818 NLM ISO Abbreviation: Int J Toxicol Subsets: MEDLINE
Imprint Name(s): Publication: 2009- : Thousand Oaks, CA : Sage Publications
Original Publication: Washington, DC : Taylor & Francis, c1997-
MeSH Terms: Cosmetics*/chemistry , Cosmetics*/toxicity , Starch*/analogs & derivatives , Starch*/toxicity , Starch*/chemistry , Starch*/pharmacokinetics , Phosphates*/toxicity , Phosphates*/chemistry , Consumer Product Safety*, Animals ; Humans
Abstract: The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 4 starch phosphates as used in cosmetic formulations. Distarch Phosphate is reported to function in cosmetics as an anticaking agent and binder. Distarch Phosphate Acetate, Hydroxypropyl Starch Phosphate, and Sodium Hydroxypropyl Starch Phosphate are all reported to function as viscosity increasing agents. The Panel considered the available data and concluded that these ingredients are safe in cosmetics in the present practices of use and concentrations described in this safety assessment.
Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Contributed Indexing: Keywords: Cosmetic Ingredient Review; Cosmetics; Distarch Phosphate; Distarch Phosphate Acetate; Expert Panel for Cosmetic Ingredient Safety; Hydroxypropyl Starch Phosphate; Safety; Sodium Hydroxypropyl Starch Phosphate
Substance Nomenclature: 0 (Cosmetics)
9005-25-8 (Starch)
0 (Phosphates)
Entry Date(s): Date Created: 20260228 Date Completed: 20260709 Latest Revision: 20260723
Update Code: 20260723
DOI: 10.1177/10915818261425590
PMID: 41761848
Database: MEDLINE
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Header DbId: cmedm
DbLabel: MEDLINE
An: 41761848
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
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  Data: Safety Assessment of Starch Phosphates as Used in Cosmetics.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Johnson+W+Jr%22">Johnson W Jr</searchLink>; Cosmetic Ingredient Review Former Senior Scientific Analyst/Writer.<br /><searchLink fieldCode="AU" term="%22Tucker+R%22">Tucker R</searchLink>; Cosmetic Ingredient Review Former Scientific Analyst/Writer.<br /><searchLink fieldCode="AU" term="%22Bergfeld+WF%22">Bergfeld WF</searchLink>; Expert Panel for Cosmetic Ingredient Safety Member.<br /><searchLink fieldCode="AU" term="%22Belsito+DV%22">Belsito DV</searchLink>; Expert Panel for Cosmetic Ingredient Safety Member.<br /><searchLink fieldCode="AU" term="%22Cohen+DE%22">Cohen DE</searchLink>; Expert Panel for Cosmetic Ingredient Safety Member.<br /><searchLink fieldCode="AU" term="%22Klaassen+CD%22">Klaassen CD</searchLink>; Expert Panel for Cosmetic Ingredient Safety Member.<br /><searchLink fieldCode="AU" term="%22Liebler+DC%22">Liebler DC</searchLink>; Expert Panel for Cosmetic Ingredient Safety Former Member.<br /><searchLink fieldCode="AU" term="%22Rettie+AE%22">Rettie AE</searchLink>; Expert Panel for Cosmetic Ingredient Safety Member.<br /><searchLink fieldCode="AU" term="%22Ross+D%22">Ross D</searchLink>; Expert Panel for Cosmetic Ingredient Safety Member.<br /><searchLink fieldCode="AU" term="%22Shank+RC%22">Shank RC</searchLink>; Expert Panel for Cosmetic Ingredient Safety Former Member.<br /><searchLink fieldCode="AU" term="%22Slaga+TJ%22">Slaga TJ</searchLink>; Expert Panel for Cosmetic Ingredient Safety Former Member.<br /><searchLink fieldCode="AU" term="%22Snyder+PW%22">Snyder PW</searchLink>; Expert Panel for Cosmetic Ingredient Safety Member.<br /><searchLink fieldCode="AU" term="%22Tilton+SC%22">Tilton SC</searchLink>; Expert Panel for Cosmetic Ingredient Safety Member.<br /><searchLink fieldCode="AU" term="%22Fiume+M%22">Fiume M</searchLink>; Cosmetic Ingredient Review Senior Director.<br /><searchLink fieldCode="AU" term="%22Heldreth+B%22">Heldreth B</searchLink>; Cosmetic Ingredient Review Executive Director.
