Academic Journal
Remodeling of Mitochondrial Networks: Cellular Adaptation and Microenvironmental Reprogramming in Hematologic Malignancies.
| Τίτλος: | Remodeling of Mitochondrial Networks: Cellular Adaptation and Microenvironmental Reprogramming in Hematologic Malignancies. |
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| Συγγραφείς: | Li Y; Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China., Hu X; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China., Zhou X; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.; National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou, China. |
| Πηγή: | Blood cancer discovery [Blood Cancer Discov] 2026 Mar 04; Vol. 7 (2), pp. 212-224. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Philadelphia, PA : American Association for Cancer Research, [2020]- |
| Ιατρικοί όροι (MeSH): | Hematologic Neoplasms*/metabolism , Hematologic Neoplasms*/pathology , Hematologic Neoplasms*/genetics , Mitochondria*/metabolism , Mitochondria*/pathology , Mitochondria*/genetics , Tumor Microenvironment* , Cellular Reprogramming*, Humans ; Animals ; Metabolic Reprogramming ; Mitophagy |
| Περίληψη: | Mitochondria regulate critical cellular processes beyond energy production, including organelle quality control, programmed cell death, and intercellular and interorganellar communication. In hematologic malignancies, mitochondria undergo adaptations through mechanisms including genetic mutations, metabolic reprogramming, mitochondrial transfer, fusion, and mitophagy. These alterations create heterogeneity, contribute to therapeutic resistance, and can also reshape the tumor microenvironment to promote progression. Collectively, these findings suggest that mitochondria represent a promising frontier in next-generation therapeutics, with emerging strategies such as mitochondrial-targeted small molecules and mitochondrial transplantation holding significant therapeutic potential. Significance: In this review, we summarize the functions of mitochondria beyond energy production and highlight the heterogeneity of mitochondrial functional adaptations in hematologic malignancies, as well as the vital role of mitochondrial alterations in reshaping the tumor microenvironment. Understanding these changes is critical to deciphering the pathophysiology of hematologic malignancies. (©2026 American Association for Cancer Research.) |
| Grant Information: | No.82570247 National Natural Science Foundation of China (NSFC); No.82170189 National Natural Science Foundation of China (NSFC); No.82500259 National Natural Science Foundation of China (NSFC); ZR2024QH392 Shandong Provincial Natural Science Foundation; No. 202134034 Technology Development Project of Jinan City; No.tstp20250756 Taishan Scholars Program of Shandong Province |
| Entry Date(s): | Date Created: 20260210 Date Completed: 20260707 Latest Revision: 20260724 |
| Update Code: | 20260724 |
| DOI: | 10.1158/2643-3230.BCD-25-0338 |
| PMID: | 41665251 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2643-3249 |
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| DOI: | 10.1158/2643-3230.BCD-25-0338 |