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Advancing universal dental adhesives: Biomimetic strategies for enhanced hybrid layer remineralisation and bond durability.

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Τίτλος: Advancing universal dental adhesives: Biomimetic strategies for enhanced hybrid layer remineralisation and bond durability.
Συγγραφείς: Alnakib Y; Department of Restorative and Aesthetic Dentistry, College of Dentistry, University of Baghdad, Baghdad, Iraq., Majeed MA; Department of Restorative and Aesthetic Dentistry, College of Dentistry, University of Baghdad, Baghdad, Iraq., Sauro S; Dental Biomaterials and Minimally Invasive Dentistry, Departamento de Odontología, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, CEU Universities, Valencia, Spain.
Πηγή: European journal of oral sciences [Eur J Oral Sci] 2026 Jun; Vol. 134 (3), pp. e70078. Date of Electronic Publication: 2026 Feb 27.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9504563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0722 (Electronic) Linking ISSN: 09098836 NLM ISO Abbreviation: Eur J Oral Sci Subsets: MEDLINE
Imprint Name(s): Publication: Chichester : Wiley-Blackwell
Original Publication: Copenhagen : Munksgaard, c1995-
Ιατρικοί όροι (MeSH): Tooth Remineralization*/methods , Biomimetic Materials*/chemistry , Dentin-Bonding Agents*/chemistry , Dental Bonding*, Calcium Phosphates/chemistry ; Silicon Dioxide/chemistry ; Nanoparticles/chemistry ; Acrylic Resins/chemistry ; Polyphosphates/chemistry ; Resin Cements/chemistry ; Dentin/ultrastructure ; Acid Etching, Dental/methods ; Tensile Strength ; Humans ; Materials Testing ; Elastic Modulus ; Spectrum Analysis, Raman ; Phosphorylation ; Biomimetics ; Microscopy, Confocal ; Surface Properties ; Porosity ; Dentin Permeability
Περίληψη: Resin-dentine bonds degrade when water-rich, resin-sparse collagen persists within the hybrid layer. This study evaluated biomimetic remineralisation strategies that aimed to enhance adhesive durability: polyacrylic acid-stabilised amorphous calcium phosphate-loaded mesoporous silica nanoparticles (PA-ACP/MSN) incorporated at 15 vol% into the primer phases of two commercially available two-step universal adhesives (G2 Bond Universal and OptiBond eXTRa Universal) applied in etch-and-rinse mode, with or without phosphorylation pretreatment (5% PA + 5% sodium trimetaphosphate). Adhesive-dentine specimens were characterised using microtensile bond strength (µTBS), confocal Raman microscopy (Phosphate peaks; Resin CH2 peaks; Mineral-Matrix ratio MMR), nanoindentation across the hybrid layer and dye-assisted micropermeability assays. The incorporation of PA-ACP/MSN did not adversely affect the immediate µTBS of either adhesive. After ageing, the biomimetic treatment group demonstrated enhanced phosphate content, improved micro-mechanical properties, preservation of resin characteristics, a higher elastic modulus across the hybrid layer and a marked reduction in permeability relative to the control group. Adding the phosphorylation pretreatment step conferred no additional benefit over PA-ACP/MSN alone. These findings indicated that embedding PA-ACP/MSN in universal-adhesive primers promoted remineralisation, stiffened and sealed the hybrid layer, and preserved bonding effectiveness without adding clinical complexity, supporting a practical path to durable, bioactive/biomimetic resin-dentine interfaces.
(© 2026 Scandinavian Division of the International Association for Dental Research. Published by John Wiley & Sons Ltd.)
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Contributed Indexing: Keywords: adhesive permeability; biomimetic remineralisation; bond strength; elastic modulus; resin–dentine interface
Substance Nomenclature: 0 (Calcium Phosphates)
7631-86-9 (Silicon Dioxide)
0 (Dentin-Bonding Agents)
0 (amorphous calcium phosphate)
4Q93RCW27E (carbopol 940)
H6C6T4285H (trimetaphosphoric acid)
0 (Acrylic Resins)
0 (Polyphosphates)
0 (Resin Cements)
Entry Date(s): Date Created: 20260227 Date Completed: 20260709 Latest Revision: 20260721
Update Code: 20260722
DOI: 10.1111/eos.70078
PMID: 41757560
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1600-0722
DOI:10.1111/eos.70078