Academic Journal
Advancing brain health equity with Indigenous peoples: A critical imperative.
| Τίτλος: | Advancing brain health equity with Indigenous peoples: A critical imperative. |
|---|---|
| Συγγραφείς: | Clarke AJ; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Whetung C; Department of Family Medicine and Biobehavioural Health, Memory Keepers Medical Discovery Team, University of Minnesota, Minneapolis, Minnesota, USA., Suchy-Dicey A; Slone Epidemiology Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, Massachusetts, USA., Withall A; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Radford K; School of Psychology, University of New South Wales, Kensington, New South Wales, Australia., Gooding DC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Letters and Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Lavrencic L; Neuroscience Research Australia, University of New South Wales, Kensington, New South Wales, Australia., Dudley M; School of Psychology, Centre for Brain Research, University of Auckland, Auckland, New Zealand., Lo Giudice D; Department of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia., Flicker L; Medical School, University of Western Australia, Perth, Western Australia, Australia., Boluarte AS; Center for Global Health, Universidad Peruana Cayetano Heredia, Heredia, Peru., Aggarwal S; Maulana Azad Medical College, New Delhi, India., Conniff KR; University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin-Madison School of Letters and Sciences, Madison, Wisconsin, USA., Brodtmann AG; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Diaz MM; Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Tremblay SA; Department of Neurology and Neurosurgery, The Neuro, McGill University, Montreal, Quebec, Canada., Nwofe ES; Centre for Applied Dementia Studies, University of Bradford, Bradford, UK., Gleason CE; Wisconsin Alzheimer's Disease Research Center, Madison Veteran's Hospital GRECC, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA., Jacklin K; Department of Family Medicine and Biobehavioural Health, University of Minnesota, Minneapolis, Minnesota, USA., Kaholokula JK; John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawai'i., Gibson C; Aboriginal Health and Ageing Team, Neuroscience Research Australia, Sydney, NSW, Australia., Souza-Talarico J; College of Nursing, University of Iowa, Iowa city, USA., Roach P; Departments of Family Medicine and Community Health Services, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. |
| Συλλογικό Έργο: | Alzheimer's Association Intermission 2025: Stronger Together Collaboration |
| Πηγή: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Feb; Vol. 22 (2), pp. e71125. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd. Original Publication: Orlando, FL : Elsevier, Inc. |
| Ιατρικοί όροι (MeSH): | Dementia*/ethnology , Dementia*/epidemiology , Brain* , Health Equity* , Indigenous Peoples*, Humans ; Health Services, Indigenous |
| Περίληψη: | Indigenous communities hold rich knowledges, cultural practices, and kinship networks that sustain cognitive resilience and nurture brain health across the life course. Yet these enduring strengths are often obscured by biomedical models that overlook the structural determinants of health-including the cumulative effects of colonization, educational inequity, and socioeconomic disadvantage-that diminish brain health. Accordingly, dementia disproportionately affects Indigenous populations globally, often presenting with earlier onset and higher prevalence compared to non-Indigenous groups. This perspective synthesizes the current epidemiological evidence, situates dementia risk within its structural and historical context, and explores how Indigenous knowledges, cultural continuity, and community leadership can inform dementia research and care more broadly. Our global insights call for a decisive shift: to decolonize dementia research and policy and move beyond deficit-based narratives toward approaches that prioritize Indigenous leadership and culturally grounded, strengths-based pathways to brain health equity. HIGHLIGHTS: This perspective synthesizes global evidence on dementia epidemiology among Indigenous populations, examining structural determinants and Indigenous perspectives on brain health and dementia care. Structural inequities and the enduring legacies of colonization, rather than biology alone, underpin the disproportionate dementia burden among Indigenous peoples worldwide. Centering culture, kinship, and connection to land and community reframes brain health beyond biomedical models and reveals cultural resilience as a powerful neuroprotective resource. Key recommendations call for Indigenous leadership and locally tailored, culturally grounded approaches to advance lifelong brain health equity and develop strengths-based models of dementia care. (© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.) |
