Academic Journal
Advancing brain health equity with Indigenous peoples: A critical imperative.
| Τίτλος: | Advancing brain health equity with Indigenous peoples: A critical imperative. |
|---|---|
| Συγγραφείς: | Clarke AJ; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Whetung C; Department of Family Medicine and Biobehavioural Health, Memory Keepers Medical Discovery Team, University of Minnesota, Minneapolis, Minnesota, USA., Suchy-Dicey A; Slone Epidemiology Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, Massachusetts, USA., Withall A; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Radford K; School of Psychology, University of New South Wales, Kensington, New South Wales, Australia., Gooding DC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Letters and Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Lavrencic L; Neuroscience Research Australia, University of New South Wales, Kensington, New South Wales, Australia., Dudley M; School of Psychology, Centre for Brain Research, University of Auckland, Auckland, New Zealand., Lo Giudice D; Department of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia., Flicker L; Medical School, University of Western Australia, Perth, Western Australia, Australia., Boluarte AS; Center for Global Health, Universidad Peruana Cayetano Heredia, Heredia, Peru., Aggarwal S; Maulana Azad Medical College, New Delhi, India., Conniff KR; University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin-Madison School of Letters and Sciences, Madison, Wisconsin, USA., Brodtmann AG; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Diaz MM; Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Tremblay SA; Department of Neurology and Neurosurgery, The Neuro, McGill University, Montreal, Quebec, Canada., Nwofe ES; Centre for Applied Dementia Studies, University of Bradford, Bradford, UK., Gleason CE; Wisconsin Alzheimer's Disease Research Center, Madison Veteran's Hospital GRECC, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Jacklin K; Department of Family Medicine and Biobehavioural Health, University of Minnesota, Minneapolis, Minnesota, USA., Kaholokula JK; John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawai'i., Gibson C; Aboriginal Health and Ageing Team, Neuroscience Research Australia, Sydney, NSW, Australia., Souza-Talarico J; College of Nursing, University of Iowa, Iowa city, USA., Roach P; Departments of Family Medicine and Community Health Services, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. |
| Συλλογικό Έργο: | Alzheimer's Association Intermission 2025: Stronger Together Collaboration |
| Πηγή: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Feb; Vol. 22 (2), pp. e71125. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd. Original Publication: Orlando, FL : Elsevier, Inc. |
| Ιατρικοί όροι (MeSH): | Dementia*/ethnology , Dementia*/epidemiology , Brain* , Health Equity* , Indigenous Peoples*, Humans ; Health Services, Indigenous |
