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Development of Bioactive Niobium Oxalate-Based Desensitizer: Permeability and Formation of Nanoprecursors.

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Τίτλος: Development of Bioactive Niobium Oxalate-Based Desensitizer: Permeability and Formation of Nanoprecursors.
Συγγραφείς: Saldanha LMSN; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil., Ferreira PVC; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil., Gomes FS; Department of Biomedical Sciences, Ethics, Research, and Education School of Dentistry, Universidad de los Andes, Santiago, Chile., Bermejo GN; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil., Santos CCD; Graduate Program in Physics, Federal University of Maranhão (UFMA), São Luís, 65085-580, Brazil., Bauer J; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil., Martins DL; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil.
Πηγή: Brazilian dental journal [Braz Dent J] 2025 Nov 21; Vol. 36, pp. e256534. Date of Electronic Publication: 2025 Nov 21 (Print Publication: 2025).
Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Dental Foundation of Ribeirão Preto Country of Publication: Brazil NLM ID: 9214652 Publication Model: eCollection Cited Medium: Internet ISSN: 1806-4760 (Electronic) Linking ISSN: 01036440 NLM ISO Abbreviation: Braz Dent J Subsets: MEDLINE
Imprint Name(s): Original Publication: Ribeirão Preto : Dental Foundation of Ribeirão Preto, [1990-
Ιατρικοί όροι (MeSH): Oxalates*/chemistry , Dentin Desensitizing Agents*/chemistry , Dentin Desensitizing Agents*/chemical synthesis , Niobium*/chemistry , Dentin Permeability*/drug effects, Microscopy, Electron, Scanning ; Humans ; Permeability
Περίληψη: To evaluate the obliteration of dentinal tubules by experimental pastes with different concentrations of niobium oxalate compared to commercial pastes. Experimental pastes were synthesized from mixtures of different concentrations of sodium carboxymethylcellulose and ammonium niobium oxalate. Twenty-five dentin discs, each 1.5 mm thick, were obtained from molars and divided into five experimental groups (n=5): 1) Oxagel (Kota, Brazil); 2) Desensibilize KF 2% (FGM, Brazil); 3) Paste with 5% niobium oxalate (wt%); 4) Paste with 10% niobium oxalate; 5) Paste with 20% niobium oxalate. The pastes were applied, and initial permeability readings were taken immediately, as well as at 7, 14, and 21 days. Measurements were made using the THDO3d device (Odeme, Brazil). Scanning electron microscopy images and analysis of precipitate formation were performed after 21 days (SEM/EDS). The commercial groups showed a greater reduction in Lp (hydraulic conductance) after 7 days, which remained constant until 21 days. The experimental groups, regardless of concentration, showed a high reduction in permeability immediately. SEM images revealed the formation of a thick layer composed of precipitate and the successive application of the material for all experimental groups. Niobium oxalate pastes are capable of significantly reducing dentinal permeability in both the short and long term, regardless of the concentration applied.
References: J Dent. 2019 Feb;81:1-6. (PMID: 30639724)
J Oral Rehabil. 2019 Oct;46(10):952-990. (PMID: 31216069)
Polymers (Basel). 2022 Feb 14;14(4):. (PMID: 35215641)
Sci Rep. 2018 Mar 20;8(1):4888. (PMID: 29559639)
J Dent. 2019 Oct;89:103180. (PMID: 31415787)
ACS Omega. 2021 Jul 20;6(30):19596-19605. (PMID: 34368546)
Braz Dent J. 2016 May-Jun;27(3):325-31. (PMID: 27224568)
J Oral Rehabil. 2017 Feb;44(2):112-118. (PMID: 27973740)
J Prosthodont Res. 2015 Apr;59(2):129-35. (PMID: 25659301)
Biomed Mater. 2006 Mar;1(1):16-23. (PMID: 18458381)
J Mech Behav Biomed Mater. 2018 Feb;78:188-195. (PMID: 29169095)
Oper Dent. 2011 Mar-Apr;36(2):222-30. (PMID: 21777102)
ACS Biomater Sci Eng. 2016 May 9;2(5):734-740. (PMID: 33440570)
J Dent Res. 1981 Mar;60(3):686-98. (PMID: 6937499)
Clin Oral Investig. 2022 Oct;26(10):6397-6407. (PMID: 35767044)
Nat Commun. 2013;4:1507. (PMID: 23422675)
Dent Mater. 2012 Mar;28(3):252-60. (PMID: 22078764)
Clin Oral Investig. 2019 May;23(5):2129-2141. (PMID: 30269174)
Arch Oral Biol. 1985;30(10):731-7. (PMID: 3866520)
J Dent. 2021 Sep;112:103745. (PMID: 34252489)
Substance Nomenclature: 0 (Oxalates)
0 (Dentin Desensitizing Agents)
05175J654G (Niobium)
Entry Date(s): Date Created: 20251126 Date Completed: 20251126 Latest Revision: 20260723
Update Code: 20260723
PubMed Central ID: PMC12641587
DOI: 10.1590/0103-644020256534
PMID: 41294207
Βάση Δεδομένων: MEDLINE
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  Data: Development of Bioactive Niobium Oxalate-Based Desensitizer: Permeability and Formation of Nanoprecursors.
