Academic Journal
Vibrating mesh nebulization increases tidal volume relative to jet nebulization during NIV in COPD exacerbation.
| Τίτλος: | Vibrating mesh nebulization increases tidal volume relative to jet nebulization during NIV in COPD exacerbation. |
|---|---|
| Συγγραφείς: | Cinesi-Gomez C; Emergency Department, Reina Sofía University General Hospital, Spain. Electronic address: ccinesi@ucam.edu., Garcia-Palacios M; Emergency Department, Reina Sofía University General Hospital, Spain. Electronic address: mgarcia76@alu.ucam.edu., Bernabe-Vera L; Emergency Department, Reina Sofía University General Hospital, Spain. Electronic address: bernabe.lorena@gmail.com., Suarez-Pineda MC; Emergency Department, Reina Sofía University General Hospital, Spain. Electronic address: mabelsuarezcp13@gmail.com., Serrano-Carrasco E; Emergency Department, Reina Sofía University General Hospital, Spain. Electronic address: elisaserrano92@gmail.com., Sanchez-Nicolas JA; Emergency Department, Reina Sofía University General Hospital, Spain. Electronic address: jasanchez2@ucam.edu. |
| Πηγή: | Respiratory medicine and research [Respir Med Res] 2026 May; Vol. 89, pp. 101248. Date of Electronic Publication: 2026 Jan 12. |
| Τύπος έκδοσης: | Journal Article; Observational Study; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Masson SAS Country of Publication: France NLM ID: 101746324 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2590-0412 (Electronic) Linking ISSN: 25900412 NLM ISO Abbreviation: Respir Med Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Issy-les-Moulineaux] : Elsevier Masson SAS, [2019]- |
| Ιατρικοί όροι (MeSH): | Pulmonary Disease, Chronic Obstructive*/therapy , Pulmonary Disease, Chronic Obstructive*/physiopathology , Noninvasive Ventilation*/methods , Noninvasive Ventilation*/instrumentation , Tidal Volume*/physiology , Bronchodilator Agents*/administration & dosage , Nebulizers and Vaporizers* , Vibration*, Humans ; Female ; Male ; Aged ; Longitudinal Studies ; Middle Aged ; Disease Progression |
| Περίληψη: | Background and Importance: Noninvasive ventilation (NIV) is the first-line treatment for acute exacerbations of chronic obstructive pulmonary disease (COPD) with hypercapnic respiratory failure (HRF). Bronchodilator therapy is essential during NIV, but real-world clinical comparisons of nebulization devices in this acute setting remain limited. Objective: To compare the clinical efficacy of vibrating mesh nebulizers (VMN) versus jet nebulizers (JN) in COPD patients undergoing NIV, using changes in tidal volume (VT) as the primary outcome. Design, Settings and Participants: A longitudinal observational study was performed in the ventilatory unit of the emergency department of a tertiary hospital. Patients requiring NIV for HRF were allocated to two cohorts: VMN (October 2023-March 2024) and JN (January 2015-May 2017). Ventilatory parameters, including VT, were recorded at baseline, 15 minutes, 1 hour, and 3 hours. The primary outcome was the percentage change in VT (ΔVT) from baseline. Main Results: Eighty-four patients were analyzed (VMN: n=41; JN: n=43). Baseline characteristics were comparable between groups. The VMN cohort exhibited a significantly greater increase in VT at 1 hour and 3 hours (p<0.05) compared with the JN cohort. ΔVT mirrored these findings. No significant correlation was observed between VT and pressure support levels. Conclusion: In this real-world ED study of COPD patients treated with continuous NIV, VMN was associated with a greater early increase in VT than JN, consistent with more effective bronchodilator delivery. Given the historical, non-randomized design across different time periods and ventilators, and the use of VT as an indirect endpoint, these findings should be interpreted as hypothesis-generating but provide a clinically relevant starting point supporting preferential VMN use in acute practice. (Copyright © 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Acute exacerbation of COPD; Jet Nebulization; Noninvasive Ventilation; Vibrating Mesh Nebulization |
| Substance Nomenclature: | 0 (Bronchodilator Agents) |
| Entry Date(s): | Date Created: 20260129 Date Completed: 20260612 Latest Revision: 20260616 |
| Update Code: | 20260617 |
| DOI: | 10.1016/j.resmer.2026.101248 |
| PMID: | 41610563 |
| Βάση Δεδομένων: | MEDLINE |
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