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Advancing climate adaptation in saffron through CRISPR-based modulation of stress tolerance and photoperiodic flowering control.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Advancing climate adaptation in saffron through CRISPR-based modulation of stress tolerance and photoperiodic flowering control.
Συγγραφείς: Ullah Q; Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat, Thailand., Haider W; Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat, Thailand., Zeshan M; Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat, Thailand., Waqar M; Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat, Thailand., Arshad MT; Functional Food and Nutrition Program, Center of Excellence in Functional Foods and Gastronomy, Faculty of Agro-Industry, Prince of Songkla University, Songkhla, Thailand., Parveen H; Organic and Medicinal Chemistry Research Lab, Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia., Mukhtar S; Organic and Medicinal Chemistry Research Lab, Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia., Zahir A; Faculty of Veterinary Sciences, Department of Food Science and Technology, Afghanistan National Agricultural Sciences & Technology University, Kandahar, Afghanistan.
Πηγή: GM crops & food [GM Crops Food] 2026 Dec; Vol. 17 (1), pp. 2626180. Date of Electronic Publication: 2026 Feb 10.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572655 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-5701 (Electronic) Linking ISSN: 21645698 NLM ISO Abbreviation: GM Crops Food Subsets: MEDLINE
Imprint Name(s): Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin, Tex. : Landes Bioscience
Ιατρικοί όροι (MeSH): Crocus*/genetics , Crocus*/physiology , Flowers*/genetics , Flowers*/physiology , Adaptation, Physiological*/genetics , CRISPR-Cas Systems*, Gene Editing/methods ; Stress, Physiological/genetics ; Plants, Genetically Modified/genetics ; Photoperiod ; Drought Resistance ; Climate
Περίληψη: Saffron (Crocus sativus L.) is a high-value crop known for its intricate harvesting process and limited production due to factors like triploid sterility and specific climatic needs. This review discusses biotechnological methods, particularly CRISPR/Cas9 genome editing, aimed at improving heat and drought tolerance and achieving year-round flowering. Such genetic edits as evidenced with experimental CRISPR/Cas9 systems that reach up to 70% callus initiation in saffron. Cultivation efficiency and quality are increased in Hydroponic systems and synthetic bioreactors, which have been proven in trials in non-traditional areas such as North Bengal, India. Nonetheless, internationalization threatens the market value and cultural integrity of saffron, and such measures as fair-trade labels, GI laws, and cooperatives of stakeholders must be implemented fairly and equally.
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Front Genet. 2022 May 20;13:900324. (PMID: 35669196)
Plants (Basel). 2025 Jan 07;14(2):. (PMID: 39861500)
Mol Biol Rep. 2022 Jun;49(6):5325-5340. (PMID: 35106686)
Plant Biotechnol J. 2020 Jan;18(1):298-309. (PMID: 31240772)
Plant Biotechnol J. 2020 Nov;18(11):2225-2240. (PMID: 32181964)
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Plant Sci. 2020 Jul;296:110499. (PMID: 32540017)
Comput Struct Biotechnol J. 2020 Oct 29;18:3278-3286. (PMID: 33209212)
Front Genet. 2022 Oct 28;13:1001001. (PMID: 36386797)
GM Crops Food. 2024 Dec 31;15(1):1-14. (PMID: 38215017)
Sci Rep. 2022 Jul 13;12(1):11925. (PMID: 35831447)
Int J Mol Sci. 2022 Nov 26;23(23):. (PMID: 36499153)
Environ Res. 2022 Jan;203:111853. (PMID: 34370989)
Cell Stress Chaperones. 2006 Summer;11(2):162-9. (PMID: 16817322)
Plant Sci. 2023 May;330:111639. (PMID: 36796649)
Int J Mol Sci. 2022 Jan 19;23(3):. (PMID: 35163008)
Front Plant Sci. 2021 Mar 15;12:657819. (PMID: 33790932)
Photosynthetica. 2022 Oct 03;60(4):497-507. (PMID: 39649390)
Front Plant Sci. 2022 Feb 25;13:834416. (PMID: 35283878)