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  Data: <searchLink fieldCode="AU" term="%22Saldanha+LMSN%22">Saldanha LMSN</searchLink>; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil.<br /><searchLink fieldCode="AU" term="%22Ferreira+PVC%22">Ferreira PVC</searchLink>; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil.<br /><searchLink fieldCode="AU" term="%22Gomes+FS%22">Gomes FS</searchLink>; Department of Biomedical Sciences, Ethics, Research, and Education School of Dentistry, Universidad de los Andes, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Bermejo+GN%22">Bermejo GN</searchLink>; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos+CCD%22">Santos CCD</searchLink>; Graduate Program in Physics, Federal University of Maranhão (UFMA), São Luís, 65085-580, Brazil.<br /><searchLink fieldCode="AU" term="%22Bauer+J%22">Bauer J</searchLink>; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil.<br /><searchLink fieldCode="AU" term="%22Martins+DL%22">Martins DL</searchLink>; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil.
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  Data: <searchLink fieldCode="JN" term="%229214652%22">Brazilian dental journal</searchLink> [Braz Dent J] 2025 Nov 21; Vol. 36, pp. e256534. <i>Date of Electronic Publication: </i>2025 Nov 21 (<i>Print Publication: </i>2025).
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: English
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Dental+Foundation+of+Ribeirão+Preto%22">Dental Foundation of Ribeirão Preto </searchLink><i>Country of Publication: </i>Brazil <i>NLM ID: </i>9214652 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1806-4760 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201036440%22">01036440 </searchLink><i>NLM ISO Abbreviation: </i>Braz Dent J <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: Ribeirão Preto : Dental Foundation of Ribeirão Preto, [1990-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Oxalates%22">Oxalates*</searchLink>/<searchLink fieldCode="MM" term="%22Oxalates+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Dentin+Desensitizing+Agents%22">Dentin Desensitizing Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Dentin+Desensitizing+Agents+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Dentin+Desensitizing+Agents%22">Dentin Desensitizing Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Dentin+Desensitizing+Agents+chemical+synthesis%22">chemical synthesis</searchLink> <br /><searchLink fieldCode="MM" term="%22Niobium%22">Niobium*</searchLink>/<searchLink fieldCode="MM" term="%22Niobium+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Dentin+Permeability%22">Dentin Permeability*</searchLink>/<searchLink fieldCode="MM" term="%22Dentin+Permeability+drug+effects%22">drug effects</searchLink><br /><searchLink fieldCode="MH" term="%22Microscopy%2C+Electron%2C+Scanning%22">Microscopy, Electron, Scanning</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Permeability%22">Permeability</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: To evaluate the obliteration of dentinal tubules by experimental pastes with different concentrations of niobium oxalate compared to commercial pastes. Experimental pastes were synthesized from mixtures of different concentrations of sodium carboxymethylcellulose and ammonium niobium oxalate. Twenty-five dentin discs, each 1.5 mm thick, were obtained from molars and divided into five experimental groups (n=5): 1) Oxagel (Kota, Brazil); 2) Desensibilize KF 2% (FGM, Brazil); 3) Paste with 5% niobium oxalate (wt%); 4) Paste with 10% niobium oxalate; 5) Paste with 20% niobium oxalate. The pastes were applied, and initial permeability readings were taken immediately, as well as at 7, 14, and 21 days. Measurements were made using the THDO3d device (Odeme, Brazil). Scanning electron microscopy images and analysis of precipitate formation were performed after 21 days (SEM/EDS). The commercial groups showed a greater reduction in Lp (hydraulic conductance) after 7 days, which remained constant until 21 days. The experimental groups, regardless of concentration, showed a high reduction in permeability immediately. SEM images revealed the formation of a thick layer composed of precipitate and the successive application of the material for all experimental groups. Niobium oxalate pastes are capable of significantly reducing dentinal permeability in both the short and long term, regardless of the concentration applied.