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A Short-Term Evaluation of the Efficacy of Two Desensitising Toothpastes in the Treatment of Dentinal Hypersensitivity.

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Title: A Short-Term Evaluation of the Efficacy of Two Desensitising Toothpastes in the Treatment of Dentinal Hypersensitivity.
Authors: Alhammadi MA; College of Dental Medicine, University of Sharjah, Sharjah, UAE., Alketbi MM; College of Dental Medicine, University of Sharjah, Sharjah, UAE., Sultan AS; College of Dental Medicine, University of Sharjah, Sharjah, UAE., Alsabek YM; College of Dental Medicine, University of Sharjah, Sharjah, UAE., Acharya AB; Department of Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE.
Source: International journal of dental hygiene [Int J Dent Hyg] 2026 May; Vol. 24 (2), pp. 170-178. Date of Electronic Publication: 2025 Dec 07.
Publication Type: Journal Article; Randomized Controlled Trial
Language: English
Journal Info: Publisher: Blackwell Pub Country of Publication: England NLM ID: 101168070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-5037 (Electronic) Linking ISSN: 16015029 NLM ISO Abbreviation: Int J Dent Hyg Subsets: MEDLINE
Imprint Name(s): Original Publication: Oxford [Eng.] : Blackwell Pub., c2003-
MeSH Terms: Dentin Sensitivity*/drug therapy , Toothpastes*/therapeutic use , Nitrates*/therapeutic use , Potassium Compounds*/therapeutic use , Dentin Desensitizing Agents*/therapeutic use , Durapatite*/therapeutic use, Humans ; Adult ; Female ; Male ; Middle Aged ; Adolescent ; Young Adult ; Pain Measurement ; Treatment Outcome
Abstract: Background: Dentine hypersensitivity (DH) is a common oral condition. The management of DH has been challenging with various treatment options, including in-office and home care.
Objective: To evaluate the efficacy of hydroxyapatite-containing toothpaste for the reduction of DH pain compared to potassium nitrate-containing toothpaste in short-term use.
Methods: A randomised; non-blinded clinical study involved 39 participants in the age group range 18-51 years. The patients were randomly divided into two groups. The test group (n = 19) was provided with hydroxyapatite toothpaste, while the control group (n = 20) received potassium nitrate toothpaste. Volunteers were examined using an air blast as the stimulus. DH pain scores (Visual Analogue Scale [VAS] and Schiff) were recorded at baseline, 2 weeks and 4 weeks.
Results: Both toothpastes significantly relieved DH in response to air-blast stimulus (p < 0.001). The relief of sensitivity was efficacious after 2 and 4 weeks for both toothpastes. The efficacy of hydroxyapatite toothpaste was comparable to that of potassium nitrate toothpaste.
Conclusion: This study shows that hydroxyapatite in higher concentrations has a similar efficacy in relieving DH as potassium nitrate.
Clinical Significance: DH affects the quality of life. The use of a desensitising toothpaste can relieve DH. However, there is no gold-standard management for DH. The outcome of this study supports the use of hydroxyapatite toothpaste for DH relief.
(© 2025 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
References: C.‐H. Chu, “Dentin Hypersensitivity: A Review Edward Chin‐Man Lo,” Hong Kong Dental Journal 7 (2010): 15–22.
A. B. Acharya, A. Chandrashekar, and S. Thakur, “A Short Term Comparative Evaluation of the Efficacy of Diode Laser With Desensitizing Toothpastes and Mouthwashes in the Treatment of Dentinal Hypersensitivity,” Journal of Clinical and Experimental Dentistry 14, no. 3 (2022): 229–234.
T. Schiff, M. Dotson, S. Cohen, W. De Vizio, J. McCool, and A. Volpe, “Efficacy of a Dentifrice Containing Potassium Nitrate, Soluble Pyrophosphate, PVM/MA Copolymer, and Sodium Fluoride on Dentinal Hypersensitivity: A Twelve‐Week Clinical Study,” Journal of Clinical Dentistry 5 (1994): 87–92.
M. Awad, D. El Kassas, L. Al Harthi, et al., “Dentine Hypersensitivity and Dentine Exposure in Arab Patient Populations,” Journal of Oral Rehabilitation 47, no. 4 (2020): 473–479.
H. Al‐Khafaji, “Observations on Dentine Hypersensitivity in General Dental Practices in The United Arab Emirates,” European Journal of Dentistry 7, no. 4 (2013): 389–394.
A. Davari, E. Ataei, and H. Assarzadeh, “Dentin Hypersensitivity: Etiology, Diagnosis and Treatment; a Literature Review,” Journal of Dentistry (Shiraz, Iran) 14, no. 3 (2013): 136–145.