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  Data: <searchLink fieldCode="JN" term="%229708436%22">International journal of toxicology</searchLink> [Int J Toxicol] 2026 Feb; Vol. 45 (1_suppl), pp. 48S-67S. <i>Date of Electronic Publication: </i>2026 Feb 28.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Review
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Sage+Publications%22">Sage Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9708436 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1092-874X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210915818%22">10915818 </searchLink><i>NLM ISO Abbreviation: </i>Int J Toxicol <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Publication</i>: 2009- : Thousand Oaks, CA : Sage Publications<br /><i>Original Publication</i>: Washington, DC : Taylor & Francis, c1997-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Cosmetics%22">Cosmetics*</searchLink>/<searchLink fieldCode="MM" term="%22Cosmetics+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Cosmetics%22">Cosmetics*</searchLink>/<searchLink fieldCode="MM" term="%22Cosmetics+toxicity%22">toxicity</searchLink> <br /><searchLink fieldCode="MM" term="%22Starch%22">Starch*</searchLink>/<searchLink fieldCode="MM" term="%22Starch+analogs+%26+derivatives%22">analogs & derivatives</searchLink> <br /><searchLink fieldCode="MM" term="%22Starch%22">Starch*</searchLink>/<searchLink fieldCode="MM" term="%22Starch+toxicity%22">toxicity</searchLink> <br /><searchLink fieldCode="MM" term="%22Starch%22">Starch*</searchLink>/<searchLink fieldCode="MM" term="%22Starch+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Starch%22">Starch*</searchLink>/<searchLink fieldCode="MM" term="%22Starch+pharmacokinetics%22">pharmacokinetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Phosphates%22">Phosphates*</searchLink>/<searchLink fieldCode="MM" term="%22Phosphates+toxicity%22">toxicity</searchLink> <br /><searchLink fieldCode="MM" term="%22Phosphates%22">Phosphates*</searchLink>/<searchLink fieldCode="MM" term="%22Phosphates+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Consumer+Product+Safety%22">Consumer Product Safety*</searchLink><br /><searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 4 starch phosphates as used in cosmetic formulations. Distarch Phosphate is reported to function in cosmetics as an anticaking agent and binder. Distarch Phosphate Acetate, Hydroxypropyl Starch Phosphate, and Sodium Hydroxypropyl Starch Phosphate are all reported to function as viscosity increasing agents. The Panel considered the available data and concluded that these ingredients are safe in cosmetics in the present practices of use and concentrations described in this safety assessment.
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>Cosmetic Ingredient Review; Cosmetics; Distarch Phosphate; Distarch Phosphate Acetate; Expert Panel for Cosmetic Ingredient Safety; Hydroxypropyl Starch Phosphate; Safety; Sodium Hydroxypropyl Starch Phosphate
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Cosmetics)<br />9005-25-8 (Starch)<br />0 (Phosphates)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260228 <i>Date Completed: </i>20260709 <i>Latest Revision: </i>20260723
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260723
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1177/10915818261425590
– Name: AN
  Label: PMID
  Group: ID
  Data: 41761848
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=41761848
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1177/10915818261425590
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 48S
    Subjects:
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Cosmetics chemistry
        Type: general
      – SubjectFull: Cosmetics toxicity
        Type: general
      – SubjectFull: Starch analogs & derivatives
        Type: general
      – SubjectFull: Starch toxicity
        Type: general
      – SubjectFull: Starch chemistry
        Type: general
      – SubjectFull: Starch pharmacokinetics
        Type: general
      – SubjectFull: Phosphates toxicity
        Type: general
      – SubjectFull: Phosphates chemistry
        Type: general
      – SubjectFull: Consumer Product Safety
        Type: general
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      – TitleFull: Safety Assessment of Starch Phosphates as Used in Cosmetics.
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              Text: 2026 Feb
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