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Cellular reprogramming of H3K27M pediatric high-grade glioma to neuron-like state.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Cellular reprogramming of H3K27M pediatric high-grade glioma to neuron-like state.
Συγγραφείς: Uthamacumaran A; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada., Horth C; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada., Bareke E; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada., Gravel M; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada., Majewski J; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada. jacek.majewski@mcgill.ca.
Πηγή: Acta neuropathologica communications [Acta Neuropathol Commun] 2025 Dec 30; Vol. 14 (1), pp. 30. Date of Electronic Publication: 2025 Dec 30.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Imprint Name(s): Original Publication: London : BioMed Central, [2013]-
Ιατρικοί όροι (MeSH): Glioma*/pathology , Glioma*/genetics , Neurons*/pathology , Neurons*/metabolism , Neurons*/drug effects , Neurons*/physiology , Cellular Reprogramming*/physiology , Cellular Reprogramming*/genetics , Brain Neoplasms*/pathology , Brain Neoplasms*/genetics , Histones*/genetics, Humans ; Cell Line, Tumor ; Child ; Cell Differentiation ; Gene Expression Regulation, Neoplastic
Περίληψη: This study explores the cell fate reprogrammability of H3K27M-mutant pediatric high-grade gliomas (pHGG) using neuronal transdifferentiation as a potential targeted therapy. We treated the BT245 patient-derived glioma cell line with pharmacological combinations targeting neuronal differentiation pathways and performed bulk RNA sequencing to characterize gene expression patterns driving cell fate transitions. Our findings reveal that the drug combinations induce transcriptomic changes consistent with differentiation towards neuronal phenotypes, including the upregulation of synaptic and dendritic signaling genes and the downregulation of malignant signatures. In comparison, astrocytic differentiation media (DM) and H3K27M knockout (KO) promote residual astrocytic phenotypes, suggesting neuronal transdifferentiation as a more effective strategy for mitigating tumor aggressiveness and progression. Differentially expressed genes such as GRIK1, GRIN1, NRXN3, NRXN1, CALB2, SCGN, SLC32A1, SLC1A2, KCNC3, and neurodevelopmental regulators including WNT7A, DLX6, ERBB4, ARX, BCL11B, SEMA3C, and FGFBP3 were identified as key markers regulating the neuron-like lineage transition. This study demonstrates that pHGGs can be phenotypically redirected toward neuronal-like identities through modulating cell fate differentiation programs. These findings advance the concept of 'differentiation therapy' as a promising intervention to reduce phenotypic plasticity and malignancy in pHGG ecosystems. While these are early in vitro findings, the potential ability to steer and control glioma cells toward stable, less malignant fates offers promising translational potential for patient-centered targeted therapies.
(© 2025. The Author(s).)
Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics approval: Only patient-derived cell cultures were used in this study, all of which complied with institutional ethical and biosafety protocol guidelines and certifications. No human participants, identifiable data, or animal experiments were involved.