G. M. Naidu, K. Chaitanya Ram, N. R. Sirisha, et al., “Prevalence of Dentin Hypersensitivity and Related Factors Among Adult Patients Visiting a Dental School in Andhra Pradesh, South India,” Journal of Clinical and Diagnostic Research 8, no. 9 (2014): ZC48–ZC51.
L. H. Berman, “Dentinal Sensation and Hypersensitivity: A Review of Mechanisms and Treatment Alternatives,” Journal of Periodontology 56, no. 4 (1985): 216–222.
F. A. Curro, “Tooth Hypersensitivity in the Spectrum of Pain,” Dental Clinics of North America 34, no. 3 (1990): 429–437.
T. Pranati, P. Ariga, D. Ganapathy, and A. Arthanari, “Etiology and Management of Hypersensitivity of Teeth—A Review,” Journal of Pharmaceutical Research International 34 (2021): 317–329.
K. Bekes and C. Hirsch, “What Is Known About the Influence of Dentine Hypersensitivity on Oral Health‐Related Quality of Life?,” Clinical Oral Investigations 17, no. SUPPL.1 (2013): 45–51.
M. L. Hu, G. Zheng, Y. D. Zhang, X. Yan, X. C. Li, and H. Lin, “Effect of Desensitizing Toothpastes on Dentine Hypersensitivity: A Systematic Review and Meta‐Analysis,” Journal of Dentistry 75, no. May (2018): 12–21.
S. Y. Shen, C. H. Tsai, L. C. Yang, and Y. C. Chang, “Clinical Efficacy of Toothpaste Containing Potassium Citrate in Treating Dentin Hypersensitivity,” Journal of Dental Sciences 4, no. 4 (2009): 173–177, https://doi.org/10.1016/S1991‐7902(09)60023‐4.
S. Miglani, V. Aggarwal, and B. Ahuja, “Dentin Hypersensitivity: Recent Trends in Management,” Journal of Conservative Dentistry 13, no. 4 (2010): 218–224.
R. Orchardson and D. G. Gillam, “The Efficacy of Potassium Salts as Agents for Treating Dentin Hypersensitivity,” Journal of Orofacial Pain 14, no. 1 (2000): 9–19.
S. Poulsen, M. Errboe, Y. Lescay Mevil, and A.‐M. Glenny, “Potassium Containing Toothpastes for Dentine Hypersensitivity,” Cochrane Database of Systematic Reviews 2006, no. 3 (2006): CD001476.
C. C. Martins, J. J. Riva, R. T. Firmino, and H. J. Schünemann, “Formulations of Desensitizing Toothpastes for Dentin Hypersensitivity: A Scoping Review,” Journal of Applied Oral Science 30 (2022): 1–9.
F. Carrouel, S. Viennot, L. Ottolenghi, C. Gaillard, and D. Bourgeois, “Nanoparticles as Anti‐Microbial, Anti‐Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation,” Nanomaterials 10 (2020): 140.
P. Yuan, X. Shen, J. Liu, et al., “Effects of Dentifrice Containing Hydroxyapatite on Dentinal Tubule Occlusion and Aqueous Hexavalent Chromium Cations Sorption: A Preliminary Study,” PLoS One 7, no. 12 (2012): e45283.
H. Gul, M. Ghaffar, M. Kaleem, and A. Khan, “Hydroxyapatite, a Potent Agent to Reduce Dentin Hypersensitivity,” Journal of the Pakistan Medical Association 71, no. 11 (2021): 2604–2610.
L. Chen, S. Al‐Bayatee, Z. Khurshid, A. Shavandi, P. Brunton, and J. Ratnayake, “Hydroxyapatite in Oral Care Products—A Review,” Materials (Basel) 14, no. 17 (2021): 4865.
C. Hall, F. Sufi, J. L. Milleman, and K. R. Milleman, “Efficacy of a 3% Potassium Nitrate Mouthrinse for the Relief of Dentinal Hypersensitivity: An 8‐Week Randomized Controlled Study,” Journal of the American Dental Association 150, no. 3 (2019): 204–212.
S. Sen, M. K. Anand, and P. K. Pratibha, “Comparative Desensitizing Effect of a Toothpaste & Mouthwash Containing Potassium Nitrate: An In Vivo & In Vitro Scanning Electron Microscopic Study,” Advanced Dentistry & Oral Health 8 (2018): 555749.
