Academic Journal
Prevalent and incident latent tuberculosis infection among healthcare workers in Taiwan: A multi-center observational study.
| Τίτλος: | Prevalent and incident latent tuberculosis infection among healthcare workers in Taiwan: A multi-center observational study. |
|---|---|
| Συγγραφείς: | Wu CJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan., Lee SS; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan., Shu CC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lin SM; Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan; School of Medicine, National Tsing Hua University, Hsinchu, Taiwan., Lee CC; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan., Huang JR; Department of Pulmonary Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Wang TY; Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan., Pan SW; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Feng JY; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: jyfeng@vghtpe.gov.tw., Chen YM; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. |
| Πηγή: | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [J Microbiol Immunol Infect] 2026 Oct; Vol. 59 (5), pp. 594-600. Date of Electronic Publication: 2025 Nov 20. |
| Τύπος έκδοσης: | Journal Article; Observational Study; Multicenter Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: published by Elsevier for the Taiwan Society of Microbiology Country of Publication: England NLM ID: 100956211 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-9133 (Electronic) Linking ISSN: 16841182 NLM ISO Abbreviation: J Microbiol Immunol Infect Subsets: MEDLINE |
| Imprint Name(s): | Publication: Feb. 2010- : Oxford, England : published by Elsevier for the Taiwan Society of Microbiology Original Publication: Taipei, Taiwan : Chinese Society of Microbiology : Chinese Society of Immunology [and] : Infectious Diseases Society of the Republic of China |
| Ιατρικοί όροι (MeSH): | Latent Tuberculosis*/epidemiology , Latent Tuberculosis*/diagnosis , Latent Tuberculosis*/drug therapy , Health Personnel*/statistics & numerical data, Taiwan/epidemiology ; Humans ; Adult ; Male ; Female ; Prevalence ; Incidence ; Middle Aged ; Risk Factors ; Interferon-gamma Release Tests ; Intensive Care Units |
| Περίληψη: | Background: Healthcare workers (HCWs) have increased risks of active tuberculosis, yet there are limited reports of incidence and risk factors of latent tuberculosis infection (LTBI) among HCWs. Methods: HCWs were enrolled from four medical centers in Taiwan. Quantiferon-TB Gold Plus Test (QFT-Plus) was performed initially and 9-12 months afterwards. The prevalence, incidence, and clinical factors associated with LTBI, and willingness to receive LTBI treatment were explored. Results: Among 297 HCWs, the prevalence rate of LTBI was 10.8 %. The independent factors associated with prevalent LTBI were age >40 years old (aOR 3.52, 95 % CI 1.46-8.45), health professionals (aOR 3.99, 95 % CI 1.02-15.65), and working in intensive care units (ICUs) (aOR 4.06, 95 % CI 1.28-12.86). Having all three factors escalated the risk of prevalent LTBI (aOR 13.81, 95 % CI 3.16-60.37). Of 129 LTBI-free HCWs undergoing 2nd QFT-Plus, seven (5.4 %) had positive conversion, indicating incident LTBI, among which four had TB contacts without wearing N95 mask. Two had a TB2-TB1 value > 0.6 IU/ml. 40.6 % prevalent LTBI patients refused LTBI preventive therapy. Conclusions: More advanced age, health professionals, and working in ICUs were independent factors associated with prevalent LTBI. Most healthcare workers with incident LTBI cases had TB contacts without wearing N95 masks. (Copyright © 2025. Published by Elsevier B.V.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no competing interests. |
| Contributed Indexing: | Keywords: Healthcare workers; Interferon-gamma responses; Latent tuberculosis infection; Risk factors; Taiwan |
| Entry Date(s): | Date Created: 20251127 Date Completed: 20260918 Latest Revision: 20260921 |
| Update Code: | 20260921 |
| DOI: | 10.1016/j.jmii.2025.11.006 |
| PMID: | 41309403 |
| Βάση Δεδομένων: | MEDLINE |
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