Academic Journal
Adipocyte Deficiency Promotes Early Development of Mammary Gland Alveolar Epithelial Cell.
| Τίτλος: | Adipocyte Deficiency Promotes Early Development of Mammary Gland Alveolar Epithelial Cell. |
|---|---|
| Συγγραφείς: | Xu J; Nanjing Women and Children's Healthcare Institute, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.; Department of Pediatrics, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China., Sun Q; Nanjing Women and Children's Healthcare Institute, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.; Department of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China., Xu L; Nanjing Women and Children's Healthcare Institute, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China., Liu L; Department of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China., Liu L; Nanjing Women and Children's Healthcare Institute, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China. |
| Πηγή: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Nov 15; Vol. 39 (21), pp. e71219. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2020- : [Bethesda, Md.] : Hoboken, NJ : Federation of American Societies for Experimental Biology ; Wiley Original Publication: [Bethesda, Md.] : The Federation, [c1987- |
| Ιατρικοί όροι (MeSH): | Adipocytes*/metabolism , Adipocytes*/cytology , Mammary Glands, Animal*/cytology , Mammary Glands, Animal*/metabolism , Mammary Glands, Animal*/growth & development , Alveolar Epithelial Cells*/metabolism , Alveolar Epithelial Cells*/cytology, Cell Differentiation/physiology ; Integrin beta1/metabolism ; STAT5 Transcription Factor/metabolism ; Epithelial Cells/metabolism ; Animals ; Female ; Mice ; Pregnancy ; Lactation ; Apoptosis ; Mice, Transgenic |
| Περίληψη: | Adipocytes undergo dramatic changes during to support the development of the mammary gland. However, their precise role and mechanism of action in pregnancy and lactation remain poorly understood. To explore how adipocyte elimination influences alveolar epithelial cells (AECs) in the mammary gland, we mated mice expressing the diphtheria toxin receptor (iDTR) to those bearing the adiponectin (adipoq) cre. Using this mouse model of inducible and transient adipocyte ablation, we demonstrated that adipocyte loss promotes early development of AECs. During pregnancy, adipocyte loss induces activation of STAT5 through integrin β1/RAC1, which promotes early differentiation of AECs. During lactation, adipocyte loss results in upregulation of TGFβ/WNT5A expression, thereby triggering early apoptosis of AECs. Collectively, our findings reveal an unanticipated, stage-specific regulatory function of adipocytes in orchestrating AECs development during pregnancy and lactation. (© 2025 Federation of American Societies for Experimental Biology.) |
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| Grant Information: | 82301824 MOST | National Natural Science Foundation of China (NSFC); 82401893 MOST | National Natural Science Foundation of China (NSFC) |
| Contributed Indexing: | Keywords: adipocyte; alveolar epithelial cell; development; lactation; mammary gland |
| Substance Nomenclature: | 0 (Integrin beta1) 0 (STAT5 Transcription Factor) |
| Entry Date(s): | Date Created: 20251104 Date Completed: 20251104 Latest Revision: 20260216 |
| Update Code: | 20260216 |
| DOI: | 10.1096/fj.202503289R |
| PMID: | 41186192 |
| Βάση Δεδομένων: | MEDLINE |
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