Academic Journal
Προβολή σε EDS

Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity.
Συγγραφείς: Blyth SH; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Hill LD; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Huang A; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Woodward ND; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Rogers BP; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Vandekar S; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee., Ward HB; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: heather.b.ward@vumc.org.
Πηγή: Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2026 Aug; Vol. 11 (8), pp. 987-995. Date of Electronic Publication: 2026 Jan 13.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 101671285 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9030 (Electronic) Linking ISSN: 24519022 NLM ISO Abbreviation: Biol Psychiatry Cogn Neurosci Neuroimaging Subsets: MEDLINE
Imprint Name(s): Original Publication: New York, NY : Elsevier, Inc., [2016]-
Ιατρικοί όροι (MeSH): Executive Function*/physiology , Executive Function*/drug effects , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging , Default Mode Network*/physiopathology , Default Mode Network*/diagnostic imaging , Alcohol Drinking*/physiopathology , Brain*/physiopathology , Brain*/diagnostic imaging , Marijuana Use* , Connectome*, Memory, Short-Term/physiology ; Cognition/physiology ; Humans ; Adolescent ; Magnetic Resonance Imaging ; Female ; Male
Περίληψη: Background: Adolescent substance use is associated with increased risk of suicide, overdose, and executive dysfunction. Alcohol and marijuana are the two most-used substances among young people. Substance use is associated with dysfunctional resting-state network connectivity between the default mode network (DMN), executive control network (ECN), and salience network (SN) and executive dysfunction. There is limited research on triple-network connectivity (DMN, ECN, SN) in adolescents who use substances.
Methods: In typically developing youth from the Philadelphia Neurodevelopmental Cohort (PNC), regression models were used to examine relationships between alcohol and marijuana use and triple-network connectivity (n = 520), while adjusting for age, sex, maternal education, and head motion. In individuals with neurocognitive and substance use data (n = 4197), regression models were used to examine relationships with executive control.
Results: Alcohol use was not associated with any connectivity measures after false discovery rate correction. Higher marijuana use was associated with higher DMN-ECN connectivity (F2,507 = 5.08, p = .0066, q = .039). Higher alcohol use was associated with better working memory (p = .020), mental flexibility (p < .0001), attention (p = .019), and executive efficiency (p = .0015) and accuracy (p = .00044), which may have been due to other socioeconomic factors. Marijuana use was not associated with neurocognitive performance.
Conclusions: In typically developing youth, marijuana use was associated with DMN-ECN connectivity, while alcohol use was associated with neurocognitive performance. Future research should use interventions targeting the DMN, ECN, and SN to interrogate relationships between connectivity, cognitive performance, and substance use.
(Copyright © 2026 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
References: Am J Drug Alcohol Abuse. 2019;45(6):563-579. (PMID: 31365275)
Curr Pharm Des. 2014;20(13):2186-93. (PMID: 23829363)
Int J Environ Res Public Health. 2021 Mar 31;18(7):. (PMID: 33807491)