J Zhejiang Univ Sci B. 2023 Jul 10;24(12):1093-1105. (PMID: 38057267)
Food Sci Nutr. 2025 Aug 06;13(8):e70721. (PMID: 40772023)
Int J Mol Sci. 2022 Jun 22;23(13):. (PMID: 35805930)
Front Plant Sci. 2023 Mar 09;14:1107172. (PMID: 36968363)
GM Crops Food. 2014 Apr-Jun;5(2):97-105. (PMID: 25072266)
Heliyon. 2024 Feb 27;10(5):e27138. (PMID: 38455530)
Plants (Basel). 2024 Dec 27;14(1):. (PMID: 39795311)
Genes (Basel). 2022 Jan 28;13(2):. (PMID: 35205226)
Front Plant Sci. 2024 Sep 23;15:1478398. (PMID: 39376239)
Plant Mol Biol. 2022 Apr;108(6):621-634. (PMID: 35305221)
Mol Biotechnol. 2022 Dec;64(12):1303-1318. (PMID: 35751797)
Plants (Basel). 2023 Nov 29;12(23):. (PMID: 38068655)
Sci Rep. 2023 May 3;13(1):7175. (PMID: 37137943)
Int J Cell Biol. 2010;2010:214074. (PMID: 20182529)
PLoS One. 2025 Jan 13;20(1):e0317186. (PMID: 39804884)
Int J Mol Sci. 2023 Oct 11;24(20):. (PMID: 37894770)
Mar Drugs. 2023 Dec 28;22(1):. (PMID: 38248646)
J Exp Bot. 2015 Feb;66(3):1025-39. (PMID: 25428996)
Genes (Basel). 2024 Apr 29;15(5):. (PMID: 38790202)
PLoS One. 2024 Jul 18;19(7):e0306298. (PMID: 39024332)
Front Plant Sci. 2023 Apr 18;14:1157678. (PMID: 37143874)
Plants (Basel). 2024 Apr 17;13(8):. (PMID: 38674534)
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Planta. 2024 Aug 28;260(4):81. (PMID: 39196449)
Molecules. 2008 May 13;13(5):1135-1147. (PMID: 18560333)
Biology (Basel). 2024 Dec 04;13(12):. (PMID: 39765681)
Front Plant Sci. 2023 Feb 15;14:1097682. (PMID: 36875593)
Plant Cell Rep. 2022 Mar;41(3):815-831. (PMID: 33742256)
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Plant Biotechnol J. 2018 Jan;16(1):176-185. (PMID: 28509421)
Plant Cell Rep. 2023 Dec 26;43(1):18. (PMID: 38148416)
Plant Physiol. 2025 Sep 1;199(1):. (PMID: 40875819)
Physiol Mol Biol Plants. 2010 Dec;16(4):369-73. (PMID: 23572987)
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Front Plant Sci. 2021 Mar 04;12:615114. (PMID: 33746999)
Plant Physiol. 2015 Sep;169(1):266-82. (PMID: 26220950)
Sci Rep. 2024 Sep 29;14(1):22589. (PMID: 39343800)
Contributed Indexing: Keywords: Apo carotenoids; CRISPR/Cas9; biotechnology; hydroponics; saffron; synthetic biology
Entry Date(s): Date Created: 20260210 Date Completed: 20260707 Latest Revision: 20260707
Update Code: 20260707
PubMed Central ID: PMC12893690
DOI: 10.1080/21645698.2026.2626180
PMID: 41664621
Βάση Δεδομένων: MEDLINE
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  Label: Title
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  Data: Advancing climate adaptation in saffron through CRISPR-based modulation of stress tolerance and photoperiodic flowering control.
– Name: Author
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  Data: <searchLink fieldCode="AU" term="%22Ullah+Q%22">Ullah Q</searchLink>; Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat, Thailand.<br /><searchLink fieldCode="AU" term="%22Haider+W%22">Haider W</searchLink>; Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat, Thailand.<br /><searchLink fieldCode="AU" term="%22Zeshan+M%22">Zeshan M</searchLink>; Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat, Thailand.<br /><searchLink fieldCode="AU" term="%22Waqar+M%22">Waqar M</searchLink>; Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat, Thailand.<br /><searchLink fieldCode="AU" term="%22Arshad+MT%22">Arshad MT</searchLink>; Functional Food and Nutrition Program, Center of Excellence in Functional Foods and Gastronomy, Faculty of Agro-Industry, Prince of Songkla University, Songkhla, Thailand.<br /><searchLink fieldCode="AU" term="%22Parveen+H%22">Parveen H</searchLink>; Organic and Medicinal Chemistry Research Lab, Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Mukhtar+S%22">Mukhtar S</searchLink>; Organic and Medicinal Chemistry Research Lab, Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Zahir+A%22">Zahir A</searchLink>; Faculty of Veterinary Sciences, Department of Food Science and Technology, Afghanistan National Agricultural Sciences & Technology University, Kandahar, Afghanistan.
