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Reproductive Urologist Preferences for Sperm Extraction in Congenital Bilateral Absence of the Vas Deferens.

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Title: Reproductive Urologist Preferences for Sperm Extraction in Congenital Bilateral Absence of the Vas Deferens.
Authors: Passarelli R; Division of Urology, Rutgers Robert Wood Johnson, New Brunswick, New Jersey., Moore K; Division of Urology, Rutgers Robert Wood Johnson, New Brunswick, New Jersey., Islam R; Division of Urology, Rutgers Robert Wood Johnson, New Brunswick, New Jersey., Vij S; Department of Surgery and Perioperative Care, Dell Medical School, University of Texas at Austin, Austin, Texas., Leitner DV; Division of Urology, Rutgers Robert Wood Johnson, New Brunswick, New Jersey. Electronic address: Velezd1@rwjms.rutgers.edu.
Source: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists [Endocr Pract] 2026 Jun; Vol. 32 (6), pp. 972-976. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9607439 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1530-891X (Print) Linking ISSN: 1530891X NLM ISO Abbreviation: Endocr Pract Subsets: MEDLINE
Imprint Name(s): Publication: 2021- : [New York] : Elsevier Inc.
Original Publication: Jacksonville, Fla. : The College and the Association
MeSH Terms: Vas Deferens*/abnormalities , Sperm Retrieval*/statistics & numerical data , Urologists*/statistics & numerical data , Infertility, Male*/etiology , Infertility, Male*/therapy , Male Urogenital Diseases*/complications , Practice Patterns, Physicians'*/statistics & numerical data, Humans ; Male ; Adult ; Surveys and Questionnaires
Abstract: Objective: To assess reproductive urologists' sperm extraction preferences for patients with congenital bilateral absence of the vas deferens (CBAVD) and CBAVD with cystic fibrosis (CF).
Methods: A survey was sent to the Society for the Study of Male Reproduction: "A 30-year old male presents with his 28-year-old wife for infertility evaluation. On exam he has CBAVD, with bilateral testicular volume of 24 cc and normal epididymal head bilaterally, no varicocele. His wife's evaluation is normal. You send him for a cystic fibrosis transmembrane conductance regulator panel, which is positive for homozygous delta F 508 mutation." Responses were collected, and descriptive and comparative statistics using Χ2 analyses were performed.
Results: We received 51 survey responses: 39.2% elected for testicular extraction, 29.4% epididymal, and 31.4% a combination. Office was more common (56.9%) versus 41.2% would perform in the operating room; 68.6% would perform extraction with onsite andrology lab. On Χ2 analysis, there was no significant difference between onsite lab and extraction preference. Fertility labs would be collected by 90.2%. For a postvasectomy patient who chose sperm retrieval over reversal, 70.6% would not change their practice.
Conclusion: There is an array of sperm extraction techniques in CF, which often can be managed similarly to a non-CF patient with obstructive azoospermia. Technique preference is unrelated to procedure location or andrology lab access. As there are many options for this population, further research is needed on outcomes and resource utilization in assisted reproductive technology for these patients to define clinical guidelines and improve access to care.
(Copyright © 2026 AACE. Published by Elsevier Inc. All rights reserved.)
Competing Interests: Disclosure The authors have no conflicts of interest to disclose.
Contributed Indexing: Keywords: congenital bilateral absence of the vas deferens; male infertility; reproductive urology; sperm extraction
SCR Disease Name: Congenital bilateral aplasia of vas deferens
Entry Date(s): Date Created: 20260220 Date Completed: 20260612 Latest Revision: 20260612
Update Code: 20260613
DOI: 10.1016/j.eprac.2026.02.012
PMID: 41720344
Database: MEDLINE
FullText Text:
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  Data: Reproductive Urologist Preferences for Sperm Extraction in Congenital Bilateral Absence of the Vas Deferens.
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  Data: <searchLink fieldCode="AU" term="%22Passarelli+R%22">Passarelli R</searchLink>; Division of Urology, Rutgers Robert Wood Johnson, New Brunswick, New Jersey.<br /><searchLink fieldCode="AU" term="%22Moore+K%22">Moore K</searchLink>; Division of Urology, Rutgers Robert Wood Johnson, New Brunswick, New Jersey.<br /><searchLink fieldCode="AU" term="%22Islam+R%22">Islam R</searchLink>; Division of Urology, Rutgers Robert Wood Johnson, New Brunswick, New Jersey.<br /><searchLink fieldCode="AU" term="%22Vij+S%22">Vij S</searchLink>; Department of Surgery and Perioperative Care, Dell Medical School, University of Texas at Austin, Austin, Texas.<br /><searchLink fieldCode="AU" term="%22Leitner+DV%22">Leitner DV</searchLink>; Division of Urology, Rutgers Robert Wood Johnson, New Brunswick, New Jersey. Electronic address: Velezd1@rwjms.rutgers.edu.