Addiction. 2019 Apr;114(4):698-707. (PMID: 30474910)
Neuropsychology. 2015 Mar;29(2):235-46. (PMID: 25180981)
J Dual Diagn. 2020 Jan-Mar;16(1):58-74. (PMID: 31519143)
Am J Psychiatry. 2024 May 1;181(5):423-433. (PMID: 38706327)
Front Behav Neurosci. 2018 May 03;12:83. (PMID: 29773981)
Subst Abuse. 2023 Dec 17;17:11782218231216233. (PMID: 38115827)
Clin EEG Neurosci. 2009 Jan;40(1):31-8. (PMID: 19278130)
Alcohol Res. 2021 Sep 09;41(1):11. (PMID: 34567915)
Front Psychiatry. 2022 Jan 27;13:804055. (PMID: 35153877)
NEJM Evid. 2022 Jun;1(6):EVIDra2200051. (PMID: 38319247)
Subst Abus. 2022;43(1):514-519. (PMID: 34236277)
Addiction. 1999 Jul;94(7):981-93. (PMID: 10707437)
Curr Psychiatry Rep. 2014 Dec;16(12):513. (PMID: 25308385)
Neuroimage. 2014 Feb 1;86:544-53. (PMID: 23921101)
Curr Opin Psychiatry. 2013 Jul;26(4):305-9. (PMID: 23695532)
Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Sep;7(9):867-875. (PMID: 35292406)
Neuroimage. 2010 Aug 15;52(2):590-9. (PMID: 20441798)
Addiction. 2002 Sep;97(9):1083-6. (PMID: 12199820)
Curr Behav Neurosci Rep. 2021 Dec;8(4):134-149. (PMID: 36908333)
Am J Drug Alcohol Abuse. 2013 Nov;39(6):414-23. (PMID: 24200211)
Alcohol Alcohol. 2024 Jul 21;59(5):. (PMID: 39129375)
Harv Rev Psychiatry. 2021 May-Jun 01;29(3):185-187. (PMID: 33882534)
Psychol Addict Behav. 2017 Jun;31(4):423-434. (PMID: 28414475)
Suicide Life Threat Behav. 2004 Winter;34(4):408-20. (PMID: 15585462)
Dev Cogn Neurosci. 2017 Jun;25:29-44. (PMID: 27840157)
Dev Cogn Neurosci. 2020 Dec;46:100878. (PMID: 33181393)
Psychiatry Res Neuroimaging. 2023 Jul;332:111642. (PMID: 37086604)
Neuroimage Clin. 2021;30:102664. (PMID: 33872994)
Psychol Med. 2006 Jan;36(1):109-18. (PMID: 16194286)
Alcohol Clin Exp Res. 2022 Aug;46(8):1603-1615. (PMID: 35994040)
Psychopharmacology (Berl). 2014 Apr;231(8):1437-53. (PMID: 24464527)
Schizophr Res. 2018 Apr;194:70-77. (PMID: 28823723)
Drug Alcohol Depend. 2017 Sep 1;178:492-500. (PMID: 28715777)
JAMA Pediatr. 2021 Jun 1;175(6):640-643. (PMID: 33779715)
Addict Behav. 2021 Oct;121:106985. (PMID: 34087768)
JAMA Psychiatry. 2018 Jun 1;75(6):585-595. (PMID: 29710074)
J Neurosci Methods. 2010 Mar 30;187(2):254-62. (PMID: 19945485)
Neuropsychopharmacology. 2018 Jan;43(1):195-212. (PMID: 28853439)
Psychiatry Res Neuroimaging. 2024 Dec;345:111916. (PMID: 39579625)
Dev Cogn Neurosci. 2014 Oct;10:148-59. (PMID: 25282602)
Neuroimage. 2021 Nov;243:118562. (PMID: 34506914)
Neuron. 2018 Jan 17;97(2):263-268. (PMID: 29346749)
World Psychiatry. 2014 Oct;13(3):296-305. (PMID: 25273303)
Neuropsychopharmacology. 2002 Apr;26(4):479-88. (PMID: 11927172)
Front Hum Neurosci. 2016 Jun 24;10:296. (PMID: 27445743)
J Psychopharmacol. 2023 Sep;37(9):904-919. (PMID: 37515469)
Neuroimage. 2016 Jan 1;124(Pt B):1115-1119. (PMID: 25840117)
Brain Connect. 2011;1(1):3-12. (PMID: 22432951)
Neuropsychopharmacology. 2022 Apr;47(5):1000-1028. (PMID: 34839363)
Addict Behav. 2017 Feb;65:13-18. (PMID: 27701026)
Addict Biol. 2022 Sep;27(5):e13208. (PMID: 36001427)
Grant Information: K23 DA059690 United States DA NIDA NIH HHS; P50 HD103537 United States HD NICHD NIH HHS; T32 AA013525 United States AA NIAAA NIH HHS
Contributed Indexing: Keywords: Adolescence; Alcohol; Default mode network; Executive control network; Marijuana; Resting-state functional connectivity; Salience network
Entry Date(s): Date Created: 20260115 Date Completed: 20260806 Latest Revision: 20260920
Update Code: 20260920
PubMed Central ID: PMC12906899
DOI: 10.1016/j.bpsc.2025.12.014
PMID: 41539355
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.bpsc.2025.12.014?
