Academic Journal
Driving Pressure-Guided Tidal Volume Titration Reduces Lung Injury in Thoracic Surgery With One-Lung Ventilation: A Randomized Clinical Trial.
| Τίτλος: | Driving Pressure-Guided Tidal Volume Titration Reduces Lung Injury in Thoracic Surgery With One-Lung Ventilation: A Randomized Clinical Trial. |
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| Συγγραφείς: | Yan Y; Department of Anesthesiology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China., Liu X; Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China., Liu Z; Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China., Li Z; Department of Anesthesiology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China., Cai H; Department of Anesthesiology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China., Li W; Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China. Electronic address: liweixia12@126.com., Zhao J; Department of Anesthesiology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China. |
| Πηγή: | Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 2026 Feb; Vol. 40 (2), pp. 652-659. Date of Electronic Publication: 2025 Nov 19. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 9110208 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8422 (Electronic) Linking ISSN: 10530770 NLM ISO Abbreviation: J Cardiothorac Vasc Anesth Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Philadelphia, PA : W.B. Saunders, c1991- |
| Ιατρικοί όροι (MeSH): | One-Lung Ventilation*/methods , One-Lung Ventilation*/adverse effects , Tidal Volume*/physiology , Thoracic Surgical Procedures*/adverse effects , Thoracic Surgical Procedures*/methods , Lung Injury*/prevention & control , Lung Injury*/etiology, Humans ; Male ; Female ; Middle Aged ; Prospective Studies ; Aged ; Adult |
| Περίληψη: | Objective: The optimal tidal volume for patients undergoing thoracic surgery with one-lung ventilation (OLV) remains unclear. This study aimed to evaluate whether driving pressure-guided tidal volume titration could reduce lung injury in these patients. Design: Prospective, single-center, randomized controlled trial. Setting: Single-center academic hospital in China. Participants: A total of 96 patients undergoing thoracic surgery with OLV. Interventions: Patients were randomly assigned to either the driving pressure-guided tidal volume group (n = 46) or the control group (n = 50). In the control group, tidal volume was set at 8 mL/kg of predicted body weight (PBW) during OLV. In the driving pressure-guided group, tidal volume was adjusted to maintain a driving pressure between 8 and 10 cm H Measurements and Main Results: The primary outcome was the concentration of interleukin 6 (IL-6) in the dependent lung following OLV. The tidal volume in the driving pressure-guided group was 4.65 [4.23-5.65] mL/kg at 15 minutes and 4.58 [4.27-5.41] mL/kg at 45 minutes of OLV. The concentration of IL-6 in the dependent lung after OLV was significantly lower in the driving pressure group (5.31 [3.62]) compared to the control group (7.37 [5.21]) (mean difference: -0.46 [-0.86 to -0.05] cm H Conclusions: Driving pressure-guided tidal volume titration significantly reduces IL-6 levels in bronchoalveolar lavage fluid from the dependent lung following OLV in patients undergoing thoracic surgery, compared to conventional ventilation using 8 mL/kg PBW. (Copyright © 2025 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: driving pressure; interleukin 6; one-lung ventilation; postoperative pulmonary complications; tidal volume |
| Entry Date(s): | Date Created: 20251218 Date Completed: 20260206 Latest Revision: 20260616 |
| Update Code: | 20260617 |
| DOI: | 10.1053/j.jvca.2025.11.020 |
| PMID: | 41412843 |
| Βάση Δεδομένων: | MEDLINE |
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