Academic Journal
Fermented mealworm extract prevents concurrent bone and muscle loss by modulating RANKL-NFκB/MAPK signaling in ovariectomized mice.
| Τίτλος: | Fermented mealworm extract prevents concurrent bone and muscle loss by modulating RANKL-NFκB/MAPK signaling in ovariectomized mice. |
|---|---|
| Συγγραφείς: | Choi SY; Department of Food and Nutrition, Sunchon National University, Suncheon, 57922, Republic of Korea., Lee MK; Department of Food and Nutrition, Sunchon National University, Suncheon, 57922, Republic of Korea. Electronic address: leemk@scnu.ac.kr. |
| Πηγή: | Bone [Bone] 2026 Mar; Vol. 204, pp. 117757. Date of Electronic Publication: 2025 Dec 08. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York : Elsevier Science Original Publication: Elmsford, NY : Pergamon Press, c1985- |
| Ιατρικοί όροι (MeSH): | NF-kappa B*/metabolism , RANK Ligand*/metabolism , Signal Transduction*/drug effects , Bone and Bones*/drug effects , Bone and Bones*/pathology , Complex Mixtures*/pharmacology , Complex Mixtures*/therapeutic use , MAP Kinase Signaling System*/drug effects , Ovariectomy* , Fermentation*, Bone Density/drug effects ; Muscular Atrophy/prevention & control ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/pathology ; Mitogen-Activated Protein Kinases/metabolism ; Animals ; Female ; Mice, Inbred C57BL ; Mice |
| Περίληψη: | This study investigated whether fermented mealworms extract (FME) can simultaneously improve postmenopausal osteoporosis and muscle atrophy, along with the underlying mechanisms. Female C57BL/6 N mice were divided into five groups: sham-operated, ovariectomized (OVX), OVX treated with two doses of FME (200 and 500 mg/kg, oral), and OVX treated with alendronate (Alen, 500 μg/kg, oral) as a positive control, for 15 weeks. FME500 significantly increased grip strength, whereas FME200 showed no significant improvement compared to the OVX group. Muscle cross-sectional area significantly increased in both FME groups compared to the OVX group. FME500 also enhanced muscle protein synthesis markers (MyoD1 and MHC) and more effectively suppressed muscle degradation markers (MuRF-1, atrogin-1, myostatin, and polyubiquitinated proteins) than FME200. In bone, both FME doses improved bone density and serum levels of RANKL and CTX-1 compared to the OVX group. FME500 more effectively downregulated RANKL, IL-6, and TNF-α expression in both bone and muscle than FME200 in OVX group. Mechanistic analyses were performed mainly in the FME500 group, which downregulated NFκB/MAPK and upregulated IGF-1-PI3K-Akt in both bone and muscle. These results indicate that FME suppresses the postmenopausal concurrent bone and muscle loss by regulating RANKL-NFκB/MAPK and IGF-1-PI3K-Akt signaling pathways. (Copyright © 2025 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mi-Kyung Lee reports financial support was provided by National Research Foundation of Korea. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Bone; Fermented Tenebrio molitor larvae extract; RANKL-NFκB/MAPK; Skeletal muscle |
| Substance Nomenclature: | 0 (NF-kappa B) 0 (RANK Ligand) 0 (Tnfsf11 protein, mouse) 0 (Complex Mixtures) EC 2.7.11.24 (Mitogen-Activated Protein Kinases) |
| Entry Date(s): | Date Created: 20251210 Date Completed: 20260114 Latest Revision: 20260713 |
| Update Code: | 20260714 |
| DOI: | 10.1016/j.bone.2025.117757 |
| PMID: | 41371429 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!