    Name: ScienceDirect (all content) (s7799221)
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=24519030&ISBN=&volume=11&issue=8&date=20260801&spage=987&pages=987-995&title=Biological psychiatry. Cognitive neuroscience and neuroimaging&atitle=Associations%20Between%20Youth%20Marijuana%20and%20Alcohol%20Use%2C%20Neurocognitive%20Performance%2C%20and%20Triple-Network%20Resting-State%20Connectivity.&aulast=Blyth%20SH&id=DOI:10.1016/j.bpsc.2025.12.014
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 41539355
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Blyth+SH%22&quot;&gt;Blyth SH&lt;/searchLink&gt;; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Hill+LD%22&quot;&gt;Hill LD&lt;/searchLink&gt;; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Huang+A%22&quot;&gt;Huang A&lt;/searchLink&gt;; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Woodward+ND%22&quot;&gt;Woodward ND&lt;/searchLink&gt;; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Rogers+BP%22&quot;&gt;Rogers BP&lt;/searchLink&gt;; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Vandekar+S%22&quot;&gt;Vandekar S&lt;/searchLink&gt;; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Ward+HB%22&quot;&gt;Ward HB&lt;/searchLink&gt;; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: heather.b.ward@vumc.org.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22101671285%22&quot;&gt;Biological psychiatry. Cognitive neuroscience and neuroimaging&lt;/searchLink&gt; [Biol Psychiatry Cogn Neurosci Neuroimaging] 2026 Aug; Vol. 11 (8), pp. 987-995. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2026 Jan 13.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: &lt;i&gt;Publisher: &lt;/i&gt;&lt;searchLink fieldCode=&quot;PB&quot; term=&quot;%22Elsevier%2C+Inc%22&quot;&gt;Elsevier, Inc &lt;/searchLink&gt;&lt;i&gt;Country of Publication: &lt;/i&gt;United States &lt;i&gt;NLM ID: &lt;/i&gt;101671285 &lt;i&gt;Publication Model: &lt;/i&gt;Print-Electronic &lt;i&gt;Cited Medium: &lt;/i&gt;Internet &lt;i&gt;ISSN: &lt;/i&gt;2451-9030 (Electronic) &lt;i&gt;Linking ISSN: &lt;/i&gt;&lt;searchLink fieldCode=&quot;IS&quot; term=&quot;%2224519022%22&quot;&gt;24519022 &lt;/searchLink&gt;&lt;i&gt;NLM ISO Abbreviation: &lt;/i&gt;Biol Psychiatry Cogn Neurosci Neuroimaging &lt;i&gt;Subsets: &lt;/i&gt;MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: &lt;i&gt;Original Publication&lt;/i&gt;: New York, NY : Elsevier, Inc., [2016]-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Executive+Function%22&quot;&gt;Executive Function*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Executive+Function+physiology%22&quot;&gt;physiology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Executive+Function%22&quot;&gt;Executive Function*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Executive+Function+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Nerve+Net%22&quot;&gt;Nerve Net*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Nerve+Net+physiopathology%22&quot;&gt;physiopathology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Nerve+Net%22&quot;&gt;Nerve Net*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Nerve+Net+diagnostic+imaging%22&quot;&gt;diagnostic imaging&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Default+Mode+Network%22&quot;&gt;Default Mode Network*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Default+Mode+Network+physiopathology%22&quot;&gt;physiopathology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Default+Mode+Network%22&quot;&gt;Default Mode Network*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Default+Mode+Network+diagnostic+imaging%22&quot;&gt;diagnostic imaging&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Alcohol+Drinking%22&quot;&gt;Alcohol Drinking*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Alcohol+Drinking+physiopathology%22&quot;&gt;physiopathology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Brain%22&quot;&gt;Brain*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Brain+physiopathology%22&quot;&gt;physiopathology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Brain%22&quot;&gt;Brain*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Brain+diagnostic+imaging%22&quot;&gt;diagnostic imaging&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Marijuana+Use%22&quot;&gt;Marijuana