Academic Journal
Association Between HLA Alleles and IgA Nephropathy in a Taiwanese Population.
| Τίτλος: | Association Between HLA Alleles and IgA Nephropathy in a Taiwanese Population. |
|---|---|
| Συγγραφείς: | Huang YC; Division of Nephrology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung 407, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan.; Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan., Chen IC; Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan., Lin GC; Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan., Hsiao TH; Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan.; Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan., Tsai SF; Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan., Chen YM; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan.; Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan.; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan., Fu LS; Division of Nephrology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung 407, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan. |
| Πηγή: | International journal of molecular sciences [Int J Mol Sci] 2026 Jan 13; Vol. 27 (2). Date of Electronic Publication: 2026 Jan 13. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, [2000- |
| Ιατρικοί όροι (MeSH): | Glomerulonephritis, IGA*/genetics , Glomerulonephritis, IGA*/pathology , Glomerulonephritis, IGA*/epidemiology , HLA Antigens*/genetics , Alleles* , Genetic Predisposition to Disease*, Taiwan/epidemiology ; East Asian People/genetics ; Adult ; Female ; Humans ; Male ; Middle Aged ; Case-Control Studies ; Gene Frequency ; Genotype ; Polymorphism, Single Nucleotide |
| Περίληψη: | Genetic associations with IgA nephropathy (IgAN), particularly in the human leukocyte antigen (HLA) region, vary across ethnic groups. This study investigated the association of HLA alleles with the diagnosis, pathological findings, and prognosis of biopsy-proven IgAN in a Taiwanese population. A case-control study was conducted using data from the Taiwan Precision Medicine Initiative, including 157 patients with biopsy-proven IgAN and 1570 age- and sex-matched controls. Genetic data were obtained from single-nucleotide polymorphism arrays, and HLA imputation was performed. Most single-nucleotide polymorphisms associated with IgAN were located within the HLA region on chromosome 6. Frequencies of several alleles (including C*08:01, DQA1*03:01, and DQB1*04:01) were significantly higher in the IgAN group. Conversely, frequencies of alleles such as B*58:01 and DQB1*02:01 were significantly lower. This study identified novel risk and protective HLA alleles for IgAN in a Taiwanese population. |
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| Grant Information: | 40-05-GMM, AS-GC-110-MD02 and 236e-1100202 Academia Sinica; NSTC 111-3114-Y-001-001 National Development Fund, Executive Yuan; TCVGH-1126501A Taichung Veterans General Hospital |
| Contributed Indexing: | Keywords: HLA; IgA nephropathy; Taiwan; single-nucleotide polymorphism |
| Substance Nomenclature: | 0 (HLA Antigens) |
| Entry Date(s): | Date Created: 20260128 Date Completed: 20260128 Latest Revision: 20260131 |
| Update Code: | 20260131 |
| PubMed Central ID: | PMC12841225 |
| DOI: | 10.3390/ijms27020790 |
| PMID: | 41596442 |
| Βάση Δεδομένων: | MEDLINE |
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