Academic Journal
Reversible dissociation of mitochondrial Complex V balances anabolic and energy-generating needs in cancer.
| Τίτλος: | Reversible dissociation of mitochondrial Complex V balances anabolic and energy-generating needs in cancer. |
|---|---|
| Συγγραφείς: | Wang H; Division of Hematology/Oncology UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Lu J; Division of Hematology/Oncology UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Henchy C; Division of Hematology/Oncology UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Mullett SJ; Department of Pharmacology and Chemical Biology, The University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The University of Pittsburgh Health Sciences Mass Spectrometry Facility, Pittsburgh, PA, USA., Richert AC; Division of Genetic and Genomic Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Goetzman ES; Division of Genetic and Genomic Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Toksoz A; Division of Hematology/Oncology UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.; Kanuni Sultan Suleiman Training and Research Hospital, Istanbul, Turkey., Hale L; Division of Hematology/Oncology UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.; Brandeis University, Waltham, MA, USA., Wang BB; Division of Hematology/Oncology UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Mnatsakanyan N; Deptartment of Cell and Biological Systems, Penn State University, University Park, PA, USA., Prochownik EV; Division of Hematology/Oncology UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.; The Department of Microbiology and Molecular Genetics, The University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.; The Pittsburgh Liver Research Center, Pittsburgh, PA, USA. |
| Πηγή: | IScience [iScience] 2026 Feb 02; Vol. 29 (3), pp. 114889. Date of Electronic Publication: 2026 Feb 02 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, [2018]- |
| Περίληψη: | Cancer cell metabolic re-programming provides the additional energy and anabolic precursors necessary to sustain unregulated proliferation. This is partially mediated by the Warburg effect, which generates ATP while oxidizing glucose to a subset of these anabolites. Concurrently, mitochondrial mass and ATP generation via oxidative phosphorylation decline in most tumors. This raises the question of how increased glycolysis-derived anabolites can be balanced with those supplied by the TCA cycle. Using primary murine liver cancers and their derivative cell lines, we show that this can be explained by the dissociation of mitochondrial Complex V (CV or ATP synthase) into its component and functionally independent F (© 2026 The Authors.) |
| Competing Interests: | The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Biochemistry; Cancer; Molecular biology |
| Entry Date(s): | Date Created: 20260224 Date Completed: 20260224 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC12925242 |
| DOI: | 10.1016/j.isci.2026.114889 |
| PMID: | 41732272 |
| Βάση Δεδομένων: | MEDLINE |
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