Use*&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Connectome%22&quot;&gt;Connectome*&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Memory%2C+Short-Term%22&quot;&gt;Memory, Short-Term&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Memory%2C+Short-Term+physiology%22&quot;&gt;physiology&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Cognition%22&quot;&gt;Cognition&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Cognition+physiology%22&quot;&gt;physiology&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Adolescent%22&quot;&gt;Adolescent&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Magnetic+Resonance+Imaging%22&quot;&gt;Magnetic Resonance Imaging&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Female%22&quot;&gt;Female&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Male%22&quot;&gt;Male&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Adolescent substance use is associated with increased risk of suicide, overdose, and executive dysfunction. Alcohol and marijuana are the two most-used substances among young people. Substance use is associated with dysfunctional resting-state network connectivity between the default mode network (DMN), executive control network (ECN), and salience network (SN) and executive dysfunction. There is limited research on triple-network connectivity (DMN, ECN, SN) in adolescents who use substances.&lt;br /&gt;Methods: In typically developing youth from the Philadelphia Neurodevelopmental Cohort (PNC), regression models were used to examine relationships between alcohol and marijuana use and triple-network connectivity (n = 520), while adjusting for age, sex, maternal education, and head motion. In individuals with neurocognitive and substance use data (n = 4197), regression models were used to examine relationships with executive control.&lt;br /&gt;Results: Alcohol use was not associated with any connectivity measures after false discovery rate correction. Higher marijuana use was associated with higher DMN-ECN connectivity (F&lt;subscript&gt;2,507&lt;/subscript&gt; = 5.08, p = .0066, q = .039). Higher alcohol use was associated with better working memory (p = .020), mental flexibility (p &amp;lt; .0001), attention (p = .019), and executive efficiency (p = .0015) and accuracy (p = .00044), which may have been due to other socioeconomic factors. Marijuana use was not associated with neurocognitive performance.&lt;br /&gt;Conclusions: In typically developing youth, marijuana use was associated with DMN-ECN connectivity, while alcohol use was associated with neurocognitive performance. Future research should use interventions targeting the DMN, ECN, and SN to interrogate relationships between connectivity, cognitive performance, and substance use.&lt;br /&gt; (Copyright &#169; 2026 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Am J Drug Alcohol Abuse. 2019;45(6):563-579. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2231365275%22&quot;&gt;31365275)&lt;/searchLink&gt;&lt;br /&gt;Curr Pharm Des. 2014;20(13):2186-93. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223829363%22&quot;&gt;23829363)&lt;/searchLink&gt;&lt;br /&gt;Int J Environ Res Public Health. 2021 Mar 31;18(7):. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2233807491%22&quot;&gt;33807491)&lt;/searchLink&gt;&lt;br /&gt;Addiction. 2019 Apr;114(4):698-707. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2230474910%22&quot;&gt;30474910)&lt;/searchLink&gt;&lt;br /&gt;Neuropsychology. 2015 Mar;29(2):235-46. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2225180981%22&quot;&gt;25180981)&lt;/searchLink&gt;&lt;br /&gt;J Dual Diagn. 2020 Jan-Mar;16(1):58-74. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2231519143%22&quot;&gt;31519143)&lt;/searchLink&gt;&lt;br /&gt;Am J Psychiatry. 2024 May 1;181(5):423-433. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238706327%22&quot;&gt;38706327)&lt;/searchLink&gt;&lt;br /&gt;Front Behav Neurosci. 2018 May 03;12:83. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2229773981%22&quot;&gt;29773981)&lt;/searchLink&gt;&lt;br /&gt;Subst Abuse. 2023 Dec 17;17:11782218231216233. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238115827%22&quot;&gt;38115827)&lt;/searchLink&gt;&lt;br /&gt;Clin EEG Neurosci. 2009 Jan;40(1):31-8. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2219278130%22&quot;&gt;19278130)&lt;/searchLink&gt;&lt;br /&gt;Alcohol Res. 2021 Sep 09;41(1):11. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2234567915%22&quot;&gt;34567915)&lt;/searchLink&gt;&lt;br /&gt;Front Psychiatry. 2022 Jan 27;13:804055. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2235153877%22&quot;&gt;35153877)&lt;/searchLink&gt;&lt;br /&gt;NEJM Evid. 2022 Jun;1(6):EVIDra2200051. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238319247%22&quot;&gt;38319247)&lt;/searchLink&gt;&lt;br /&gt;Subst Abus. 2022;43(1):514-519. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2234236277%22&quot;&gt;34236277)&lt;/searchLink&gt;&lt;br /&gt;Addiction. 