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  Data: <searchLink fieldCode="JN" term="%22101572655%22">GM crops & food</searchLink> [GM Crops Food] 2026 Dec; Vol. 17 (1), pp. 2626180. <i>Date of Electronic Publication: </i>2026 Feb 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101572655 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2164-5701 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221645698%22">21645698 </searchLink><i>NLM ISO Abbreviation: </i>GM Crops Food <i>Subsets: </i>MEDLINE
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  Data: <i>Publication</i>: 2015- : Philadelphia, PA : Taylor & Francis<br /><i>Original Publication</i>: Austin, Tex. : Landes Bioscience
– Name: SubjectMESH
  Label: MeSH Terms
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  Data: <searchLink fieldCode="MM" term="%22Crocus%22">Crocus*</searchLink>/<searchLink fieldCode="MM" term="%22Crocus+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Crocus%22">Crocus*</searchLink>/<searchLink fieldCode="MM" term="%22Crocus+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Flowers%22">Flowers*</searchLink>/<searchLink fieldCode="MM" term="%22Flowers+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Flowers%22">Flowers*</searchLink>/<searchLink fieldCode="MM" term="%22Flowers+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Adaptation%2C+Physiological%22">Adaptation, Physiological*</searchLink>/<searchLink fieldCode="MM" term="%22Adaptation%2C+Physiological+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22CRISPR-Cas+Systems%22">CRISPR-Cas Systems*</searchLink><br /><searchLink fieldCode="MH" term="%22Gene+Editing%22">Gene Editing</searchLink>/<searchLink fieldCode="MH" term="%22Gene+Editing+methods%22">methods</searchLink> ; <searchLink fieldCode="MH" term="%22Stress%2C+Physiological%22">Stress, Physiological</searchLink>/<searchLink fieldCode="MH" term="%22Stress%2C+Physiological+genetics%22">genetics</searchLink> ; <searchLink fieldCode="MH" term="%22Plants%2C+Genetically+Modified%22">Plants, Genetically Modified</searchLink>/<searchLink fieldCode="MH" term="%22Plants%2C+Genetically+Modified+genetics%22">genetics</searchLink> ; <searchLink fieldCode="MH" term="%22Photoperiod%22">Photoperiod</searchLink> ; <searchLink fieldCode="MH" term="%22Drought+Resistance%22">Drought Resistance</searchLink> ; <searchLink fieldCode="MH" term="%22Climate%22">Climate</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Saffron (Crocus sativus L.) is a high-value crop known for its intricate harvesting process and limited production due to factors like triploid sterility and specific climatic needs. This review discusses biotechnological methods, particularly CRISPR/Cas9 genome editing, aimed at improving heat and drought tolerance and achieving year-round flowering. Such genetic edits as evidenced with experimental CRISPR/Cas9 systems that reach up to 70% callus initiation in saffron. Cultivation efficiency and quality are increased in Hydroponic systems and synthetic bioreactors, which have been proven in trials in non-traditional areas such as North Bengal, India. Nonetheless, internationalization threatens the market value and cultural integrity of saffron, and such measures as fair-trade labels, GI laws, and cooperatives of stakeholders must be implemented fairly and equally.
– Name: Ref
  Label: References
  Group: RefInfo
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(PMID: <searchLink fieldCode="PM" term="%2232540017%22">32540017)</searchLink><br />Comput Struct Biotechnol J. 2020 Oct 29;18:3278-3286. (PMID: <searchLink fieldCode="PM" term="%2233209212%22">33209212)</searchLink><br />Front Genet. 2022 Oct 28;13:1001001. (PMID: <searchLink fieldCode="PM" term="%2236386797%22">36386797)</searchLink><br />GM Crops Food. 2024 Dec 31;15(1):1-14. (PMID: <searchLink fieldCode="PM" term="%2238215017%22">38215017)</searchLink><br />Sci Rep. 2022 Jul 13;12(1):11925. (PMID: <searchLink fieldCode="PM" term="%2235831447%22">35831447)</searchLink><br />Int J Mol Sci. 2022 Nov 26;23(23):. (PMID: <searchLink fieldCode="PM" term="%2236499153%22">36499153)</searchLink><br />Environ Res. 2022 Jan;203:111853. (PMID: <searchLink fieldCode="PM" term="%2234370989%22">34370989)</searchLink><br />Cell Stress Chaperones. 2006 Summer;11(2):162-9. (PMID: <searchLink fieldCode="PM" term="%2216817322%22">16817322)</searchLink><br />Plant Sci. 2023 May;330:111639. 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  Data: <i>Keywords: </i>Apo carotenoids; CRISPR/Cas9; biotechnology; hydroponics; saffron; synthetic biology
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  Data: <i>Date Created: </i>20260210 <i>Date Completed: </i>20260707 <i>Latest Revision: </i>20260707
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  Data: 10.1080/21645698.2026.2626180
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/21645698.2026.2626180
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2626180
    Subjects:
      – SubjectFull: Gene Editing methods
        Type: general
      – SubjectFull: Stress, Physiological genetics
        Type: general
      – SubjectFull: Plants, Genetically Modified genetics
        Type: general
      – SubjectFull: Photoperiod
        Type: general
      – SubjectFull: Drought Resistance
        Type: general
      – SubjectFull: Climate
        Type: general
      – SubjectFull: Crocus genetics
        Type: general
      – SubjectFull: Crocus physiology
        Type: general
      – SubjectFull: Flowers genetics
        Type: general
      – SubjectFull: Flowers physiology
        Type: general
      – SubjectFull: Adaptation, Physiological genetics
        Type: general
      – SubjectFull: CRISPR-Cas Systems
        Type: general
    Titles:
      – TitleFull: Advancing climate adaptation in saffron through CRISPR-based modulation of stress tolerance and photoperiodic flowering control.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ullah Q
      – PersonEntity:
          Name:
            NameFull: Haider W
      – PersonEntity:
          Name:
            NameFull: Zeshan M
      – PersonEntity:
          Name:
            NameFull: Waqar M
      – PersonEntity:
          Name:
            NameFull: Arshad MT
      – PersonEntity:
          Name:
            NameFull: Parveen H
      – PersonEntity:
          Name:
            NameFull: Mukhtar S
      – PersonEntity:
          Name:
            NameFull: Zahir A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: 2026 Dec
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2164-5701
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: GM crops & food
              Type: main
ResultId 1