Academic Journal

Advancing brain health equity with Indigenous peoples: A critical imperative.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Advancing brain health equity with Indigenous peoples: A critical imperative.
Συγγραφείς: Clarke AJ; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Whetung C; Department of Family Medicine and Biobehavioural Health, Memory Keepers Medical Discovery Team, University of Minnesota, Minneapolis, Minnesota, USA., Suchy-Dicey A; Slone Epidemiology Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, Massachusetts, USA., Withall A; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Radford K; School of Psychology, University of New South Wales, Kensington, New South Wales, Australia., Gooding DC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Letters and Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Lavrencic L; Neuroscience Research Australia, University of New South Wales, Kensington, New South Wales, Australia., Dudley M; School of Psychology, Centre for Brain Research, University of Auckland, Auckland, New Zealand., Lo Giudice D; Department of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia., Flicker L; Medical School, University of Western Australia, Perth, Western Australia, Australia., Boluarte AS; Center for Global Health, Universidad Peruana Cayetano Heredia, Heredia, Peru., Aggarwal S; Maulana Azad Medical College, New Delhi, India., Conniff KR; University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin-Madison School of Letters and Sciences, Madison, Wisconsin, USA., Brodtmann AG; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Diaz MM; Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Tremblay SA; Department of Neurology and Neurosurgery, The Neuro, McGill University, Montreal, Quebec, Canada., Nwofe ES; Centre for Applied Dementia Studies, University of Bradford, Bradford, UK., Gleason CE; Wisconsin Alzheimer's Disease Research Center, Madison Veteran's Hospital GRECC, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Jacklin K; Department of Family Medicine and Biobehavioural Health, University of Minnesota, Minneapolis, Minnesota, USA., Kaholokula JK; John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawai'i., Gibson C; Aboriginal Health and Ageing Team, Neuroscience Research Australia, Sydney, NSW, Australia., Souza-Talarico J; College of Nursing, University of Iowa, Iowa city, USA., Roach P; Departments of Family Medicine and Community Health Services, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Συλλογικό Έργο: Alzheimer's Association Intermission 2025: Stronger Together Collaboration
Πηγή: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Feb; Vol. 22 (2), pp. e71125.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Imprint Name(s): Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd.
Original Publication: Orlando, FL : Elsevier, Inc.
Ιατρικοί όροι (MeSH): Dementia*/ethnology , Dementia*/epidemiology , Brain* , Health Equity* , Indigenous Peoples*, Humans ; Health Services, Indigenous
Περίληψη: Indigenous communities hold rich knowledges, cultural practices, and kinship networks that sustain cognitive resilience and nurture brain health across the life course. Yet these enduring strengths are often obscured by biomedical models that overlook the structural determinants of health-including the cumulative effects of colonization, educational inequity, and socioeconomic disadvantage-that diminish brain health. Accordingly, dementia disproportionately affects Indigenous populations globally, often presenting with earlier onset and higher prevalence compared to non-Indigenous groups. This perspective synthesizes the current epidemiological evidence, situates dementia risk within its structural and historical context, and explores how Indigenous knowledges, cultural continuity, and community leadership can inform dementia research and care more broadly. Our global insights call for a decisive shift: to decolonize dementia research and policy and move beyond deficit-based narratives toward approaches that prioritize Indigenous leadership and culturally grounded, strengths-based pathways to brain health equity. HIGHLIGHTS: This perspective synthesizes global evidence on dementia epidemiology among Indigenous populations, examining structural determinants and Indigenous perspectives on brain health and dementia care. Structural inequities and the enduring legacies of colonization, rather than biology alone, underpin the disproportionate dementia burden among Indigenous peoples worldwide. Centering culture, kinship, and connection to land and community reframes brain health beyond biomedical models and reveals cultural resilience as a powerful neuroprotective resource. Key recommendations call for Indigenous leadership and locally tailored, culturally grounded approaches to advance lifelong brain health equity and develop strengths-based models of dementia care.
(© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
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Grant Information: Applied Research Collaboration; U54GM138062 United States GM NIGMS NIH HHS; R01 AG080398 United States AG NIA NIH HHS; R01 AG070822 United States AG NIA NIH HHS; D43TW009345 Fogarty International Center of the National Institutes of Health; Dementia Australia Research Foundation Post-Doctoral Fellowship; 366201 Fonds de recherche du Québec (FRQ) secteur Santé; K23MH131466 United States MH NIMH NIH HHS; Avant Research Foundation; UH2AG083258 Scientific Advisory Board; AG000213 Madison Biology of Aging; IDSMB; R01 AG074971 United States AG NIA NIH HHS; R36 AG078781 United States AG NIA NIH HHS; RF1 AG071677 United States AG NIA NIH HHS; GNT2022/202240 NHMRC; ANZAN Education and Research Fund; R01 AG062307 United States AG NIA NIH HHS; R01AG080398 American Indians; United States ALZ Alzheimer's Association; R01AG070822 American Indians; K23 MH131466 United States MH NIMH NIH HHS; Eastern Health Foundation; R01 AG027161 United States AG NIA NIH HHS; 3ODT2OD036478-01S1 Madison All of Us Program; U54 GM138062 United States GM NIGMS NIH HHS; NIHR200166 National Institute of Health and Care Research; D43TW009137 Northern Pacific Global Health Fellows Program; T32 AG000213 United States AG NIA NIH HHS; D43 TW009137 United States TW FIC NIH HHS; Universidad Cesar Vallejo; 75N92019D00028 United States HL NHLBI NIH HHS; OT2 OD036478 United States OD NIH HHS; University of North Carolina at Chapel Hill; P30 AG066509 United States AG NIA NIH HHS; P30 AG062715 United States AG NIA NIH HHS; RF1AG071677 American Indians; D43 TW009345 United States TW FIC NIH HHS; Dementia Australia Research Foundation; Interdisciplinary Cerebrovascular Diseases Training Program in South America; UH2 AG083258 United States AG NIA NIH HHS; R01 AG054059 United States AG NIA NIH HHS; University of Wisconsin
Contributed Indexing: Keywords: Alzheimer's disease and related dementias; First Nations; Indigenous peoples; Indigenous research methodologies; brain health; culturally safe care; decolonizing health research; dementia; epidemiology; health equity; neurodegeneration; social determinants of health
Entry Date(s): Date Created: 20260225 Date Completed: 20260709 Latest Revision: 20260927
Update Code: 20260927
PubMed Central ID: PMC12933636
DOI: 10.1002/alz.71125
PMID: 41738518
Βάση Δεδομένων: MEDLINE
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  Data: Advancing brain health equity with Indigenous peoples: A critical imperative.
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  Data: <searchLink fieldCode="AU" term="%22Clarke+AJ%22">Clarke AJ</searchLink>; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Whetung+C%22">Whetung C</searchLink>; Department of Family Medicine and Biobehavioural Health, Memory Keepers Medical Discovery Team, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Suchy-Dicey+A%22">Suchy-Dicey A</searchLink>; Slone Epidemiology Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Withall+A%22">Withall A</searchLink>; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Radford+K%22">Radford K</searchLink>; School of Psychology, University of New South Wales, Kensington, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Gooding+DC%22">Gooding DC</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Letters and Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Lavrencic+L%22">Lavrencic L</searchLink>; Neuroscience Research Australia, University of New South Wales, Kensington, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Dudley+M%22">Dudley M</searchLink>; School of Psychology, Centre for Brain Research, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Lo+Giudice+D%22">Lo Giudice D</searchLink>; Department of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Flicker+L%22">Flicker L</searchLink>; Medical School, University of Western Australia, Perth, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Boluarte+AS%22">Boluarte AS</searchLink>; Center for Global Health, Universidad Peruana Cayetano Heredia, Heredia, Peru.<br /><searchLink fieldCode="AU" term="%22Aggarwal+S%22">Aggarwal S</searchLink>; Maulana Azad Medical College, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Conniff+KR%22">Conniff KR</searchLink>; University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin-Madison School of Letters and Sciences, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Brodtmann+AG%22">Brodtmann AG</searchLink>; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Diaz+MM%22">Diaz MM</searchLink>; Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Tremblay+SA%22">Tremblay SA</searchLink>; Department of Neurology and Neurosurgery, The Neuro, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Nwofe+ES%22">Nwofe ES</searchLink>; Centre for Applied Dementia Studies, University of Bradford, Bradford, UK.<br /><searchLink fieldCode="AU" term="%22Gleason+CE%22">Gleason CE</searchLink>; Wisconsin Alzheimer's Disease Research Center, Madison Veteran's Hospital GRECC, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Jacklin+K%22">Jacklin K</searchLink>; Department of Family Medicine and Biobehavioural Health, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Kaholokula+JK%22">Kaholokula JK</searchLink>; John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawai'i.<br /><searchLink fieldCode="AU" term="%22Gibson+C%22">Gibson C</searchLink>; Aboriginal Health and Ageing Team, Neuroscience Research Australia, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Souza-Talarico+J%22">Souza-Talarico J</searchLink>; College of Nursing, University of Iowa, Iowa city, USA.<br /><searchLink fieldCode="AU" term="%22Roach+P%22">Roach P</searchLink>; Departments of Family Medicine and Community Health Services, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Feb; Vol. 22 (2), pp. e71125.