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  Data: <searchLink fieldCode="JN" term="%229607439%22">Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists</searchLink> [Endocr Pract] 2026 Jun; Vol. 32 (6), pp. 972-976. <i>Date of Electronic Publication: </i>2026 Feb 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%22">Elsevier Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9607439 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1530-891X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221530891X%22">1530891X </searchLink><i>NLM ISO Abbreviation: </i>Endocr Pract <i>Subsets: </i>MEDLINE
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  Data: <i>Publication</i>: 2021- : [New York] : Elsevier Inc.<br /><i>Original Publication</i>: Jacksonville, Fla. : The College and the Association
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  Data: <searchLink fieldCode="MM" term="%22Vas+Deferens%22">Vas Deferens*</searchLink>/<searchLink fieldCode="MM" term="%22Vas+Deferens+abnormalities%22">abnormalities</searchLink> <br /><searchLink fieldCode="MM" term="%22Sperm+Retrieval%22">Sperm Retrieval*</searchLink>/<searchLink fieldCode="MM" term="%22Sperm+Retrieval+statistics+%26+numerical+data%22">statistics & numerical data</searchLink> <br /><searchLink fieldCode="MM" term="%22Urologists%22">Urologists*</searchLink>/<searchLink fieldCode="MM" term="%22Urologists+statistics+%26+numerical+data%22">statistics & numerical data</searchLink> <br /><searchLink fieldCode="MM" term="%22Infertility%2C+Male%22">Infertility, Male*</searchLink>/<searchLink fieldCode="MM" term="%22Infertility%2C+Male+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Infertility%2C+Male%22">Infertility, Male*</searchLink>/<searchLink fieldCode="MM" term="%22Infertility%2C+Male+therapy%22">therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Male+Urogenital+Diseases%22">Male Urogenital Diseases*</searchLink>/<searchLink fieldCode="MM" term="%22Male+Urogenital+Diseases+complications%22">complications</searchLink> <br /><searchLink fieldCode="MM" term="%22Practice+Patterns%2C+Physicians'%22">Practice Patterns, Physicians'*</searchLink>/<searchLink fieldCode="MM" term="%22Practice+Patterns%2C+Physicians'+statistics+%26+numerical+data%22">statistics & numerical data</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Surveys+and+Questionnaires%22">Surveys and Questionnaires</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To assess reproductive urologists' sperm extraction preferences for patients with congenital bilateral absence of the vas deferens (CBAVD) and CBAVD with cystic fibrosis (CF).<br />Methods: A survey was sent to the Society for the Study of Male Reproduction: "A 30-year old male presents with his 28-year-old wife for infertility evaluation. On exam he has CBAVD, with bilateral testicular volume of 24 cc and normal epididymal head bilaterally, no varicocele. His wife's evaluation is normal. You send him for a cystic fibrosis transmembrane conductance regulator panel, which is positive for homozygous delta F 508 mutation." Responses were collected, and descriptive and comparative statistics using Χ<superscript>2</superscript> analyses were performed.<br />Results: We received 51 survey responses: 39.2% elected for testicular extraction, 29.4% epididymal, and 31.4% a combination. Office was more common (56.9%) versus 41.2% would perform in the operating room; 68.6% would perform extraction with onsite andrology lab. On Χ<superscript>2</superscript> analysis, there was no significant difference between onsite lab and extraction preference. Fertility labs would be collected by 90.2%. For a postvasectomy patient who chose sperm retrieval over reversal, 70.6% would not change their practice.<br />Conclusion: There is an array of sperm extraction techniques in CF, which often can be managed similarly to a non-CF patient with obstructive azoospermia. Technique preference is unrelated to procedure location or andrology lab access. As there are many options for this population, further research is needed on outcomes and resource utilization in assisted reproductive technology for these patients to define clinical guidelines and improve access to care.<br /> (Copyright © 2026 AACE. Published by Elsevier Inc. All rights reserved.)
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  Data: Disclosure The authors have no conflicts of interest to disclose.
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  Data: <i>Keywords: </i>congenital bilateral absence of the vas deferens; male infertility; reproductive urology; sperm extraction
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  Data: Congenital bilateral aplasia of vas deferens
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        Value: 10.1016/j.eprac.2026.02.012
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        Text: English
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        StartPage: 972
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      – TitleFull: Reproductive Urologist Preferences for Sperm Extraction in Congenital Bilateral Absence of the Vas Deferens.
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