Academic Journal
Burden of Central Nervous System Cancer in the United States, 1990-2021.
| Τίτλος: | Burden of Central Nervous System Cancer in the United States, 1990-2021. |
|---|---|
| Συγγραφείς: | Han HJ; Department of Neurosurgery, Yonsei University, Seoul, South Korea., Kim YS; Department of Medicine, Yonsei University, Seoul, South Korea., Park S; Department of Biomedical Data Science, Stanford University, Stanford, California., Shin JI; Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea., Kim MS; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Massachusetts General Hospital, Boston., Moon JH; Severance Hospital, Yonsei University, Seoul, South Korea., Kim YB; Department of Neurosurgery, Yonsei University, Seoul, South Korea., Ababneh HS; Department of Radiation Oncology, Massachusetts General Hospital, Boston., Abu-Zaid A; Department of Biochemistry and Molecular Medicine, Alfaisal University, Riyadh, Saudi Arabia.; College of Graduate Health Sciences, University of Tennessee, Memphis., Areda D; College of Art and Science, Ottawa University, Surprise, Arizona.; School of Life Sciences, Arizona State University, Tempe., Arul S; Department of Neurological Surgery, University of California, San Francisco., Azzam AY; ASIDE Healthcare, Lewes, Delaware.; Faculty of Medicine, October 6 University, 6th of October City, Egypt., Bardhan M; Miller School of Medicine, University of Miami, Miami, Florida., Bayat Tork MA; Biological Science Division, University of Chicago, Chicago, Illinois., Behnam B; Avicenna Biotech Research, Germantown, Maryland.; Department of Regulatory Affairs, Amarex Clinical Research, Germantown, Maryland., Bilgin GB; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Bhardwaj PV; Division of Hematology Oncology, University of Massachusetts Medical School, Springfield., Bhuyan SS; Department of Health Administration, Rutgers University, New Brunswick, New Jersey., Lomer NB; Department of Radiology, University of Pennsylvania, Philadelphia., Chen MX; School of Dentistry, University of Michigan, Ann Arbor., Chennapragada SS; Department of Hematology-Oncology, LSU Health Shreveport, Shreveport, Louisiana., Dai X; Institute for Health Metrics and Evaluation, University of Washington, Seattle.; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle., Dean FE; Institute for Health Metrics and Evaluation, University of Washington, Seattle.; Department of Mathematics, University of California, Berkeley., Deekonda S; Department of Pediatrics, Brookdale University Hospital Medical Center, Brooklyn, New York., Ding X; Joe C. Wen School of Population & Public Health, University of California, Irvine., Doshi OP; Independent Consultant, South Plainfield, New Jersey., E'mar AR; Department of Pediatrics, Cleveland Clinic, Cleveland, Ohio., Elhadi M; Faculty of Medicine, University of Tripoli, Tripoli, Libya.; Houston Methodist Hospital, Houston, Texas., Fares J; Department of Neurological Surgery, Northwestern University, Chicago, Illinois., Fazeli P; Department of Biology and Medicine, Brown University, Providence, Rhode Island., Fisher JL; James Cancer Hospital at The Ohio State University, Ohio State University, Columbus., Fotouhi M; Department of Radiology, University of Southern California, Los Angeles.; Department of Medicine, Iran University of Medical Sciences, Tehran, Iran., Gholamrezanezhad A; Department of Radiology, University of Southern California, Los Angeles., Ida F; Pharmacoepidemiology Department, Sanofi, Cambridge, Massachusetts., Iwu CD; School of Health Systems and Public Health, University of Washington, Seattle., Jalloh M; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee.; Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran., Jani CT; Department of Internal Medicine, Harvard University, Cambridge, Massachusetts., Kalani R; Department of Neurology, University of Washington, Seattle., Kankam SB; Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts., Kazemi F; Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland., Keshwani A; Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Khosla AA; Department of Internal Medicine, Corewell Health East William Beaumont University Hospital, Royal Oak, Michigan.; Department of Medical Oncology, Miami Cancer Institute, Miami, Florida., Lim SS; Institute for Health Metrics and Evaluation, University of Washington, Seattle.; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle., Mehboob R; National Heart, Lung, and Blood Institute, Bethesda, Maryland.; Research and Development Department, Lahore Medical Research Center, Lahore, Pakistan., Mestrovic T; Institute for Health Metrics and Evaluation, University of Washington, Seattle.; University Centre Varazdin, University North, Varazdin, Croatia., Mokdad AH; Institute for Health Metrics and Evaluation, University of Washington, Seattle.; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle., Murray CJL; Institute for Health Metrics and Evaluation, University of Washington, Seattle.; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle., Naik G; Department of Health Services Research, University of Alabama at Birmingham., Natto ZS; Department of Dental Public Health, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Health Policy and Oral Epidemiology, Harvard University, Boston, Massachusetts., Nguyen D; Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.; Department of Medical Engineering, University of South Florida, Tampa., Nugen F; Department of Radiology, Mayo Clinic, Rochester, Minnesota.; School of Information, University of California, Berkeley., Orscelik A; Department of Neurosurgery, University of California, San Francisco., Parikh RR; Division of Health Policy and Management, University