| Περίληψη: | Indigenous communities hold rich knowledges, cultural practices, and kinship networks that sustain cognitive resilience and nurture brain health across the life course. Yet these enduring strengths are often obscured by biomedical models that overlook the structural determinants of health-including the cumulative effects of colonization, educational inequity, and socioeconomic disadvantage-that diminish brain health. Accordingly, dementia disproportionately affects Indigenous populations globally, often presenting with earlier onset and higher prevalence compared to non-Indigenous groups. This perspective synthesizes the current epidemiological evidence, situates dementia risk within its structural and historical context, and explores how Indigenous knowledges, cultural continuity, and community leadership can inform dementia research and care more broadly. Our global insights call for a decisive shift: to decolonize dementia research and policy and move beyond deficit-based narratives toward approaches that prioritize Indigenous leadership and culturally grounded, strengths-based pathways to brain health equity. HIGHLIGHTS: This perspective synthesizes global evidence on dementia epidemiology among Indigenous populations, examining structural determinants and Indigenous perspectives on brain health and dementia care. Structural inequities and the enduring legacies of colonization, rather than biology alone, underpin the disproportionate dementia burden among Indigenous peoples worldwide. Centering culture, kinship, and connection to land and community reframes brain health beyond biomedical models and reveals cultural resilience as a powerful neuroprotective resource. Key recommendations call for Indigenous leadership and locally tailored, culturally grounded approaches to advance lifelong brain health equity and develop strengths-based models of dementia care. (© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.) |
| References: | Arch Clin Neuropsychol. 2010 Dec;25(8):689-712. (PMID: 21075867) Int Psychogeriatr. 2015 Dec;27(12):1959-70. (PMID: 26088474) Lancet Reg Health West Pac. 2025 Apr 03;57:101529. (PMID: 40242462) J Clin Transl Sci. 2017 Jun;1(3):167-175. (PMID: 28856013) Alzheimer Dis Assoc Disord. 2016 Jul-Sep;30(3):281-7. (PMID: 26840546) Public Health. 2019 Jul;172:15-21. (PMID: 31153045) Int J Environ Res Public Health. 2022 May 30;19(11):. (PMID: 35682275) Lancet Reg Health Am. 2025 Aug 12;50:101207. (PMID: 40832662) Behav Brain Sci. 2010 Jun;33(2-3):61-83; discussion 83-135. (PMID: 20550733) J Alzheimers Dis. 2021;81(4):1589-1599. (PMID: 33967039) Med J Aust. 2024 Dec 9;221(11):578-586. (PMID: 39529207) J Alzheimers Dis. 2020;78(4):1439-1451. (PMID: 33185601) Nature. 2025 Feb;638(8049):58-68. (PMID: 39910384) Fam Community Health. 2019 Jan/Mar;42(1):1-7. (PMID: 30431464) Dement Neuropsychol. 2014 Oct-Dec;8(4):345-350. (PMID: 29213924) Med J Aust. 2014 May 5;200(8):465-9. (PMID: 24794609) Int J Circumpolar Health. 2021 Dec;80(1):1964173. (PMID: 34375158) Alzheimers Dement (Amst). 2024 May 02;16(2):e12591. (PMID: 38706953) J Prev Alzheimers Dis. 2023;10(1):83-94. (PMID: 36641612) Int J Equity Health. 2024 Apr 16;23(1):75. (PMID: 38627768) Alzheimers Dement. 2026 Feb;22(2):e71125. (PMID: 41738518) Alzheimers Dement. 2023 Jan;19(1):44-55. (PMID: 35262289) Ann Neurol. 2025 Apr;97(4):642-656. (PMID: 39786167) Int Psychogeriatr. 2006 Jun;18(2):269-80. (PMID: 16403247) J Geriatr Psychiatry Neurol. 2021 Sep;34(5):434-444. (PMID: 32552216) Can J Aging. 2020 Jun;39(2):247-262. (PMID: 31666149) Lancet Healthy Longev. 2024 Dec;5(12):100658. (PMID: 39709981) Cogn Behav Neurol. 2021 Sep 2;34(3):200-206. (PMID: 34473671) J Alzheimers Dis. 2023;91(1):183-189. (PMID: 36373315) Australas J Ageing. 