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| Grant Information: | Applied Research Collaboration; U54GM138062 United States GM NIGMS NIH HHS; R01 AG080398 United States AG NIA NIH HHS; R01 AG070822 United States AG NIA NIH HHS; D43TW009345 Fogarty International Center of the National Institutes of Health; Dementia Australia Research Foundation Post-Doctoral Fellowship; 366201 Fonds de recherche du Québec (FRQ) secteur Santé; K23MH131466 United States MH NIMH NIH HHS; Avant Research Foundation; UH2AG083258 Scientific Advisory Board; AG000213 Madison Biology of Aging; IDSMB; R01 AG074971 United States AG NIA NIH HHS; R36 AG078781 United States AG NIA NIH HHS; RF1 AG071677 United States AG NIA NIH HHS; GNT2022/202240 NHMRC; ANZAN Education and Research Fund; R01 AG062307 United States AG NIA NIH HHS; R01AG080398 American Indians; United States ALZ Alzheimer's Association; R01AG070822 American Indians; K23 MH131466 United States MH NIMH NIH HHS; Eastern Health Foundation; R01 AG027161 United States AG NIA NIH HHS; 3ODT2OD036478-01S1 Madison All of Us Program; U54 GM138062 United States GM NIGMS NIH HHS; NIHR200166 National Institute of Health and Care Research; D43TW009137 Northern Pacific Global Health Fellows Program; T32 AG000213 United States AG NIA NIH HHS; D43 TW009137 United States TW FIC NIH HHS; Universidad Cesar Vallejo; 75N92019D00028 United States HL NHLBI NIH HHS; OT2 OD036478 United States OD NIH HHS; University of North Carolina at Chapel Hill; P30 AG066509 United States AG NIA NIH HHS; P30 AG062715 United States AG NIA NIH HHS; RF1AG071677 American Indians; D43 TW009345 United States TW FIC NIH HHS; Dementia Australia Research Foundation; Interdisciplinary Cerebrovascular Diseases Training Program in South America; UH2 AG083258 United States AG NIA NIH HHS; R01 AG054059 United States AG NIA NIH HHS; University of Wisconsin |
| Contributed Indexing: | Keywords: Alzheimer's disease and related dementias; First Nations; Indigenous peoples; Indigenous research methodologies; brain health; culturally safe care; decolonizing health research; dementia; epidemiology; health equity; neurodegeneration; social determinants of health |
| Entry Date(s): | Date Created: 20260225 Date Completed: 20260709 Latest Revision: 20260927 |
| Update Code: | 20260927 |
| PubMed Central ID: | PMC12933636 |
| DOI: | 10.1002/alz.71125 |
| PMID: | 41738518 |
| Βάση Δεδομένων: | MEDLINE |
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| Items | – Name: Title Label: Title Group: Ti Data: Advancing brain health equity with Indigenous peoples: A critical imperative. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Clarke+AJ%22">Clarke AJ</searchLink>; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Whetung+C%22">Whetung C</searchLink>; Department of Family Medicine and Biobehavioural Health, Memory Keepers Medical Discovery Team, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Suchy-Dicey+A%22">Suchy-Dicey A</searchLink>; Slone Epidemiology Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Withall+A%22">Withall A</searchLink>; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Radford+K%22">Radford K</searchLink>; School of Psychology, University of New South Wales, Kensington, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Gooding+DC%22">Gooding DC</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Letters and Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Lavrencic+L%22">Lavrencic L</searchLink>; Neuroscience Research Australia, University of New South Wales, Kensington, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Dudley+M%22">Dudley M</searchLink>; School of Psychology, Centre for Brain Research, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Lo+Giudice+D%22">Lo Giudice D</searchLink>; Department of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Flicker+L%22">Flicker L</searchLink>; Medical School, University of Western Australia, Perth, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Boluarte+AS%22">Boluarte AS</searchLink>; Center for Global Health, Universidad Peruana Cayetano Heredia, Heredia, Peru.