of Minnesota, Minneapolis., Penberthy L; Institute for Health Metrics and Evaluation, University of Washington, Seattle., Pestell RG; Pennsylvania Cancer and Regenerative Medicine Center, Baruch S. Blumberg Institute, Doylestown.; Department of Medicine, Xavier University School of Medicine, Woodbury, New York., Prabhu D; Independent Consultant, San Diego, California., Puvvula J; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia., Ramasamy SK; Department of Radiology, Stanford University, Stanford, California., Sabet CJ; Department of Medicine, Georgetown University, Washington, DC., Schumacher AE; Institute for Health Metrics and Evaluation, University of Washington, Seattle., Senol YC; Department of Neurosurgery, University of California, San Francisco., Sham S; Department of Pathology and Laboratory Medicine, Northwell Health, New York, New York., Sherchan SP; Department of Biology, Morgan State University, Baltimore, Maryland.; Department of Environmental Health Sciences, Tulane University, New Orleans, Louisiana., Simegn GL; Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland., Singh JA; School of Medicine, Baylor College of Medicine, Houston, Texas.; Department of Medicine Service, US Department of Veterans Affairs, Houston, Texas., Solanki R; Department of Systemic Pathology, Touro College of Osteopathic Medicine, Middletown, New York.; Department of Pathology, American University of the Caribbean School of Medicine, Cupecoy, Saint Martin., Srichawla BS; Department of Neurology, University of Massachusetts Medical School, Worcester., Taiba J; Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha.; Sri Ramachandra Medical College and Research Institute, Chennai, India., Tanwar M; Department of Radiology, University of Alabama at Birmingham., Amirikah MT; Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts., Verma A; Department of Internal Medicine, Texas Tech University, Odessa., Yunusa I; Department of Clinical Pharmacy and Outcomes Sciences, University of South Carolina, Columbia., Zheng DX; Department of Medicine, Massachusetts General Hospital, Boston., Yon DK; Department of Pediatrics, Kyung Hee University, Seoul, South Korea., Park KY; Department of Neurosurgery, Yonsei University, Seoul, South Korea. |
| Συλλογικό Έργο: | GBD 2021 US CNS Cancer Collaborators |
| Πηγή: | JAMA neurology [JAMA Neurol] 2026 Jan 01; Vol. 83 (1), pp. 35-48. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Chicago, IL : American Medical Association, [2013]- |
| Ιατρικοί όροι (MeSH): | Central Nervous System Neoplasms*/epidemiology , Central Nervous System Neoplasms*/mortality , Cost of Illness*, United States/epidemiology ; Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Cross-Sectional Studies ; Incidence ; Disability-Adjusted Life Years ; Young Adult ; Adolescent ; Child, Preschool ; Child ; Aged, 80 and over ; Infant ; Prevalence ; Global Burden of Disease ; Infant, Newborn |
| Περίληψη: | Importance: Primary brain and central nervous system cancer (collectively referred to as CNS cancer) comprises 2% of all human cancers and poses significant health and economic challenges in the United States. Objective: To analyze CNS cancer burden in the US, stratified by time, location (state and division), sex, age group, and Sociodemographic Index (SDI). Design, Setting, and Participants: This cross-sectional study involved a repeated analysis of Global Burden of Disease Study (GBD) 2021 data in 2024. Using data from 183 sources, CNS cancer metrics in the US were estimated across states and years. US CNS cancer metrics across all sexes and age groups were included in the GBD. Exposure: CNS cancer diagnosis. Main Outcomes and Measures: Overall and age-standardized estimates of the incidence, prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost, and years lived with disability per 100 000 population, including 95% uncertainty intervals (UIs), and time trends. Results: In 2021, for all age groups and sexes across the US, there were 31 780 incident cases (95% UI, 29971.1 to 32843.9). Age-standardized incidence, DALYs, and mortality rates per 100 000 population were 6.91 (95% UI, 6.58 to 7.12), 134.38 (95% UI, 129.83 to 137.95), and 4.1 (95% UI, 3.87 to 4.22), respectively. Despite no significant change observed in the overall incidence between 1990 and 2021, DALY and mortality rates decreased by 15.77% (95% UI, -17.75% to -13.68%) and 8.41% (95% UI, -11.09% to -6.22%), respectively. Substantial geographic variability was noted. Mississippi, Alabama, Kentucky, and Kansas (West North Central and East South Central divisions) and West Virginia faced persistently high burdens over the past 30 years. Sex differences were evident; disease burden was consistently higher in males compared with females. Age-specific estimates showed a bimodal distribution: the youngest group (<5 years) showed a significant decrease in incidence rate (-34.42% to -11.56%), whereas older age groups (>70 years) experienced increasing trends. DALYs and mortality rates were negatively correlated with SDI (ρ = -0.6860 and ρ = -0.6391; P < .001). Conclusions and Relevance: These findings provide valuable insights into the CNS cancer burden across the US by age, sex, location, and SDI, enabling better public health status assessments, health care policy restructuring, and resource redistribution for improved care. |
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| Entry Date(s): | Date Created: 20251103 Date Completed: 20260112 Latest Revision: 20260917 |
| Update Code: | 20260917 |
| PubMed Central ID: | PMC12584065 |
| DOI: | 10.1001/jamaneurol.2025.4286 |
| PMID: | 41182787 |
| Βάση Δεδομένων: | MEDLINE |
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