Academic Journal
Spatial hearing and temporal processing ability of the Mongolian gerbil (Meriones unguiculatus) measured using prepulse inhibition of acoustic startle.
| Τίτλος: | Spatial hearing and temporal processing ability of the Mongolian gerbil (Meriones unguiculatus) measured using prepulse inhibition of acoustic startle. |
|---|---|
| Συγγραφείς: | Sergison MD; Neuroscience Graduate Program, University of Colorado School of Medicine, Aurora, CO 80045; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045., Poleg S; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045., Greene NT; Neuroscience Graduate Program, University of Colorado School of Medicine, Aurora, CO 80045; Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO 80045., Klug A; Neuroscience Graduate Program, University of Colorado School of Medicine, Aurora, CO 80045; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045., Tollin DJ; Neuroscience Graduate Program, University of Colorado School of Medicine, Aurora, CO 80045; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045; Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO 80045. Electronic address: Daniel.Tollin@CUAnschutz.edu. |
| Πηγή: | Hearing research [Hear Res] 2026 Jan; Vol. 470, pp. 109507. Date of Electronic Publication: 2025 Dec 11. |
| Τύπος έκδοσης: | Journal Article; Research Support, N.I.H., Extramural |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7900445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5891 (Electronic) Linking ISSN: 03785955 NLM ISO Abbreviation: Hear Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Gerbillinae*/physiology , Reflex, Startle* , Prepulse Inhibition* , Sound Localization* , Hearing* , Time Perception*, Animals ; Acoustic Stimulation ; Male ; Female ; Cues ; Time Factors ; Behavior, Animal ; Perceptual Masking ; Auditory Threshold |
| Περίληψη: | The Mongolian gerbil is a common model organism for studying the neural and behavioral mechanisms of binaural and spatial hearing, largely because of its ability to hear lower frequencies better than other rodents and thus utilize both interaural time and level difference cues for sound localization. Prior spatial hearing studies in gerbils have relied on operant conditioning paradigms, requiring large amounts of time-consuming training and testing on multiple different tasks needed to make a comprehensive assessment of spatial hearing ability (including temporal processing, spatial acuity and spatial unmasking). This limits the ability of researchers to thoroughly assess behavioral performance in a population of animals. In this study, we used the prepulse inhibition of the acoustic startle reflex (PPI) to extensively assess spatial hearing and temporal processing abilities in a population of gerbils of both sexes. Results show that gerbils inhibit a startle response to a brief loud sound based on prepulse acoustical cues consisting of a 1) temporal gap in ongoing sounds, 2) change in sound source location, and 3) target sound in the presence of a masker. In each test, the magnitude of the suppression of startle increased monotonically as a function of the magnitude of the acoustical prepulse, not unlike a psychometric function, from which threshold performance could be measured. Thresholds in the gerbils in each task measured using PPI matched those acquired using operant conditioning methods. (Copyright © 2025. Published by Elsevier B.V.) |
| Competing Interests: | Conflict of interest statement The authors report no conflicts of interest. |
| Σχόλια: | Update of: bioRxiv. 2025 Mar 13:2025.03.12.642882. doi: 10.1101/2025.03.12.642882.. (PMID: 40161580) |
| References: | Hear Res. 1988 Nov;36(2-3):221-32. (PMID: 3209494) Behav Neurosci. 2010 Apr;124(2):265-77. (PMID: 20364886) Prog Neurobiol. 1999 Oct;59(2):107-28. (PMID: 10463792) Hear Res. 2018 Dec;370:65-73. (PMID: 30326382) J Neurophysiol. 1999 Nov;82(5):2294-309. (PMID: 10561407) J Neurosci. 2010 Sep 1;30(35):11696-702. (PMID: 20810890) J Acoust Soc Am. 2006 Feb;119(2):1029-36. (PMID: 16521765) J Neurophysiol. 2013 Nov;110(9):2140-51. (PMID: 23945782) J Neurophysiol. 1995 Mar;73(3):1043-62. (PMID: 7608754) J Acoust Soc Am. 1976 May;59(5):1222-6. (PMID: 956517) Hear Res. 2018 Aug;365:62-76. (PMID: 29778290) Comp Med. 2005 Feb;55(1):12-23. (PMID: 15766204) eNeuro. 2020 Jan 31;7(1):. (PMID: 31953317) Hear Res. 2025 Feb;456:109166. (PMID: 39693785) Hear Res. 2014 Oct;316:1-15. (PMID: 25051197) Ear Hear. 2011 Nov-Dec;32(6):741-9. (PMID: 21730860) Hear Res. 2016 Mar;333:167-178. (PMID: 26807797) J Assoc Res Otolaryngol. 2004 Mar;5(1):49-57. (PMID: 14976587) Hear Res. 2011 Feb;272(1-2):135-47. (PMID: 20971180) Hear Res. 2011 May;275(1-2):89-95. (PMID: 21147208) J Neurophysiol. 2010 Jan;103(1):38-46. (PMID: 19846624) Neurobiol Aging. 2021 Dec;108:133-145. (PMID: 34601244) J Acoust Soc Am. 2005 Aug;118(2):872-86. (PMID: 16158644) PLoS Biol. 2005 Mar;3(3):e78. (PMID: 15736980) Brain Res. 2008 Jul 18;1220:47-57. (PMID: 18343357) J Neurophysiol. 1990 Aug;64(2):465-88. (PMID: 2213127) Physiol Rev. 2010 Jul;90(3):983-1012. (PMID: 20664077) Neuroscientist. 2003 Apr;9(2):127-43. (PMID: 12708617) Psicothema. 2017 Nov;29(4):552-557. (PMID: 29048317) Physiol Behav. 2009 Oct 19;98(4):460-6. (PMID: 19660482) J Acoust Soc Am. 2008 Jun;123(6):4297-309. (PMID: 18537381) J Acoust Soc Am. 1982 Dec;72(6):1804-11. (PMID: 7153427) Behav Neurosci. 1986 Apr;100(2):200-5. (PMID: 3083839) J Assoc Res Otolaryngol. 2012 Apr;13(2):237-248. (PMID: 22245918) Front Behav Neurosci. 2016 Jun 30;10:133. (PMID: 27445728) Hear Res. 2016 Jul;337:46-58. (PMID: 27173973) Hear Res. 2003 Feb;176(1-2):11-6. (PMID: 12583877) Behav Neurosci. 2020 Apr;134(2):119-132. (PMID: 31971416) Hear Res. 1985;19(2):151-5. (PMID: 4055534) Eur J Neurosci. 2024 Sep;60(5):4954-4981. (PMID: 39085952) Neurology. 1993 Oct;43(10):1893-9. (PMID: 8413944) J Neurophysiol. 1969 Jul;32(4):613-36. (PMID: 5810617) PLoS One. 2017 Apr 10;12(4):e0175142. (PMID: 28394906) Behav Neurosci. 1988 Jun;102(3):422-8. (PMID: 3395452) Compr Physiol. 2019 Sep 19;9(4):1503-1575. (PMID: 31688966) |
| Grant Information: | R01 DC023100 United States DC NIDCD NIH HHS; F31 DC021622 United States DC NIDCD NIH HHS |
| Contributed Indexing: | Keywords: Acoustic startle reflex; Gap detection; Gerbil; Prepulse inhibition; Sound localization; Spatial release from masking |
| Entry Date(s): | Date Created: 20251225 Date Completed: 20260115 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13220346 |
| DOI: | 10.1016/j.heares.2025.109507 |
| PMID: | 41448075 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!