<br /><searchLink fieldCode="AU" term="%22Aggarwal+S%22">Aggarwal S</searchLink>; Maulana Azad Medical College, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Conniff+KR%22">Conniff KR</searchLink>; University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin-Madison School of Letters and Sciences, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Brodtmann+AG%22">Brodtmann AG</searchLink>; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Diaz+MM%22">Diaz MM</searchLink>; Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Tremblay+SA%22">Tremblay SA</searchLink>; Department of Neurology and Neurosurgery, The Neuro, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Nwofe+ES%22">Nwofe ES</searchLink>; Centre for Applied Dementia Studies, University of Bradford, Bradford, UK.<br /><searchLink fieldCode="AU" term="%22Gleason+CE%22">Gleason CE</searchLink>; Wisconsin Alzheimer's Disease Research Center, Madison Veteran's Hospital GRECC, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Jacklin+K%22">Jacklin K</searchLink>; Department of Family Medicine and Biobehavioural Health, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Kaholokula+JK%22">Kaholokula JK</searchLink>; John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawai'i.<br /><searchLink fieldCode="AU" term="%22Gibson+C%22">Gibson C</searchLink>; Aboriginal Health and Ageing Team, Neuroscience Research Australia, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Souza-Talarico+J%22">Souza-Talarico J</searchLink>; College of Nursing, University of Iowa, Iowa city, USA.<br /><searchLink fieldCode="AU" term="%22Roach+P%22">Roach P</searchLink>; Departments of Family Medicine and Community Health Services, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22Alzheimer's+Association+Intermission+2025%3A+Stronger+Together+Collaboration%22">Alzheimer's Association Intermission 2025: Stronger Together Collaboration</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Feb; Vol. 22 (2), pp. e71125. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Review – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Publication</i>: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd.<br /><i>Original Publication</i>: Orlando, FL : Elsevier, Inc. – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Dementia%22">Dementia*</searchLink>/<searchLink fieldCode="MM" term="%22Dementia+ethnology%22">ethnology</searchLink> <br /><searchLink fieldCode="MM" term="%22Dementia%22">Dementia*</searchLink>/<searchLink fieldCode="MM" term="%22Dementia+epidemiology%22">epidemiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain%22">Brain*</searchLink> <br /><searchLink fieldCode="MM" term="%22Health+Equity%22">Health Equity*</searchLink> <br /><searchLink fieldCode="MM" term="%22Indigenous+Peoples%22">Indigenous Peoples*</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Health+Services%2C+Indigenous%22">Health Services, Indigenous</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Indigenous communities hold rich knowledges, cultural practices, and kinship networks that sustain cognitive resilience and nurture brain health across the life course. Yet these enduring strengths are often obscured by biomedical models that overlook the structural determinants of health-including the cumulative effects of colonization, educational inequity, and socioeconomic disadvantage-that diminish brain health. Accordingly, dementia disproportionately affects Indigenous populations globally, often presenting with earlier onset and higher prevalence compared to non-Indigenous groups. This perspective synthesizes the current epidemiological evidence, situates dementia risk within its structural and historical context, and explores how Indigenous knowledges, cultural continuity, and community leadership can inform dementia research and care more broadly. Our global insights call for a decisive shift: to decolonize dementia research and policy and move beyond deficit-based narratives toward approaches that prioritize Indigenous leadership and culturally grounded, strengths-based pathways to brain health equity. HIGHLIGHTS: This perspective synthesizes global evidence on dementia epidemiology among Indigenous populations, examining structural determinants and Indigenous perspectives on brain health and dementia care. Structural inequities and the enduring legacies of colonization, rather than biology alone, underpin the disproportionate dementia burden among Indigenous peoples worldwide. Centering culture, kinship, and connection to land and community reframes brain health beyond biomedical models and reveals cultural resilience as a powerful neuroprotective resource. Key recommendations call for Indigenous leadership and locally tailored, culturally grounded approaches to advance lifelong brain health equity and develop strengths-based models of dementia care.<br /> (© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.) – Name: Ref Label: References Group: RefInfo Data: Arch Clin Neuropsychol. 