Academic Journal
Comparative assessment of early neointimal formation: P8RI-coated Silk Vista versus Pipeline Vantage (Shield) in a rabbit model using optical coherence tomography.
| Τίτλος: | Comparative assessment of early neointimal formation: P8RI-coated Silk Vista versus Pipeline Vantage (Shield) in a rabbit model using optical coherence tomography. |
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| Συγγραφείς: | Cortese J; EMIS Research Laboratory, CHU Limoges, Limoges, France jon.cortese@live.fr.; NEURI Vascular Center, Hôpital Bicêtre NEURI, Le Kremlin-Bicêtre, France.; CNRS, XLIM, UMR 7252, University of Limoges, Limoges, France.; INSERM U1195, Paris-Saclay University Faculty of Medecine, Le Kremlin-Bicetre, France., Forestier G; EMIS Research Laboratory, CHU Limoges, Limoges, France., Bardet SM; EMIS Research Laboratory, CHU Limoges, Limoges, France.; CNRS, XLIM, UMR 7252, University of Limoges, Limoges, France., Baudouin M; EMIS Research Laboratory, CHU Limoges, Limoges, France.; Interventional neuroradiology, Centre Hospitalier Universitaire de Limoges, Limoges, France., Chauvet R; EMIS Research Laboratory, CHU Limoges, Limoges, France.; Vascular Surgery, CHU Limoges, Limoges, France., Perrin ML; EMIS Research Laboratory, CHU Limoges, Limoges, France.; CNRS, XLIM, UMR 7252, University of Limoges, Limoges, France., Belgacem A; EMIS Research Laboratory, CHU Limoges, Limoges, France., Diana F; EMIS Research Laboratory, CHU Limoges, Limoges, France.; Interventional Neuroradiology, Vall d'Hebron University Hospital, Barcelona, Spain.; Vall d'Hebron Research Institute, Barcelona, Spain., Ratsimbazafy V; Pharmacy, University-hospital of Limoges, Limoges, France.; Inserm U1094, IRD U270, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d'Epidémiologie et de Neurologie Tropicale, OmegaHealth, University of Limoges, Limoges, France., Coulomb M; Pharmacy, University-hospital of Limoges, Limoges, France.; Inserm U1094, IRD U270, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d'Epidémiologie et de Neurologie Tropicale, OmegaHealth, University of Limoges, Limoges, France., D'Arrigo M; Pharmacy, University-hospital of Limoges, Limoges, France.; Inserm U1094, IRD U270, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d'Epidémiologie et de Neurologie Tropicale, OmegaHealth, University of Limoges, Limoges, France., Lefebvre E; Pharmacy, University-hospital of Limoges, Limoges, France.; Inserm U1094, IRD U270, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d'Epidémiologie et de Neurologie Tropicale, OmegaHealth, University of Limoges, Limoges, France., Dulaurent S; Pharmacy, University-hospital of Limoges, Limoges, France.; Inserm U1094, IRD U270, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d'Epidémiologie et de Neurologie Tropicale, OmegaHealth, University of Limoges, Limoges, France., Sasselina G; EMIS Research Laboratory, CHU Limoges, Limoges, France., Chandellier D; EMIS Research Laboratory, CHU Limoges, Limoges, France., Mounier J; EMIS Research Laboratory, CHU Limoges, Limoges, France., Couquet C; EMIS Research Laboratory, CHU Limoges, Limoges, France., Croguennec C; EMIS Research Laboratory, CHU Limoges, Limoges, France., Micallef L; EMIS Research Laboratory, CHU Limoges, Limoges, France., Le Flahec A; EMIS Research Laboratory, CHU Limoges, Limoges, France., Dubois N; EMIS Research Laboratory, CHU Limoges, Limoges, France., Spelle L; NEURI Vascular Center, Hôpital Bicêtre NEURI, Le Kremlin-Bicêtre, France.; INSERM U1195, Paris-Saclay University Faculty of Medecine, Le Kremlin-Bicetre, France., Mounayer C; EMIS Research Laboratory, CHU Limoges, Limoges, France.; Interventional Neuroradiology, CHU Limoges, Limoges, France., Terro F; CNRS, XLIM, UMR 7252, University of Limoges, Limoges, France.; Cell Biology, CHU Limoges, Limoges, France., Rouchaud A; EMIS Research Laboratory, CHU Limoges, Limoges, France.; CNRS, XLIM, UMR 7252, University of Limoges, Limoges, France.; Interventional neuroradiology, Centre Hospitalier Universitaire de Limoges, Limoges, France. |
