Academic Journal
Pre-Neural Source of the Envelope-Following Response Revealed in Cases of Auditory Neuropathy.
| Τίτλος: | Pre-Neural Source of the Envelope-Following Response Revealed in Cases of Auditory Neuropathy. |
|---|---|
| Συγγραφείς: | Díaz M; Bio-, Electro- and Mechanical Systems, Université Libre de Bruxelles, Brussels, Belgium., Lucchetti F; Center for Psychiatric Neuroscience, Lausanne University Hospital and the University of Lausanne, Switzerland., Avan P; Université Paris Cité, Institut Pasteur, AP-HP, INSERM, CNRS, Fondation Pour l'Audition, Institut de l'Audition, IHU reConnect, Paris, France., Niesen M; Ear, Nose and Throat (ENT) Department, Hôpital Erasme, Brussels, Belgium., Devroede B; Ear, Nose and Throat (ENT) Department HUB (Hôpital de Bruxelles): Queen Fabiola University Children's Hospital, Brussels, Belgium., Deltenre P; Ear, Nose and Throat (ENT) Department, Hôpital Erasme, Brussels, Belgium.; Ear, Nose and Throat (ENT) Department HUB (Hôpital de Bruxelles): Queen Fabiola University Children's Hospital, Brussels, Belgium., Nonclercq A; Bio-, Electro- and Mechanical Systems, Université Libre de Bruxelles, Brussels, Belgium. |
| Πηγή: | Ear and hearing [Ear Hear] 2026 Jul-Aug 01; Vol. 47 (4), pp. 976-991. Date of Electronic Publication: 2026 Feb 13. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Williams And Wilkins Country of Publication: United States NLM ID: 8005585 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-4667 (Electronic) Linking ISSN: 01960202 NLM ISO Abbreviation: Ear Hear Subsets: MEDLINE |
| Imprint Name(s): | Publication: Baltimore Md : Williams And Wilkins Original Publication: Baltimore, Williams & Wilkins. |
| Ιατρικοί όροι (MeSH): | Hearing Loss, Central*/physiopathology , Hearing Loss, Central*/diagnosis , Evoked Potentials, Auditory, Brain Stem*/physiology , Evoked Potentials, Auditory*/physiology , Auditory Pathways*/physiopathology, Otoacoustic Emissions, Spontaneous/physiology ; Humans ; Female ; Child ; Male ; Child, Preschool ; Auditory Threshold ; Adolescent ; Acoustic Stimulation ; Case-Control Studies |
| Περίληψη: | Objectives: Complex stimuli such as two-tone stimuli (f 1 and f 2 ) elicit frequency-following responses that reflect phase-locking to the stimulus envelope (f 2 - f 1 ) and temporal fine structure at multiple stages of the auditory pathway, from the cochlea to the cortex. The relative contribution of these structures to the scalp-recorded envelope-following response (EFR) remains a matter of debate. Although subcortical sources have been proposed as the main contributors, near-field recordings close to the cochlea contain pre-neural components and have recently been reported in auditory steady-state responses (ASSRs), a version of the EFR used to measure thresholds at the four frequencies (0.5, 1, 2, 4 kHz) most relevant for objective audiogram estimations. The present study evaluated the EFR in 26 auditory neuropathy spectrum disorder (ANSD) cases and 79 children with normal electrophysiological thresholds and distortion product otoacoustic emissions (controls). In addition, this study presents data from a battery of auditory neurophysiological objective tests applied to the 26 ANSD cases. Design: EFRs were recorded using horizontal (EFR-H) and vertical (EFR-V) channels and the generalized primary tone phase variation method, allowing isolation of the EFR waveforms in the time domain to obtain direct latency and phase-locking value (PLV) measurements. EFRs detected in ANSD cases were compared with those of the controls. The standard audiological objective tests included tympanograms, distortion product otoacoustic emissions, click-evoked auditory brainstem responses (ABRs), and ASSRs. Results: EFR-H was detected in five ANSD cases, showing shorter onset latencies, shorter response durations, and lower PLVs than controls. Lower PLVs were also observed in the EFR-H from the contralateral ears of unilateral ANSD cases. The EFR-V was undetected in all ANSD patients except for two, who showed milder neural desynchronization in their click-evoked ABRs and exhibited the lowest ABR thresholds within the ANSD cases. In 15 ANSD cases, with totally absent neural click-evoked ABRs, ASSRs were detected for at least one tested frequency, indicating a discrepancy between ABR and ASSR-estimated thresholds. Conclusions: The EFR-H observations suggested a pre-neural origin, with the asymmetrical mechanoelectrical transduction process at the sensory hair cells as the main contributor. These findings provide further evidence of a pre-neural potential explaining the discrepancy between ABR and ASSR threshold estimations in ANSD. In addition, the results from the contralateral ears of unilateral ANSD cases may reveal subtle deficits typically undetected by standard audiological techniques. Overall, the study of noninvasive EFR recordings in ANSD may contribute to refining their diagnosis, ultimately improving their treatment. (Copyright © 2026 The American Auditory Society.) |
| Competing Interests: | The authors have no conflicts of interest to disclose. |
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| Grant Information: | J.0092.13 Belgian Fonds National de la Recherche Scientifique |
| Contributed Indexing: | Keywords: Auditory evoked potentials; Auditory neuropathy spectrum disorder; Auditory steady-state response; Click-evoked auditory brainstem response; Envelope-following response; Pre-neural source |
| SCR Disease Name: | Auditory neuropathy |
| Entry Date(s): | Date Created: 20260213 Date Completed: 20260616 Latest Revision: 20260622 |
| Update Code: | 20260622 |
| DOI: | 10.1097/AUD.0000000000001790 |
| PMID: | 41680992 |
| Βάση Δεδομένων: | MEDLINE |
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