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  Data: <searchLink fieldCode="MM" term="%22Dementia%22">Dementia*</searchLink>/<searchLink fieldCode="MM" term="%22Dementia+ethnology%22">ethnology</searchLink> <br /><searchLink fieldCode="MM" term="%22Dementia%22">Dementia*</searchLink>/<searchLink fieldCode="MM" term="%22Dementia+epidemiology%22">epidemiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain%22">Brain*</searchLink> <br /><searchLink fieldCode="MM" term="%22Health+Equity%22">Health Equity*</searchLink> <br /><searchLink fieldCode="MM" term="%22Indigenous+Peoples%22">Indigenous Peoples*</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Health+Services%2C+Indigenous%22">Health Services, Indigenous</searchLink>
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  Label: Abstract
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  Data: Indigenous communities hold rich knowledges, cultural practices, and kinship networks that sustain cognitive resilience and nurture brain health across the life course. Yet these enduring strengths are often obscured by biomedical models that overlook the structural determinants of health-including the cumulative effects of colonization, educational inequity, and socioeconomic disadvantage-that diminish brain health. Accordingly, dementia disproportionately affects Indigenous populations globally, often presenting with earlier onset and higher prevalence compared to non-Indigenous groups. This perspective synthesizes the current epidemiological evidence, situates dementia risk within its structural and historical context, and explores how Indigenous knowledges, cultural continuity, and community leadership can inform dementia research and care more broadly. Our global insights call for a decisive shift: to decolonize dementia research and policy and move beyond deficit-based narratives toward approaches that prioritize Indigenous leadership and culturally grounded, strengths-based pathways to brain health equity. HIGHLIGHTS: This perspective synthesizes global evidence on dementia epidemiology among Indigenous populations, examining structural determinants and Indigenous perspectives on brain health and dementia care. Structural inequities and the enduring legacies of colonization, rather than biology alone, underpin the disproportionate dementia burden among Indigenous peoples worldwide. Centering culture, kinship, and connection to land and community reframes brain health beyond biomedical models and reveals cultural resilience as a powerful neuroprotective resource. Key recommendations call for Indigenous leadership and locally tailored, culturally grounded approaches to advance lifelong brain health equity and develop strengths-based models of dementia care.<br /> (© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
– Name: Ref
  Label: References
  Group: RefInfo
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  Group: Grant
  Data: Applied Research Collaboration; U54GM138062 United States GM NIGMS NIH HHS; R01 AG080398 United States AG NIA NIH HHS; R01 AG070822 United States AG NIA NIH HHS; D43TW009345 Fogarty International Center of the National Institutes of Health; Dementia Australia Research Foundation Post-Doctoral Fellowship; 366201 Fonds de recherche du Québec (FRQ) secteur Santé; K23MH131466 United States MH NIMH NIH HHS; Avant Research Foundation; UH2AG083258 Scientific Advisory Board; AG000213 Madison Biology of Aging; IDSMB; R01 AG074971 United States AG NIA NIH HHS; R36 AG078781 United States AG NIA NIH HHS; RF1 AG071677 United States AG NIA NIH HHS; GNT2022/202240 NHMRC; ANZAN Education and Research Fund; R01 AG062307 United States AG NIA NIH HHS; R01AG080398 American Indians; United States ALZ Alzheimer's Association; R01AG070822 American Indians; K23 MH131466 United States MH NIMH NIH HHS; Eastern Health Foundation; R01 AG027161 United States AG NIA NIH HHS; 3ODT2OD036478-01S1 Madison All of Us Program; U54 GM138062 United States GM NIGMS NIH HHS; NIHR200166 National Institute of Health and Care Research; D43TW009137 Northern Pacific Global Health Fellows Program; T32 AG000213 United States AG NIA NIH HHS; D43 TW009137 United States TW FIC NIH HHS; Universidad Cesar Vallejo; 75N92019D00028 United States HL NHLBI NIH HHS; OT2 OD036478 United States OD NIH HHS; University of North Carolina at Chapel Hill; P30 AG066509 United States AG NIA NIH HHS; P30 AG062715 United States AG NIA NIH HHS; RF1AG071677 American Indians; D43 TW009345 United States TW FIC NIH HHS; Dementia Australia Research Foundation; Interdisciplinary Cerebrovascular Diseases Training Program in South America; UH2 AG083258 United States AG NIA NIH HHS; R01 AG054059 United States AG NIA NIH HHS; University of Wisconsin
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>Alzheimer's disease and related dementias; First Nations; Indigenous peoples; Indigenous research methodologies; brain health; culturally safe care; decolonizing health research; dementia; epidemiology; health equity; neurodegeneration; social determinants of health
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  Data: <i>Date Created: </i>20260225 <i>Date Completed: </i>20260709 <i>Latest Revision: </i>20260927
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        Text: English
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        StartPage: e71125
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      – SubjectFull: Humans
        Type: general
      – SubjectFull: Health Services, Indigenous
        Type: general
      – SubjectFull: Dementia ethnology
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      – SubjectFull: Dementia epidemiology
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      – SubjectFull: Brain
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      – SubjectFull: Health Equity
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      – TitleFull: Advancing brain health equity with Indigenous peoples: A critical imperative.
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              Text: 2026 Feb
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              Y: 2026
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            – TitleFull: Alzheimer's & dementia : the journal of the Alzheimer's Association
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