| Πηγή: | Journal of neurointerventional surgery [J Neurointerv Surg] 2026 Sep 14; Vol. 18 (10), pp. 2027-2033. Date of Electronic Publication: 2026 Sep 14. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101517079 Publication Model: Electronic Cited Medium: Internet ISSN: 1759-8486 (Electronic) Linking ISSN: 17598478 NLM ISO Abbreviation: J Neurointerv Surg Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BMJ Publishing Group, c2009- |
| Ιατρικοί όροι (MeSH): | Tomography, Optical Coherence*/methods , Tomography, Optical Coherence*/standards , Neointima*/diagnostic imaging , Neointima*/pathology , Stents* , Silk* , Coated Materials, Biocompatible*, Animals ; Rabbits ; Disease Models, Animal ; Male |
| Περίληψη: | Background: Several coating strategies have been recently introduced to reduce thrombogenicity of flow diverters (FDs), while the P8RI coating focuses on stimulating endothelial cells for faster arterial healing. This study aims to evaluate early neointimal growth over the FD struts by comparing these two strategies in an animal model. Methods: Bare Silk Vista (bare-SV), P8RI Silk Vista (P8RI-SV), and Pipeline Vantage with Shield technology (Shield-PV) were implanted in rabbits to treat elastase-induced aneurysms (n=6, 10, and 7, respectively) and in the aorta (n=6, 7, and 4, respectively). At 5 and 28 days, the devices were imaged with optical coherence tomography (OCT) to evaluate the stent-coverage ratio. Conventional histology and multiphoton microscopy were also performed. Results: The aneurysm occlusion rate was similar in all three groups (P=0.577). On OCT images, the stent-coverage ratio on day 5 and day 28 (overall and at each location) was significantly higher with P8RI-SV compared with both bare-SV and Shield-PV (Kruskal-Wallis P<0.0001, Dunn post-test P<0.001 for both timepoints). Histological and multiphoton microscopy evaluations confirmed that the struts of P8RI-SV were covered by well-organized neointima expressing a high rate of collagen at the aneurysm neck and in the aorta, compatible with an advanced stage of tissue remodeling and stabilized neointima. Conclusion: P8RI-SV demonstrated higher rates of neointimal formation covering the FD struts compared with bare-SV and Shield-PV at day 5 and day 28 in rabbits. These results confirm faster and improved arterial healing with P8RI coating; however, further studies are needed to evaluate the clinical benefits in patients. (© Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group.) |
| Competing Interests: | Competing interests: JC received an educational grant from Balt, Medtronic, Phenox, Microvention, the Philippe Foundation, the French Society of Radiology, and the French Society of Neuroradiology; and received honoraria for lectures from Balt. CM received honoraria for lectures from Balt. LS is a consultant for Microvention, Balt, Phenox, Stryker, Medtronic. AR received honoraria for lectures from Balt. |
| Contributed Indexing: | Keywords: Aneurysm; Flow Diverter; Intervention |
| Substance Nomenclature: | 0 (Silk) 0 (Coated Materials, Biocompatible) |
| Entry Date(s): | Date Created: 20251024 Date Completed: 20260914 Latest Revision: 20260914 |
| Update Code: | 20260915 |
| DOI: | 10.1136/jnis-2025-024213 |
| PMID: | 41136214 |
| Βάση Δεδομένων: | MEDLINE |
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