References: Aging (Albany NY). 2019 Sep 12;11(17):6638-6656. (PMID: 31514171)
Nat Commun. 2024 Nov 9;15(1):9699. (PMID: 39516198)
Exp Mol Med. 2023 Apr;55(4):692-705. (PMID: 37009794)
Cell. 2020 Dec 10;183(6):1617-1633.e22. (PMID: 33259802)
JAMA Netw Open. 2022 Aug 1;5(8):e2226551. (PMID: 35972743)
Cell. 2019 Aug 8;178(4):835-849.e21. (PMID: 31327527)
iScience. 2019 Sep 27;19:1160-1172. (PMID: 31541920)
Bioinformatics. 2009 Mar 15;25(6):765-71. (PMID: 19176553)
Nature. 2012 Jan 29;482(7384):226-31. (PMID: 22286061)
NPJ Precis Oncol. 2025 Feb 11;9(1):44. (PMID: 39934275)
Neuro Oncol. 2017 Feb 1;19(2):153-161. (PMID: 27282398)
Bioinformatics. 2014 Apr 1;30(7):923-30. (PMID: 24227677)
Epilepsia. 2023 Dec;64(12):3377-3388. (PMID: 37734923)
Biophys J. 2024 Sep 3;123(17):2849-2859. (PMID: 38504523)
Nat Genet. 2019 Dec;51(12):1702-1713. (PMID: 31768071)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Bioinformatics. 2016 Jan 15;32(2):292-4. (PMID: 26428292)
J Theor Biol. 2021 Feb 21;511:110552. (PMID: 33309530)
Nucleic Acids Res. 2023 Jul 5;51(W1):W207-W212. (PMID: 37144459)
Semin Cancer Biol. 2022 Feb;79:83-90. (PMID: 32920125)
PeerJ. 2017 Aug 30;5:e3720. (PMID: 28875074)
Cell Rep. 2020 Nov 17;33(7):108390. (PMID: 33207202)
Cancer Cell. 2017 Oct 9;32(4):520-537.e5. (PMID: 28966033)
Neurosci Res. 2022 Sep;182:15-24. (PMID: 35688290)
ACS Chem Neurosci. 2018 Dec 19;9(12):3175-3185. (PMID: 30091580)
Cancer Cell. 2024 Aug 27;:. (PMID: 39232581)
Cancer Res. 2019 May 1;79(9):2111-2123. (PMID: 30877103)
FEBS J. 2022 Mar;289(5):1315-1328. (PMID: 33969633)
Bioinformatics. 2016 Oct 1;32(19):3047-8. (PMID: 27312411)
Adv Sci (Weinh). 2025 Jan;12(3):e2402132. (PMID: 39661721)
Trends Cell Biol. 2021 Oct;31(10):814-828. (PMID: 34092471)
Cancer Lett. 2024 Dec 8;611:217387. (PMID: 39657829)
Drug Discov Today. 2020 Apr;25(4):731-738. (PMID: 32027971)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
Nat Commun. 2019 Mar 19;10(1):1262. (PMID: 30890717)
Sci Rep. 2019 Mar 5;9(1):3462. (PMID: 30837577)
Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: 19505943)
Pharmacol Res. 2025 Feb;212:107599. (PMID: 39818258)
Nucleic Acids Res. 2024 Jan 5;52(D1):D1033-D1041. (PMID: 37904591)
Neurooncol Adv. 2025 Jan 23;7(1):vdaf016. (PMID: 40321621)
Grant Information: P01-CA196539 National Institutes of Health (NIH); CIHR PJT-183939 the Canadian Institutes of Health Research (CIHR); McGill University William Dawson Scholar Program
Contributed Indexing: Keywords: Cell fate control; Differentiation therapy; Glioma; Neurons; Pediatric cancers; Phenotypic plasticity; Precision oncology
Substance Nomenclature: 0 (Histones)
Entry Date(s): Date Created: 20251230 Date Completed: 20260131 Latest Revision: 20260512
Update Code: 20260512
PubMed Central ID: PMC12860116
DOI: 10.1186/s40478-025-02185-8
PMID: 41469740
Βάση Δεδομένων: MEDLINE
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  Data: Cellular reprogramming of H3K27M pediatric high-grade glioma to neuron-like state.
