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Synthesizing expert consensus to define a core condition set for multimorbidity measurement: A narrative review.

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Τίτλος: Synthesizing expert consensus to define a core condition set for multimorbidity measurement: A narrative review.
Συγγραφείς: Shao W; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Lu Z; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Wei X; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Kong Y; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Long Y; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Zhang Y; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Shao R; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; State Key Laboratory of Respiratory Health and Multimorbidity, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Πηγή: Science progress [Sci Prog] 2026 Jan-Mar; Vol. 109 (1), pp. 368504251409841. Date of Electronic Publication: 2026 Feb 09.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: SAGE Publications Country of Publication: England NLM ID: 0411361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-7163 (Electronic) Linking ISSN: 00368504 NLM ISO Abbreviation: Sci Prog Subsets: MEDLINE
Imprint Name(s): Publication: <2019-> : [London] : SAGE Publications
Original Publication: Oxford, Blackwell Scientific Publications [etc.]
Ιατρικοί όροι (MeSH): Multimorbidity* , Consensus Statements as Topic* , Chronic Disease Indicators*, Humans ; Consensus ; International Classification of Diseases
Περίληψη: Inconsistent measurement of multimorbidity hinders comparative research and evidence synthesis. To address this, this study is a narrative review, informed by a structured scoping search of three major databases. We synthesized formal expert-consensus studies to identify a foundational core set of conditions that can serve as a pragmatic starting point for improving research comparability. Our synthesis of three expert consensus studies identified a comprehensive core set of 105 consistently recommended condition categories at the International Classification of Diseases, 10th revision (ICD-10) three-digit level. These conditions span 10 major clinical domains, covering key conditions such as ischemic heart disease, diabetes, dementia, and depression. To facilitate application, we mapped this core set to both ICD-10 and preliminary ICD-11 codes. A foundational consensus for measuring multimorbidity is emerging. We propose a "Core-plus-Customization" framework, where the identified core set serves as an evidence-based starting point for research, requiring local adaptation rather than being a prescriptive "minimum dataset." This operationalized core set provides a practical tool to begin standardizing measurement in the field.
Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
References: JBI Evid Synth. 2020 Oct;18(10):2119-2126. (PMID: 33038124)
Eur J Public Health. 2019 Feb 1;29(1):182-189. (PMID: 29878097)
Lancet Public Health. 2021 Aug;6(8):e587-e597. (PMID: 34166630)
Commun Med (Lond). 2024 Jul 8;4(1):94. (PMID: 38977844)
Nat Rev Dis Primers. 2022 Jul 14;8(1):48. (PMID: 35835758)
Health Qual Life Outcomes. 2015 Oct 15;13:168. (PMID: 26467295)
Nat Commun. 2023 Dec 12;14(1):8236. (PMID: 38086884)
J Multimorb Comorb. 2023 Oct 27;13:26335565231208994. (PMID: 37900010)
Lancet Diabetes Endocrinol. 2024 Mar;12(3):196-208. (PMID: 38310921)
Trials. 2017 Jun 20;18(Suppl 3):280. (PMID: 28681707)
BMJ Glob Health. 2020 Apr 16;5(4):e002269. (PMID: 32377405)
Nat Med. 2023 Jul;29(7):1649-1657. (PMID: 37464031)
Lancet. 2024 Aug 17;404(10453):707-724. (PMID: 39096925)
J Gerontol A Biol Sci Med Sci. 2017 Oct 01;72(10):1417-1423. (PMID: 28003375)
Prev Chronic Dis. 2021 Apr 08;18:E33. (PMID: 33830913)
Br J Gen Pract. 2023 Jul 27;73(733):373-376. (PMID: 37500453)
Ann Fam Med. 2012 Mar-Apr;10(2):142-51. (PMID: 22412006)
JBI Evid Synth. 2023 Mar 01;21(3):520-532. (PMID: 36081365)
Lancet Digit Health. 2023 Jan;5(1):e16-e27. (PMID: 36460578)
PLoS One. 2022 Dec 1;17(12):e0278559. (PMID: 36455000)
J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):297-300. (PMID: 30721991)
Ann Intern Med. 2018 Oct 2;169(7):467-473. (PMID: 30178033)
Lancet. 2024 May 18;403(10440):2133-2161. (PMID: 38642570)
Res Integr Peer Rev. 2019 Mar 26;4:5. (PMID: 30962953)
BMC Med. 2019 Apr 10;17(1):74. (PMID: 30967141)
BMJ Med. 2022 Jul 27;1(1):e000247. (PMID: 36936594)
Implement Sci. 2020 Nov 25;15(1):103. (PMID: 33239097)
BMC Med. 2023 Dec 13;21(1):495. (PMID: 38093264)
Annu Rev Public Health. 2020 Apr 2;41:417-432. (PMID: 31900101)
J Multimorb Comorb. 2022 Sep 1;12:26335565221112593. (PMID: 36081708)
Contributed Indexing: Keywords: Multimorbidity; core condition set; expert consensus; measurement; narrative review
Entry Date(s): Date Created: 20260210 Date Completed: 20260210 Latest Revision: 20260306
Update Code: 20260307
PubMed Central ID: PMC12891385
DOI: 10.1177/00368504251409841
PMID: 41664474
Βάση Δεδομένων: MEDLINE
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  Data: Inconsistent measurement of multimorbidity hinders comparative research and evidence synthesis. To address this, this study is a narrative review, informed by a structured scoping search of three major databases. We synthesized formal expert-consensus studies to identify a foundational core set of conditions that can serve as a pragmatic starting point for improving research comparability. Our synthesis of three expert consensus studies identified a comprehensive core set of 105 consistently recommended condition categories at the International Classification of Diseases, 10th revision (ICD-10) three-digit level. These conditions span 10 major clinical domains, covering key conditions such as ischemic heart disease, diabetes, dementia, and depression. To facilitate application, we mapped this core set to both ICD-10 and preliminary ICD-11 codes. A foundational consensus for measuring multimorbidity is emerging. We propose a &quot;Core-plus-Customization&quot; framework, where the identified core set serves as an evidence-based starting point for research, requiring local adaptation rather than being a prescriptive &quot;minimum dataset.&quot; This operationalized core set provides a practical tool to begin standardizing measurement in the field.
