Academic Journal
Aprepitant and Postoperative Nausea and Vomiting in Patients Undergoing Acoustic Neuroma Surgery: A Retrospective Database Analysis.
| Τίτλος: | Aprepitant and Postoperative Nausea and Vomiting in Patients Undergoing Acoustic Neuroma Surgery: A Retrospective Database Analysis. |
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| Συγγραφείς: | Krause M; Division of Perioperative Informatics, Department of Anesthesiology., Mehdipour S; Division of Perioperative Informatics, Department of Anesthesiology., Tran K; School of Medicine., Tran M; Division of Neuroanesthesiology, Department of Anesthesiology., Lemkuil B; Division of Neuroanesthesiology, Department of Anesthesiology., Pearn M; Division of Neuroanesthesiology, Department of Anesthesiology., Fejleh A; Division of Neuroanesthesiology, Department of Anesthesiology., Filipovic M; Division of Neuroanesthesiology, Department of Anesthesiology., Srejic U; Division of Neuroanesthesiology, Department of Anesthesiology., Schwartz M; Department of Neurological Surgery., Friedman R; Department of Otolaryngology, Head and Neck Surgery, University of California San Diego, San Diego, CA., Gabriel RA; Division of Perioperative Informatics, Department of Anesthesiology. |
| Πηγή: | Journal of neurosurgical anesthesiology [J Neurosurg Anesthesiol] 2026 Oct 01; Vol. 38 (4), pp. 348-352. Date of Electronic Publication: 2026 Jan 23. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8910749 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-1921 (Electronic) Linking ISSN: 08984921 NLM ISO Abbreviation: J Neurosurg Anesthesiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [New York, N.Y.] : Raven Press, [c1989- |
| Ιατρικοί όροι (MeSH): | Neuroma, Acoustic*/surgery , Postoperative Nausea and Vomiting*/prevention & control , Postoperative Nausea and Vomiting*/epidemiology , Aprepitant*/therapeutic use , Antiemetics*/therapeutic use, Humans ; Female ; Male ; Retrospective Studies ; Middle Aged ; Aged ; Adult ; Databases, Factual ; Cohort Studies |
| Περίληψη: | Background: Postoperative nausea and vomiting (PONV) are common complications, leading to prolonged hospital stays and reduced patient satisfaction. Acoustic neuroma (AN) resections are associated with a higher risk of PONV than other craniotomies. We aimed to detect if preoperative aprepitant is associated with less PONV following AN surgery. Methods: Perioperative data were collected from the electronic medical record for patients undergoing AN resection between December 19, 2017 and April 26, 2022. Variables were compared between a cohort that received aprepitant and a matched cohort. Univariable and multivariable regression analyses were performed. Our primary outcome was PONV on the day of surgery. Results: A total of 579 patients were included, of which 49% (n=283) developed PONV. A cohort of 108 patients who received aprepitant was matched in a 1:2 manner. Aprepitant was not associated with reduced PONV ( P =0.239, odds ratio=0.756 [95% CI: 0.475-1.204]). On the basis of our univariable logistic regression model, tumor size, a translabyrinthine approach, total dose of propofol, total volume of crystalloids, highest nitrous oxide concentration, and anesthetic duration were associated with decreased odds of PONV. In multivariable regression modeling, none of these characteristics were associated with decreased odds of PONV. Conclusion: Our results confirm that PONV is a common complication following AN resection. Preoperative aprepitant administration was not associated with reduced PONV. Intraoperative variables such as the surgical approach and duration of anesthesia might play a role in mitigating the risk of PONV. Future studies should identify other perioperative interventions to allow for the development of protocols addressing PONV. (Copyright © 2026 Wolters Kluwer Health, LLC. All rights reserved.) |
| Competing Interests: | The authors have no conflicts of interest to declare. |