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  Data: <searchLink fieldCode="AU" term="%22Uthamacumaran+A%22">Uthamacumaran A</searchLink>; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada.<br /><searchLink fieldCode="AU" term="%22Horth+C%22">Horth C</searchLink>; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada.<br /><searchLink fieldCode="AU" term="%22Bareke+E%22">Bareke E</searchLink>; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada.<br /><searchLink fieldCode="AU" term="%22Gravel+M%22">Gravel M</searchLink>; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada.<br /><searchLink fieldCode="AU" term="%22Majewski+J%22">Majewski J</searchLink>; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada. jacek.majewski@mcgill.ca.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study explores the cell fate reprogrammability of H3K27M-mutant pediatric high-grade gliomas (pHGG) using neuronal transdifferentiation as a potential targeted therapy. We treated the BT245 patient-derived glioma cell line with pharmacological combinations targeting neuronal differentiation pathways and performed bulk RNA sequencing to characterize gene expression patterns driving cell fate transitions. Our findings reveal that the drug combinations induce transcriptomic changes consistent with differentiation towards neuronal phenotypes, including the upregulation of synaptic and dendritic signaling genes and the downregulation of malignant signatures. In comparison, astrocytic differentiation media (DM) and H3K27M knockout (KO) promote residual astrocytic phenotypes, suggesting neuronal transdifferentiation as a more effective strategy for mitigating tumor aggressiveness and progression. Differentially expressed genes such as GRIK1, GRIN1, NRXN3, NRXN1, CALB2, SCGN, SLC32A1, SLC1A2, KCNC3, and neurodevelopmental regulators including WNT7A, DLX6, ERBB4, ARX, BCL11B, SEMA3C, and FGFBP3 were identified as key markers regulating the neuron-like lineage transition. This study demonstrates that pHGGs can be phenotypically redirected toward neuronal-like identities through modulating cell fate differentiation programs. These findings advance the concept of 'differentiation therapy' as a promising intervention to reduce phenotypic plasticity and malignancy in pHGG ecosystems. While these are early in vitro findings, the potential ability to steer and control glioma cells toward stable, less malignant fates offers promising translational potential for patient-centered targeted therapies.<br /> (© 2025. The Author(s).)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Competing interests: The authors declare no competing interests. Ethics approval: Only patient-derived cell cultures were used in this study, all of which complied with institutional ethical and biosafety protocol guidelines and certifications. No human participants, identifiable data, or animal experiments were involved.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Aging (Albany NY). 2019 Sep 12;11(17):6638-6656. (PMID: <searchLink fieldCode="PM" term="%2231514171%22">31514171)</searchLink><br />Nat Commun. 2024 Nov 9;15(1):9699. (PMID: <searchLink fieldCode="PM" term="%2239516198%22">39516198)</searchLink><br />Exp Mol Med. 2023 Apr;55(4):692-705. (PMID: <searchLink fieldCode="PM" term="%2237009794%22">37009794)</searchLink><br />Cell. 2020 Dec 10;183(6):1617-1633.e22. (PMID: <searchLink fieldCode="PM" term="%2233259802%22">33259802)</searchLink><br />JAMA Netw Open. 2022 Aug 1;5(8):e2226551. (PMID: <searchLink fieldCode="PM" term="%2235972743%22">35972743)</searchLink><br />Cell. 2019 Aug 8;178(4):835-849.e21. (PMID: <searchLink fieldCode="PM" term="%2231327527%22">31327527)</searchLink><br />iScience. 2019 Sep 27;19:1160-1172. (PMID: <searchLink fieldCode="PM" term="%2231541920%22">31541920)</searchLink><br />Bioinformatics. 2009 Mar 15;25(6):765-71. (PMID: <searchLink fieldCode="PM" term="%2219176553%22">19176553)</searchLink><br />Nature. 2012 Jan 29;482(7384):226-31. (PMID: <searchLink fieldCode="PM" term="%2222286061%22">22286061)</searchLink><br />NPJ Precis Oncol. 2025 Feb 11;9(1):44. (PMID: <searchLink fieldCode="PM" term="%2239934275%22">39934275)</searchLink><br />Neuro Oncol. 