Academic Journal
Hirsutanines H-O, monoterpene indole alkaloids from Uncaria hirsuta with neuroprotective effects.
| Title: | Hirsutanines H-O, monoterpene indole alkaloids from Uncaria hirsuta with neuroprotective effects. |
|---|---|
| Authors: | An N; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Wu LM; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Wu SQ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Huang JL; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Huang D; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Yuan FY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Liao YL; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Fan RZ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Yang XY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Tang GH; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Gan L; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: ganlu36@mail.sysu.edu.cn., Yin S; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: yinsh2@mail.sysu.edu.cn. |
| Source: | Phytochemistry [Phytochemistry] 2026 Jun; Vol. 246, pp. 114834. Date of Electronic Publication: 2026 Feb 14. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : London : Elsevier Original Publication: 1961-2003: Oxford : Pergamon Press. |
| MeSH Terms: | Neuroprotective Agents*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/isolation & purification , Uncaria*/chemistry , Secologanin Tryptamine Alkaloids*/chemistry , Secologanin Tryptamine Alkaloids*/pharmacology , Secologanin Tryptamine Alkaloids*/isolation & purification , Indole Alkaloids*/chemistry , Indole Alkaloids*/pharmacology , Indole Alkaloids*/isolation & purification , Monoterpenes*/chemistry , Monoterpenes*/pharmacology , Monoterpenes*/isolation & purification, Oxidative Stress/drug effects ; Plant Leaves/chemistry ; Plant Stems/chemistry ; Animals ; PC12 Cells ; Rats ; Molecular Structure ; Structure-Activity Relationship |
| Abstract: | Hirsutanines H-O (1-8), eight previously undescribed monoterpene indole alkaloids, along with five known analogues (9-13), were isolated from the stems and leaves of Uncaria hirsuta. Compounds 1-4 represent a rare subclass of 3-oxo-3,7-seco-oxindole alkaloids. The structures of 1-13 were elucidated by spectroscopic, computational, and chemical means. All the isolates were evaluated for their neuroprotective effects against sodium nitroprusside-induced damage in PC-12 cells. Among them, compounds 1, 4, and 9 exhibited pronounced activity, being comparable to that of the positive control, edaravone. Mechanistic studies revealed that 1, the most active compound, exerted its neuroprotective effect via attenuating oxidative stress. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: 3-Oxo-3,7-seco-oxindole alkaloids; Monoterpene indole alkaloids; N-oxide; Neuroprotective effect; PC-12 cells; Rubiaceae; Uncaria hirsuta |
| Substance Nomenclature: | 0 (Neuroprotective Agents) 0 (Secologanin Tryptamine Alkaloids) 0 (Indole Alkaloids) 0 (Monoterpenes) |
| Entry Date(s): | Date Created: 20260216 Date Completed: 20260707 Latest Revision: 20260707 |
| Update Code: | 20260708 |
| DOI: | 10.1016/j.phytochem.2026.114834 |
| PMID: | 41698517 |
| Database: | MEDLINE |
| ISSN: | 1873-3700 |
|---|---|
| DOI: | 10.1016/j.phytochem.2026.114834 |