Contributed Indexing: Keywords: dentinal hypersensitivity; desensitising toothpaste; hydroxyapatite; potassium nitrate
Substance Nomenclature: 0 (Toothpastes)
0 (Nitrates)
RU45X2JN0Z (potassium nitrate)
0 (Potassium Compounds)
0 (Dentin Desensitizing Agents)
91D9GV0Z28 (Durapatite)
Entry Date(s): Date Created: 20251207 Date Completed: 20260404 Latest Revision: 20260404
Update Code: 20260405
DOI: 10.1111/idh.70026
PMID: 41353765
Database: MEDLINE
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Alhammadi+MA%22&quot;&gt;Alhammadi MA&lt;/searchLink&gt;; College of Dental Medicine, University of Sharjah, Sharjah, UAE.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Alketbi+MM%22&quot;&gt;Alketbi MM&lt;/searchLink&gt;; College of Dental Medicine, University of Sharjah, Sharjah, UAE.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Sultan+AS%22&quot;&gt;Sultan AS&lt;/searchLink&gt;; College of Dental Medicine, University of Sharjah, Sharjah, UAE.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Alsabek+YM%22&quot;&gt;Alsabek YM&lt;/searchLink&gt;; College of Dental Medicine, University of Sharjah, Sharjah, UAE.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Acharya+AB%22&quot;&gt;Acharya AB&lt;/searchLink&gt;; Department of Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Dentine hypersensitivity (DH) is a common oral condition. The management of DH has been challenging with various treatment options, including in-office and home care.&lt;br /&gt;Objective: To evaluate the efficacy of hydroxyapatite-containing toothpaste for the reduction of DH pain compared to potassium nitrate-containing toothpaste in short-term use.&lt;br /&gt;Methods: A randomised; non-blinded clinical study involved 39 participants in the age group range 18-51 years. The patients were randomly divided into two groups. The test group (n = 19) was provided with hydroxyapatite toothpaste, while the control group (n = 20) received potassium nitrate toothpaste. Volunteers were examined using an air blast as the stimulus. DH pain scores (Visual Analogue Scale [VAS] and Schiff) were recorded at baseline, 2 weeks and 4 weeks.&lt;br /&gt;Results: Both toothpastes significantly relieved DH in response to air-blast stimulus (p &amp;lt; 0.001). The relief of sensitivity was efficacious after 2 and 4 weeks for both toothpastes. The efficacy of hydroxyapatite toothpaste was comparable to that of potassium nitrate toothpaste.&lt;br /&gt;Conclusion: This study shows that hydroxyapatite in higher concentrations has a similar efficacy in relieving DH as potassium nitrate.&lt;br /&gt;Clinical Significance: DH affects the quality of life. The use of a desensitising toothpaste can relieve DH. However, there is no gold-standard management for DH. The outcome of this study supports the use of hydroxyapatite toothpaste for DH relief.&lt;br /&gt; (&#169; 2025 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd.)
– Name: Ref
  Label: References
  Group: RefInfo
  Data: C.‐H. Chu, “Dentin Hypersensitivity: A Review Edward Chin‐Man Lo,” Hong Kong Dental Journal 7 (2010): 15–22.&lt;br /&gt;A. B. Acharya, A. Chandrashekar, and S. Thakur, “A Short Term Comparative Evaluation of the Efficacy of Diode Laser With Desensitizing Toothpastes and Mouthwashes in the Treatment of Dentinal Hypersensitivity,” Journal of Clinical and Experimental Dentistry 14, no. 3 (2022): 229–234.&lt;br /&gt;T. Schiff, M. Dotson, S. Cohen, W. De Vizio, J. McCool, and A. Volpe, “Efficacy of a Dentifrice Containing Potassium Nitrate, Soluble Pyrophosphate, PVM/MA Copolymer, and Sodium Fluoride on Dentinal Hypersensitivity: A Twelve‐Week Clinical Study,” Journal of Clinical Dentistry 5 (1994): 87–92.&lt;br /&gt;M. Awad, D. El Kassas, L. Al Harthi, et&#160;al., “Dentine Hypersensitivity and Dentine Exposure in Arab Patient Populations,” Journal of Oral Rehabilitation 47, no. 4 (2020): 473–479.&lt;br /&gt;H. Al‐Khafaji, “Observations on Dentine Hypersensitivity in General Dental Practices in The United Arab Emirates,” European Journal of Dentistry 7, no. 4 (2013): 389–394.&lt;br /&gt;A. Davari, E. Ataei, and H. Assarzadeh, “Dentin Hypersensitivity: Etiology, Diagnosis and Treatment; a Literature Review,” Journal of Dentistry (Shiraz, Iran) 14, no. 3 (2013): 136–145.