1999 Jul;94(7):981-93. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210707437%22&quot;&gt;10707437)&lt;/searchLink&gt;&lt;br /&gt;Curr Psychiatry Rep. 2014 Dec;16(12):513. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2225308385%22&quot;&gt;25308385)&lt;/searchLink&gt;&lt;br /&gt;Neuroimage. 2014 Feb 1;86:544-53. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223921101%22&quot;&gt;23921101)&lt;/searchLink&gt;&lt;br /&gt;Curr Opin Psychiatry. 2013 Jul;26(4):305-9. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223695532%22&quot;&gt;23695532)&lt;/searchLink&gt;&lt;br /&gt;Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Sep;7(9):867-875. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2235292406%22&quot;&gt;35292406)&lt;/searchLink&gt;&lt;br /&gt;Neuroimage. 2010 Aug 15;52(2):590-9. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2220441798%22&quot;&gt;20441798)&lt;/searchLink&gt;&lt;br /&gt;Addiction. 2002 Sep;97(9):1083-6. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2212199820%22&quot;&gt;12199820)&lt;/searchLink&gt;&lt;br /&gt;Curr Behav Neurosci Rep. 2021 Dec;8(4):134-149. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2236908333%22&quot;&gt;36908333)&lt;/searchLink&gt;&lt;br /&gt;Am J Drug Alcohol Abuse. 2013 Nov;39(6):414-23. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2224200211%22&quot;&gt;24200211)&lt;/searchLink&gt;&lt;br /&gt;Alcohol Alcohol. 2024 Jul 21;59(5):. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2239129375%22&quot;&gt;39129375)&lt;/searchLink&gt;&lt;br /&gt;Harv Rev Psychiatry. 2021 May-Jun 01;29(3):185-187. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2233882534%22&quot;&gt;33882534)&lt;/searchLink&gt;&lt;br /&gt;Psychol Addict Behav. 2017 Jun;31(4):423-434. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2228414475%22&quot;&gt;28414475)&lt;/searchLink&gt;&lt;br /&gt;Suicide Life Threat Behav. 2004 Winter;34(4):408-20. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2215585462%22&quot;&gt;15585462)&lt;/searchLink&gt;&lt;br /&gt;Dev Cogn Neurosci. 2017 Jun;25:29-44. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2227840157%22&quot;&gt;27840157)&lt;/searchLink&gt;&lt;br /&gt;Dev Cogn Neurosci. 2020 Dec;46:100878. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2233181393%22&quot;&gt;33181393)&lt;/searchLink&gt;&lt;br /&gt;Psychiatry Res Neuroimaging. 2023 Jul;332:111642. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2237086604%22&quot;&gt;37086604)&lt;/searchLink&gt;&lt;br /&gt;Neuroimage Clin. 2021;30:102664. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2233872994%22&quot;&gt;33872994)&lt;/searchLink&gt;&lt;br /&gt;Psychol Med. 2006 Jan;36(1):109-18. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2216194286%22&quot;&gt;16194286)&lt;/searchLink&gt;&lt;br /&gt;Alcohol Clin Exp Res. 2022 Aug;46(8):1603-1615. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2235994040%22&quot;&gt;35994040)&lt;/searchLink&gt;&lt;br /&gt;Psychopharmacology (Berl). 2014 Apr;231(8):1437-53. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2224464527%22&quot;&gt;24464527)&lt;/searchLink&gt;&lt;br /&gt;Schizophr Res. 2018 Apr;194:70-77. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2228823723%22&quot;&gt;28823723)&lt;/searchLink&gt;&lt;br /&gt;Drug Alcohol Depend. 2017 Sep 1;178:492-500. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2228715777%22&quot;&gt;28715777)&lt;/searchLink&gt;&lt;br /&gt;JAMA Pediatr. 2021 Jun 1;175(6):640-643. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2233779715%22&quot;&gt;33779715)&lt;/searchLink&gt;&lt;br /&gt;Addict Behav. 2021 Oct;121:106985. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2234087768%22&quot;&gt;34087768)&lt;/searchLink&gt;&lt;br /&gt;JAMA Psychiatry. 2018 Jun 1;75(6):585-595. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2229710074%22&quot;&gt;29710074)&lt;/searchLink&gt;&lt;br /&gt;J Neurosci Methods. 2010 Mar 30;187(2):254-62. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2219945485%22&quot;&gt;19945485)&lt;/searchLink&gt;&lt;br /&gt;Neuropsychopharmacology. 2018 Jan;43(1):195-212. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2228853439%22&quot;&gt;28853439)&lt;/searchLink&gt;&lt;br /&gt;Psychiatry Res Neuroimaging. 2024 Dec;345:111916. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2239579625%22&quot;&gt;39579625)&lt;/searchLink&gt;&lt;br /&gt;Dev Cogn Neurosci. 2014 Oct;10:148-59. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2225282602%22&quot;&gt;25282602)&lt;/searchLink&gt;&lt;br /&gt;Neuroimage. 