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: J Dent. 2019 Feb;81:1-6. (PMID: <searchLink fieldCode="PM" term="%2230639724%22">30639724)</searchLink><br />J Oral Rehabil. 2019 Oct;46(10):952-990. (PMID: <searchLink fieldCode="PM" term="%2231216069%22">31216069)</searchLink><br />Polymers (Basel). 2022 Feb 14;14(4):. (PMID: <searchLink fieldCode="PM" term="%2235215641%22">35215641)</searchLink><br />Sci Rep. 2018 Mar 20;8(1):4888. (PMID: <searchLink fieldCode="PM" term="%2229559639%22">29559639)</searchLink><br />J Dent. 2019 Oct;89:103180. (PMID: <searchLink fieldCode="PM" term="%2231415787%22">31415787)</searchLink><br />ACS Omega. 2021 Jul 20;6(30):19596-19605. (PMID: <searchLink fieldCode="PM" term="%2234368546%22">34368546)</searchLink><br />Braz Dent J. 2016 May-Jun;27(3):325-31. (PMID: <searchLink fieldCode="PM" term="%2227224568%22">27224568)</searchLink><br />J Oral Rehabil. 2017 Feb;44(2):112-118. (PMID: <searchLink fieldCode="PM" term="%2227973740%22">27973740)</searchLink><br />J Prosthodont Res. 2015 Apr;59(2):129-35. (PMID: <searchLink fieldCode="PM" term="%2225659301%22">25659301)</searchLink><br />Biomed Mater. 2006 Mar;1(1):16-23. (PMID: <searchLink fieldCode="PM" term="%2218458381%22">18458381)</searchLink><br />J Mech Behav Biomed Mater. 2018 Feb;78:188-195. (PMID: <searchLink fieldCode="PM" term="%2229169095%22">29169095)</searchLink><br />Oper Dent. 2011 Mar-Apr;36(2):222-30. (PMID: <searchLink fieldCode="PM" term="%2221777102%22">21777102)</searchLink><br />ACS Biomater Sci Eng. 2016 May 9;2(5):734-740. (PMID: <searchLink fieldCode="PM" term="%2233440570%22">33440570)</searchLink><br />J Dent Res. 1981 Mar;60(3):686-98. (PMID: <searchLink fieldCode="PM" term="%226937499%22">6937499)</searchLink><br />Clin Oral Investig. 2022 Oct;26(10):6397-6407. (PMID: <searchLink fieldCode="PM" term="%2235767044%22">35767044)</searchLink><br />Nat Commun. 2013;4:1507. (PMID: <searchLink fieldCode="PM" term="%2223422675%22">23422675)</searchLink><br />Dent Mater. 2012 Mar;28(3):252-60. (PMID: <searchLink fieldCode="PM" term="%2222078764%22">22078764)</searchLink><br />Clin Oral Investig. 2019 May;23(5):2129-2141. (PMID: <searchLink fieldCode="PM" term="%2230269174%22">30269174)</searchLink><br />Arch Oral Biol. 1985;30(10):731-7. (PMID: <searchLink fieldCode="PM" term="%223866520%22">3866520)</searchLink><br />J Dent. 2021 Sep;112:103745. (PMID: <searchLink fieldCode="PM" term="%2234252489%22">34252489)</searchLink>
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        Value: 10.1590/0103-644020256534
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        Text: English
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      Pagination:
        StartPage: e256534
    Subjects:
      – SubjectFull: Microscopy, Electron, Scanning
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Permeability
        Type: general
      – SubjectFull: Oxalates chemistry
        Type: general
      – SubjectFull: Dentin Desensitizing Agents chemistry
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      – SubjectFull: Dentin Desensitizing Agents chemical synthesis
        Type: general
      – SubjectFull: Niobium chemistry
        Type: general
      – SubjectFull: Dentin Permeability drug effects
        Type: general
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              Text: 2025 Nov 21
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