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CEST MRI Processing Pipeline in Pilot Study of Alzheimer's Disease Patients.

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Τίτλος: CEST MRI Processing Pipeline in Pilot Study of Alzheimer's Disease Patients.
Συγγραφείς: Asturias A; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Yu FF; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Davenport EM; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Kelley BJ; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Dimitrov IE; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Philips, Cambridge, Massachusetts, USA., Keupp J; Philips Innovative Technologies, Hamburg, Germany., Vinogradov E; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Πηγή: Magnetic resonance in medicine [Magn Reson Med] 2026 May; Vol. 95 (5), pp. 2828-2839. Date of Electronic Publication: 2026 Jan 04.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: United States NLM ID: 8505245 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2594 (Electronic) Linking ISSN: 07403194 NLM ISO Abbreviation: Magn Reson Med Subsets: MEDLINE
Imprint Name(s): Publication: 1999- : New York, NY : Wiley
Original Publication: San Diego : Academic Press
Ιατρικοί όροι (MeSH): Alzheimer Disease*/diagnostic imaging , Magnetic Resonance Imaging*/methods , Brain*/diagnostic imaging , Image Processing, Computer-Assisted*/methods, Image Interpretation, Computer-Assisted/methods ; Humans ; Pilot Projects ; Male ; Female ; Aged ; Middle Aged ; Imaging, Three-Dimensional ; Artifacts ; Aged, 80 and over ; Algorithms
Περίληψη: Purpose: To develop a processing pipeline combining neuroimaging analysis tools with CEST postprocessing and utilize it in a pilot study probing differences between cognitively impaired (CI) Alzheimer's disease (AD) patients and cognitively normal (CN) individuals.
Methods: Eight subjects (4 biomarker confirmed CI with underlying AD and 4 CN) were scanned on a 3T MRI scanner. The processing pipeline included rigid motion correction and co-registration of the CEST images with the 3D T1w images using Advanced Normalization Tools (ANTs). MTRasym maps at 1 ppm, 2 ppm and 3.5 ppm were generated on a voxel-by-voxel basis. Each subject's 3D T1w images were processed with FreeSurfer to generate brain region specific ROIs, and the MTRasym values were averaged over the generated ROIs. In addition, a 6-pool Lorentzian multi-peak model was fitted to averaged Z-spectrum data per ROI. Between-group (CI vs. CN) CEST effects were evaluated using Mann-Whitney U tests.
Results: Motion correction reduced artifacts and visually improved CEST results. Multiple cortical and white matter ROIs showed differences in MTRasym values between CI and CN groups (p < 0.05). Overall, the mean MTRasym and Lorentzian amplitudes were lower in the CI than in the CN group.
Conclusion: Our proposed pipeline enables robust data analysis using either MTRasym or multi-pool Lorentzian quantification approaches. The results suggest feasibility for detecting CEST differences between CI and CN groups in brain regions previously implicated in AD, motivating future validation in larger cohorts.
(© 2026 Philips GmbH Innovative Technologies, Philips Healthcare and The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
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Grant Information: 1029408 Texas Alzheimer's Research & Care Consortium; R01CA252281 United States GF NIH HHS; R01 CA252281 United States CA NCI NIH HHS; Southwestern Medical Foundation and G.R. White Trust; T32-EB028093 United States GF NIH HHS
Entry Date(s): Date Created: 20260104 Date Completed: 20260307 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC12962198
DOI: 10.1002/mrm.70240
PMID: 41486095
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1522-2594
DOI:10.1002/mrm.70240