2021 Nov;243:118562. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2234506914%22&quot;&gt;34506914)&lt;/searchLink&gt;&lt;br /&gt;Neuron. 2018 Jan 17;97(2):263-268. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2229346749%22&quot;&gt;29346749)&lt;/searchLink&gt;&lt;br /&gt;World Psychiatry. 2014 Oct;13(3):296-305. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2225273303%22&quot;&gt;25273303)&lt;/searchLink&gt;&lt;br /&gt;Neuropsychopharmacology. 2002 Apr;26(4):479-88. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2211927172%22&quot;&gt;11927172)&lt;/searchLink&gt;&lt;br /&gt;Front Hum Neurosci. 2016 Jun 24;10:296. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2227445743%22&quot;&gt;27445743)&lt;/searchLink&gt;&lt;br /&gt;J Psychopharmacol. 2023 Sep;37(9):904-919. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2237515469%22&quot;&gt;37515469)&lt;/searchLink&gt;&lt;br /&gt;Neuroimage. 2016 Jan 1;124(Pt B):1115-1119. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2225840117%22&quot;&gt;25840117)&lt;/searchLink&gt;&lt;br /&gt;Brain Connect. 2011;1(1):3-12. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2222432951%22&quot;&gt;22432951)&lt;/searchLink&gt;&lt;br /&gt;Neuropsychopharmacology. 2022 Apr;47(5):1000-1028. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2234839363%22&quot;&gt;34839363)&lt;/searchLink&gt;&lt;br /&gt;Addict Behav. 2017 Feb;65:13-18. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2227701026%22&quot;&gt;27701026)&lt;/searchLink&gt;&lt;br /&gt;Addict Biol. 2022 Sep;27(5):e13208. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2236001427%22&quot;&gt;36001427)&lt;/searchLink&gt;
– Name: GrantInfo
  Label: Grant Information
  Group: Grant
  Data: K23 DA059690 United States DA NIDA NIH HHS; P50 HD103537 United States HD NICHD NIH HHS; T32 AA013525 United States AA NIAAA NIH HHS
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: &lt;i&gt;Keywords: &lt;/i&gt;Adolescence; Alcohol; Default mode network; Executive control network; Marijuana; Resting-state functional connectivity; Salience network
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: &lt;i&gt;Date Created: &lt;/i&gt;20260115 &lt;i&gt;Date Completed: &lt;/i&gt;20260806 &lt;i&gt;Latest Revision: &lt;/i&gt;20260920
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260920
– Name: PubmedCentralID
  Label: PubMed Central ID
  Group: ID
  Data: PMC12906899
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.bpsc.2025.12.014
– Name: AN
  Label: PMID
  Group: ID
  Data: 41539355
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=41539355
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.bpsc.2025.12.014
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 987
    Subjects:
      – SubjectFull: Memory, Short-Term physiology
        Type: general
      – SubjectFull: Cognition physiology
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Adolescent
        Type: general
      – SubjectFull: Magnetic Resonance Imaging
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Executive Function physiology
        Type: general
      – SubjectFull: Executive Function drug effects
        Type: general
      – SubjectFull: Nerve Net physiopathology
        Type: general
      – SubjectFull: Nerve Net diagnostic imaging
        Type: general
      – SubjectFull: Default Mode Network physiopathology
        Type: general
      – SubjectFull: Default Mode Network diagnostic imaging
        Type: general
      – SubjectFull: Alcohol Drinking physiopathology
        Type: general
      – SubjectFull: Brain physiopathology
        Type: general
      – SubjectFull: Brain diagnostic imaging
        Type: general
      – SubjectFull: Marijuana Use
        Type: general
      – SubjectFull: Connectome
        Type: general
    Titles:
      – TitleFull: Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Blyth SH
      – PersonEntity:
          Name:
            NameFull: Hill LD
      – PersonEntity:
          Name:
            NameFull: Huang A
      – PersonEntity:
          Name:
            NameFull: Woodward ND
      – PersonEntity:
          Name:
            NameFull: Rogers BP
      – PersonEntity:
          Name:
            NameFull: Vandekar S
      – PersonEntity:
          Name:
            NameFull: Ward HB
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: 2026 Aug
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2451-9030
          Numbering:
            – Type: volume
              Value: 11
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Biological psychiatry. Cognitive neuroscience and neuroimaging
              Type: main
ResultId 1