Academic Journal
Recurrent IgA1-λ-Type PGNMID Achieving Remission with Conventional Immunosuppressive Therapy.
| Τίτλος: | Recurrent IgA1-λ-Type PGNMID Achieving Remission with Conventional Immunosuppressive Therapy. |
|---|---|
| Συγγραφείς: | Chida K; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Oura A; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Takahashi T; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Kiyohara M; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Matsumoto K; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Kyo T; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Ishizuka Y; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Kamei H; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Nakamura Y; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Nakaya I; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan. |
| Πηγή: | Internal medicine (Tokyo, Japan) [Intern Med] 2026 Jun 15; Vol. 65 (12), pp. 1650-1656. Date of Electronic Publication: 2025 Nov 06. |
| Τύπος έκδοσης: | Journal Article; Case Reports |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Japanese Society of Internal Medicine Country of Publication: Japan NLM ID: 9204241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7235 (Electronic) Linking ISSN: 09182918 NLM ISO Abbreviation: Intern Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Tokyo, Japan : Japanese Society of Internal Medicine, [1992- |
| Ιατρικοί όροι (MeSH): | Immunosuppressive Agents*/therapeutic use , Glomerulonephritis, Membranoproliferative*/drug therapy , Glomerulonephritis, Membranoproliferative*/immunology , Immunoglobulin A* , Immunoglobulin lambda-Chains*, Mycophenolic Acid/therapeutic use ; Cyclophosphamide/therapeutic use ; Humans ; Male ; Middle Aged ; Remission Induction ; Recurrence |
| Περίληψη: | A 58-year-old man was admitted to our hospital in April 2013 with elevated serum creatinine levels, proteinuria, and hematuria. A renal biopsy revealed membranoproliferative glomerulonephritis-like changes. Immunofluorescence showed IgA1 and λ light chain deposits along the capillary walls, confirming IgA-λ type proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Complete remission was achieved with glucocorticoid monotherapy in December 2013. After a relapse in April 2021, immunosuppressive treatment, including intravenous cyclophosphamide and subsequent mycophenolate mofetil, led to a complete remission. This case indicates that conventional immunosuppressive therapy may be effective for IgA-type PGNMID. |
| Contributed Indexing: | Keywords: IgA-type PGNMID; clone-directed therapy; immunosuppressive therapy; monoclonal gammopathy of renal significance; proliferative glomerulonephritis with monoclonal immunoglobulin deposits |
| Substance Nomenclature: | 0 (Immunosuppressive Agents) 0 (Immunoglobulin A) HU9DX48N0T (Mycophenolic Acid) 0 (Immunoglobulin lambda-Chains) 8N3DW7272P (Cyclophosphamide) |
| Entry Date(s): | Date Created: 20251105 Date Completed: 20260614 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13349478 |
| DOI: | 10.2169/internalmedicine.6357-25 |
| PMID: | 41192914 |
| Βάση Δεδομένων: | MEDLINE |
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