Academic Journal
Bile Acids Metabolism in Symptomatic Hand Osteoarthritis.
| Τίτλος: | Bile Acids Metabolism in Symptomatic Hand Osteoarthritis. |
|---|---|
| Συγγραφείς: | Li J; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China., Ye J; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China., Yang T; Health Management Center, Xiangya Hospital, Central South University, Changsha, China., Hunter DJ; Rheumatology Department, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia., Zhang W; Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom.; Pain Centre, Versus Arthritis UK, Nottingham, United Kingdom.; National Institute for Health and Care Research Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Doherty M; Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom.; Pain Centre, Versus Arthritis UK, Nottingham, United Kingdom., Zhang Y; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.; The Mongan Institute, Massachusetts General Hospital and Harvard Medical School, Boston., Yang Z; Key Laboratory of Aging-Related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.; Bioinformatics Center, Xiangya Hospital, Central South University, Changsha, China., Li H; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Aging-Related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China., Wang Y; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Aging-Related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China., Xie D; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Aging-Related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China., Wu Z; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China., Li W; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China., Wen Z; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China., Li C; Key Laboratory of Aging-Related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.; Laboratory Animal Center, Xiangya Hospital, Central South University, Changsha, China., Zhao K; Department of Hematology and Critical Care Medicine, the Third Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, Changsha, China., Zeng C; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Aging-Related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.; Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, China., Lei G; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Aging-Related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.; FuRong Laboratory, Changsha, China., Wei J; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Aging-Related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.; Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, China.; FuRong Laboratory, Changsha, China. |
| Πηγή: | Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2026 Jul; Vol. 78 (7), pp. 1465-1476. Date of Electronic Publication: 2026 Mar 30. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Malden, MA : Wiley, [2014]- |
| Ιατρικοί όροι (MeSH): | Bile Acids and Salts*/metabolism , Bile Acids and Salts*/blood , Osteoarthritis*/metabolism , Osteoarthritis*/genetics , Osteoarthritis*/microbiology , Osteoarthritis*/blood , Hand Joints* , Gastrointestinal Microbiome*, Organic Anion Transporters, Sodium-Dependent/genetics ; Humans ; Female ; Middle Aged ; Male ; Aged ; Receptor, Farnesoid X-Activated |
| Περίληψη: | Objective: Although gut microbiome dysbiosis is associated with symptomatic hand osteoarthritis (SHOA), the role of bile acids (BAs), key metabolites in host-microbiota interactions, in SHOA pathogenesis remains unexplored. We investigated the association between plasma BA metabolism and SHOA. Methods: The associations between plasma BAs and SHOA were examined in the Xiangya Osteoarthritis (XO) Study and validated in an independent cohort through logistic regression models. Gut microbiome data from a previous study conducted within the XO Study were integrated to explore associations between SHOA-related gut microbes and key BAs. As an exploratory analysis, gene-based meta-analyses evaluated associations between genes encoding key BA receptors and hand OA. Results: In the discovery cohort (n = 1,359, mean age ± SD 63.1 ± 9.0 years, 58.4% women, SHOA prevalence 5.2%, all participants being Asian), elevated levels of deoxycholic acid (DCA) species (odds ratio [OR] 1.75, 95% confidence interval [CI] 1.03-2.96) and DCA (OR 2.14, 95% CI 1.24-3.70) were positively associated with SHOA presence and severity. These associations were replicated in an independent cohort (n = 142). Multiomics analyses revealed significant correlations of DCA species, DCA, and the DCA species-to-total BAs ratio with SHOA-related gut microbes. DCA interacted with SHOA-related gut microbes and was associated with SHOA. Gene-based meta-analyses identified significant associations between genes encoding the Farnesoid X receptor and the pregnane X receptor and hand OA. Conclusion: Dysregulated BA metabolism, particularly elevated DCA levels, is associated with SHOA. The observation that DCA interacts with SHOA-related gut microbes, together with genes encoding DCA receptors, may help guide future biologically and clinically relevant studies. (© 2025 American College of Rheumatology.) |
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| Grant Information: | U21A20352 National Natural Science Foundation Regional Innovation and Development Joint Fund of China; 82530084 National Natural Science Foundation of China; 81930071 National Natural Science Foundation of China; 82430081 National Natural Science Foundation of China; 82472524 National Natural Science Foundation of China; 2022YFC2505500 National Key Research and Development Plan; 2022YFC3601900 National Key Research and Development Plan; W20241003 Health Research Project of Hunan Provincial Health Commission; 2023SK2100 Scientific Research Program of FuRong Laboratory; 2024PT5108 Scientific Research Program of FuRong Laboratory; 2024JJ3047 Natural Science Foundation of Hunan Province; GZC20251392 Postdoctoral Fellowship Program (Grade C) of China Postdoctoral Science Foundation |
| Substance Nomenclature: | 0 (Bile Acids and Salts) 0 (Receptor, Farnesoid X-Activated) 0 (Organic Anion Transporters, Sodium-Dependent) |
| Entry Date(s): | Date Created: 20251226 Date Completed: 20260629 Latest Revision: 20260629 |
| Update Code: | 20260629 |
| DOI: | 10.1002/art.70048 |
| PMID: | 41451559 |
| Βάση Δεδομένων: | MEDLINE |
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