Development of Bioactive Niobium Oxalate-Based Desensitizer: Permeability and Formation of Nanoprecursors.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Development of Bioactive Niobium Oxalate-Based Desensitizer: Permeability and Formation of Nanoprecursors.
Συγγραφείς:	Saldanha LMSN; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil., Ferreira PVC; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil., Gomes FS; Department of Biomedical Sciences, Ethics, Research, and Education School of Dentistry, Universidad de los Andes, Santiago, Chile., Bermejo GN; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil., Santos CCD; Graduate Program in Physics, Federal University of Maranhão (UFMA), São Luís, 65085-580, Brazil., Bauer J; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil., Martins DL; Dentistry Biomaterials Laboratory (Biomma), Postgraduate Program in Dentistry at the Federal University of Maranhão (PPGO-UFMA), Zip Code 65080-805 São Luís, MA, Brazil.
Πηγή:	Brazilian dental journal [Braz Dent J] 2025 Nov 21; Vol. 36, pp. e256534. Date of Electronic Publication: 2025 Nov 21 (Print Publication: 2025).
Τύπος έκδοσης:	Journal Article; Research Support, Non-U.S. Gov't
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Dental Foundation of Ribeirão Preto Country of Publication: Brazil NLM ID: 9214652 Publication Model: eCollection Cited Medium: Internet ISSN: 1806-4760 (Electronic) Linking ISSN: 01036440 NLM ISO Abbreviation: Braz Dent J Subsets: MEDLINE
Imprint Name(s):	Original Publication: Ribeirão Preto : Dental Foundation of Ribeirão Preto, [1990-
Ιατρικοί όροι (MeSH):	Oxalates/chemistry , Dentin Desensitizing Agents/chemistry , Dentin Desensitizing Agents/chemical synthesis , Niobium/chemistry , Dentin Permeability*/drug effects, Microscopy, Electron, Scanning ; Humans ; Permeability
Περίληψη:	To evaluate the obliteration of dentinal tubules by experimental pastes with different concentrations of niobium oxalate compared to commercial pastes. Experimental pastes were synthesized from mixtures of different concentrations of sodium carboxymethylcellulose and ammonium niobium oxalate. Twenty-five dentin discs, each 1.5 mm thick, were obtained from molars and divided into five experimental groups (n=5): 1) Oxagel (Kota, Brazil); 2) Desensibilize KF 2% (FGM, Brazil); 3) Paste with 5% niobium oxalate (wt%); 4) Paste with 10% niobium oxalate; 5) Paste with 20% niobium oxalate. The pastes were applied, and initial permeability readings were taken immediately, as well as at 7, 14, and 21 days. Measurements were made using the THDO3d device (Odeme, Brazil). Scanning electron microscopy images and analysis of precipitate formation were performed after 21 days (SEM/EDS). The commercial groups showed a greater reduction in Lp (hydraulic conductance) after 7 days, which remained constant until 21 days. The experimental groups, regardless of concentration, showed a high reduction in permeability immediately. SEM images revealed the formation of a thick layer composed of precipitate and the successive application of the material for all experimental groups. Niobium oxalate pastes are capable of significantly reducing dentinal permeability in both the short and long term, regardless of the concentration applied.
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Substance Nomenclature:	0 (Oxalates) 0 (Dentin Desensitizing Agents) 05175J654G (Niobium)
Entry Date(s):	Date Created: 20251126 Date Completed: 20251126 Latest Revision: 20260723
Update Code:	20260723
PubMed Central ID:	PMC12641587
DOI:	10.1590/0103-644020256534
PMID:	41294207
Βάση Δεδομένων:	MEDLINE

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ISSN:	1806-4760
DOI:	10.1590/0103-644020256534