| References: | Liu Y, Chen X, Wang X, et al. The efficacy of aprepitant for the prevention of postoperative nausea and vomiting: a meta-analysis. Medicine (Baltimore). 2023;102:e34385. doi:10.1097/MD.0000000000034385. (PMID: 10.1097/MD.0000000000034385) Fabling JM, Gan TJ, El-Moalem HE, et al. A randomized, double-blind comparison of ondansetron versus placebo for prevention of nausea and vomiting after infratentorial craniotomy. J Neurosurg Anesthesiol. 2002;14:102–107. doi:10.1097/00008506-200204000-00003. (PMID: 10.1097/00008506-200204000-00003) Uribe AA, Stoicea N, Echeverria-Villalobos M, et al. Postoperative nausea and vomiting after craniotomy: an evidence-based review of general considerations, risk factors, and management. J Neurosurg Anesthesiol. 2021;33:212–220. doi:10.1097/ANA.0000000000000667. (PMID: 10.1097/ANA.0000000000000667) Tan C, Ries CR, Mayson K, et al. Indication for surgery and the risk of postoperative nausea and vomiting after craniotomy: a case-control study. J Neurosurg Anesthesiol. 2012;24:325–330. doi:10.1097/ANA.0b013e3182611a30. (PMID: 10.1097/ANA.0b013e3182611a30) Stieglitz LH, Samii A, Kaminsky J, et al. Nausea and dizziness after vestibular schwannoma surgery: a multivariate analysis of preoperative symptoms. Neurosurgery. 2005;57:887–890; discussion 887-890. doi:10.1227/01.neu.0000179920.21593.1b. (PMID: 10.1227/01.neu.0000179920.21593.1b) Chamoun R, MacDonald J, Shelton C, et al. Surgical approaches for resection of vestibular schwannomas: translabyrinthine, retrosigmoid, and middle fossa approaches. Neurosurg Focus. 2012;33:E9. doi:10.3171/2012.6.FOCUS12190. (PMID: 10.3171/2012.6.FOCUS12190) Bi Y, Ni Y, Gao D, et al. Endoscope-assisted retrosigmoid approach for vestibular schwannomas with intracanalicular extensions: facial nerve outcomes. Front Oncol. 2021;11:774462. doi:10.3389/fonc.2021.774462. (PMID: 10.3389/fonc.2021.774462) Gress K, Urits I, Viswanath O, et al. Clinical and economic burden of postoperative nausea and vomiting: analysis of existing cost data. Best Pract Res Clin Anaesthesiol. 2020;34:681–686. doi:10.1016/j.bpa.2020.07.003. (PMID: 10.1016/j.bpa.2020.07.003) Bergese SD, Puente EG, Antor MA, et al. A prospective, randomized, double-blinded, double-dummy pilot study to assess the preemptive effect of triple therapy with aprepitant, dexamethasone, and promethazine versus ondansetron, dexamethasone and promethazine on reducing the incidence of postoperative nausea and vomiting experienced by patients undergoing craniotomy under general anesthesia. Front Med (Lausanne). 2016;3:29. doi:10.3389/fmed.2016.00029. (PMID: 10.3389/fmed.2016.00029) Habib AS, Keifer JC, Borel CO, et al. A comparison of the combination of aprepitant and dexamethasone versus the combination of ondansetron and dexamethasone for the prevention of postoperative nausea and vomiting in patients undergoing craniotomy. Anesth Analg. 2011;112:813–818. doi:10.1213/ANE.0b013e3181ff47e2. (PMID: 10.1213/ANE.0b013e3181ff47e2) Lee DJ, Douglas JE, Chang J, et al. The use of aprepitant for the prevention of postoperative nausea and vomiting in endoscopic transsphenoidal pituitary surgery. Int Forum Allergy Rhinol. 2023;13:2180–2186. doi:10.1002/alr.23208. (PMID: 10.1002/alr.23208) von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370:1453–1457. doi:10.1016/S0140-6736(07)61602-X. (PMID: 10.1016/S0140-6736(07)61602-X) Cada Z, Balatkova Z, Cakrt O, et al. Predictors of central vestibular compensation after surgery for vestibular schwannomas. Acta Otorhinolaryngol Ital. 2019;39:46–52. doi:10.14639/0392-100X-1963. (PMID: 10.14639/0392-100X-1963) Lanman TH, Brackmann DE, Hitselberger WE, et al. Report of 190 consecutive cases of large acoustic tumors (vestibular schwannoma) removed via the translabyrinthine approach. J Neurosurg. 1999;90:617–623. doi:10.3171/jns.1999.90.4.0617. (PMID: 10.3171/jns.1999.90.4.0617) Walia A, Lander D, Durakovic N, et al. Outcomes after mini-craniotomy middle fossa approach combined with mastoidectomy for lateral skull base defects. Am J Otolaryngol. 2021;42:102794. doi:10.1016/j.amjoto.2020.102794. (PMID: 10.1016/j.amjoto.2020.102794) Padilla A, Habib AS. A pharmacological overview of aprepitant for the prevention of postoperative nausea and vomiting. Expert Rev Clin Pharmacol. 2023;16:491–505. doi:10.1080/17512433.2023.2209722. (PMID: 10.1080/17512433.2023.2209722) Gan TJ, Belani KG, Bergese S, et al. Fourth consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2020;131:411–448. doi:10.1213/ANE.0000000000004833. (PMID: 10.1213/ANE.0000000000004833) Eberhart LH, Hogel J, Seeling W, et al. Evaluation of three risk scores to predict postoperative nausea and vomiting. Acta Anaesthesiol Scand. 2000;44:480–488. doi:10.1034/j.1399-6576.2000.440422.x. (PMID: 10.1034/j.1399-6576.2000.440422.x) |
| Grant Information: | T15 LM011271 United States LM NLM NIH HHS |
| Contributed Indexing: | Keywords: acoustic neuroma surgery; aprepitant; craniotomy; postoperative nausea and vomiting; prevention |
| Substance Nomenclature: | 1NF15YR6UY (Aprepitant) 0 (Antiemetics) |
| Entry Date(s): | Date Created: 20260122 Date Completed: 20260914 Latest Revision: 20260914 |
| Update Code: | 20260914 |
| DOI: | 10.1097/ANA.0000000000001093 |
| PMID: | 41568453 |
| Βάση Δεδομένων: | MEDLINE |
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