Academic Journal
Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity.
| Τίτλος: | Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity. |
|---|---|
| Συγγραφείς: | Blyth SH; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Hill LD; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Huang A; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Woodward ND; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Rogers BP; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Vandekar S; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee., Ward HB; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: heather.b.ward@vumc.org. |
| Πηγή: | Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2026 Aug; Vol. 11 (8), pp. 987-995. Date of Electronic Publication: 2026 Jan 13. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 101671285 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9030 (Electronic) Linking ISSN: 24519022 NLM ISO Abbreviation: Biol Psychiatry Cogn Neurosci Neuroimaging Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Elsevier, Inc., [2016]- |
| Ιατρικοί όροι (MeSH): | Executive Function*/physiology , Executive Function*/drug effects , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging , Default Mode Network*/physiopathology , Default Mode Network*/diagnostic imaging , Alcohol Drinking*/physiopathology , Brain*/physiopathology , Brain*/diagnostic imaging , Marijuana Use* , Connectome*, Memory, Short-Term/physiology ; Cognition/physiology ; Humans ; Adolescent ; Magnetic Resonance Imaging ; Female ; Male |
| Περίληψη: | Background: Adolescent substance use is associated with increased risk of suicide, overdose, and executive dysfunction. Alcohol and marijuana are the two most-used substances among young people. Substance use is associated with dysfunctional resting-state network connectivity between the default mode network (DMN), executive control network (ECN), and salience network (SN) and executive dysfunction. There is limited research on triple-network connectivity (DMN, ECN, SN) in adolescents who use substances. Methods: In typically developing youth from the Philadelphia Neurodevelopmental Cohort (PNC), regression models were used to examine relationships between alcohol and marijuana use and triple-network connectivity (n = 520), while adjusting for age, sex, maternal education, and head motion. In individuals with neurocognitive and substance use data (n = 4197), regression models were used to examine relationships with executive control. Results: Alcohol use was not associated with any connectivity measures after false discovery rate correction. Higher marijuana use was associated with higher DMN-ECN connectivity (F Conclusions: In typically developing youth, marijuana use was associated with DMN-ECN connectivity, while alcohol use was associated with neurocognitive performance. Future research should use interventions targeting the DMN, ECN, and SN to interrogate relationships between connectivity, cognitive performance, and substance use. (Copyright © 2026 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.) |
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| Grant Information: | K23 DA059690 United States DA NIDA NIH HHS; P50 HD103537 United States HD NICHD NIH HHS; T32 AA013525 United States AA NIAAA NIH HHS |
| Contributed Indexing: | Keywords: Adolescence; Alcohol; Default mode network; Executive control network; Marijuana; Resting-state functional connectivity; Salience network |
| Entry Date(s): | Date Created: 20260115 Date Completed: 20260806 Latest Revision: 20260920 |
| Update Code: | 20260920 |
| PubMed Central ID: | PMC12906899 |
| DOI: | 10.1016/j.bpsc.2025.12.014 |
| PMID: | 41539355 |
| Βάση Δεδομένων: | MEDLINE |
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