Academic Journal
Effects of Randomized Multivitamin Supplementation on Carotenoids and α-Tocopherol in the COcoa Supplement and Multivitamin Outcomes Study.
| Τίτλος: | Effects of Randomized Multivitamin Supplementation on Carotenoids and α-Tocopherol in the COcoa Supplement and Multivitamin Outcomes Study. |
|---|---|
| Συγγραφείς: | Christopher CN; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Electronic address: cchristopher@fas.harvard.edu., Erdman JW Jr; Division of Nutritional Sciences and Beckman Institute, Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois., Kim E; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Black M; Division of Nutritional Sciences and Beckman Institute, Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois., Rist PM; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Tobias DK; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Rautiainen S; Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Division of Obstetrics, Department of Women's Health, Karolinska University Hospital, Stockholm, Sweden., Manson JE; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Sesso HD; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. |
| Πηγή: | Journal of the Academy of Nutrition and Dietetics [J Acad Nutr Diet] 2026 May; Vol. 126 (5), pp. 156299. Date of Electronic Publication: 2026 Jan 24. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 101573920 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-2672 (Print) Linking ISSN: 22122672 NLM ISO Abbreviation: J Acad Nutr Diet Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York : Elsevier |
| Ιατρικοί όροι (MeSH): | Carotenoids*/blood , Vitamins*/administration & dosage , Vitamins*/blood , alpha-Tocopherol*/blood , Cacao*/chemistry , Dietary Supplements*, Lycopene/blood ; Humans ; Male ; Aged ; Female ; Middle Aged ; Follow-Up Studies |
| Περίληψη: | Background: Adequate intake of carotenoids and vitamin E supports healthy aging, yet evidence is limited on whether multivitamin-multimineral (MVM) supplementation changes serum concentrations over time. Objective: The aim of this investigation was to evaluate the effect of daily MVM supplementation among older adults on serum carotenoid and vitamin E concentrations over a 2-year period. Design: The COcoa Supplement and Multivitamin Outcomes Study is a large-scale, randomized, placebo-controlled, 2 × 2 factorial trial, designed to test the effects of daily MVM and cocoa extract supplementation for chronic disease prevention. Participants completed semiannual questionnaires and provided optional biospecimen samples at baseline, 1-year, and 2-year follow-up. Participants and Setting: Between 2015 and 2020, US adults (women aged 65 years and older, men aged 60 years and older) without major cardiovascular disease or recent cancer were enrolled in the COcoa Supplement and Multivitamin Outcomes Study. This analysis included biospecimen substudy participants with blood samples provided at baseline and ≥1 follow-up timepoint (n = 400; 1 excluded due to unusable sample; final N = 399). Intervention: Participants were randomized to receive daily MVM supplementation or a placebo, with or without cocoa extract. Main Outcome Measures: Changes in serum carotenoids and α-tocopherol concentrations were evaluated over the 2-year follow-up. Statistical Analyses: Multivariable linear mixed models estimated changes in serum biomarker concentrations, comparing MVM with placebo, adjusting for covariates (age, sex, and cocoa extract intervention). Results: Increases in serum carotenoids and α-tocopherol levels with MVM supplementation emerged at year 1 and persisted through year 2. MVM supplementation led to significantly higher serum concentrations of total carotenoids (percent change: 15.5%; 95% CI, 8.72 to 22.70), lutein (percent change: 17.17%; 95% CI, 7.53 to 27.66), beta carotene (percent change: 46.96%; 95% CI, 35.10 to 59.85), and α-tocopherol (percent change: 29.50%; 95% CI, 22.88 to 36.47) over 2 years compared with placebo. No significant differences were observed for lycopene, β-cryptoxanthin, zeaxanthin, or α-carotene. Cocoa extract supplementation did not modify the effect of MVM on serum carotenoid and vitamin E levels (P ≥ .05). Conclusions: Daily MVM supplementation increased specific serum carotenoids and α-tocopherol concentrations over 2 years. These findings suggest regular MVM use may support nutritional status in older adults; future research is needed to examine links with aging-related outcomes. (Copyright © 2026 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.) |
| Grant Information: | R01 AG071611 United States AG NIA NIH HHS; R01 AG050657 United States AG NIA NIH HHS; R01 HL157665 United States HL NHLBI NIH HHS; T32 DK007703 United States DK NIDDK NIH HHS; R01 EY025623 United States EY NEI NIH HHS |
| Contributed Indexing: | Keywords: Carotenoids; Dietary supplementation; Multivitamin/mineral supplements; Randomized clinical trial; Vitamin E |
| Substance Nomenclature: | 36-88-4 (Carotenoids) 0 (Vitamins) H4N855PNZ1 (alpha-Tocopherol) SB0N2N0WV6 (Lycopene) |
| Entry Date(s): | Date Created: 20260126 Date Completed: 20260630 Latest Revision: 20260729 |
| Update Code: | 20260730 |
| PubMed Central ID: | PMC13075385 |
| DOI: | 10.1016/j.jand.2026.156299 |
| PMID: | 41587736 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!