&lt;br /&gt;G. M. Naidu, K. Chaitanya Ram, N. R. Sirisha, et&#160;al., “Prevalence of Dentin Hypersensitivity and Related Factors Among Adult Patients Visiting a Dental School in Andhra Pradesh, South India,” Journal of Clinical and Diagnostic Research 8, no. 9 (2014): ZC48–ZC51.&lt;br /&gt;L. H. Berman, “Dentinal Sensation and Hypersensitivity: A Review of Mechanisms and Treatment Alternatives,” Journal of Periodontology 56, no. 4 (1985): 216–222.&lt;br /&gt;F. A. Curro, “Tooth Hypersensitivity in the Spectrum of Pain,” Dental Clinics of North America 34, no. 3 (1990): 429–437.&lt;br /&gt;T. Pranati, P. Ariga, D. Ganapathy, and A. Arthanari, “Etiology and Management of Hypersensitivity of Teeth—A Review,” Journal of Pharmaceutical Research International 34 (2021): 317–329.&lt;br /&gt;K. Bekes and C. Hirsch, “What Is Known About the Influence of Dentine Hypersensitivity on Oral Health‐Related Quality of Life?,” Clinical Oral Investigations 17, no. SUPPL.1 (2013): 45–51.&lt;br /&gt;M. L. Hu, G. Zheng, Y. D. Zhang, X. Yan, X. C. Li, and H. Lin, “Effect of Desensitizing Toothpastes on Dentine Hypersensitivity: A Systematic Review and Meta‐Analysis,” Journal of Dentistry 75, no. May (2018): 12–21.&lt;br /&gt;S. Y. Shen, C. H. Tsai, L. C. Yang, and Y. C. Chang, “Clinical Efficacy of Toothpaste Containing Potassium Citrate in Treating Dentin Hypersensitivity,” Journal of Dental Sciences 4, no. 4 (2009): 173–177, https://doi.org/10.1016/S1991‐7902(09)60023‐4.&lt;br /&gt;S. Miglani, V. Aggarwal, and B. Ahuja, “Dentin Hypersensitivity: Recent Trends in Management,” Journal of Conservative Dentistry 13, no. 4 (2010): 218–224.&lt;br /&gt;R. Orchardson and D. G. Gillam, “The Efficacy of Potassium Salts as Agents for Treating Dentin Hypersensitivity,” Journal of Orofacial Pain 14, no. 1 (2000): 9–19.&lt;br /&gt;S. Poulsen, M. Errboe, Y. Lescay Mevil, and A.‐M. Glenny, “Potassium Containing Toothpastes for Dentine Hypersensitivity,” Cochrane Database of Systematic Reviews 2006, no. 3 (2006): CD001476.&lt;br /&gt;C. C. Martins, J. J. Riva, R. T. Firmino, and H. J. Sch&#252;nemann, “Formulations of Desensitizing Toothpastes for Dentin Hypersensitivity: A Scoping Review,” Journal of Applied Oral Science 30 (2022): 1–9.&lt;br /&gt;F. Carrouel, S. Viennot, L. Ottolenghi, C. Gaillard, and D. Bourgeois, “Nanoparticles as Anti‐Microbial, Anti‐Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation,” Nanomaterials 10 (2020): 140.&lt;br /&gt;P. Yuan, X. Shen, J. Liu, et&#160;al., “Effects of Dentifrice Containing Hydroxyapatite on Dentinal Tubule Occlusion and Aqueous Hexavalent Chromium Cations Sorption: A Preliminary Study,” PLoS One 7, no. 12 (2012): e45283.&lt;br /&gt;H. Gul, M. Ghaffar, M. Kaleem, and A. Khan, “Hydroxyapatite, a Potent Agent to Reduce Dentin Hypersensitivity,” Journal of the Pakistan Medical Association 71, no. 11 (2021): 2604–2610.&lt;br /&gt;L. Chen, S. Al‐Bayatee, Z. Khurshid, A. Shavandi, P. Brunton, and J. Ratnayake, “Hydroxyapatite in Oral Care Products—A Review,” Materials (Basel) 14, no. 17 (2021): 4865.&lt;br /&gt;C. Hall, F. Sufi, J. L. Milleman, and K. R. Milleman, “Efficacy of a 3% Potassium Nitrate Mouthrinse for the Relief of Dentinal Hypersensitivity: An 8‐Week Randomized Controlled Study,” Journal of the American Dental Association 150, no. 3 (2019): 204–212.&lt;br /&gt;S. Sen, M. K. Anand, and P. K. Pratibha, “Comparative Desensitizing Effect of a Toothpaste &amp; Mouthwash Containing Potassium Nitrate: An In&#160;Vivo &amp; In&#160;Vitro Scanning Electron Microscopic Study,” Advanced Dentistry &amp; Oral Health 8 (2018): 555749.
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  Data: &lt;i&gt;Keywords: &lt;/i&gt;dentinal hypersensitivity; desensitising toothpaste; hydroxyapatite; potassium nitrate
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      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1601-5037
          Numbering:
            – Type: volume
              Value: 24
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: International journal of dental hygiene
              Type: main
ResultId 1