2010 Dec;25(8):689-712. 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(PMID: <searchLink fieldCode="PM" term="%2236858467%22">36858467)</searchLink> – Name: GrantInfo Label: Grant Information Group: Grant Data: Applied Research Collaboration; U54GM138062 United States GM NIGMS NIH HHS; R01 AG080398 United States AG NIA NIH HHS; R01 AG070822 United States AG NIA NIH HHS; D43TW009345 Fogarty International Center of the National Institutes of Health; Dementia Australia Research Foundation Post-Doctoral Fellowship; 366201 Fonds de recherche du Québec (FRQ) secteur Santé; K23MH131466 United States MH NIMH NIH HHS; Avant Research Foundation; UH2AG083258 Scientific Advisory Board; AG000213 Madison Biology of Aging; IDSMB; R01 AG074971 United States AG NIA NIH HHS; R36 AG078781 United States AG NIA NIH HHS; RF1 AG071677 United States AG NIA NIH HHS; GNT2022/202240 NHMRC; ANZAN Education and Research Fund; R01 AG062307 United States AG NIA NIH HHS; R01AG080398 American Indians; United States ALZ Alzheimer's Association; R01AG070822 American Indians; K23 MH131466 United States MH NIMH NIH HHS; Eastern Health Foundation; R01 AG027161 United States AG NIA NIH HHS; 3ODT2OD036478-01S1 Madison All of Us Program; U54 GM138062 United States GM NIGMS NIH HHS; NIHR200166 National Institute of Health and Care Research; D43TW009137 Northern Pacific Global Health Fellows Program; T32 AG000213 United States AG NIA NIH HHS; D43 TW009137 United States TW FIC NIH HHS; Universidad Cesar Vallejo; 75N92019D00028 United States HL NHLBI NIH HHS; OT2 OD036478 United States OD NIH HHS; University of North Carolina at Chapel Hill; P30 AG066509 United States AG NIA NIH HHS; P30 AG062715 United States AG NIA NIH HHS; RF1AG071677 American Indians; D43 TW009345 United States TW FIC NIH HHS; Dementia Australia Research Foundation; Interdisciplinary Cerebrovascular Diseases Training Program in South America; UH2 AG083258 United States AG NIA NIH HHS; R01 AG054059 United States AG NIA NIH HHS; University of Wisconsin – Name: SubjectMinor Label: Contributed Indexing Group: Data: <i>Keywords: </i>Alzheimer's disease and related dementias; First Nations; Indigenous peoples; Indigenous research methodologies; brain health; culturally safe care; decolonizing health research; dementia; epidemiology; health equity; neurodegeneration; social determinants of health – Name: DateEntry Label: Entry Date(s) Group: Date Data: <i>Date Created: </i>20260225 <i>Date Completed: </i>20260709 <i>Latest Revision: </i>20260927 – Name: DateUpdate Label: Update Code Group: Date Data: 20260927 – Name: PubmedCentralID Label: PubMed Central ID Group: ID Data: PMC12933636 – Name: DOI Label: DOI Group: ID Data: 10.1002/alz.71125 – Name: AN Label: PMID Group: ID Data: 41738518 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/alz.71125 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e71125 Subjects: – SubjectFull: Humans Type: general – SubjectFull: Health Services, Indigenous Type: general – SubjectFull: Dementia ethnology Type: general – SubjectFull: Dementia epidemiology Type: general – SubjectFull: Brain Type: general – SubjectFull: Health Equity Type: general – SubjectFull: Indigenous Peoples Type: general Titles: – TitleFull: Advancing brain health equity with Indigenous peoples: A critical imperative. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Clarke AJ – PersonEntity: Name: NameFull: Whetung C – PersonEntity: Name: NameFull: Suchy-Dicey A – PersonEntity: Name: NameFull: Withall A – PersonEntity: Name: NameFull: Radford K – PersonEntity: Name: NameFull: Gooding DC – PersonEntity: Name: NameFull: Lavrencic L – PersonEntity: Name: NameFull: Dudley M – PersonEntity: Name: NameFull: Lo Giudice D – PersonEntity: Name: NameFull: Flicker L – PersonEntity: Name: NameFull: Boluarte AS – PersonEntity: Name: NameFull: Aggarwal S – PersonEntity: Name: NameFull: Conniff KR – PersonEntity: Name: NameFull: Brodtmann AG – PersonEntity: Name: NameFull: Diaz MM – PersonEntity: Name: NameFull: Tremblay SA – PersonEntity: Name: NameFull: Nwofe ES – PersonEntity: Name: NameFull: Gleason CE – PersonEntity: Name: NameFull: Jacklin K – PersonEntity: Name: NameFull: Kaholokula JK – PersonEntity: Name: NameFull: Gibson C – PersonEntity: Name: NameFull: Souza-Talarico J – PersonEntity: Name: NameFull: Roach P IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: 2026 Feb Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1552-5279 Numbering: – Type: volume Value: 22 – Type: issue Value: 2 Titles: – TitleFull: Alzheimer's & dementia : the journal of the Alzheimer's Association Type: main |
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