Academic Journal
Open problems in ageing science: a roadmap for biogerontology.
| Τίτλος: | Open problems in ageing science: a roadmap for biogerontology. |
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| Συγγραφείς: | Talay A; Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Belikov AV; Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., To PKP; Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Alfatemi HH; Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Alon U; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Deelen J; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, 2333 ZC, Leiden, Netherlands.; Max Planck Institute for Biology of Ageing, 50931, Cologne, Germany.; Cologne Excellence Cluster On Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, 50931, Cologne, Germany., Ewald CY; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland., Gems D; Institute of Healthy Ageing, University College London, London, UK., Gorbunova V; Department of Biology, University of Rochester, Rochester, NY, 14627, USA., Gruber J; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Center for Healthy Longevity, National University Health System, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Hägg S; Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet, Stockholm, Sweden., Hemming J; Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Horvath S; Altos Labs, Cambridge, UK., Kaya A; School of Medicine, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908, USA., Lewis CJ; Longevity Escape Velocity Foundation, Francisco, CA, USA., Maier AB; Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Van Der Boechorstsraat 7, 1081 BT, Amsterdam, Netherlands.; NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore, MD11 Clinical Research Centre, #03-01, 10 Medical Drive, Singapore, 117597, Singapore.; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Marinova MB; The Thalion Initiative, 177 Huntington Avenue, 17 Floor, Boston, MA, 02115, USA., Pawelec G; Institute of Immunology, University of Tuebingen, Tuebingen, Germany.; Health Sciences North Research Institute, Sudbury, ON, Canada., Peleg S; Research Group Epigenetics, Metabolism and Longevity, Institute for Farm Animal Biology, 18196, Dummerstorf, Germany., Rattan S; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Scheibye-Knudsen M; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Schmauck-Medina T; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway., Saroyan V; Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Seluanov A; Department of Medicine, University of Rochester Medical Center, Rochester, NY, 14627, USA., Stolzing A; Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Ashby Rd, Loughborough, LE11 3TU, UK., Teeling E; School of Biology and Environmental Science, University College Dublin, Dublin, Ireland., Williams RW; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., White T; The Thalion Initiative, 177 Huntington Avenue, 17 Floor, Boston, MA, 02115, USA., Unfried M; The Thalion Initiative, 177 Huntington Avenue, 17 Floor, Boston, MA, 02115, USA.; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., de Magalhães JP; Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. jp@senescence.info. |
| Πηγή: | GeroScience [Geroscience] 2026 Jun; Vol. 48 (3), pp. 3351-3360. Date of Electronic Publication: 2025 Nov 08. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cham : Springer International Publishing, [2017]- |
| Ιατρικοί όροι (MeSH): | Aging*/physiology , Geroscience*/trends , Geriatrics*/trends , Longevity*/physiology, Humans ; Animals ; Natural Language Processing |
| Περίληψη: | The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These questions were collected through community engagement and further analysed using Natural Language Processing to assess their prevalence in the literature and to identify both well-established and emerging research gaps. The final list is categorised into different topics, including molecular and cellular mechanisms of ageing, comparative biology and the use of model organisms, biomarkers and the development of therapeutic interventions. Both long-standing questions and more recent and specific questions are featured. Our comprehensive compilation is available to the biogerontology community on our website ( www.longevityknowledge.app ). Overall, this work highlights current key research questions in ageing biology and offers a roadmap for fostering future progress in biogerontology. (© 2025. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interest: JPM is CSO of YouthBio Therapeutics, an advisor/consultant for the BOLD Longevity Growth Fund and NOVOS, and the founder of Magellan Science Ltd, a company providing consulting services in longevity science. SH is a founder and paid consultant of the non-profit Epigenetic Clock Development Foundation and a Principal Investigator at the Altos Labs, Cambridge Institute of Science, a biomedical company that works on rejuvenation. With no relation to the present manuscript, CYE declares to be a co-founder and shareholder of Avea Life AG and Lichi3 GmbH and is employed by Novartis. |
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| Grant Information: | P01 AG047200 United States AG NIA NIH HHS; R01 AG043930 United States AG NIA NIH HHS |
| Contributed Indexing: | Keywords: Ageing and longevity science; Biogerontology; Biology of ageing; Database; Natural language processing |
| Entry Date(s): | Date Created: 20251108 Date Completed: 20260714 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13356218 |
| DOI: | 10.1007/s11357-025-01964-4 |
| PMID: | 41205028 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2509-2723 |
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| DOI: | 10.1007/s11357-025-01964-4 |