2022 Sep;41(3):e284-e290. (PMID: 35187775) Alzheimers Dement. 2016 Mar;12(3):216-24. (PMID: 26874595) Lancet. 2024 Aug 10;404(10452):572-628. (PMID: 39096926) PLOS Digit Health. 2025 May 29;4(5):e0000807. (PMID: 40440407) BMJ Open. 2024 Sep 13;14(9):e088281. (PMID: 39277208) Gerontologist. 2022 May 26;62(5):694-703. (PMID: 34919705) SSM Ment Health. 2025 Jun;7:. (PMID: 42147774) J Gen Intern Med. 2006 Jun;21(6):648-51. (PMID: 16808751) Neurology. 2008 Nov 4;71(19):1470-3. (PMID: 18799785) Neurology. 2007 May 22;68(21):1772-81. (PMID: 17515539) Gerontologist. 2022 May 26;62(5):e282-e292. (PMID: 35183065) Aging Ment Health. 2020 Aug;24(8):1183-1195. (PMID: 31074290) Can J Aging. 2020 Jun;39(2):220-234. (PMID: 31179965) J Alzheimers Dis. 2025 Feb;103(3):865-878. (PMID: 39772842) AMA J Ethics. 2016 Jul 01;18(7):743-53. (PMID: 27437825) Dementia (London). 2024 Jan;23(1):5-6. (PMID: 38112060) Contemp Clin Trials Commun. 2025 Feb 12;44:101457. (PMID: 40027277) PLoS One. 2014 Jan 28;9(1):e86278. (PMID: 24489710) EBioMedicine. 2025 Oct;120:105950. (PMID: 41004922) Dementia (London). 2020 Feb;19(2):397-415. (PMID: 29877735) Nat Med. 2025 Aug;31(8):2518-2531. (PMID: 40731089) Int Psychogeriatr. 2020 Nov;32(11):1267-1270. (PMID: 33292910) Int Psychogeriatr. 2020 Nov;32(11):1303-1315. (PMID: 31747978) Alzheimer Dis Assoc Disord. 2005 Oct-Dec;19(4):272-4. (PMID: 16327358) Healthcare (Basel). 2020 Apr 26;8(2):. (PMID: 32357396) Alzheimers Dement. 2024 Mar;20(3):2072-2079. (PMID: 38215191) Gerontol Geriatr Educ. 2022 Jul-Sep;43(3):315-327. (PMID: 33888037) Can Geriatr J. 2015 Sep 30;18(3):152-8. (PMID: 26495049) Neuropsychology. 2019 Nov;33(8):1078-1088. (PMID: 31343235) Ann Behav Med. 2021 Oct 4;55(10):1006-1018. (PMID: 33677520) J Adv Nurs. 2021 Mar;77(3):1155-1171. (PMID: 33270270) Lancet Reg Health West Pac. 2021 Jul 05;13:100191. (PMID: 34527984) J Health Serv Res Policy. 2024 Jul;29(3):210-221. (PMID: 38099443) Curr Opin Psychiatry. 2025 Mar 01;38(2):119-125. (PMID: 39804216) Can J Public Health. 2012 Nov 08;104(1):e39-44. (PMID: 23618107) Alzheimers Dement. 2016 Mar;12(3):252-61. (PMID: 25998515) J Alzheimers Dis. 2022;88(3):943-948. (PMID: 35723102) Alzheimers Dement (Amst). 2021 Jun 09;13(1):e12213. (PMID: 34136637) Neurology. 2022 Dec 12;99(24):e2637-e2647. (PMID: 36289000) J Alzheimers Dis. 2022;90(2):461-473. (PMID: 36093713) Int J Qual Methods. 2023 Jan-Dec;22:. (PMID: 38223457) Alzheimers Dement. 2024 Jun;20(6):4174-4184. (PMID: 38747387) J Gerontol A Biol Sci Med Sci. 2021 Nov 15;76(12):2147-2155. (PMID: 34038540) Am J Geriatr Psychiatry. 2017 Oct;25(10):1097-1106. (PMID: 28689644) J Cross Cult Gerontol. 2010 Dec;25(4):317-42. (PMID: 20593232) ANS Adv Nurs Sci. 2010 Apr-Jun;33(2):113-25. (PMID: 20460958) Int J Geriatr Psychiatry. 2021 Apr 30;37(1):. (PMID: 34131954) Aging Ment Health. 2020 Mar;24(3):481-488. (PMID: 30588837) Aust N Z J Psychiatry. 2010 Oct;44(10):888-93. (PMID: 20932202) Australas J Ageing. 2024 Sep;43(3):545-552. (PMID: 38497228) Lancet Public Health. 2023 Sep;8(9):e717-e725. (PMID: 37633680) Clin Psychol (New York). 2025 Mar;32(1):73-76. (PMID: 41459249) Front Public Health. 2023 Jul 11;11:1137428. (PMID: 37533522) Rural Remote Health. 2012;12:2078. (PMID: 23259852) Alzheimers Dement. 2024 Jan;20(1):563-592. (PMID: 37746888) Front Public Health. 