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  Data: JBI Evid Synth. 2020 Oct;18(10):2119-2126. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2233038124%22&quot;&gt;33038124)&lt;/searchLink&gt;&lt;br /&gt;Eur J Public Health. 2019 Feb 1;29(1):182-189. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2229878097%22&quot;&gt;29878097)&lt;/searchLink&gt;&lt;br /&gt;Lancet Public Health. 2021 Aug;6(8):e587-e597. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2234166630%22&quot;&gt;34166630)&lt;/searchLink&gt;&lt;br /&gt;Commun Med (Lond). 2024 Jul 8;4(1):94. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238977844%22&quot;&gt;38977844)&lt;/searchLink&gt;&lt;br /&gt;Nat Rev Dis Primers. 2022 Jul 14;8(1):48. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2235835758%22&quot;&gt;35835758)&lt;/searchLink&gt;&lt;br /&gt;Health Qual Life Outcomes. 2015 Oct 15;13:168. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2226467295%22&quot;&gt;26467295)&lt;/searchLink&gt;&lt;br /&gt;Nat Commun. 2023 Dec 12;14(1):8236. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238086884%22&quot;&gt;38086884)&lt;/searchLink&gt;&lt;br /&gt;J Multimorb Comorb. 2023 Oct 27;13:26335565231208994. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2237900010%22&quot;&gt;37900010)&lt;/searchLink&gt;&lt;br /&gt;Lancet Diabetes Endocrinol. 2024 Mar;12(3):196-208. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238310921%22&quot;&gt;38310921)&lt;/searchLink&gt;&lt;br /&gt;Trials. 2017 Jun 20;18(Suppl 3):280. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2228681707%22&quot;&gt;28681707)&lt;/searchLink&gt;&lt;br /&gt;BMJ Glob Health. 2020 Apr 16;5(4):e002269. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2232377405%22&quot;&gt;32377405)&lt;/searchLink&gt;&lt;br /&gt;Nat Med. 2023 Jul;29(7):1649-1657. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2237464031%22&quot;&gt;37464031)&lt;/searchLink&gt;&lt;br /&gt;Lancet. 2024 Aug 17;404(10453):707-724. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2239096925%22&quot;&gt;39096925)&lt;/searchLink&gt;&lt;br /&gt;J Gerontol A Biol Sci Med Sci. 2017 Oct 01;72(10):1417-1423. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2228003375%22&quot;&gt;28003375)&lt;/searchLink&gt;&lt;br /&gt;Prev Chronic Dis. 2021 Apr 08;18:E33. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2233830913%22&quot;&gt;33830913)&lt;/searchLink&gt;&lt;br /&gt;Br J Gen Pract. 2023 Jul 27;73(733):373-376. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2237500453%22&quot;&gt;37500453)&lt;/searchLink&gt;&lt;br /&gt;Ann Fam Med. 2012 Mar-Apr;10(2):142-51. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2222412006%22&quot;&gt;22412006)&lt;/searchLink&gt;&lt;br /&gt;JBI Evid Synth. 2023 Mar 01;21(3):520-532. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2236081365%22&quot;&gt;36081365)&lt;/searchLink&gt;&lt;br /&gt;Lancet Digit Health. 2023 Jan;5(1):e16-e27. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2236460578%22&quot;&gt;36460578)&lt;/searchLink&gt;&lt;br /&gt;PLoS One. 2022 Dec 1;17(12):e0278559. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2236455000%22&quot;&gt;36455000)&lt;/searchLink&gt;&lt;br /&gt;J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):297-300. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2230721991%22&quot;&gt;30721991)&lt;/searchLink&gt;&lt;br /&gt;Ann Intern Med. 2018 Oct 2;169(7):467-473. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2230178033%22&quot;&gt;30178033)&lt;/searchLink&gt;&lt;br /&gt;Lancet. 2024 May 18;403(10440):2133-2161. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238642570%22&quot;&gt;38642570)&lt;/searchLink&gt;&lt;br /&gt;Res Integr Peer Rev. 2019 Mar 26;4:5. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2230962953%22&quot;&gt;30962953)&lt;/searchLink&gt;&lt;br /&gt;BMC Med. 2019 Apr 10;17(1):74. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2230967141%22&quot;&gt;30967141)&lt;/searchLink&gt;&lt;br /&gt;BMJ Med. 2022 Jul 27;1(1):e000247. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2236936594%22&quot;&gt;36936594)&lt;/searchLink&gt;&lt;br /&gt;Implement Sci. 2020 Nov 25;15(1):103. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2233239097%22&quot;&gt;33239097)&lt;/searchLink&gt;&lt;br /&gt;BMC Med. 2023 Dec 13;21(1):495. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238093264%22&quot;&gt;38093264)&lt;/searchLink&gt;&lt;br /&gt;Annu Rev Public Health. 2020 Apr 2;41:417-432. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2231900101%22&quot;&gt;31900101)&lt;/searchLink&gt;&lt;br /&gt;J Multimorb Comorb. 2022 Sep 1;12:26335565221112593. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2236081708%22&quot;&gt;36081708)&lt;/searchLink&gt;
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