2017 Feb 1;19(2):153-161. (PMID: <searchLink fieldCode="PM" term="%2227282398%22">27282398)</searchLink><br />Bioinformatics. 2014 Apr 1;30(7):923-30. (PMID: <searchLink fieldCode="PM" term="%2224227677%22">24227677)</searchLink><br />Epilepsia. 2023 Dec;64(12):3377-3388. (PMID: <searchLink fieldCode="PM" term="%2237734923%22">37734923)</searchLink><br />Biophys J. 2024 Sep 3;123(17):2849-2859. (PMID: <searchLink fieldCode="PM" term="%2238504523%22">38504523)</searchLink><br />Nat Genet. 2019 Dec;51(12):1702-1713. (PMID: <searchLink fieldCode="PM" term="%2231768071%22">31768071)</searchLink><br />Genome Biol. 2014;15(12):550. (PMID: <searchLink fieldCode="PM" term="%2225516281%22">25516281)</searchLink><br />Bioinformatics. 2016 Jan 15;32(2):292-4. (PMID: <searchLink fieldCode="PM" term="%2226428292%22">26428292)</searchLink><br />J Theor Biol. 2021 Feb 21;511:110552. (PMID: <searchLink fieldCode="PM" term="%2233309530%22">33309530)</searchLink><br />Nucleic Acids Res. 2023 Jul 5;51(W1):W207-W212. (PMID: <searchLink fieldCode="PM" term="%2237144459%22">37144459)</searchLink><br />Semin Cancer Biol. 2022 Feb;79:83-90. (PMID: <searchLink fieldCode="PM" term="%2232920125%22">32920125)</searchLink><br />PeerJ. 2017 Aug 30;5:e3720. (PMID: <searchLink fieldCode="PM" term="%2228875074%22">28875074)</searchLink><br />Cell Rep. 2020 Nov 17;33(7):108390. (PMID: <searchLink fieldCode="PM" term="%2233207202%22">33207202)</searchLink><br />Cancer Cell. 2017 Oct 9;32(4):520-537.e5. (PMID: <searchLink fieldCode="PM" term="%2228966033%22">28966033)</searchLink><br />Neurosci Res. 2022 Sep;182:15-24. (PMID: <searchLink fieldCode="PM" term="%2235688290%22">35688290)</searchLink><br />ACS Chem Neurosci. 2018 Dec 19;9(12):3175-3185. (PMID: <searchLink fieldCode="PM" term="%2230091580%22">30091580)</searchLink><br />Cancer Cell. 2024 Aug 27;:. (PMID: <searchLink fieldCode="PM" term="%2239232581%22">39232581)</searchLink><br />Cancer Res. 2019 May 1;79(9):2111-2123. (PMID: <searchLink fieldCode="PM" term="%2230877103%22">30877103)</searchLink><br />FEBS J. 2022 Mar;289(5):1315-1328. (PMID: <searchLink fieldCode="PM" term="%2233969633%22">33969633)</searchLink><br />Bioinformatics. 2016 Oct 1;32(19):3047-8. (PMID: <searchLink fieldCode="PM" term="%2227312411%22">27312411)</searchLink><br />Adv Sci (Weinh). 2025 Jan;12(3):e2402132. (PMID: <searchLink fieldCode="PM" term="%2239661721%22">39661721)</searchLink><br />Trends Cell Biol. 2021 Oct;31(10):814-828. (PMID: <searchLink fieldCode="PM" term="%2234092471%22">34092471)</searchLink><br />Cancer Lett. 2024 Dec 8;611:217387. (PMID: <searchLink fieldCode="PM" term="%2239657829%22">39657829)</searchLink><br />Drug Discov Today. 2020 Apr;25(4):731-738. (PMID: <searchLink fieldCode="PM" term="%2232027971%22">32027971)</searchLink><br />Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: <searchLink fieldCode="PM" term="%2223104886%22">23104886)</searchLink><br />Nat Commun. 2019 Mar 19;10(1):1262. (PMID: <searchLink fieldCode="PM" term="%2230890717%22">30890717)</searchLink><br />Sci Rep. 2019 Mar 5;9(1):3462. (PMID: <searchLink fieldCode="PM" term="%2230837577%22">30837577)</searchLink><br />Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: <searchLink fieldCode="PM" term="%2219505943%22">19505943)</searchLink><br />Pharmacol Res. 2025 Feb;212:107599. (PMID: <searchLink fieldCode="PM" term="%2239818258%22">39818258)</searchLink><br />Nucleic Acids Res. 2024 Jan 5;52(D1):D1033-D1041. (PMID: <searchLink fieldCode="PM" term="%2237904591%22">37904591)</searchLink><br />Neurooncol Adv. 2025 Jan 23;7(1):vdaf016. (PMID: <searchLink fieldCode="PM" term="%2240321621%22">40321621)</searchLink>
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  Data: <i>Keywords: </i>Cell fate control; Differentiation therapy; Glioma; Neurons; Pediatric cancers; Phenotypic plasticity; Precision oncology
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      – TitleFull: Cellular reprogramming of H3K27M pediatric high-grade glioma to neuron-like state.
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            – Type: issn-electronic
              Value: 2051-5960
          Numbering:
            – Type: volume
              Value: 14
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Acta neuropathologica communications
              Type: main
ResultId 1