2024 Feb 07;12:1346753. (PMID: 38425465) Neurology. 2022 Mar 15;98(11):e1124-e1136. (PMID: 35140131) N Z Med J. 2019 Oct 4;132(1503):66-74. (PMID: 31581183) Alzheimers Dement (Amst). 2024 Oct 16;16(4):e12620. (PMID: 39416487) J Neurosci Rural Pract. 2013 Apr;4(2):147-53. (PMID: 23914088) J Racial Ethn Health Disparities. 2020 Aug;7(4):698-739. (PMID: 31974734) Lancet. 2016 Jul 9;388(10040):131-57. (PMID: 27108232) Care Manag J. 2015;16(2):106-20. (PMID: 26171510) J Aging Health. 2021 Aug-Sep;33(7-8_suppl):60S-67S. (PMID: 34167346) BMC Health Serv Res. 2021 Jul 16;21(1):699. (PMID: 34271930) BMC Health Serv Res. 2020 Mar 12;20(1):208. (PMID: 32164678) Annu Rev Public Health. 2025 Apr;46(1):21-42. (PMID: 39883940) Gerontologist. 2021 Jul 13;61(5):e163-e172. (PMID: 32191314) Am J Epidemiol. 2025 Sep 3;194(9):2524-2531. (PMID: 40320252) Australas J Ageing. 2022 Dec;41(4):e320-e327. (PMID: 35993283) BMJ Open. 2023 Mar 1;13(3):e068974. (PMID: 36858467) |
| Grant Information: | Applied Research Collaboration; U54GM138062 United States GM NIGMS NIH HHS; R01 AG080398 United States AG NIA NIH HHS; R01 AG070822 United States AG NIA NIH HHS; D43TW009345 Fogarty International Center of the National Institutes of Health; Dementia Australia Research Foundation Post-Doctoral Fellowship; 366201 Fonds de recherche du Québec (FRQ) secteur Santé; K23MH131466 United States MH NIMH NIH HHS; Avant Research Foundation; UH2AG083258 Scientific Advisory Board; AG000213 Madison Biology of Aging; IDSMB; R01 AG074971 United States AG NIA NIH HHS; R36 AG078781 United States AG NIA NIH HHS; RF1 AG071677 United States AG NIA NIH HHS; GNT2022/202240 NHMRC; ANZAN Education and Research Fund; R01 AG062307 United States AG NIA NIH HHS; R01AG080398 American Indians; United States ALZ Alzheimer's Association; R01AG070822 American Indians; K23 MH131466 United States MH NIMH NIH HHS; Eastern Health Foundation; R01 AG027161 United States AG NIA NIH HHS; 3ODT2OD036478-01S1 Madison All of Us Program; U54 GM138062 United States GM NIGMS NIH HHS; NIHR200166 National Institute of Health and Care Research; D43TW009137 Northern Pacific Global Health Fellows Program; T32 AG000213 United States AG NIA NIH HHS; D43 TW009137 United States TW FIC NIH HHS; Universidad Cesar Vallejo; 75N92019D00028 United States HL NHLBI NIH HHS; OT2 OD036478 United States OD NIH HHS; University of North Carolina at Chapel Hill; P30 AG066509 United States AG NIA NIH HHS; P30 AG062715 United States AG NIA NIH HHS; RF1AG071677 American Indians; D43 TW009345 United States TW FIC NIH HHS; Dementia Australia Research Foundation; Interdisciplinary Cerebrovascular Diseases Training Program in South America; UH2 AG083258 United States AG NIA NIH HHS; R01 AG054059 United States AG NIA NIH HHS; University of Wisconsin |
| Contributed Indexing: | Keywords: Alzheimer's disease and related dementias; First Nations; Indigenous peoples; Indigenous research methodologies; brain health; culturally safe care; decolonizing health research; dementia; epidemiology; health equity; neurodegeneration; social determinants of health |
| Entry Date(s): | Date Created: 20260225 Date Completed: 20260709 Latest Revision: 20260927 |
| Update Code: | 20260927 |
| PubMed Central ID: | PMC12933636 |
| DOI: | 10.1002/alz.71125 |
| PMID: | 41738518 |
| Βάση Δεδομένων: | MEDLINE |
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